Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	116039
Gene name	Odd-skipped related transciption factor 2
Gene symbol	OSR2
Synonyms (NCBI Gene)	-
Chromosome	8
Chromosome location	8q22.2
Summary	OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al., 2004 [PubMed 15175245]).[supplied by OMIM, Mar 2008]

153

Show/Hide all (153)

miRTarBase ID	miRNA	Experiments
MIRT1206894	hsa-miR-103a	CLIP-seq
MIRT1206895	hsa-miR-107	CLIP-seq
MIRT1206896	hsa-miR-1184	CLIP-seq
MIRT1206897	hsa-miR-1205	CLIP-seq
MIRT1206898	hsa-miR-1244	CLIP-seq
MIRT1206899	hsa-miR-139-5p	CLIP-seq
MIRT1206900	hsa-miR-142-3p	CLIP-seq
MIRT1206901	hsa-miR-147	CLIP-seq
MIRT1206902	hsa-miR-1910	CLIP-seq
MIRT1206903	hsa-miR-2115	CLIP-seq
MIRT1206904	hsa-miR-302a	CLIP-seq
MIRT1206905	hsa-miR-302b	CLIP-seq
MIRT1206906	hsa-miR-302c	CLIP-seq
MIRT1206907	hsa-miR-302d	CLIP-seq
MIRT1206908	hsa-miR-302e	CLIP-seq
MIRT1206909	hsa-miR-3065-5p	CLIP-seq
MIRT1206910	hsa-miR-3119	CLIP-seq
MIRT1206911	hsa-miR-3160-5p	CLIP-seq
MIRT1206912	hsa-miR-3163	CLIP-seq
MIRT1206913	hsa-miR-3179	CLIP-seq
MIRT1206914	hsa-miR-3185	CLIP-seq
MIRT1206915	hsa-miR-324-5p	CLIP-seq
MIRT1206916	hsa-miR-330-3p	CLIP-seq
MIRT1206917	hsa-miR-361-3p	CLIP-seq
MIRT1206918	hsa-miR-3647-3p	CLIP-seq
MIRT1206919	hsa-miR-3662	CLIP-seq
MIRT1206920	hsa-miR-3665	CLIP-seq
MIRT1206921	hsa-miR-3667-5p	CLIP-seq
MIRT1206922	hsa-miR-372	CLIP-seq
MIRT1206923	hsa-miR-373	CLIP-seq
MIRT1206924	hsa-miR-3911	CLIP-seq
MIRT1206925	hsa-miR-3924	CLIP-seq
MIRT1206926	hsa-miR-3960	CLIP-seq
MIRT1206927	hsa-miR-4254	CLIP-seq
MIRT1206928	hsa-miR-4264	CLIP-seq
MIRT1206929	hsa-miR-4277	CLIP-seq
MIRT1206930	hsa-miR-4282	CLIP-seq
MIRT1206931	hsa-miR-4292	CLIP-seq
MIRT1206932	hsa-miR-4308	CLIP-seq
MIRT1206933	hsa-miR-4424	CLIP-seq
MIRT1206934	hsa-miR-4466	CLIP-seq
MIRT1206935	hsa-miR-4474-3p	CLIP-seq
MIRT1206936	hsa-miR-4487	CLIP-seq
MIRT1206937	hsa-miR-455-3p	CLIP-seq
MIRT1206938	hsa-miR-4633-3p	CLIP-seq
MIRT1206939	hsa-miR-4728-5p	CLIP-seq
MIRT1206940	hsa-miR-4731-5p	CLIP-seq
MIRT1206941	hsa-miR-4733-5p	CLIP-seq
MIRT1206942	hsa-miR-4764-3p	CLIP-seq
MIRT1206943	hsa-miR-4797-3p	CLIP-seq
MIRT1206944	hsa-miR-4797-5p	CLIP-seq
MIRT1206945	hsa-miR-503	CLIP-seq
MIRT1206946	hsa-miR-519a	CLIP-seq
MIRT1206947	hsa-miR-519b-3p	CLIP-seq
MIRT1206948	hsa-miR-519c-3p	CLIP-seq
MIRT1206949	hsa-miR-520a-3p	CLIP-seq
MIRT1206950	hsa-miR-520b	CLIP-seq
MIRT1206951	hsa-miR-520c-3p	CLIP-seq
MIRT1206952	hsa-miR-520d-3p	CLIP-seq
MIRT1206953	hsa-miR-520e	CLIP-seq
MIRT1206954	hsa-miR-558	CLIP-seq
MIRT1206955	hsa-miR-564	CLIP-seq
MIRT1206956	hsa-miR-577	CLIP-seq
MIRT1206957	hsa-miR-582-5p	CLIP-seq
MIRT1206958	hsa-miR-587	CLIP-seq
MIRT1206959	hsa-miR-615-5p	CLIP-seq
MIRT1206960	hsa-miR-644	CLIP-seq
MIRT1206961	hsa-miR-648	CLIP-seq
MIRT1206962	hsa-miR-657	CLIP-seq
MIRT1206963	hsa-miR-675	CLIP-seq
MIRT1206964	hsa-miR-764	CLIP-seq
