Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	114883
Gene name	Oxysterol binding protein like 9
Gene symbol	OSBPL9
Synonyms (NCBI Gene)	ORP-9ORP9
Chromosome	1
Chromosome location	1p32.3
Summary	This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although

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Show/Hide all (194)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020828	hsa-miR-155-5p	Proteomics	18668040
MIRT045719	hsa-miR-125a-5p	CLASH	23622248
MIRT038381	hsa-miR-296-3p	CLASH	23622248
MIRT071838	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT547242	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT555900	hsa-miR-4740-3p	HITS-CLIP	21572407
MIRT555899	hsa-miR-4711-5p	HITS-CLIP	21572407
MIRT555898	hsa-miR-3713	HITS-CLIP	21572407
MIRT547241	hsa-miR-567	HITS-CLIP	21572407
MIRT547240	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT071840	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT071834	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT071837	hsa-miR-3924	HITS-CLIP	21572407
MIRT071836	hsa-miR-297	HITS-CLIP	21572407
MIRT547239	hsa-miR-6083	HITS-CLIP	21572407
MIRT547243	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT071838	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT547242	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT555899	hsa-miR-4711-5p	PAR-CLIP	20371350
MIRT547241	hsa-miR-567	PAR-CLIP	20371350
MIRT547240	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT071840	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT071834	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT071837	hsa-miR-3924	PAR-CLIP	20371350
MIRT071836	hsa-miR-297	PAR-CLIP	20371350
MIRT547239	hsa-miR-6083	PAR-CLIP	20371350
MIRT071838	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT547242	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT555900	hsa-miR-4740-3p	PAR-CLIP	21572407
MIRT555899	hsa-miR-4711-5p	PAR-CLIP	21572407
MIRT555898	hsa-miR-3713	PAR-CLIP	21572407
MIRT547241	hsa-miR-567	PAR-CLIP	21572407
MIRT547240	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT071840	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT071834	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT071837	hsa-miR-3924	PAR-CLIP	21572407
MIRT555897	hsa-miR-4642	PAR-CLIP	21572407
MIRT071836	hsa-miR-297	PAR-CLIP	21572407
MIRT547239	hsa-miR-6083	PAR-CLIP	21572407
MIRT547243	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT547243	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT071838	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT547242	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT547241	hsa-miR-567	PAR-CLIP	21572407
MIRT547240	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT071840	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT071834	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT071837	hsa-miR-3924	PAR-CLIP	21572407
MIRT071836	hsa-miR-297	PAR-CLIP	21572407
MIRT547239	hsa-miR-6083	PAR-CLIP	21572407
MIRT071838	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT547242	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT555900	hsa-miR-4740-3p	HITS-CLIP	21572407
MIRT555899	hsa-miR-4711-5p	HITS-CLIP	21572407
MIRT555898	hsa-miR-3713	HITS-CLIP	21572407
MIRT547241	hsa-miR-567	HITS-CLIP	21572407
MIRT547240	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT071840	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT071834	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT071837	hsa-miR-3924	HITS-CLIP	21572407
MIRT071836	hsa-miR-297	HITS-CLIP	21572407
MIRT547239	hsa-miR-6083	HITS-CLIP	21572407
MIRT547243	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT071838	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT547242	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT555899	hsa-miR-4711-5p	PAR-CLIP	20371350
MIRT547241	hsa-miR-567	PAR-CLIP	20371350
MIRT547240	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT071840	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT071834	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT071837	hsa-miR-3924	PAR-CLIP	20371350
MIRT071836	hsa-miR-297	PAR-CLIP	20371350
MIRT547239	hsa-miR-6083	PAR-CLIP	20371350
MIRT071838	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT547242	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT555900	hsa-miR-4740-3p	PAR-CLIP	21572407
MIRT555899	hsa-miR-4711-5p	PAR-CLIP	21572407
MIRT555898	hsa-miR-3713	PAR-CLIP	21572407
