Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	114879
Gene name	Oxysterol binding protein like 5
Gene symbol	OSBPL5
Synonyms (NCBI Gene)	OBPH1ORP5
Chromosome	11
Chromosome location	11p15.4
Summary	This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain a

123

Show/Hide all (123)

miRTarBase ID	miRNA	Experiments	Reference
MIRT526466	hsa-miR-449b-3p	PAR-CLIP	22012620
MIRT526465	hsa-miR-6801-3p	PAR-CLIP	22012620
MIRT526464	hsa-miR-6810-3p	PAR-CLIP	22012620
MIRT526463	hsa-miR-1539	PAR-CLIP	22012620
MIRT526462	hsa-miR-744-5p	PAR-CLIP	22012620
MIRT526461	hsa-miR-4640-5p	PAR-CLIP	22012620
MIRT526460	hsa-miR-4726-5p	PAR-CLIP	22012620
MIRT526459	hsa-miR-6762-5p	PAR-CLIP	22012620
MIRT526458	hsa-miR-6845-5p	PAR-CLIP	22012620
MIRT526466	hsa-miR-449b-3p	PAR-CLIP	22012620
MIRT526465	hsa-miR-6801-3p	PAR-CLIP	22012620
MIRT526464	hsa-miR-6810-3p	PAR-CLIP	22012620
MIRT526463	hsa-miR-1539	PAR-CLIP	22012620
MIRT526462	hsa-miR-744-5p	PAR-CLIP	22012620
MIRT526461	hsa-miR-4640-5p	PAR-CLIP	22012620
MIRT526460	hsa-miR-4726-5p	PAR-CLIP	22012620
MIRT526459	hsa-miR-6762-5p	PAR-CLIP	22012620
MIRT526458	hsa-miR-6845-5p	PAR-CLIP	22012620
MIRT1206251	hsa-miR-1184	CLIP-seq
MIRT1206252	hsa-miR-1224-3p	CLIP-seq
MIRT1206253	hsa-miR-128	CLIP-seq
MIRT1206254	hsa-miR-1301	CLIP-seq
MIRT1206255	hsa-miR-25	CLIP-seq
MIRT1206256	hsa-miR-27a	CLIP-seq
MIRT1206257	hsa-miR-27b	CLIP-seq
MIRT1206258	hsa-miR-31	CLIP-seq
MIRT1206259	hsa-miR-32	CLIP-seq
MIRT1206260	hsa-miR-363	CLIP-seq
MIRT1206261	hsa-miR-367	CLIP-seq
MIRT1206262	hsa-miR-3690	CLIP-seq
MIRT1206263	hsa-miR-378	CLIP-seq
MIRT1206264	hsa-miR-378b	CLIP-seq
MIRT1206265	hsa-miR-378c	CLIP-seq
MIRT1206266	hsa-miR-378d	CLIP-seq
MIRT1206267	hsa-miR-378e	CLIP-seq
MIRT1206268	hsa-miR-378f	CLIP-seq
MIRT1206269	hsa-miR-378h	CLIP-seq
MIRT1206270	hsa-miR-378i	CLIP-seq
MIRT1206271	hsa-miR-3929	CLIP-seq
MIRT1206272	hsa-miR-422a	CLIP-seq
MIRT1206273	hsa-miR-4307	CLIP-seq
MIRT1206274	hsa-miR-4418	CLIP-seq
MIRT1206275	hsa-miR-4419b	CLIP-seq
MIRT1206276	hsa-miR-4426	CLIP-seq
MIRT1206277	hsa-miR-4433	CLIP-seq
MIRT1206278	hsa-miR-4435	CLIP-seq
MIRT1206279	hsa-miR-4478	CLIP-seq
MIRT1206280	hsa-miR-4493	CLIP-seq
MIRT1206281	hsa-miR-4647	CLIP-seq
MIRT1206282	hsa-miR-4660	CLIP-seq
MIRT1206283	hsa-miR-4662b	CLIP-seq
MIRT1206284	hsa-miR-4687-3p	CLIP-seq
MIRT1206285	hsa-miR-4690-3p	CLIP-seq
MIRT1206286	hsa-miR-5047	CLIP-seq