MIRT1206965	hsa-miR-939	CLIP-seq
MIRT1206898	hsa-miR-1244	CLIP-seq
MIRT1206900	hsa-miR-142-3p	CLIP-seq
MIRT1206901	hsa-miR-147	CLIP-seq
MIRT1206913	hsa-miR-3179	CLIP-seq
MIRT1206924	hsa-miR-3911	CLIP-seq
MIRT1206936	hsa-miR-4487	CLIP-seq
MIRT1206954	hsa-miR-558	CLIP-seq
MIRT1206960	hsa-miR-644	CLIP-seq
MIRT1206961	hsa-miR-648	CLIP-seq
MIRT2059459	hsa-miR-758	CLIP-seq
MIRT2287891	hsa-miR-1231	CLIP-seq
MIRT1206898	hsa-miR-1244	CLIP-seq
MIRT1206900	hsa-miR-142-3p	CLIP-seq
MIRT2287892	hsa-miR-185	CLIP-seq
MIRT2287893	hsa-miR-3150a-3p	CLIP-seq
MIRT2287894	hsa-miR-3175	CLIP-seq
MIRT2287895	hsa-miR-4306	CLIP-seq
MIRT2287896	hsa-miR-4644	CLIP-seq
MIRT2287897	hsa-miR-4667-5p	CLIP-seq
MIRT2287898	hsa-miR-4700-5p	CLIP-seq
MIRT1206939	hsa-miR-4728-5p	CLIP-seq
MIRT2287899	hsa-miR-637	CLIP-seq
MIRT1206961	hsa-miR-648	CLIP-seq
MIRT1206965	hsa-miR-939	CLIP-seq
MIRT1206898	hsa-miR-1244	CLIP-seq
MIRT2431813	hsa-miR-1257	CLIP-seq
MIRT2431814	hsa-miR-1283	CLIP-seq
MIRT1206899	hsa-miR-139-5p	CLIP-seq
MIRT1206900	hsa-miR-142-3p	CLIP-seq
MIRT1206901	hsa-miR-147	CLIP-seq
MIRT1206902	hsa-miR-1910	CLIP-seq
MIRT1206903	hsa-miR-2115	CLIP-seq
MIRT1206904	hsa-miR-302a	CLIP-seq
MIRT1206905	hsa-miR-302b	CLIP-seq
MIRT1206906	hsa-miR-302c	CLIP-seq
MIRT1206907	hsa-miR-302d	CLIP-seq
MIRT1206908	hsa-miR-302e	CLIP-seq
MIRT1206909	hsa-miR-3065-5p	CLIP-seq
MIRT1206910	hsa-miR-3119	CLIP-seq
MIRT1206911	hsa-miR-3160-5p	CLIP-seq
MIRT1206912	hsa-miR-3163	CLIP-seq
MIRT1206913	hsa-miR-3179	CLIP-seq
MIRT1206914	hsa-miR-3185	CLIP-seq
MIRT1206915	hsa-miR-324-5p	CLIP-seq
MIRT1206916	hsa-miR-330-3p	CLIP-seq
MIRT2431815	hsa-miR-3611	CLIP-seq
MIRT1206917	hsa-miR-361-3p	CLIP-seq
MIRT1206918	hsa-miR-3647-3p	CLIP-seq
MIRT1206921	hsa-miR-3667-5p	CLIP-seq
MIRT1206922	hsa-miR-372	CLIP-seq
MIRT1206923	hsa-miR-373	CLIP-seq
MIRT1206924	hsa-miR-3911	CLIP-seq
MIRT1206928	hsa-miR-4264	CLIP-seq
MIRT1206929	hsa-miR-4277	CLIP-seq
MIRT1206930	hsa-miR-4282	CLIP-seq
MIRT1206935	hsa-miR-4474-3p	CLIP-seq
MIRT1206937	hsa-miR-455-3p	CLIP-seq
MIRT1206941	hsa-miR-4733-5p	CLIP-seq
MIRT1206943	hsa-miR-4797-3p	CLIP-seq
MIRT2431816	hsa-miR-494	CLIP-seq
MIRT2431817	hsa-miR-495	CLIP-seq
MIRT1206946	hsa-miR-519a	CLIP-seq
MIRT1206947	hsa-miR-519b-3p	CLIP-seq
MIRT1206948	hsa-miR-519c-3p	CLIP-seq
MIRT1206949	hsa-miR-520a-3p	CLIP-seq
MIRT1206950	hsa-miR-520b	CLIP-seq
MIRT1206951	hsa-miR-520c-3p	CLIP-seq
MIRT1206952	hsa-miR-520d-3p	CLIP-seq
MIRT1206953	hsa-miR-520e	CLIP-seq
MIRT2431818	hsa-miR-561	CLIP-seq
MIRT1206956	hsa-miR-577	CLIP-seq
MIRT1206957	hsa-miR-582-5p	CLIP-seq
MIRT1206958	hsa-miR-587	CLIP-seq
MIRT1206960	hsa-miR-644	CLIP-seq
MIRT1206961	hsa-miR-648	CLIP-seq
MIRT2059459	hsa-miR-758	CLIP-seq
MIRT1206903	hsa-miR-2115	CLIP-seq
MIRT1206912	hsa-miR-3163	CLIP-seq
MIRT1206930	hsa-miR-4282	CLIP-seq
MIRT1206956	hsa-miR-577	CLIP-seq
MIRT1206958	hsa-miR-587	CLIP-seq

