Gene Gene information from NCBI Gene database.
Entrez ID 114826
Gene name SET and MYND domain containing 4
Gene symbol SMYD4
Synonyms (NCBI Gene)
ZMYND21
Chromosome 17
Chromosome location 17p13.3
miRNA miRNA information provided by mirtarbase database.
467
miRTarBase ID miRNA Experiments Reference
MIRT037610 hsa-miR-744-5p CLASH 23622248
MIRT664253 hsa-miR-6796-3p HITS-CLIP 23824327
MIRT664252 hsa-miR-6890-3p HITS-CLIP 23824327
MIRT664251 hsa-miR-6741-3p HITS-CLIP 23824327
MIRT664250 hsa-miR-1304-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 30110327
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 38438251
GO:0005634 Component Nucleus IEA
GO:0005634 Component Nucleus ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619134 21067 ENSG00000186532
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IYR2
Protein name Protein-lysine N-methyltransferase SMYD4 (EC 2.1.1.-) (SET and MYND domain-containing protein 4)
Protein function Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity (PubMed:38438251). May also act as a histone methyltransferase (By similarity). Plays a critical role in cardiac development. Acts as a key epigene
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00856 SET 244 574 SET domain Family
PF01753 zf-MYND 296 335 MYND finger Domain
Sequence
MDLPVDEWKSYLLQKWASLPTSVQVTISTAETLRDIFLHSSSLLQPEDELFLKRLSKGYL
VGKDSDAPLFYREEGNKKFQEKDYTGAAVLYSKGVSHSRPNTEDMSLCHANRSAALFHLG
QYETCLKDINRAQTHGYPERLQPKIMLRKAECLVALGRLQEASQTISDLERNFTATPALA
DVLPQTLQRNLHRLKMKMQEKDSLTESFPAALAKTLEDAALREENEQLSNASSSIGLCVD
PLKGRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCL
KHTLATVPCDGCSYAKYCSQECLQQAWELYHRTEC
PLGGLLLTLGVFCHIALRLTLLVGF
EDVRKIITKLCDKISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDINGKYEN
NYNAVFNLLPHTENHSPEHKFLCALCVSALCRQLEAASLQAIPTERIVNSSQLKAAVTPE
LCPDVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNH
SCSPNTSVSFISTVATIRASQRIRKGQEILHCYG
PHKSRMGVAERQQKLRSQYFFDCACP
ACQTEAHRMAAGPRWEAFCCNSCGAPMQGDDVLRCGSRSCAESAVSRDHLVSRLQDLQQQ
VRVAQKLLRDGELERAVQRLSGCQRDAESFLWAEHAVVGEIADGLARACAALGDWQKSAT
HLQRSLYVVEVRHGPSSVEMGHELFKLAQIFFNGFAVPEALSTIQKAEEVLSLHCGPWDD
EIQELQKMKSCLLDLPPTPVGPAL
Sequence length 804
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Lung cancer Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MEDULLOBLASTOMA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adult Medulloblastoma Medulloblastoma CTD_human_DG 19270706
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 19383909, 30719138, 30930987
★☆☆☆☆
Found in Text Mining only
Childhood Medulloblastoma Medulloblastoma CTD_human_DG 19270706
★☆☆☆☆
Found in Text Mining only
Congenital Heart Defects Congenital heart defects BEFREE 30110327
★☆☆☆☆
Found in Text Mining only
Desmoplastic Medulloblastoma Medulloblastoma CTD_human_DG 19270706
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer BEFREE 19383909, 30719138
★☆☆☆☆
Found in Text Mining only
Medulloblastoma Medulloblastoma CTD_human_DG 19270706
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Medullomyoblastoma Medullomyoblastoma CTD_human_DG 19270706
★☆☆☆☆
Found in Text Mining only
Melanotic medulloblastoma Medulloblastoma CTD_human_DG 19270706
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 19383909, 30930987
★☆☆☆☆
Found in Text Mining only