MIRT547241	hsa-miR-567	PAR-CLIP	21572407
MIRT547240	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT071840	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT071834	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT071837	hsa-miR-3924	PAR-CLIP	21572407
MIRT555897	hsa-miR-4642	PAR-CLIP	21572407
MIRT071836	hsa-miR-297	PAR-CLIP	21572407
MIRT547239	hsa-miR-6083	PAR-CLIP	21572407
MIRT547243	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT547243	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT071838	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT547242	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT547241	hsa-miR-567	PAR-CLIP	21572407
MIRT547240	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT071840	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT071834	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT071837	hsa-miR-3924	PAR-CLIP	21572407
MIRT071836	hsa-miR-297	PAR-CLIP	21572407
MIRT547239	hsa-miR-6083	PAR-CLIP	21572407
MIRT1206486	hsa-miR-101	CLIP-seq
MIRT1206487	hsa-miR-1253	CLIP-seq
MIRT1206488	hsa-miR-1266	CLIP-seq
MIRT1206489	hsa-miR-1273d	CLIP-seq
MIRT1206490	hsa-miR-144	CLIP-seq
MIRT1206491	hsa-miR-2115	CLIP-seq
MIRT1206492	hsa-miR-2682	CLIP-seq
MIRT1206493	hsa-miR-3064-3p	CLIP-seq
MIRT1206494	hsa-miR-3125	CLIP-seq
MIRT1206495	hsa-miR-3148	CLIP-seq
MIRT1206496	hsa-miR-3168	CLIP-seq
MIRT1206497	hsa-miR-3169	CLIP-seq
MIRT1206498	hsa-miR-3617	CLIP-seq
MIRT1206499	hsa-miR-3664-3p	CLIP-seq
MIRT1206500	hsa-miR-3682-3p	CLIP-seq
MIRT1206501	hsa-miR-3691-3p	CLIP-seq
MIRT1206502	hsa-miR-3913-3p	CLIP-seq
MIRT1206503	hsa-miR-3914	CLIP-seq
MIRT1206504	hsa-miR-3916	CLIP-seq
MIRT1206505	hsa-miR-3920	CLIP-seq
MIRT1206506	hsa-miR-3928	CLIP-seq
MIRT1206507	hsa-miR-3978	CLIP-seq
MIRT1206508	hsa-miR-4257	CLIP-seq
MIRT1206509	hsa-miR-4263	CLIP-seq
MIRT1206510	hsa-miR-4428	CLIP-seq
MIRT1206511	hsa-miR-4434	CLIP-seq
MIRT1206512	hsa-miR-4436a	CLIP-seq
MIRT1206513	hsa-miR-449c	CLIP-seq
MIRT1206514	hsa-miR-4516	CLIP-seq
MIRT1206515	hsa-miR-4518	CLIP-seq
MIRT1206516	hsa-miR-4668-5p	CLIP-seq
MIRT1206517	hsa-miR-4670-3p	CLIP-seq
MIRT1206518	hsa-miR-4686	CLIP-seq
MIRT1206519	hsa-miR-4698	CLIP-seq
MIRT1206520	hsa-miR-4699-3p	CLIP-seq
MIRT1206521	hsa-miR-4740-5p	CLIP-seq
MIRT1206522	hsa-miR-4799-5p	CLIP-seq
MIRT1206523	hsa-miR-576-5p	CLIP-seq
MIRT1206524	hsa-miR-582-5p	CLIP-seq
MIRT1206525	hsa-miR-641	CLIP-seq
MIRT1206526	hsa-miR-940	CLIP-seq
MIRT1206527	hsa-miR-1290	CLIP-seq
MIRT1206528	hsa-miR-1305	CLIP-seq
MIRT1206529	hsa-miR-141	CLIP-seq
MIRT1206530	hsa-miR-200a	CLIP-seq
MIRT1206531	hsa-miR-28-3p	CLIP-seq
MIRT1206532	hsa-miR-3160-5p	CLIP-seq
MIRT1206533	hsa-miR-3167	CLIP-seq
MIRT1206534	hsa-miR-340	CLIP-seq
MIRT1206535	hsa-miR-3667-5p	CLIP-seq
MIRT1206536	hsa-miR-3685	CLIP-seq
MIRT1206537	hsa-miR-374c	CLIP-seq
MIRT1206538	hsa-miR-384	CLIP-seq
MIRT1206539	hsa-miR-3942-3p	CLIP-seq
MIRT1206540	hsa-miR-4494	CLIP-seq
MIRT1206541	hsa-miR-4694-5p	CLIP-seq
MIRT1206542	hsa-miR-499a-5p	CLIP-seq
MIRT1206543	hsa-miR-513a-3p	CLIP-seq
MIRT1206544	hsa-miR-591	CLIP-seq
MIRT1206545	hsa-miR-655	CLIP-seq
MIRT1206546	hsa-miR-876-5p	CLIP-seq
MIRT1206547	hsa-miR-890	CLIP-seq
MIRT1206548	hsa-miR-95	CLIP-seq
MIRT1206503	hsa-miR-3914	CLIP-seq
MIRT1206503	hsa-miR-3914	CLIP-seq
MIRT1206493	hsa-miR-3064-3p	CLIP-seq
MIRT2391976	hsa-miR-3127-3p	CLIP-seq
MIRT2391977	hsa-miR-3679-3p	CLIP-seq
MIRT2391978	hsa-miR-4446-5p	CLIP-seq
MIRT1206516	hsa-miR-4668-5p	CLIP-seq
MIRT2585921	hsa-miR-1	CLIP-seq
MIRT2585922	hsa-miR-1206	CLIP-seq
MIRT2585923	hsa-miR-125b	CLIP-seq
MIRT2585924	hsa-miR-150	CLIP-seq
MIRT2585925	hsa-miR-188-5p	CLIP-seq
MIRT2585926	hsa-miR-206	CLIP-seq
MIRT1206493	hsa-miR-3064-3p	CLIP-seq
MIRT2391976	hsa-miR-3127-3p	CLIP-seq
MIRT2585927	hsa-miR-3673	CLIP-seq
MIRT2391977	hsa-miR-3679-3p	CLIP-seq
MIRT1206503	hsa-miR-3914	CLIP-seq
MIRT2585928	hsa-miR-4319	CLIP-seq
MIRT2585929	hsa-miR-4324	CLIP-seq
MIRT2391978	hsa-miR-4446-5p	CLIP-seq
MIRT2585930	hsa-miR-4520a-5p	CLIP-seq
MIRT2585931	hsa-miR-4520b-5p	CLIP-seq
MIRT1206516	hsa-miR-4668-5p	CLIP-seq
MIRT2585932	hsa-miR-4699-5p	CLIP-seq
MIRT2585933	hsa-miR-4712-5p	CLIP-seq
MIRT2585934	hsa-miR-4713-5p	CLIP-seq
MIRT2585935	hsa-miR-4732-3p	CLIP-seq
MIRT2585936	hsa-miR-532-3p	CLIP-seq
MIRT2585937	hsa-miR-613	CLIP-seq
MIRT2585938	hsa-miR-670	CLIP-seq
MIRT2585939	hsa-miR-770-5p	CLIP-seq
MIRT2585932	hsa-miR-4699-5p	CLIP-seq
MIRT2585932	hsa-miR-4699-5p	CLIP-seq