Show/Hide all (74)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISS
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	ISS
GO:0001655	Process	Urogenital system development	IBA
GO:0001656	Process	Metanephros development	IEA
GO:0001656	Process	Metanephros development	ISS
GO:0001823	Process	Mesonephros development	IEA
GO:0001823	Process	Mesonephros development	ISS
GO:0002062	Process	Chondrocyte differentiation	IEA
GO:0002062	Process	Chondrocyte differentiation	ISS
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0007389	Process	Pattern specification process	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	ISS
GO:0009792	Process	Embryo development ending in birth or egg hatching	IEA
GO:0009792	Process	Embryo development ending in birth or egg hatching	ISS
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0010628	Process	Positive regulation of gene expression	ISS
GO:0030154	Process	Cell differentiation	IEA
GO:0030154	Process	Cell differentiation	ISS
GO:0030501	Process	Positive regulation of bone mineralization	IEA
GO:0030501	Process	Positive regulation of bone mineralization	ISS
GO:0033687	Process	Osteoblast proliferation	IEA
GO:0033687	Process	Osteoblast proliferation	ISS
GO:0035115	Process	Embryonic forelimb morphogenesis	IEA
GO:0035115	Process	Embryonic forelimb morphogenesis	ISS
GO:0035116	Process	Embryonic hindlimb morphogenesis	IEA
GO:0035116	Process	Embryonic hindlimb morphogenesis	ISS
GO:0036023	Process	Embryonic skeletal limb joint morphogenesis	IEA
GO:0036023	Process	Embryonic skeletal limb joint morphogenesis	ISS
GO:0042474	Process	Middle ear morphogenesis	IEA
GO:0042474	Process	Middle ear morphogenesis	ISS
GO:0042476	Process	Odontogenesis	IEA
GO:0042476	Process	Odontogenesis	ISS
GO:0042733	Process	Embryonic digit morphogenesis	IEA
GO:0042733	Process	Embryonic digit morphogenesis	ISS
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0043565	Function	Sequence-specific DNA binding	ISS
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048704	Process	Embryonic skeletal system morphogenesis	IEA
GO:0048704	Process	Embryonic skeletal system morphogenesis	ISS
GO:0048793	Process	Pronephros development	IBA
GO:0050679	Process	Positive regulation of epithelial cell proliferation	IEA
GO:0050679	Process	Positive regulation of epithelial cell proliferation	ISS
GO:0060021	Process	Roof of mouth development	IEA
GO:0060021	Process	Roof of mouth development	ISS
GO:0060272	Process	Embryonic skeletal joint morphogenesis	IEA
GO:0060272	Process	Embryonic skeletal joint morphogenesis	ISS
GO:0060322	Process	Head development	IEA
GO:0060322	Process	Head development	ISS
GO:0060349	Process	Bone morphogenesis	IEA
GO:0060349	Process	Bone morphogenesis	ISS
GO:0061029	Process	Eyelid development in camera-type eye	IEA
GO:0061029	Process	Eyelid development in camera-type eye	ISS
GO:0072089	Process	Stem cell proliferation	IEA
GO:0072498	Process	Embryonic skeletal joint development	IEA
GO:0072498	Process	Embryonic skeletal joint development	ISS
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IEA
GO:2000648	Process	Positive regulation of stem cell proliferation	IEA

