Gene Gene information from NCBI Gene database.
Entrez ID 1164
Gene name CDC28 protein kinase regulatory subunit 2
Gene symbol CKS2
Synonyms (NCBI Gene)
CKSHS2
Chromosome 9
Chromosome location 9q22.2
Summary CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role
miRNA miRNA information provided by mirtarbase database.
242
miRTarBase ID miRNA Experiments Reference
MIRT022264 hsa-miR-124-3p Microarray 18668037
MIRT052270 hsa-let-7b-5p CLASH 23622248
MIRT053077 hsa-miR-26a-5p FlowWestern blot 23861775
MIRT325435 hsa-miR-548ae-3p HITS-CLIP 19536157
MIRT325436 hsa-miR-548ah-3p HITS-CLIP 19536157
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
YBX1 Repression 20596676
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IBA
GO:0003682 Function Chromatin binding IEA
GO:0005515 Function Protein binding IPI 2227411, 28514442, 32296183, 33961781
GO:0006357 Process Regulation of transcription by RNA polymerase II IEA
GO:0007127 Process Meiosis I IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
116901 2000 ENSG00000123975
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P33552
Protein name Cyclin-dependent kinases regulatory subunit 2 (CKS-2)
Protein function Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
PDB 1CKS , 4Y72 , 4YC3 , 5HQ0 , 5LQF , 6GU2 , 6GU3 , 6GU4 , 6GU6 , 6GU7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01111 CKS 6 73 Cyclin-dependent kinase regulatory subunit Domain
Sequence
Sequence length 79
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Pathways in cancer
Small cell lung cancer
 
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PELVIC ORGAN PROLAPSE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
POLYCYSTIC OVARY SYNDROME CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 10360827
★☆☆☆☆
Found in Text Mining only
Adrenocortical Carcinoma Adrenocortical carcinoma Pubtator 33667214 Associate
★☆☆☆☆
Found in Text Mining only
Adult Acute Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 10360827
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 35789606 Stimulate
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 35844557 Associate
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma Pubtator 34494924 Stimulate
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm BEFREE 16865252, 20920335, 21672358
★☆☆☆☆
Found in Text Mining only
Bone Diseases Bone disease Pubtator 18005268 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 30957190
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 25674223, 33066779, 33959662, 36284444, 37958803 Associate
★☆☆☆☆
Found in Text Mining only