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19615732, 20599956, 22906437, 29547901, 35271311
GO:0005768	Component	Endosome	IEA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006699	Process	Bile acid biosynthetic process	TAS
GO:0006869	Process	Lipid transport	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0015918	Process	Sterol transport	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0031902	Component	Late endosome membrane	IEA
GO:0032934	Function	Sterol binding	IBA
GO:0120015	Function	Sterol transfer activity	TAS

MIM	HGNC	e!Ensembl
606737	16386	ENSG00000117859

Q96SU4

Protein name

Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9)

Protein function

Interacts with OSBPL11 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-se

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	3 → 99	PH domain	Domain
PF01237	Oxysterol_BP	377 → 729	Oxysterol-binding protein	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11735225}.

Sequence

MASIMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGI
DDEDDSTFTITVDQKTFHFQARDADEREKWIHALEETILRHTLQLQGLDSGFVPSVQDFD
KKLTEADAYLQILIEQLKLFDDKLQNCKEDEQRKKIETLKETTNSMVESIKHCIVLLQIA
KDQSNAEKHADGMISTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKSEQRPSSLP
VGPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFSYSSSEDEFYDADE
FHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRD
DDAEAGSVEEHKSVIMHLLSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSI
SDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVS
EGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIG
QGCVSCLDYDEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIIFHTKPFYGG
KKHRITAEIFSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQ
NEYESRSLWKDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGEC
WVYDEPLLKRLGAAKH

Sequence length

736

Interactions

View interactions

	Reactome
			Synthesis of bile acids and bile salts

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMPLEX NEURODEVELOPMENTAL DISORDER	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VASCULAR DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36918840	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Cerebral Infarction	BEFREE	24190612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	27609023	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperlipidemia, Familial Combined	Hyperlipidemia	BEFREE	19554302		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	40108662	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	28507274	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	36761744	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

OSBPL9 (oxysterol binding protein like 9)