Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	114823
Gene name	Leukocyte receptor cluster member 8
Gene symbol	LENG8
Synonyms (NCBI Gene)	pp13842
Chromosome	19
Chromosome location	19q13.42

262

Show/Hide all (262)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047171	hsa-miR-183-5p	CLASH	23622248
MIRT045355	hsa-miR-185-5p	CLASH	23622248
MIRT040373	hsa-miR-615-3p	CLASH	23622248
MIRT483946	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT483945	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT483944	hsa-miR-4779	PAR-CLIP	20371350
MIRT483943	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT483942	hsa-miR-3179	PAR-CLIP	20371350
MIRT483941	hsa-miR-6124	PAR-CLIP	20371350
MIRT483940	hsa-miR-3202	PAR-CLIP	20371350
MIRT483939	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT483938	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT483936	hsa-miR-6731-5p	PAR-CLIP	20371350
MIRT483937	hsa-miR-8085	PAR-CLIP	20371350
MIRT483935	hsa-miR-4271	PAR-CLIP	20371350
MIRT483934	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT483933	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT483932	hsa-miR-3175	PAR-CLIP	20371350
MIRT483931	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT483946	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT483945	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT483944	hsa-miR-4779	PAR-CLIP	20371350
MIRT483943	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT483942	hsa-miR-3179	PAR-CLIP	20371350
MIRT483941	hsa-miR-6124	PAR-CLIP	20371350
MIRT483940	hsa-miR-3202	PAR-CLIP	20371350
MIRT483939	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT483938	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT483936	hsa-miR-6731-5p	PAR-CLIP	20371350
MIRT483937	hsa-miR-8085	PAR-CLIP	20371350
MIRT483935	hsa-miR-4271	PAR-CLIP	20371350
MIRT483934	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT483933	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT483932	hsa-miR-3175	PAR-CLIP	20371350
MIRT483931	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT483946	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT483945	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT483944	hsa-miR-4779	PAR-CLIP	23592263
MIRT483943	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT483942	hsa-miR-3179	PAR-CLIP	23592263
MIRT489453	hsa-miR-1827	PAR-CLIP	23592263
MIRT483941	hsa-miR-6124	PAR-CLIP	23592263
MIRT483940	hsa-miR-3202	PAR-CLIP	23592263
MIRT489452	hsa-miR-3612	PAR-CLIP	23592263
MIRT489451	hsa-miR-650	PAR-CLIP	23592263
MIRT483939	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483938	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT483936	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT483937	hsa-miR-8085	PAR-CLIP	23592263
MIRT483935	hsa-miR-4271	PAR-CLIP	23592263
MIRT483934	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT483933	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT483932	hsa-miR-3175	PAR-CLIP	23592263
MIRT489450	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT483931	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT483946	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT483945	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT483944	hsa-miR-4779	PAR-CLIP	23592263
MIRT483943	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT483942	hsa-miR-3179	PAR-CLIP	23592263
MIRT483941	hsa-miR-6124	PAR-CLIP	23592263
MIRT483940	hsa-miR-3202	PAR-CLIP	23592263
MIRT483939	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483938	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT483936	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT483937	hsa-miR-8085	PAR-CLIP	23592263
MIRT483935	hsa-miR-4271	PAR-CLIP	23592263
MIRT483934	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT483933	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT483932	hsa-miR-3175	PAR-CLIP	23592263
