Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	114928
Gene name	G protein-coupled receptor associated sorting protein 2
Gene symbol	GPRASP2
Synonyms (NCBI Gene)	DFNX7GASP2
Chromosome	X
Chromosome location	Xq22.1
Summary	The protein encoded by this gene is a member of a family that regulates the activity of G protein-coupled receptors (GPCRs). The encoded protein has been shown to be capable of interacting with several GPCRs, including the M1 muscarinic acetylcholine rece

Show/Hide all (46)

miRTarBase ID	miRNA	Experiments	Reference
MIRT037464	hsa-miR-744-5p	CLASH	23622248
MIRT1032146	hsa-miR-1271	CLIP-seq
MIRT1032147	hsa-miR-182	CLIP-seq
MIRT1032148	hsa-miR-3662	CLIP-seq
MIRT1032149	hsa-miR-4642	CLIP-seq
MIRT1032150	hsa-miR-4698	CLIP-seq
MIRT1032151	hsa-miR-579	CLIP-seq
MIRT1032152	hsa-miR-640	CLIP-seq
MIRT1032153	hsa-miR-96	CLIP-seq
MIRT1032154	hsa-miR-3065-5p	CLIP-seq
MIRT1032155	hsa-miR-3120-3p	CLIP-seq
MIRT1032156	hsa-miR-378	CLIP-seq
MIRT1032157	hsa-miR-378b	CLIP-seq
MIRT1032158	hsa-miR-378c	CLIP-seq
MIRT1032159	hsa-miR-378d	CLIP-seq
MIRT1032160	hsa-miR-378e	CLIP-seq
MIRT1032161	hsa-miR-378f	CLIP-seq
MIRT1032162	hsa-miR-378h	CLIP-seq
MIRT1032163	hsa-miR-378i	CLIP-seq
MIRT1032164	hsa-miR-422a	CLIP-seq
MIRT1032165	hsa-miR-451b	CLIP-seq
MIRT1032166	hsa-miR-4520a-3p	CLIP-seq
MIRT1032167	hsa-miR-4638-3p	CLIP-seq
MIRT1032168	hsa-miR-4696	CLIP-seq
MIRT2542532	hsa-miR-200b	CLIP-seq
MIRT2542533	hsa-miR-200c	CLIP-seq
MIRT1032155	hsa-miR-3120-3p	CLIP-seq
MIRT2542534	hsa-miR-374c	CLIP-seq
MIRT1032156	hsa-miR-378	CLIP-seq
MIRT1032157	hsa-miR-378b	CLIP-seq
MIRT1032158	hsa-miR-378c	CLIP-seq
MIRT1032159	hsa-miR-378d	CLIP-seq
MIRT1032160	hsa-miR-378e	CLIP-seq
MIRT1032161	hsa-miR-378f	CLIP-seq
MIRT1032162	hsa-miR-378h	CLIP-seq
MIRT1032163	hsa-miR-378i	CLIP-seq
MIRT1032164	hsa-miR-422a	CLIP-seq
MIRT2542535	hsa-miR-429	CLIP-seq
MIRT1032165	hsa-miR-451b	CLIP-seq
MIRT1032166	hsa-miR-4520a-3p	CLIP-seq
MIRT1032167	hsa-miR-4638-3p	CLIP-seq
MIRT1032168	hsa-miR-4696	CLIP-seq
MIRT2542536	hsa-miR-4724-5p	CLIP-seq
MIRT2542537	hsa-miR-570	CLIP-seq
MIRT2542538	hsa-miR-642b	CLIP-seq
MIRT2542539	hsa-miR-655	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	IEA
GO:0001664	Function	G protein-coupled receptor binding	IBA
GO:0001664	Function	G protein-coupled receptor binding	IDA	15086532
GO:0005515	Function	Protein binding	IPI	15383276, 21988832, 25416956, 25910212, 26871637, 27107012, 28514442, 31515488, 32296183, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA
GO:0005737	Component	Cytoplasm	IDA
GO:0005829	Component	Cytosol	IBA
GO:0061484	Process	Hematopoietic stem cell homeostasis	IEA

MIM	HGNC	e!Ensembl
300969	25169	ENSG00000158301

Q96D09

Protein name

G-protein coupled receptor-associated sorting protein 2 (GASP-2)

Protein function

May play a role in regulation of a variety of G-protein coupled receptors.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04826	Arm_2	584 → 837	Armadillo-like	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in the brain. {ECO:0000269|PubMed:15086532}.

Sequence

MTGAEIEPSAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQATTGARPKTETKSVPAA
RPKTEAQAMSGARPKTEVQVMGGARPKTEAQGITGARPKTDARAVGGARSKTDAKAIPGA
RPKDEAQAWAQSEFGTEAVSQAEGVSQTNAVAWPLATAESGSVTKSKGLSMDRELVNVDA
ETFPGTQGQKGIQPWFGPGEETNMGSWCYSRPRAREEASNESGFWSADETSTASSFWTGE
ETSVRSWPREESNTRSRHRAKHQTNPRSRPRSKQEAYVDSWSGSEDEASNPFSFWVGENT
NNLFRPRVREEANIRSKLRTNREDCFESESEDEFYKQSWVLPGEEANSRFRHRDKEDPNT
ALKLRAQKDVDSDRVKQEPRFEEEVIIGSWFWAEKEASLEGGASAICESEPGTEEGAIGG
SAYWAEEKSSLGAVAREEAKPESEEEAIFGSWFWDRDEACFDLNPCPVYKVSDRFRDAAE
ELNASSRPQTWDEVTVEFKPGLFHGVGFRSTSPFGIPEEASEMLEAKPKNLELSPEGEEQ
ESLLQPDQPSPEFTFQYDPSYRSVREIREHLRARESAESESWSCSCIQCELKIGSEEFEE
FLLLMDKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLE
NMIHMAPPYPNLNMIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYM
SGFLSLLTTANARTKFHVLKMLLNLSENPAVAKKLFSAKALSIFVGLFNIEETNDNIQIV
IKMFQNISNIIKSGKMSLIDDDFSLEPLISAFREFEELAKQLQAQIDNQNDPEVGQQS

Sequence length

838

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
X-linked external auditory canal atresia-dilated internal auditory canal-facial dysmorphism syndrome	Likely pathogenic; Pathogenic	rs2521622160, rs1569491884	RCV002474263 RCV000721928	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DEAFNESS, X-LINKED 7	—	Disgenet, HPO Disgenet, HPO	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GPRASP2-related disorder	Uncertain significance; Likely benign; Benign; Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
X-LINKED EXTERNAL AUDITORY CANAL ATRESIA, DILATED INTERNAL AUDITORY CANAL, FACIAL DYSMORPHISM SYNDROME	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	30926797		★★★★★ ★☆☆☆☆ Found in Text Mining only
Blepharoptosis	Ptosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
DEAFNESS, X-LINKED 7	Deafness	ORPHANET_DG	28096187		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, X-LINKED 7	Deafness	UNIPROT_DG	28096187		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hearing Loss	Hearing loss	Pubtator	28096187	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26854063		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	23345134		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ptosis	Ptosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
X-linked external auditory canal atresia-dilated internal auditory canal-facial dysmorphism syndrome	External Auditory Canal Atresia-Dilated Internal Auditory Canal-Facial Dysmorphism Syndrome, X-Linked	Orphanet			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

GPRASP2 (G protein-coupled receptor associated sorting protein 2)