MIM	HGNC	e!Ensembl
611297	15830	ENSG00000164920

Q8N2R0

Protein name

Protein odd-skipped-related 2

Protein function

May be involved in the development of the mandibular molar tooth germ at the bud stage.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00096	zf-C2H2	172 → 194	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	200 → 222	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	228 → 250	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	256 → 278	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	284 → 306	Zinc finger, C2H2 type	Domain

Sequence

MGSKALPAPIPLHPSLQLTNYSFLQAVNTFPATVDHLQGLYGLSAVQTMHMNHWTLGYPN
VHEITRSTITEMAAAQGLVDARFPFPALPFTTHLFHPKQGAIAHVLPALHKDRPRFDFAN
LAVAATQEDPPKMGDLSKLSPGLGSPISGLSKLTPDRKPSRGRLPSKTKKEFICKFCGRH
FTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDHRYIHSKEKPFKCQECGKGFCQS
RTLAVHKTLHMQESPHKCPTCGRTFNQRSNLKTHLLTHTDIKPYSCEQCGKVFRRNCDLR
RHSLTHTPRQDF

Sequence length

312

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ENDOMETRIOSIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
BLEPHAROPHIMOSIS, PTOSIS, AND EPICANTHUS INVERSUS (disorder)	Blepharophimosis, ptosis, and epicanthus inversus syndrome	BEFREE	19429596		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	32555395	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrioma	Endometrioma	CTD_human_DG	20864642		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	CTD_human_DG	20864642		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian Failure, Premature	Ovarian Failure	BEFREE	19429596		★★★★★ ★☆☆☆☆ Found in Text Mining only
Premature Menopause	Premature Menopause	BEFREE	19429596		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	27143812	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uranostaphyloschisis	Uranostaphyloschisis	BEFREE	15175245, 29526646		★★★★★ ★☆☆☆☆ Found in Text Mining only

OSR2 (odd-skipped related transciption factor 2)