Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	116835
Gene name	Heat shock protein family A (Hsp70) member 12B
Gene symbol	HSPA12B
Synonyms (NCBI Gene)	C20orf60
Chromosome	20
Chromosome location	20p13
Summary	The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results

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miRTarBase ID	miRNA	Experiments	Reference
MIRT616052	hsa-miR-6873-5p	HITS-CLIP	23824327
MIRT616051	hsa-miR-4496	HITS-CLIP	23824327
MIRT616050	hsa-miR-9500	HITS-CLIP	23824327
MIRT616049	hsa-miR-33b-3p	HITS-CLIP	23824327
MIRT616048	hsa-miR-515-3p	HITS-CLIP	23824327
MIRT616047	hsa-miR-519e-3p	HITS-CLIP	23824327
MIRT616046	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT616045	hsa-miR-6719-3p	HITS-CLIP	23824327
MIRT616044	hsa-miR-1271-3p	HITS-CLIP	23824327
MIRT616043	hsa-miR-550a-3-5p	HITS-CLIP	23824327
MIRT616042	hsa-miR-550a-5p	HITS-CLIP	23824327
MIRT616041	hsa-miR-877-5p	HITS-CLIP	23824327
MIRT616040	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT616039	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT616038	hsa-miR-651-5p	HITS-CLIP	23824327
MIRT616052	hsa-miR-6873-5p	HITS-CLIP	23824327
MIRT616051	hsa-miR-4496	HITS-CLIP	23824327
MIRT616050	hsa-miR-9500	HITS-CLIP	23824327
MIRT616049	hsa-miR-33b-3p	HITS-CLIP	23824327
MIRT616048	hsa-miR-515-3p	HITS-CLIP	23824327
MIRT616047	hsa-miR-519e-3p	HITS-CLIP	23824327
MIRT616046	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT616045	hsa-miR-6719-3p	HITS-CLIP	23824327
MIRT616044	hsa-miR-1271-3p	HITS-CLIP	23824327
MIRT616043	hsa-miR-550a-3-5p	HITS-CLIP	23824327
MIRT616042	hsa-miR-550a-5p	HITS-CLIP	23824327
MIRT616041	hsa-miR-877-5p	HITS-CLIP	23824327
MIRT616040	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT616039	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT616038	hsa-miR-651-5p	HITS-CLIP	23824327
MIRT1056004	hsa-miR-519e	CLIP-seq
MIRT1056005	hsa-miR-550a	CLIP-seq
MIRT1056006	hsa-miR-877	CLIP-seq
MIRT1056007	hsa-miR-1539	CLIP-seq
MIRT1056008	hsa-miR-1976	CLIP-seq
MIRT1056009	hsa-miR-3193	CLIP-seq
MIRT1056010	hsa-miR-3667-3p	CLIP-seq
MIRT1056011	hsa-miR-4691-5p	CLIP-seq
MIRT1056004	hsa-miR-519e	CLIP-seq
MIRT1056005	hsa-miR-550a	CLIP-seq
MIRT1056006	hsa-miR-877	CLIP-seq
MIRT1056004	hsa-miR-519e	CLIP-seq
MIRT1056005	hsa-miR-550a	CLIP-seq
MIRT1056006	hsa-miR-877	CLIP-seq
MIRT1056004	hsa-miR-519e	CLIP-seq
MIRT1056005	hsa-miR-550a	CLIP-seq
MIRT1056006	hsa-miR-877	CLIP-seq
MIRT1056004	hsa-miR-519e	CLIP-seq
MIRT1056005	hsa-miR-550a	CLIP-seq
MIRT1056006	hsa-miR-877	CLIP-seq
MIRT2245176	hsa-miR-1289	CLIP-seq
MIRT1056007	hsa-miR-1539	CLIP-seq
MIRT1056009	hsa-miR-3193	CLIP-seq
MIRT2245177	hsa-miR-3198	CLIP-seq
MIRT2245178	hsa-miR-4294	CLIP-seq
MIRT2245179	hsa-miR-4309	CLIP-seq
MIRT2245180	hsa-miR-4436b-5p	CLIP-seq
MIRT2245181	hsa-miR-516b	CLIP-seq
MIRT1056004	hsa-miR-519e	CLIP-seq
MIRT1056005	hsa-miR-550a	CLIP-seq
MIRT2245182	hsa-miR-642a	CLIP-seq
MIRT1056006	hsa-miR-877	CLIP-seq
MIRT1056004	hsa-miR-519e	CLIP-seq
MIRT1056005	hsa-miR-550a	CLIP-seq
MIRT1056006	hsa-miR-877	CLIP-seq
MIRT2682468	hsa-miR-3176	CLIP-seq
MIRT2682469	hsa-miR-3922-3p	CLIP-seq
MIRT2682470	hsa-miR-4317	CLIP-seq
MIRT2682471	hsa-miR-4469	CLIP-seq
MIRT2682472	hsa-miR-4757-5p	CLIP-seq
MIRT2245182	hsa-miR-642a	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001525	Process	Angiogenesis	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0043542	Process	Endothelial cell migration	IEA

MIM	HGNC	e!Ensembl
610702	16193	ENSG00000132622

Q96MM6

Protein name

Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B)

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Highest expression in muscle and heart. Lower levels in liver and kidney. {ECO:0000269|PubMed:12552099}.

Sequence

MLAVPEMGLQGLYIGSSPERSPVPSPPGSPRTQESCGIAPLTPSQSPKPEVRAPQQASFS
VVVAIDFGTTSSGYAFSFASDPEAIHMMRKWEGGDPGVAHQKTPTCLLLTPEGAFHSFGY
TARDYYHDLDPEEARDWLYFEKFKMKIHSATDLTLKTQLEAVNGKTMPALEVFAHALRFF
REHALQELREQSPSLPEKDTVRWVLTVPAIWKQPAKQFMREAAYLAGLVSRENAEQLLIA
LEPEAASVYCRKLRLHQLLDLSGRAPGGGRLGERRSIDSSFRQAREQLRRSRHSRTFLVE
SGVGELWAEMQAGDRYVVADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAF
EQLLCRIFGEDFIATFKRQRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFSFIDFYRK
QRGHNVETALRRSSVNFVKWSSQGMLRMSCEAMNELFQPTVSGIIQHIEALLARPEVQGV
KLLFLVGGFAESAVLQHAVQAALGARGLRVVVPHDVGLTILKGAVLFGQAPGVVRVRRSP
LTYGVGVLNRFVPGRHPPEKLLVRDGRRWCTDVFERFVAAEQSVALGEEVRRSYCPARPG
QRRVLINLYCCAAEDARFITDPGVRKCGALSLELEPADCGQDTAGAPPGRREIRAAMQFG
DTEIKVTAVDVSTNRSVRASIDFLSN

Sequence length

686

Interactions

View interactions

	Reactome
			Regulation of HSF1-mediated heat shock response

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PULMONARY EDEMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Asthma	Asthma	BEFREE	23331525		★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	27387956	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	29556279		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	29954368	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	25909170, 30195756		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	29411514		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	37033211	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	23046810, 29411514		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	25909170		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	25909170, 30195756		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	28281242		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29556279		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	29556279		★★★★★ ★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	20733008, 28535510		★★★★★ ★☆☆☆☆ Found in Text Mining only

HSPA12B (heat shock protein family A (Hsp70) member 12B)