Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	115727
Gene name	RAS guanyl releasing protein 4
Gene symbol	RASGRP4
Synonyms (NCBI Gene)	-
Chromosome	19
Chromosome location	19q13.2
Summary	The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. Th

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Show/Hide all (237)

miRTarBase ID	miRNA	Experiments
MIRT1292428	hsa-miR-1262	CLIP-seq
MIRT1292429	hsa-miR-1268	CLIP-seq
MIRT1292430	hsa-miR-1268b	CLIP-seq
MIRT1292431	hsa-miR-1321	CLIP-seq
MIRT1292432	hsa-miR-1827	CLIP-seq
MIRT1292433	hsa-miR-24	CLIP-seq
MIRT1292434	hsa-miR-28-5p	CLIP-seq
MIRT1292435	hsa-miR-298	CLIP-seq
MIRT1292436	hsa-miR-3120-5p	CLIP-seq
MIRT1292437	hsa-miR-3139	CLIP-seq
MIRT1292438	hsa-miR-3159	CLIP-seq
MIRT1292439	hsa-miR-3160-3p	CLIP-seq
MIRT1292440	hsa-miR-3162-5p	CLIP-seq
MIRT1292441	hsa-miR-3165	CLIP-seq
MIRT1292442	hsa-miR-34b	CLIP-seq
MIRT1292443	hsa-miR-3529	CLIP-seq
MIRT1292444	hsa-miR-3613-3p	CLIP-seq
MIRT1292445	hsa-miR-3614-5p	CLIP-seq
MIRT1292446	hsa-miR-3664-5p	CLIP-seq
MIRT1292447	hsa-miR-3672	CLIP-seq
MIRT1292448	hsa-miR-3689a-3p	CLIP-seq
MIRT1292449	hsa-miR-3689c	CLIP-seq
MIRT1292450	hsa-miR-371-5p	CLIP-seq
MIRT1292451	hsa-miR-371b-5p	CLIP-seq
MIRT1292452	hsa-miR-379	CLIP-seq
MIRT1292453	hsa-miR-3929	CLIP-seq
MIRT1292454	hsa-miR-4284	CLIP-seq
MIRT1292455	hsa-miR-4419b	CLIP-seq
MIRT1292456	hsa-miR-4432	CLIP-seq
MIRT1292457	hsa-miR-4433	CLIP-seq
MIRT1292458	hsa-miR-4451	CLIP-seq
MIRT1292459	hsa-miR-4456	CLIP-seq
MIRT1292460	hsa-miR-4459	CLIP-seq
MIRT1292461	hsa-miR-4478	CLIP-seq
MIRT1292462	hsa-miR-4486	CLIP-seq
MIRT1292463	hsa-miR-4487	CLIP-seq
MIRT1292464	hsa-miR-451b	CLIP-seq
MIRT1292465	hsa-miR-4522	CLIP-seq
MIRT1292466	hsa-miR-4649-3p	CLIP-seq
MIRT1292467	hsa-miR-4650-3p	CLIP-seq
MIRT1292468	hsa-miR-4695-5p	CLIP-seq
MIRT1292469	hsa-miR-4696	CLIP-seq
MIRT1292470	hsa-miR-4701-3p	CLIP-seq
MIRT1292471	hsa-miR-4728-5p	CLIP-seq
MIRT1292472	hsa-miR-4739	CLIP-seq
MIRT1292473	hsa-miR-4742-3p	CLIP-seq
MIRT1292474	hsa-miR-4756-5p	CLIP-seq
MIRT1292475	hsa-miR-4768-3p	CLIP-seq
MIRT1292476	hsa-miR-4786-5p	CLIP-seq
MIRT1292477	hsa-miR-485-5p	CLIP-seq
MIRT1292478	hsa-miR-542-3p	CLIP-seq
MIRT1292479	hsa-miR-558	CLIP-seq
MIRT1292480	hsa-miR-571	CLIP-seq
MIRT1292481	hsa-miR-585	CLIP-seq
MIRT1292482	hsa-miR-630	CLIP-seq
MIRT1292483	hsa-miR-661	CLIP-seq
MIRT1292484	hsa-miR-665	CLIP-seq
MIRT1292485	hsa-miR-708	CLIP-seq
MIRT1292486	hsa-miR-769-5p	CLIP-seq
MIRT1292487	hsa-miR-890	CLIP-seq
MIRT1292488	hsa-miR-103a	CLIP-seq
MIRT1292489	hsa-miR-107	CLIP-seq
MIRT1292445	hsa-miR-3614-5p	CLIP-seq
MIRT1292490	hsa-miR-3622a-5p	CLIP-seq
MIRT1292491	hsa-miR-4423-3p	CLIP-seq
MIRT1292492	hsa-miR-4450	CLIP-seq
MIRT1292460	hsa-miR-4459	CLIP-seq
MIRT1292493	hsa-miR-4519	CLIP-seq
MIRT1292494	hsa-miR-4667-5p	CLIP-seq
MIRT1292468	hsa-miR-4695-5p	CLIP-seq
MIRT1292495	hsa-miR-4700-5p	CLIP-seq
MIRT1292496	hsa-miR-645	CLIP-seq
MIRT1292484	hsa-miR-665	CLIP-seq
