Gene Gene information from NCBI Gene database.
Entrez ID 115019
Gene name Solute carrier family 26 member 9
Gene symbol SLC26A9
Synonyms (NCBI Gene)
-
Chromosome 1
Chromosome location 1q32.1
Summary This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns.
miRNA miRNA information provided by mirtarbase database.
213
miRTarBase ID miRNA Experiments Reference
MIRT646128 hsa-miR-618 HITS-CLIP 23824327
MIRT646127 hsa-miR-4640-3p HITS-CLIP 23824327
MIRT646126 hsa-miR-6871-3p HITS-CLIP 23824327
MIRT646125 hsa-miR-3065-3p HITS-CLIP 23824327
MIRT646124 hsa-miR-6887-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IDA 26801567
GO:0005254 Function Chloride channel activity IDA 17673510, 18769029, 19289574, 20658517, 22544634, 32818062
GO:0005254 Function Chloride channel activity TAS
GO:0005452 Function Solute:inorganic anion antiporter activity IDA 15800055, 22544634
GO:0005515 Function Protein binding IPI 28360110
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608481 14469 ENSG00000174502
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q7LBE3
Protein name Solute carrier family 26 member 9 (Anion transporter/exchanger protein 9)
Protein function Ion transporter that can act both as an ion channel and anion exchanger (PubMed:15800055, PubMed:17673510, PubMed:26801567, PubMed:32818062). Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-acc
PDB 7CH1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00916 Sulfate_transp 71 469 Sulfate permease family Family
PF01740 STAS 520 733 STAS domain Domain
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in lung at the luminal side of the bronchiolar and alveolar epithelium of lung. To a lower extent, also expressed in pancreas and prostate. {ECO:0000269|PubMed:11834742}.
Sequence
Sequence length 791
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Mineral absorption
Chemical carcinogenesis - reactive oxygen species
  Multifunctional anion exchangers
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CYSTIC FIBROSIS Disgenet, GWAS catalog, Orphanet
Disgenet, GWAS catalog, Orphanet
Disgenet, GWAS catalog, Orphanet
Disgenet, GWAS catalog, Orphanet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CYSTIC FIBROSIS ASSOCIATED MECONIUM ILEUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CYSTIC FIBROSIS, MODIFIER OF, 1 CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CYSTIC FIBROSIS-RELATED DIABETES GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Asthma Asthma BEFREE 22945630, 30327603
★☆☆☆☆
Found in Text Mining only
Asthma Asthma Pubtator 34884866, 35328418 Associate
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Autoimmune disease Pubtator 34944008 Associate
★☆☆☆☆
Found in Text Mining only
Bronchiectasis Bronchiectasis BEFREE 30327603
★☆☆☆☆
Found in Text Mining only
Bronchiectasis Bronchiectasis Pubtator 34884866 Associate
★☆☆☆☆
Found in Text Mining only
Cystic Fibrosis Cystic Fibrosis BEFREE 23670970, 24057835, 24550193, 25771386, 26115565, 30327603, 30807572, 31339488, 31581148, 31645438, 31697830
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cystic Fibrosis Cystic fibrosis Pubtator 23670970, 24550193, 25771386, 28171547, 30716472, 30807572, 31581148, 31697830, 33674211, 34884866, 36206743 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CYSTIC FIBROSIS MODIFIER 1 Cystic Fibrosis CTD_human_DG 22466613
★☆☆☆☆
Found in Text Mining only
Diabetes Diabetes BEFREE 23670970, 31581148
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Diabetes Mellitus BEFREE 23670970, 31581148
★★☆☆☆
Found in Text Mining + Unknown/Other Associations