Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	115290
Gene name	F-box protein 17
Gene symbol	FBXO17
Synonyms (NCBI Gene)	FBG4FBX26FBXO26Fbx17
Chromosome	19
Chromosome location	19q13.2
Summary	This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphoryla

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022574	hsa-miR-124-3p	Microarray	18668037
MIRT615882	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT615882	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT615882	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT615882	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT615884	hsa-miR-320e	HITS-CLIP	23824327
MIRT513246	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT615883	hsa-miR-6131	HITS-CLIP	23824327
MIRT615882	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT513257	hsa-miR-4714-3p	PAR-CLIP	23446348
MIRT513255	hsa-miR-4742-5p	PAR-CLIP	23446348
MIRT513254	hsa-miR-4269	PAR-CLIP	23446348
MIRT513253	hsa-miR-6715b-5p	PAR-CLIP	23446348
MIRT513252	hsa-miR-4514	PAR-CLIP	23446348
MIRT513251	hsa-miR-4692	PAR-CLIP	23446348
MIRT513249	hsa-miR-660-3p	PAR-CLIP	23446348
MIRT513250	hsa-miR-3664-3p	PAR-CLIP	23446348
MIRT513248	hsa-miR-1266-5p	PAR-CLIP	23446348
MIRT513247	hsa-miR-4518	PAR-CLIP	23446348
MIRT513246	hsa-miR-3663-5p	PAR-CLIP	23446348
MIRT513245	hsa-miR-6843-3p	PAR-CLIP	23446348
MIRT513244	hsa-miR-6848-3p	PAR-CLIP	23446348
MIRT615882	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT615882	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT615882	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT615882	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT615882	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT615884	hsa-miR-320e	HITS-CLIP	23824327
MIRT513246	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT615883	hsa-miR-6131	HITS-CLIP	23824327
MIRT615882	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT513257	hsa-miR-4714-3p	PAR-CLIP	23446348
MIRT513255	hsa-miR-4742-5p	PAR-CLIP	23446348
MIRT513254	hsa-miR-4269	PAR-CLIP	23446348
MIRT513253	hsa-miR-6715b-5p	PAR-CLIP	23446348
MIRT513252	hsa-miR-4514	PAR-CLIP	23446348
MIRT513251	hsa-miR-4692	PAR-CLIP	23446348
MIRT513249	hsa-miR-660-3p	PAR-CLIP	23446348
MIRT513250	hsa-miR-3664-3p	PAR-CLIP	23446348
MIRT513248	hsa-miR-1266-5p	PAR-CLIP	23446348
MIRT513247	hsa-miR-4518	PAR-CLIP	23446348
MIRT513246	hsa-miR-3663-5p	PAR-CLIP	23446348
MIRT513245	hsa-miR-6843-3p	PAR-CLIP	23446348
MIRT513244	hsa-miR-6848-3p	PAR-CLIP	23446348
MIRT991301	hsa-miR-1184	CLIP-seq
MIRT991302	hsa-miR-122	CLIP-seq
MIRT991303	hsa-miR-1229	CLIP-seq
MIRT991304	hsa-miR-1245b-3p	CLIP-seq
MIRT991305	hsa-miR-1253	CLIP-seq
MIRT991306	hsa-miR-1286	CLIP-seq
MIRT991307	hsa-miR-2277-3p	CLIP-seq
MIRT991308	hsa-miR-2355-5p	CLIP-seq
MIRT991309	hsa-miR-3135b	CLIP-seq
MIRT991310	hsa-miR-323-5p	CLIP-seq
MIRT991311	hsa-miR-3591-3p	CLIP-seq