MIRT2086896	hsa-miR-138	CLIP-seq
MIRT2086897	hsa-miR-2467-5p	CLIP-seq
MIRT2086898	hsa-miR-3122	CLIP-seq
MIRT2086899	hsa-miR-3188	CLIP-seq
MIRT1292448	hsa-miR-3689a-3p	CLIP-seq
MIRT1292449	hsa-miR-3689c	CLIP-seq
MIRT2086900	hsa-miR-3913-5p	CLIP-seq
MIRT1292453	hsa-miR-3929	CLIP-seq
MIRT2086901	hsa-miR-3975	CLIP-seq
MIRT1292455	hsa-miR-4419b	CLIP-seq
MIRT1292461	hsa-miR-4478	CLIP-seq
MIRT1292466	hsa-miR-4649-3p	CLIP-seq
MIRT1292471	hsa-miR-4728-5p	CLIP-seq
MIRT1292477	hsa-miR-485-5p	CLIP-seq
MIRT2311805	hsa-miR-1224-5p	CLIP-seq
MIRT1292428	hsa-miR-1262	CLIP-seq
MIRT2311806	hsa-miR-1267	CLIP-seq
MIRT2086896	hsa-miR-138	CLIP-seq
MIRT1292432	hsa-miR-1827	CLIP-seq
MIRT2086897	hsa-miR-2467-5p	CLIP-seq
MIRT2311807	hsa-miR-25	CLIP-seq
MIRT1292435	hsa-miR-298	CLIP-seq
MIRT2086898	hsa-miR-3122	CLIP-seq
MIRT1292441	hsa-miR-3165	CLIP-seq
MIRT2086899	hsa-miR-3188	CLIP-seq
MIRT2311808	hsa-miR-32	CLIP-seq
MIRT1292442	hsa-miR-34b	CLIP-seq
MIRT1292445	hsa-miR-3614-5p	CLIP-seq
MIRT2311809	hsa-miR-363	CLIP-seq
MIRT2311810	hsa-miR-367	CLIP-seq
MIRT1292448	hsa-miR-3689a-3p	CLIP-seq
MIRT1292449	hsa-miR-3689c	CLIP-seq
MIRT2086900	hsa-miR-3913-5p	CLIP-seq
MIRT2311811	hsa-miR-3915	CLIP-seq
MIRT2311812	hsa-miR-3928	CLIP-seq
MIRT1292453	hsa-miR-3929	CLIP-seq
MIRT2086901	hsa-miR-3975	CLIP-seq
MIRT2311813	hsa-miR-4317	CLIP-seq
MIRT2311814	hsa-miR-4325	CLIP-seq
MIRT1292455	hsa-miR-4419b	CLIP-seq
MIRT1292459	hsa-miR-4456	CLIP-seq
MIRT1292460	hsa-miR-4459	CLIP-seq
MIRT1292461	hsa-miR-4478	CLIP-seq
MIRT1292466	hsa-miR-4649-3p	CLIP-seq
MIRT2311815	hsa-miR-4689	CLIP-seq
MIRT1292468	hsa-miR-4695-5p	CLIP-seq
MIRT1292470	hsa-miR-4701-3p	CLIP-seq
MIRT1292471	hsa-miR-4728-5p	CLIP-seq
MIRT1292477	hsa-miR-485-5p	CLIP-seq
MIRT2311816	hsa-miR-508-5p	CLIP-seq
MIRT1292478	hsa-miR-542-3p	CLIP-seq
MIRT2311817	hsa-miR-550a	CLIP-seq
MIRT1292483	hsa-miR-661	CLIP-seq
MIRT1292484	hsa-miR-665	CLIP-seq
MIRT2311818	hsa-miR-766	CLIP-seq
MIRT1292487	hsa-miR-890	CLIP-seq
MIRT2311819	hsa-miR-92a	CLIP-seq
MIRT2311820	hsa-miR-92b	CLIP-seq
MIRT2086898	hsa-miR-3122	CLIP-seq
MIRT1292448	hsa-miR-3689a-3p	CLIP-seq
MIRT1292449	hsa-miR-3689c	CLIP-seq
MIRT2086900	hsa-miR-3913-5p	CLIP-seq
MIRT1292453	hsa-miR-3929	CLIP-seq
MIRT2393509	hsa-miR-3938	CLIP-seq
MIRT1292455	hsa-miR-4419b	CLIP-seq
MIRT1292461	hsa-miR-4478	CLIP-seq
MIRT1292471	hsa-miR-4728-5p	CLIP-seq
MIRT1292473	hsa-miR-4742-3p	CLIP-seq
MIRT1292477	hsa-miR-485-5p	CLIP-seq
MIRT1292482	hsa-miR-630	CLIP-seq
MIRT2457780	hsa-miR-146b-3p	CLIP-seq
MIRT1292490	hsa-miR-3622a-5p	CLIP-seq
MIRT2457781	hsa-miR-3622b-5p	CLIP-seq
MIRT2457782	hsa-miR-4253	CLIP-seq
MIRT1292491	hsa-miR-4423-3p	CLIP-seq
MIRT1292492	hsa-miR-4450	CLIP-seq
MIRT2457783	hsa-miR-4634	CLIP-seq
MIRT1292494	hsa-miR-4667-5p	CLIP-seq
MIRT2457784	hsa-miR-4684-5p	CLIP-seq
MIRT1292495	hsa-miR-4700-5p	CLIP-seq
MIRT2457785	hsa-miR-548c-3p	CLIP-seq
MIRT1292496	hsa-miR-645	CLIP-seq
