Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	115072896
Gene name	SLCO1B3-SLCO1B7 readthrough
Gene symbol	SLCO1B3-SLCO1B7
Synonyms (NCBI Gene)	LST-3TM12OATP1B3-1B7
Chromosome	12
Chromosome location	12p12.2
Summary	This locus represents naturally occurring readthrough transcription between the neighboring SLCO1B3 (solute carrier organic anion transporter family member 1B3) and SLCO1B7 (solute carrier organic anion transporter family member 1B7 (putative)) genes on c

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006869	Process	Lipid transport	IEA
GO:0015125	Function	Bile acid transmembrane transporter activity	IBA
GO:0015347	Function	Sodium-independent organic anion transmembrane transporter activity	IBA
GO:0015721	Process	Bile acid and bile salt transport	IBA
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IBA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0030414	Function	Peptidase inhibitor activity	IEA
GO:0030868	Component	Smooth endoplasmic reticulum membrane	IEA
GO:0043252	Process	Sodium-independent organic anion transport	IBA
GO:0055085	Process	Transmembrane transport	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

F5H094

Protein name

SLCO1B3-SLCO1B7 readthrough transcript protein (Liver specific transporter-3 transmembrane 12) (LST-3TM12) (Organic anion transporting polypeptide 1B3-1B7) (OATP1B3-1B7) (Solute carrier organic anion transporter family member 1B3-1B7) (SLCO1B3-SLCO1B7)

Protein function

Mediates the Na(+)-independent uptake of organic anions (PubMed:29248594). Transports the conjugated steroids 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate) or E2G) and dehydroepiandrosterone 3-sulfate (DHEAS) at the

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed in the perivenular areas (centrilobular) of the liver (at protein level). {ECO:0000269|PubMed:29248594}.

Sequence



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Sequence length

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Interactions

View interactions

	KEGG
	Bile secretion Folate transport and metabolism

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ROTOR SYNDROME	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Leukopenia	Leukopenia	BEFREE	30767710	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neutropenia	Neutropenia	BEFREE	30767710	★★★★★ ★☆☆☆☆ Found in Text Mining only

SLCO1B3-SLCO1B7 (SLCO1B3-SLCO1B7 readthrough)