MIRT1206287	hsa-miR-509-3-5p	CLIP-seq
MIRT1206288	hsa-miR-509-5p	CLIP-seq
MIRT1206289	hsa-miR-548al	CLIP-seq
MIRT1206290	hsa-miR-665	CLIP-seq
MIRT1206291	hsa-miR-92a	CLIP-seq
MIRT1206292	hsa-miR-92b	CLIP-seq
MIRT1206258	hsa-miR-31	CLIP-seq
MIRT1206276	hsa-miR-4426	CLIP-seq
MIRT1206277	hsa-miR-4433	CLIP-seq
MIRT1206278	hsa-miR-4435	CLIP-seq
MIRT1206293	hsa-miR-4466	CLIP-seq
MIRT1206281	hsa-miR-4647	CLIP-seq
MIRT1206283	hsa-miR-4662b	CLIP-seq
MIRT1206294	hsa-miR-4706	CLIP-seq
MIRT1206295	hsa-miR-4749-5p	CLIP-seq
MIRT1206289	hsa-miR-548al	CLIP-seq
MIRT1206290	hsa-miR-665	CLIP-seq
MIRT1206296	hsa-miR-675	CLIP-seq
MIRT1206297	hsa-miR-744	CLIP-seq
MIRT2287748	hsa-miR-106a	CLIP-seq
MIRT2287749	hsa-miR-106b	CLIP-seq
MIRT2287750	hsa-miR-17	CLIP-seq
MIRT2287751	hsa-miR-20a	CLIP-seq
MIRT2287752	hsa-miR-20b	CLIP-seq
MIRT2287753	hsa-miR-3183	CLIP-seq
MIRT2287754	hsa-miR-3609	CLIP-seq
MIRT2287755	hsa-miR-4723-3p	CLIP-seq
MIRT2287756	hsa-miR-4728-5p	CLIP-seq
MIRT2287757	hsa-miR-4757-5p	CLIP-seq
MIRT2287758	hsa-miR-4796-3p	CLIP-seq
MIRT2287759	hsa-miR-519d	CLIP-seq
MIRT2287760	hsa-miR-548ah	CLIP-seq
MIRT2287761	hsa-miR-93	CLIP-seq
MIRT2465776	hsa-miR-1266	CLIP-seq
MIRT2465777	hsa-miR-1913	CLIP-seq
MIRT2465778	hsa-miR-28-5p	CLIP-seq
MIRT2465779	hsa-miR-3127-5p	CLIP-seq
MIRT2465780	hsa-miR-3139	CLIP-seq
MIRT2465781	hsa-miR-3194-3p	CLIP-seq
MIRT2465782	hsa-miR-324-3p	CLIP-seq
MIRT2465783	hsa-miR-3918	CLIP-seq
MIRT2465784	hsa-miR-4290	CLIP-seq
MIRT2465785	hsa-miR-4518	CLIP-seq
MIRT1206290	hsa-miR-665	CLIP-seq
MIRT2465786	hsa-miR-708	CLIP-seq
MIRT2465776	hsa-miR-1266	CLIP-seq
MIRT2465777	hsa-miR-1913	CLIP-seq
MIRT2465778	hsa-miR-28-5p	CLIP-seq
MIRT2465779	hsa-miR-3127-5p	CLIP-seq
MIRT2465780	hsa-miR-3139	CLIP-seq
MIRT2465781	hsa-miR-3194-3p	CLIP-seq
MIRT2465782	hsa-miR-324-3p	CLIP-seq
MIRT2465783	hsa-miR-3918	CLIP-seq
MIRT2465784	hsa-miR-4290	CLIP-seq
MIRT2465785	hsa-miR-4518	CLIP-seq
MIRT1206290	hsa-miR-665	CLIP-seq
MIRT2465786	hsa-miR-708	CLIP-seq
MIRT2465776	hsa-miR-1266	CLIP-seq
MIRT2465777	hsa-miR-1913	CLIP-seq
MIRT2465778	hsa-miR-28-5p	CLIP-seq
MIRT2465779	hsa-miR-3127-5p	CLIP-seq
MIRT2465780	hsa-miR-3139	CLIP-seq
MIRT2465781	hsa-miR-3194-3p	CLIP-seq
MIRT2465782	hsa-miR-324-3p	CLIP-seq
MIRT2465783	hsa-miR-3918	CLIP-seq
MIRT2465784	hsa-miR-4290	CLIP-seq
MIRT2465785	hsa-miR-4518	CLIP-seq
MIRT1206290	hsa-miR-665	CLIP-seq
MIRT2465786	hsa-miR-708	CLIP-seq