MIRT483931	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT483946	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT483945	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT483944	hsa-miR-4779	PAR-CLIP	20371350
MIRT483943	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT483942	hsa-miR-3179	PAR-CLIP	20371350
MIRT483941	hsa-miR-6124	PAR-CLIP	20371350
MIRT483940	hsa-miR-3202	PAR-CLIP	20371350
MIRT483939	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT483938	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT483936	hsa-miR-6731-5p	PAR-CLIP	20371350
MIRT483937	hsa-miR-8085	PAR-CLIP	20371350
MIRT483935	hsa-miR-4271	PAR-CLIP	20371350
MIRT483934	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT483933	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT483932	hsa-miR-3175	PAR-CLIP	20371350
MIRT483931	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT483946	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT483945	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT483944	hsa-miR-4779	PAR-CLIP	20371350
MIRT483943	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT483942	hsa-miR-3179	PAR-CLIP	20371350
MIRT483941	hsa-miR-6124	PAR-CLIP	20371350
MIRT483940	hsa-miR-3202	PAR-CLIP	20371350
MIRT483939	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT483938	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT483936	hsa-miR-6731-5p	PAR-CLIP	20371350
MIRT483937	hsa-miR-8085	PAR-CLIP	20371350
MIRT483935	hsa-miR-4271	PAR-CLIP	20371350
MIRT483934	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT483933	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT483932	hsa-miR-3175	PAR-CLIP	20371350
MIRT483931	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT483946	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT483945	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT483944	hsa-miR-4779	PAR-CLIP	23592263
MIRT483943	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT483942	hsa-miR-3179	PAR-CLIP	23592263
MIRT489453	hsa-miR-1827	PAR-CLIP	23592263
MIRT483941	hsa-miR-6124	PAR-CLIP	23592263
MIRT483940	hsa-miR-3202	PAR-CLIP	23592263
MIRT489452	hsa-miR-3612	PAR-CLIP	23592263
MIRT489451	hsa-miR-650	PAR-CLIP	23592263
MIRT483939	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483938	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT483936	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT483937	hsa-miR-8085	PAR-CLIP	23592263
MIRT483935	hsa-miR-4271	PAR-CLIP	23592263
MIRT483934	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT483933	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT483932	hsa-miR-3175	PAR-CLIP	23592263
MIRT489450	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT483931	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT483946	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT483945	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT483944	hsa-miR-4779	PAR-CLIP	23592263
MIRT483943	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT483942	hsa-miR-3179	PAR-CLIP	23592263
MIRT483941	hsa-miR-6124	PAR-CLIP	23592263
MIRT483940	hsa-miR-3202	PAR-CLIP	23592263
MIRT483939	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483938	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT483936	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT483937	hsa-miR-8085	PAR-CLIP	23592263
MIRT483935	hsa-miR-4271	PAR-CLIP	23592263
MIRT483934	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT483933	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT483932	hsa-miR-3175	PAR-CLIP	23592263
MIRT483931	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT1107414	hsa-miR-1207-5p	CLIP-seq
MIRT1107415	hsa-miR-1299	CLIP-seq
MIRT1107416	hsa-miR-1321	CLIP-seq
MIRT1107417	hsa-miR-1914	CLIP-seq
MIRT1107418	hsa-miR-2467-3p	CLIP-seq
MIRT1107419	hsa-miR-3127-5p	CLIP-seq
MIRT1107420	hsa-miR-3131	CLIP-seq
MIRT1107421	hsa-miR-3148	CLIP-seq
MIRT1107422	hsa-miR-3153	CLIP-seq
MIRT1107423	hsa-miR-3660	CLIP-seq
MIRT1107424	hsa-miR-3928	CLIP-seq