MIRT2457781	hsa-miR-3622b-5p	CLIP-seq
MIRT2457782	hsa-miR-4253	CLIP-seq
MIRT2457783	hsa-miR-4634	CLIP-seq
MIRT2457784	hsa-miR-4684-5p	CLIP-seq
MIRT2457785	hsa-miR-548c-3p	CLIP-seq
MIRT1292428	hsa-miR-1262	CLIP-seq
MIRT1292432	hsa-miR-1827	CLIP-seq
MIRT2608217	hsa-miR-2110	CLIP-seq
MIRT2086897	hsa-miR-2467-5p	CLIP-seq
MIRT1292435	hsa-miR-298	CLIP-seq
MIRT1292436	hsa-miR-3120-5p	CLIP-seq
MIRT2086898	hsa-miR-3122	CLIP-seq
MIRT2086899	hsa-miR-3188	CLIP-seq
MIRT1292442	hsa-miR-34b	CLIP-seq
MIRT1292444	hsa-miR-3613-3p	CLIP-seq
MIRT1292445	hsa-miR-3614-5p	CLIP-seq
MIRT2457781	hsa-miR-3622b-5p	CLIP-seq
MIRT1292446	hsa-miR-3664-5p	CLIP-seq
MIRT1292448	hsa-miR-3689a-3p	CLIP-seq
MIRT1292449	hsa-miR-3689c	CLIP-seq
MIRT1292450	hsa-miR-371-5p	CLIP-seq
MIRT1292451	hsa-miR-371b-5p	CLIP-seq
MIRT2086900	hsa-miR-3913-5p	CLIP-seq
MIRT1292453	hsa-miR-3929	CLIP-seq
MIRT2393509	hsa-miR-3938	CLIP-seq
MIRT2086901	hsa-miR-3975	CLIP-seq
MIRT2457782	hsa-miR-4253	CLIP-seq
MIRT2608218	hsa-miR-4271	CLIP-seq
MIRT1292455	hsa-miR-4419b	CLIP-seq
MIRT1292456	hsa-miR-4432	CLIP-seq
MIRT1292461	hsa-miR-4478	CLIP-seq
MIRT1292464	hsa-miR-451b	CLIP-seq
MIRT1292465	hsa-miR-4522	CLIP-seq
MIRT2457783	hsa-miR-4634	CLIP-seq
MIRT1292466	hsa-miR-4649-3p	CLIP-seq
MIRT2457784	hsa-miR-4684-5p	CLIP-seq
MIRT2608219	hsa-miR-4694-3p	CLIP-seq
MIRT1292469	hsa-miR-4696	CLIP-seq
MIRT1292470	hsa-miR-4701-3p	CLIP-seq
MIRT2608220	hsa-miR-4725-3p	CLIP-seq
MIRT1292471	hsa-miR-4728-5p	CLIP-seq
MIRT1292473	hsa-miR-4742-3p	CLIP-seq
MIRT1292477	hsa-miR-485-5p	CLIP-seq
MIRT2311816	hsa-miR-508-5p	CLIP-seq
MIRT1292478	hsa-miR-542-3p	CLIP-seq
MIRT2457785	hsa-miR-548c-3p	CLIP-seq
MIRT1292482	hsa-miR-630	CLIP-seq
MIRT1292483	hsa-miR-661	CLIP-seq
MIRT2311818	hsa-miR-766	CLIP-seq
MIRT2608217	hsa-miR-2110	CLIP-seq
MIRT2086897	hsa-miR-2467-5p	CLIP-seq
MIRT1292436	hsa-miR-3120-5p	CLIP-seq
MIRT2086898	hsa-miR-3122	CLIP-seq
MIRT2086899	hsa-miR-3188	CLIP-seq
MIRT1292444	hsa-miR-3613-3p	CLIP-seq
MIRT2457781	hsa-miR-3622b-5p	CLIP-seq
MIRT1292446	hsa-miR-3664-5p	CLIP-seq
MIRT1292448	hsa-miR-3689a-3p	CLIP-seq
MIRT1292449	hsa-miR-3689c	CLIP-seq
MIRT1292450	hsa-miR-371-5p	CLIP-seq
MIRT1292451	hsa-miR-371b-5p	CLIP-seq
MIRT2086900	hsa-miR-3913-5p	CLIP-seq
MIRT1292453	hsa-miR-3929	CLIP-seq
MIRT2393509	hsa-miR-3938	CLIP-seq
MIRT2086901	hsa-miR-3975	CLIP-seq
MIRT2457782	hsa-miR-4253	CLIP-seq
MIRT2608218	hsa-miR-4271	CLIP-seq
MIRT1292455	hsa-miR-4419b	CLIP-seq
MIRT1292456	hsa-miR-4432	CLIP-seq
MIRT1292461	hsa-miR-4478	CLIP-seq
MIRT1292465	hsa-miR-4522	CLIP-seq
MIRT2457783	hsa-miR-4634	CLIP-seq
MIRT1292466	hsa-miR-4649-3p	CLIP-seq
MIRT2457784	hsa-miR-4684-5p	CLIP-seq
MIRT2608219	hsa-miR-4694-3p	CLIP-seq
MIRT2608220	hsa-miR-4725-3p	CLIP-seq
MIRT1292471	hsa-miR-4728-5p	CLIP-seq
MIRT1292473	hsa-miR-4742-3p	CLIP-seq
MIRT1292477	hsa-miR-485-5p	CLIP-seq
MIRT2457785	hsa-miR-548c-3p	CLIP-seq
MIRT2311817	hsa-miR-550a	CLIP-seq
MIRT1292482	hsa-miR-630	CLIP-seq

Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002717	Process	Positive regulation of natural killer cell mediated immunity	IEA
GO:0002717	Process	Positive regulation of natural killer cell mediated immunity	ISS
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	11880369
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	11956218
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	11880369
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	ISS
GO:0007264	Process	Small GTPase-mediated signal transduction	IEA
GO:0007265	Process	Ras protein signal transduction	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	IDA	11956218
GO:0009898	Component	Cytoplasmic side of plasma membrane	IEA
GO:0016020	Component	Membrane	IDA	11880369
GO:0016020	Component	Membrane	IEA
GO:0019992	Function	Diacylglycerol binding	IEA
GO:0019992	Function	Diacylglycerol binding	ISS
GO:0019992	Function	Diacylglycerol binding	TAS	11880369
GO:0030099	Process	Myeloid cell differentiation	TAS	11880369
GO:0030154	Process	Cell differentiation	IEA
GO:0030695	Function	GTPase regulator activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0140367	Process	Antibacterial innate immune response	IEA
GO:0140367	Process	Antibacterial innate immune response	ISS

MIM	HGNC	e!Ensembl
607320	18958	ENSG00000171777

Q8TDF6

Protein name

RAS guanyl-releasing protein 4

Protein function

Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP (PubMed:11880369, PubMed:11956218, PubMed:12493770, PubMed:18024961). In neutrophils, participates in a

PDB

6AXG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00617	RasGEF	204 → 380	RasGEF domain	Family
PF00130	C1_1	541 → 593	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, p

Sequence

MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
MDPPSTASSKLDS

Sequence length

673

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway Ras signaling pathway Pathways in cancer		RAF/MAP kinase cascade

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASPERGER SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adult Diffuse Large B-Cell Lymphoma	B-cell Lymphoma	BEFREE	31409422		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	21933395	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	11956218, 16364194		★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	LHGDN	11956218		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	31409422		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Mast-Cell	Leukemia	LHGDN	11956218		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	11880369		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, T-Cell	T-cell leukemia	BEFREE	19350351		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	22116551		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mastocytosis	Mastocytosis	LHGDN	11956218		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	22116551		★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	34905506, 35909123	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

RASGRP4 (RAS guanyl releasing protein 4)