MIRT991312	hsa-miR-362-5p	CLIP-seq
MIRT991313	hsa-miR-3647-3p	CLIP-seq
MIRT991314	hsa-miR-3652	CLIP-seq
MIRT991315	hsa-miR-3679-3p	CLIP-seq
MIRT991316	hsa-miR-3915	CLIP-seq
MIRT991317	hsa-miR-3928	CLIP-seq
MIRT991318	hsa-miR-4260	CLIP-seq
MIRT991319	hsa-miR-4282	CLIP-seq
MIRT991320	hsa-miR-4284	CLIP-seq
MIRT991321	hsa-miR-4328	CLIP-seq
MIRT991322	hsa-miR-4418	CLIP-seq
MIRT991323	hsa-miR-4430	CLIP-seq
MIRT991324	hsa-miR-4434	CLIP-seq
MIRT991325	hsa-miR-4435	CLIP-seq
MIRT991326	hsa-miR-4516	CLIP-seq
MIRT991327	hsa-miR-4523	CLIP-seq
MIRT991328	hsa-miR-4640-5p	CLIP-seq
MIRT991329	hsa-miR-4656	CLIP-seq
MIRT991330	hsa-miR-4722-5p	CLIP-seq
MIRT991331	hsa-miR-4726-5p	CLIP-seq
MIRT991332	hsa-miR-4735-5p	CLIP-seq
MIRT991333	hsa-miR-4752	CLIP-seq
MIRT991334	hsa-miR-4756-3p	CLIP-seq
MIRT991335	hsa-miR-4768-3p	CLIP-seq
MIRT991336	hsa-miR-4775	CLIP-seq
MIRT991337	hsa-miR-500b	CLIP-seq
MIRT991338	hsa-miR-502-5p	CLIP-seq
MIRT991339	hsa-miR-509-3-5p	CLIP-seq
MIRT991340	hsa-miR-509-5p	CLIP-seq
MIRT991341	hsa-miR-548c-3p	CLIP-seq
MIRT991342	hsa-miR-590-3p	CLIP-seq
MIRT991343	hsa-miR-637	CLIP-seq
MIRT991344	hsa-miR-876-3p	CLIP-seq
MIRT991345	hsa-miR-922	CLIP-seq
MIRT991346	hsa-miR-944	CLIP-seq
MIRT991347	hsa-miR-103a	CLIP-seq
MIRT991348	hsa-miR-107	CLIP-seq
MIRT991301	hsa-miR-1184	CLIP-seq
MIRT991349	hsa-miR-1205	CLIP-seq
MIRT991350	hsa-miR-1224-3p	CLIP-seq
MIRT991305	hsa-miR-1253	CLIP-seq
MIRT991351	hsa-miR-1260	CLIP-seq
MIRT991352	hsa-miR-1260b	CLIP-seq
MIRT991353	hsa-miR-1266	CLIP-seq
MIRT991354	hsa-miR-1280	CLIP-seq
MIRT991306	hsa-miR-1286	CLIP-seq
MIRT991355	hsa-miR-149	CLIP-seq
MIRT991356	hsa-miR-193a-5p	CLIP-seq
MIRT991357	hsa-miR-214	CLIP-seq
MIRT991358	hsa-miR-3064-5p	CLIP-seq
MIRT991359	hsa-miR-3158-5p	CLIP-seq
MIRT991310	hsa-miR-323-5p	CLIP-seq
MIRT991360	hsa-miR-3545-3p	CLIP-seq
MIRT991361	hsa-miR-3619-5p	CLIP-seq
MIRT991312	hsa-miR-362-5p	CLIP-seq
MIRT991313	hsa-miR-3647-3p	CLIP-seq
MIRT991362	hsa-miR-377	CLIP-seq
MIRT991319	hsa-miR-4282	CLIP-seq
MIRT991320	hsa-miR-4284	CLIP-seq
MIRT991322	hsa-miR-4418	CLIP-seq
MIRT991363	hsa-miR-4423-5p	CLIP-seq
MIRT991324	hsa-miR-4434	CLIP-seq
MIRT991326	hsa-miR-4516	CLIP-seq
MIRT991327	hsa-miR-4523	CLIP-seq
MIRT991364	hsa-miR-4635	CLIP-seq
MIRT991365	hsa-miR-4680-5p	CLIP-seq
MIRT991366	hsa-miR-4686	CLIP-seq
MIRT991367	hsa-miR-4700-3p	CLIP-seq
MIRT991330	hsa-miR-4722-5p	CLIP-seq
MIRT991368	hsa-miR-4740-3p	CLIP-seq
MIRT991335	hsa-miR-4768-3p	CLIP-seq
MIRT991369	hsa-miR-4781-3p	CLIP-seq
MIRT991370	hsa-miR-4794	CLIP-seq
MIRT991337	hsa-miR-500b	CLIP-seq
MIRT991338	hsa-miR-502-5p	CLIP-seq
MIRT991339	hsa-miR-509-3-5p	CLIP-seq
MIRT991371	hsa-miR-5095	CLIP-seq
MIRT991340	hsa-miR-509-5p	CLIP-seq
MIRT991372	hsa-miR-532-3p	CLIP-seq
MIRT991373	hsa-miR-600	CLIP-seq
MIRT991374	hsa-miR-761	CLIP-seq
MIRT991375	hsa-miR-873	CLIP-seq
MIRT991344	hsa-miR-876-3p	CLIP-seq
MIRT1548633	hsa-miR-3136-5p	CLIP-seq