MIRT1107425	hsa-miR-4270	CLIP-seq
MIRT1107426	hsa-miR-4293	CLIP-seq
MIRT1107427	hsa-miR-4419a	CLIP-seq
MIRT1107428	hsa-miR-4441	CLIP-seq
MIRT1107429	hsa-miR-4447	CLIP-seq
MIRT1107430	hsa-miR-4472	CLIP-seq
MIRT1107431	hsa-miR-451	CLIP-seq
MIRT1107432	hsa-miR-4510	CLIP-seq
MIRT1107433	hsa-miR-4526	CLIP-seq
MIRT1107434	hsa-miR-4645-3p	CLIP-seq
MIRT1107435	hsa-miR-4668-5p	CLIP-seq
MIRT1107436	hsa-miR-4739	CLIP-seq
MIRT1107437	hsa-miR-4756-5p	CLIP-seq
MIRT1107438	hsa-miR-4763-3p	CLIP-seq
MIRT1107439	hsa-miR-548c-3p	CLIP-seq
MIRT1107440	hsa-miR-611	CLIP-seq
MIRT1107441	hsa-miR-658	CLIP-seq
MIRT1107442	hsa-miR-875-3p	CLIP-seq
MIRT2029664	hsa-miR-1292	CLIP-seq
MIRT2029665	hsa-miR-141	CLIP-seq
MIRT2029666	hsa-miR-200a	CLIP-seq
MIRT1107419	hsa-miR-3127-5p	CLIP-seq
MIRT1107420	hsa-miR-3131	CLIP-seq
MIRT2029667	hsa-miR-361-3p	CLIP-seq
MIRT2029668	hsa-miR-4311	CLIP-seq
MIRT1107429	hsa-miR-4447	CLIP-seq
MIRT2029669	hsa-miR-4471	CLIP-seq
MIRT1107430	hsa-miR-4472	CLIP-seq
MIRT2029670	hsa-miR-4492	CLIP-seq
MIRT2029671	hsa-miR-4498	CLIP-seq
MIRT2029672	hsa-miR-4505	CLIP-seq
MIRT2029673	hsa-miR-4646-5p	CLIP-seq
MIRT2029674	hsa-miR-4660	CLIP-seq
MIRT1107440	hsa-miR-611	CLIP-seq
MIRT2029675	hsa-miR-646	CLIP-seq
MIRT2029676	hsa-miR-762	CLIP-seq
MIRT2260547	hsa-miR-103b	CLIP-seq
MIRT2029664	hsa-miR-1292	CLIP-seq
MIRT2260548	hsa-miR-145	CLIP-seq
MIRT2260549	hsa-miR-1913	CLIP-seq
MIRT1107417	hsa-miR-1914	CLIP-seq
MIRT1107418	hsa-miR-2467-3p	CLIP-seq
MIRT1107419	hsa-miR-3127-5p	CLIP-seq
MIRT1107420	hsa-miR-3131	CLIP-seq
MIRT1107422	hsa-miR-3153	CLIP-seq
MIRT2260550	hsa-miR-3195	CLIP-seq
MIRT2260551	hsa-miR-324-3p	CLIP-seq
MIRT2029667	hsa-miR-361-3p	CLIP-seq
MIRT1107423	hsa-miR-3660	CLIP-seq
MIRT2260552	hsa-miR-3925-3p	CLIP-seq
MIRT1107424	hsa-miR-3928	CLIP-seq
MIRT2260553	hsa-miR-4267	CLIP-seq
MIRT2260554	hsa-miR-4313	CLIP-seq
MIRT1107429	hsa-miR-4447	CLIP-seq
MIRT2029669	hsa-miR-4471	CLIP-seq
MIRT1107430	hsa-miR-4472	CLIP-seq
MIRT2029670	hsa-miR-4492	CLIP-seq
MIRT2029671	hsa-miR-4498	CLIP-seq
MIRT2029672	hsa-miR-4505	CLIP-seq
MIRT2260555	hsa-miR-450b-5p	CLIP-seq
MIRT1107433	hsa-miR-4526	CLIP-seq
MIRT2260556	hsa-miR-455-3p	CLIP-seq
MIRT2260557	hsa-miR-4640-5p	CLIP-seq
MIRT1107434	hsa-miR-4645-3p	CLIP-seq
MIRT2029673	hsa-miR-4646-5p	CLIP-seq
MIRT2029674	hsa-miR-4660	CLIP-seq
MIRT2260558	hsa-miR-4667-3p	CLIP-seq
MIRT1107435	hsa-miR-4668-5p	CLIP-seq
MIRT2260559	hsa-miR-4685-5p	CLIP-seq
MIRT2260560	hsa-miR-4691-5p	CLIP-seq
MIRT2260561	hsa-miR-4726-5p	CLIP-seq
MIRT2260562	hsa-miR-4749-3p	CLIP-seq
MIRT2260563	hsa-miR-518a-5p	CLIP-seq
MIRT2260564	hsa-miR-527	CLIP-seq
MIRT1107440	hsa-miR-611	CLIP-seq
MIRT2029675	hsa-miR-646	CLIP-seq
MIRT2029676	hsa-miR-762	CLIP-seq
MIRT2260565	hsa-miR-935	CLIP-seq
MIRT1107419	hsa-miR-3127-5p	CLIP-seq
MIRT1107420	hsa-miR-3131	CLIP-seq
MIRT2029667	hsa-miR-361-3p	CLIP-seq
MIRT1107429	hsa-miR-4447	CLIP-seq
MIRT1107430	hsa-miR-4472	CLIP-seq
MIRT2029674	hsa-miR-4660	CLIP-seq
MIRT1107440	hsa-miR-611	CLIP-seq
MIRT2029675	hsa-miR-646	CLIP-seq
MIRT2260547	hsa-miR-103b	CLIP-seq
MIRT2260548	hsa-miR-145	CLIP-seq
MIRT2260552	hsa-miR-3925-3p	CLIP-seq
MIRT2260553	hsa-miR-4267	CLIP-seq
MIRT2260555	hsa-miR-450b-5p	CLIP-seq
MIRT2260556	hsa-miR-455-3p	CLIP-seq
MIRT1107434	hsa-miR-4645-3p	CLIP-seq
MIRT2560584	hsa-miR-4666-5p	CLIP-seq
MIRT2260560	hsa-miR-4691-5p	CLIP-seq
MIRT2560585	hsa-miR-4802-3p	CLIP-seq
MIRT2260563	hsa-miR-518a-5p	CLIP-seq
MIRT2260564	hsa-miR-527	CLIP-seq
MIRT2260565	hsa-miR-935	CLIP-seq
MIRT2260547	hsa-miR-103b	CLIP-seq
MIRT2260548	hsa-miR-145	CLIP-seq
MIRT2260552	hsa-miR-3925-3p	CLIP-seq
MIRT2260553	hsa-miR-4267	CLIP-seq
MIRT2260555	hsa-miR-450b-5p	CLIP-seq
MIRT2260556	hsa-miR-455-3p	CLIP-seq
MIRT1107434	hsa-miR-4645-3p	CLIP-seq
MIRT2560584	hsa-miR-4666-5p	CLIP-seq
MIRT2260560	hsa-miR-4691-5p	CLIP-seq
MIRT2560585	hsa-miR-4802-3p	CLIP-seq
MIRT2260563	hsa-miR-518a-5p	CLIP-seq
MIRT2260564	hsa-miR-527	CLIP-seq
MIRT2260565	hsa-miR-935	CLIP-seq

