DHRS1 (dehydrogenase/reductase 1)

Gene

• Entrez ID: 115817
• Gene name: Dehydrogenase/reductase 1
• Gene symbol: DHRS1
• Synonyms (NCBI Gene): SDR19C1
• Chromosome: 14
• Chromosome location: 14q12
• Summary: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded enzyme contains a conserved catalytic domain and likely functions as an oxidoreductase. Multiple alternatively spliced variants, encoding the same protein, h

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022646	hsa-miR-124-3p	Microarray	18668037
MIRT023693	hsa-miR-1-3p	Proteomics	18668040
MIRT934912	hsa-miR-124	CLIP-seq
MIRT934913	hsa-miR-506	CLIP-seq
MIRT934914	hsa-miR-548aa	CLIP-seq
MIRT1976824	hsa-miR-2467-3p	CLIP-seq
MIRT1976825	hsa-miR-922	CLIP-seq
MIRT2515871	hsa-miR-1236	CLIP-seq
MIRT2515872	hsa-miR-1253	CLIP-seq
MIRT1976824	hsa-miR-2467-3p	CLIP-seq
MIRT2515873	hsa-miR-30a	CLIP-seq
MIRT2515874	hsa-miR-30b	CLIP-seq
MIRT2515875	hsa-miR-30c	CLIP-seq
MIRT2515876	hsa-miR-30d	CLIP-seq
MIRT2515877	hsa-miR-30e	CLIP-seq
MIRT2515878	hsa-miR-3115	CLIP-seq
MIRT2515879	hsa-miR-3158-3p	CLIP-seq
MIRT2515880	hsa-miR-3691-3p	CLIP-seq
MIRT2515881	hsa-miR-4700-3p	CLIP-seq
MIRT2515882	hsa-miR-4721	CLIP-seq
MIRT2515883	hsa-miR-4753-3p	CLIP-seq
MIRT2515884	hsa-miR-555	CLIP-seq
MIRT1976825	hsa-miR-922	CLIP-seq
MIRT2515885	hsa-miR-942	CLIP-seq
MIRT2515871	hsa-miR-1236	CLIP-seq
MIRT2515872	hsa-miR-1253	CLIP-seq
MIRT1976824	hsa-miR-2467-3p	CLIP-seq
MIRT2515879	hsa-miR-3158-3p	CLIP-seq
MIRT2515880	hsa-miR-3691-3p	CLIP-seq
MIRT2515881	hsa-miR-4700-3p	CLIP-seq
MIRT2515882	hsa-miR-4721	CLIP-seq
MIRT2515883	hsa-miR-4753-3p	CLIP-seq
MIRT1976825	hsa-miR-922	CLIP-seq
MIRT2515885	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004090	Function	Carbonyl reductase (NADPH) activity	IDA	30031147
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 32296183, 32814053
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA	30031147
GO:0047045	Function	Testosterone dehydrogenase (NADP+) activity	IEA
GO:0047881	Function	Estradiol 17-alpha-dehydrogenase [NAD(P)+] activity	IEA

Other IDs

• MIM: 610410
• HGNC: 16445
• e!Ensembl: ENSG00000157379

Protein

• UniProt ID: Q96LJ7
• Protein name: Dehydrogenase/reductase SDR family member 1 (EC 1.1.1.-) (Short chain dehydrogenase/reductase family 19C member 1) (Protein SDR19C1)
• Protein function: NADPH-dependent oxidoreductase which catalyzes the reduction of steroids (estrone, androstene-3,17-dione and cortisone) as well as prostaglandin E1, isatin and xenobiotics in vitro (PubMed:30031147). May have a role in steroid and/or xenobiotic
• PDB: 2QQ5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00106	adh_short	8 → 209	short chain dehydrogenase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in heart, liver, adrenal glands, and at low levels in skeletal muscle, kidney, pancreas and brain. {ECO:0000269|PubMed:12153138, ECO:0000269|PubMed:30031147}.
• Sequence:

  MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVP
  VVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDIN
  NVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHE
  LRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETTELSGKCVVALA
  TDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYLSLSSVLSHVSGLGWLASYLPSFLR
  VPKWIIALYTSKF

• Sequence length: 313

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTISM SPECTRUM DISORDER	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34498498	Inhibit	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37861541	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	21356389		★☆☆☆☆ Found in Text Mining only