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001786	Function	Phosphatidylserine binding	IDA	23934110, 26206935
GO:0001786	Function	Phosphatidylserine binding	IEA
GO:0005548	Function	Phospholipid transporter activity	IEA
GO:0005548	Function	Phospholipid transporter activity	TAS
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	NAS	10588946
GO:0005829	Component	Cytosol	TAS
GO:0006869	Process	Lipid transport	IEA
GO:0006893	Process	Golgi to plasma membrane transport	NAS	10588946
GO:0008142	Function	Oxysterol binding	NAS	10588946
GO:0008203	Process	Cholesterol metabolic process	NAS	10588946
GO:0008289	Function	Lipid binding	IEA
GO:0015485	Function	Cholesterol binding	IBA
GO:0015485	Function	Cholesterol binding	IDA	17428193
GO:0015485	Function	Cholesterol binding	IEA
GO:0015914	Process	Phospholipid transport	IBA
GO:0015914	Process	Phospholipid transport	IDA	26206935
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0030301	Process	Cholesterol transport	NAS	10588946
GO:0036150	Process	Phosphatidylserine acyl-chain remodeling	IEA
GO:0036150	Process	Phosphatidylserine acyl-chain remodeling	TAS
GO:0070273	Function	Phosphatidylinositol-4-phosphate binding	IDA	26206935
GO:0070273	Function	Phosphatidylinositol-4-phosphate binding	IEA
GO:0120009	Process	Intermembrane lipid transfer	IEA
GO:0140268	Component	Endoplasmic reticulum-plasma membrane contact site	IDA	26206935, 30220461
GO:0140343	Function	Phosphatidylserine transfer activity	IDA	26206935
GO:0140343	Function	Phosphatidylserine transfer activity	IEA

MIM	HGNC	e!Ensembl
606733	16392	ENSG00000021762

Q9H0X9

Protein name

Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1)

Protein function

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma m

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	126 → 243	PH domain	Domain
PF01237	Oxysterol_BP	371 → 716	Oxysterol-binding protein	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:12504849, ECO:0000269|PubMed:21220512}.

Sequence

MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDE
GPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSA
LTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTPKVGQWVGTVLLHCCELIERP
SKKDGFCFKLFHPLDQSVWAVKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALEL
ALRCSSLLRLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAF
SDKSERENPEESDTETQDHSRKTESGSDQSETPGAPVRRGTTYVEQVQEELGELGEASQV
ETVSEENKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEE
DAYSRMKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHP
PVSAFHVSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCK
GILYGTMTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASLS
GHWDRDVFIKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISK
GDQHRATQEKFALEEAQRQRARERQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKD
IAQFEQDGILRTLQQEAVARQTTFLGSPGPRHERSGPDQRLRKASDQPSGHSQATESSGS
TPESCPELSDEEQDGDFVPGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAML
SSTARAAQAPTPGLLQSPRSWFLLCVFLACQLFINHILK

Sequence length

879

Interactions

View interactions

	KEGG		Reactome
	Cholesterol metabolism		Acyl chain remodelling of PS

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OROFACIAL CLEFT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSBPL5-related disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arthropathy	Arthropathy	BEFREE	30779748		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36918840	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	19032366, 20128820		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	19032366, 29358326		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-alcoholic Fatty Liver Disease	Non-Alcoholic Fatty Liver Disease	GWASCAT_DG	31311600		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	36366750	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	19032366, 20128820		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasm	Pancreatic Neoplasm	LHGDN	19032366		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	20128820	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	32048780	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Russell-Silver syndrome	Russell-Silver Syndrome	BEFREE	28624953		★★★★★ ★☆☆☆☆ Found in Text Mining only
Skin Diseases	Skin disease	Pubtator	30779748	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

OSBPL5 (oxysterol binding protein like 5)