Show/Hide all (3)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16239144, 19060904, 25416956, 26382858, 32296183, 32814053, 32960270, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0032991	Component	Protein-containing complex	IEA

MIM	HGNC	e!Ensembl
616575	15500	ENSG00000167615

Q96PV6

Protein name

Leukocyte receptor cluster member 8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03399	SAC3_GANP	532 → 782	SAC3/GANP family	Family

Sequence

MAANVGDQRSTDWSSQYSMVAGAGRENGMETPMHENPEWEKARQALASISKSGAAGGSAK
SSSNGPVASAQYVSQAEASALQQQQYYQWYQQYNYAYPYSYYYPMSMYQSYGSPSQYGMA
GSYGSATPQQPSAPQHQGTLNQPPVPGMDESMSYQAPPQQLPSAQPPQPSNPPHGAHTLN
SGPQPGTAPATQHSQAGPATGQAYGPHTYTEPAKPKKGQQLWNRMKPAPGTGGLKFNIQK
RPFAVTTQSFGSNAEGQHSGFGPQPNPEKVQNHSGSSARGNLSGKPDDWPQDMKEYVERC
FTACESEEDKDRTEKLLKEVLQARLQDGSAYTIDWSREPLPGLTREPVAESPKKKRWEAA
SSLHPPRGAGSATRGGGAPSQRGTPGAGGAGRARGNSFTKFGNRNVFMKDNSSSSSTDSR
SRSSSRSPTRHFRRSDSHSDSDSSYSGNECHPVGRRNPPPKGRGGRGAHMDRGRGRAQRG
KRHDLAPTKRSRKKMAALECEDPERELKKQKRAARFQHGHSRRLRLEPLVLQMSSLESSG
ADPDWQELQIVGTCPDITKHYLRLTCAPDPSTVRPVAVLKKSLCMVKCHWKEKQDYAFAC
EQMKSIRQDLTVQGIRTEFTVEVYETHARIALEKGDHEEFNQCQTQLKSLYAENLPGNVG
EFTAYRILYYIFTKNSGDITTELAYLTRELKADPCVAHALALRTAWALGNYHRFFRLYCH
APCMSGYLVDKFADRERKVALKAMIKTFRPALPVSYLQAELAFEGEAACRAFLEPLGLAY
TGPDNSSIDCRLSLAQLSAF

Sequence length

800

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Cervical cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LENG8-related disorder	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	31140607	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36949429	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pemphigus	Pemphigus	Pubtator	30216441	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pemphigus Foliaceus	Pemphigus Foliaceus	BEFREE	30216441		★★★★★ ★☆☆☆☆ Found in Text Mining only

LENG8 (leukocyte receptor cluster member 8)