MIRT1548634	hsa-miR-4439	CLIP-seq
MIRT1548635	hsa-miR-4513	CLIP-seq
MIRT1548636	hsa-miR-4708-3p	CLIP-seq
MIRT1548637	hsa-miR-549	CLIP-seq
MIRT1548638	hsa-miR-943	CLIP-seq
MIRT1993995	hsa-miR-2467-3p	CLIP-seq
MIRT1993996	hsa-miR-3193	CLIP-seq
MIRT1993997	hsa-miR-4292	CLIP-seq
MIRT2227976	hsa-miR-15a	CLIP-seq
MIRT2227977	hsa-miR-15b	CLIP-seq
MIRT2227978	hsa-miR-16	CLIP-seq
MIRT2227979	hsa-miR-195	CLIP-seq
MIRT1993995	hsa-miR-2467-3p	CLIP-seq
MIRT2227980	hsa-miR-3120-3p	CLIP-seq
MIRT2227981	hsa-miR-3161	CLIP-seq
MIRT1993996	hsa-miR-3193	CLIP-seq
MIRT2227982	hsa-miR-424	CLIP-seq
MIRT2227983	hsa-miR-4676-5p	CLIP-seq
MIRT2227984	hsa-miR-497	CLIP-seq
MIRT2227985	hsa-miR-575	CLIP-seq
MIRT2449509	hsa-miR-128	CLIP-seq
MIRT2449510	hsa-miR-27a	CLIP-seq
MIRT2449511	hsa-miR-27b	CLIP-seq
MIRT2449512	hsa-miR-3145-3p	CLIP-seq
MIRT991359	hsa-miR-3158-5p	CLIP-seq
MIRT991321	hsa-miR-4328	CLIP-seq
MIRT991325	hsa-miR-4435	CLIP-seq
MIRT2449513	hsa-miR-512-3p	CLIP-seq
MIRT991301	hsa-miR-1184	CLIP-seq
MIRT2531515	hsa-miR-1237	CLIP-seq
MIRT2531516	hsa-miR-1254	CLIP-seq
MIRT2531517	hsa-miR-3116	CLIP-seq
MIRT2531518	hsa-miR-3117-5p	CLIP-seq
MIRT2531519	hsa-miR-3127-3p	CLIP-seq
MIRT991362	hsa-miR-377	CLIP-seq
MIRT991316	hsa-miR-3915	CLIP-seq
MIRT991317	hsa-miR-3928	CLIP-seq
MIRT2531520	hsa-miR-3937	CLIP-seq
MIRT991320	hsa-miR-4284	CLIP-seq
MIRT2531521	hsa-miR-4314	CLIP-seq
MIRT991322	hsa-miR-4418	CLIP-seq
MIRT2531522	hsa-miR-4640-3p	CLIP-seq
MIRT991329	hsa-miR-4656	CLIP-seq
MIRT2531523	hsa-miR-4667-5p	CLIP-seq
MIRT2531524	hsa-miR-4700-5p	CLIP-seq
MIRT991332	hsa-miR-4735-5p	CLIP-seq
MIRT991336	hsa-miR-4775	CLIP-seq
MIRT991370	hsa-miR-4794	CLIP-seq
MIRT991339	hsa-miR-509-3-5p	CLIP-seq
MIRT991340	hsa-miR-509-5p	CLIP-seq
MIRT991342	hsa-miR-590-3p	CLIP-seq
MIRT991343	hsa-miR-637	CLIP-seq
MIRT2531525	hsa-miR-661	CLIP-seq
MIRT2531526	hsa-miR-767-3p	CLIP-seq
MIRT991301	hsa-miR-1184	CLIP-seq
MIRT2449509	hsa-miR-128	CLIP-seq
MIRT2449510	hsa-miR-27a	CLIP-seq
MIRT2449511	hsa-miR-27b	CLIP-seq
MIRT2449512	hsa-miR-3145-3p	CLIP-seq
MIRT991359	hsa-miR-3158-5p	CLIP-seq
MIRT991320	hsa-miR-4284	CLIP-seq
MIRT991321	hsa-miR-4328	CLIP-seq
MIRT991322	hsa-miR-4418	CLIP-seq
MIRT991325	hsa-miR-4435	CLIP-seq
MIRT991370	hsa-miR-4794	CLIP-seq
MIRT991339	hsa-miR-509-3-5p	CLIP-seq
MIRT991340	hsa-miR-509-5p	CLIP-seq
MIRT2449513	hsa-miR-512-3p	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IDA	18203720
GO:0005515	Function	Protein binding	IPI	18203720, 21145461, 25416956, 27705803, 28514442, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006516	Process	Glycoprotein catabolic process	IBA
GO:0019005	Component	SCF ubiquitin ligase complex	IBA
GO:0019005	Component	SCF ubiquitin ligase complex	IDA	18203720
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA
GO:0036503	Process	ERAD pathway	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA

MIM	HGNC	e!Ensembl
609094	18754	ENSG00000269190

Q96EF6

Protein name

F-box only protein 17 (F-box only protein 26)

Protein function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12937	F-box-like	18 → 60	F-box-like	Domain
PF04300	FBA	100 → 273	F-box associated region	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and brain. {ECO:0000269|PubMed:12383498}.

Sequence

MGARLSRRRLPADPSLALDALPPELLVQVLSHVPPRSLVTRCRPVCRAWRDIVDGPTVWL
LQLARDRSAEGRALYAVAQRCLPSNEDKEEFPLCALARYCLRAPFGRNLIFNSCGEQGFR
GWEVEHGGNGWAIEKNLTPVPGAPSQTCFVTSFEWCSKRQLVDLVMEGVWQELLDSAQIE
ICVADWWGARENCGCVYQLRVRLLDVYEKEVVKFSASPDPVLQWTERGCRQVSHVFTNFG
KGIRYVSFEQYGRDVSSWVGHYGALVTHSSVRVRIRLS

Sequence length

278

Interactions

View interactions

	Reactome
			Neddylation Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
SAPHO SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	18820369	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	31646557	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	34702278	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	36035375	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	30064493	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31646557		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	30359271	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Glioma	Glioma	BEFREE	30064493		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	30359271		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30359271		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30359271		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	30359271		★★★★★ ★☆☆☆☆ Found in Text Mining only

FBXO17 (F-box protein 17)