Gene Gene information from NCBI Gene database.
Entrez ID 115761
Gene name ARF like GTPase 11
Gene symbol ARL11
Synonyms (NCBI Gene)
ARLTS1
Chromosome 13
Chromosome location 13q14.2
Summary This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancer
miRNA miRNA information provided by mirtarbase database.
253
miRTarBase ID miRNA Experiments Reference
MIRT719233 hsa-miR-4274 HITS-CLIP 19536157
MIRT719232 hsa-miR-6892-3p HITS-CLIP 19536157
MIRT719231 hsa-miR-2276-5p HITS-CLIP 19536157
MIRT719230 hsa-miR-6515-3p HITS-CLIP 19536157
MIRT719229 hsa-miR-1236-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0002244 Process Hematopoietic progenitor cell differentiation IEA
GO:0003924 Function GTPase activity IEA
GO:0005515 Function Protein binding IPI 16189514, 19060904, 31515488
GO:0005525 Function GTP binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609351 24046 ENSG00000152213
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q969Q4
Protein name ADP-ribosylation factor-like protein 11 (ADP-ribosylation factor-like tumor suppressor protein 1)
Protein function May play a role in apoptosis. May act as a tumor suppressor.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00025 Arf 3 173 ADP-ribosylation factor family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in lung and leukocytes. {ECO:0000269|PubMed:15843669}.
Sequence
Sequence length 196
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA Orphanet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OVARIAN NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
B-cell chronic lymphocytic leukemia Lymphocytic Leukemia Orphanet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
B-CELL MALIGNANCY, LOW-GRADE Lymphocytic Leukemia ORPHANET_DG 15843669
★☆☆☆☆
Found in Text Mining only
B-CELL MALIGNANCY, LOW-GRADE Lymphocytic Leukemia BEFREE 17079447
★☆☆☆☆
Found in Text Mining only
Benign Prostatic Hyperplasia Benign Prostatic Hyperplasia BEFREE 22028916
★☆☆☆☆
Found in Text Mining only
Breast Cancer, Familial Breast Cancer BEFREE 16353159, 16488076, 17079447, 20358297
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 17079447, 20358297
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 18337727 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma BEFREE 17079447, 17699778
★☆☆☆☆
Found in Text Mining only
Carcinoma of larynx Laryngeal carcinoma BEFREE 16570116
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 17699778, 18375053
★☆☆☆☆
Found in Text Mining only