Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	114822
Gene name	Rhophilin Rho GTPase binding protein 1
Gene symbol	RHPN1
Synonyms (NCBI Gene)	ODF5RHOPHILINRHPN
Chromosome	8
Chromosome location	8q24.3

175

Show/Hide all (175)

miRTarBase ID	miRNA	Experiments	Reference
MIRT040941	hsa-miR-18a-3p	CLASH	23622248
MIRT1306179	hsa-miR-10a	CLIP-seq
MIRT1306180	hsa-miR-10b	CLIP-seq
MIRT1306181	hsa-miR-1182	CLIP-seq
MIRT1306182	hsa-miR-1233	CLIP-seq
MIRT1306183	hsa-miR-1237	CLIP-seq
MIRT1306184	hsa-miR-1248	CLIP-seq
MIRT1306185	hsa-miR-1266	CLIP-seq
MIRT1306186	hsa-miR-1273e	CLIP-seq
MIRT1306187	hsa-miR-1285	CLIP-seq
MIRT1306188	hsa-miR-1290	CLIP-seq
MIRT1306189	hsa-miR-1294	CLIP-seq
MIRT1306190	hsa-miR-1343	CLIP-seq
MIRT1306191	hsa-miR-15a	CLIP-seq
MIRT1306192	hsa-miR-15b	CLIP-seq
MIRT1306193	hsa-miR-16	CLIP-seq
MIRT1306194	hsa-miR-1827	CLIP-seq
MIRT1306195	hsa-miR-1909	CLIP-seq
MIRT1306196	hsa-miR-1915	CLIP-seq
MIRT1306197	hsa-miR-195	CLIP-seq
MIRT1306198	hsa-miR-214	CLIP-seq
MIRT1306199	hsa-miR-2277-3p	CLIP-seq
MIRT1306200	hsa-miR-28-5p	CLIP-seq
MIRT1306201	hsa-miR-3126-5p	CLIP-seq
MIRT1306202	hsa-miR-3135b	CLIP-seq
MIRT1306203	hsa-miR-3136-3p	CLIP-seq
MIRT1306204	hsa-miR-3138	CLIP-seq
MIRT1306205	hsa-miR-3139	CLIP-seq
MIRT1306206	hsa-miR-3150a-3p	CLIP-seq
MIRT1306207	hsa-miR-3150b-3p	CLIP-seq
MIRT1306208	hsa-miR-3151	CLIP-seq
MIRT1306209	hsa-miR-3173-3p	CLIP-seq
MIRT1306210	hsa-miR-3175	CLIP-seq
MIRT1306211	hsa-miR-3182	CLIP-seq
MIRT1306212	hsa-miR-3187-5p	CLIP-seq
MIRT1306213	hsa-miR-3197	CLIP-seq
MIRT1306214	hsa-miR-3199	CLIP-seq
MIRT1306215	hsa-miR-331-3p	CLIP-seq
MIRT1306216	hsa-miR-338-3p	CLIP-seq
MIRT1306217	hsa-miR-3619-5p	CLIP-seq
MIRT1306218	hsa-miR-3620	CLIP-seq
MIRT1306219	hsa-miR-3660	CLIP-seq
MIRT1306220	hsa-miR-3663-3p	CLIP-seq
MIRT1306221	hsa-miR-3665	CLIP-seq
MIRT1306222	hsa-miR-3672	CLIP-seq
MIRT1306223	hsa-miR-3940-3p	CLIP-seq
MIRT1306224	hsa-miR-3940-5p	CLIP-seq
MIRT1306225	hsa-miR-424	CLIP-seq
MIRT1306226	hsa-miR-4316	CLIP-seq
MIRT1306227	hsa-miR-4323	CLIP-seq
MIRT1306228	hsa-miR-4329	CLIP-seq
MIRT1306229	hsa-miR-4428	CLIP-seq
MIRT1306230	hsa-miR-4436b-3p	CLIP-seq
MIRT1306231	hsa-miR-4446-3p	CLIP-seq
MIRT1306232	hsa-miR-4470	CLIP-seq
MIRT1306233	hsa-miR-4487	CLIP-seq
MIRT1306234	hsa-miR-4492	CLIP-seq
MIRT1306235	hsa-miR-4498	CLIP-seq
MIRT1306236	hsa-miR-4505	CLIP-seq
MIRT1306237	hsa-miR-4506	CLIP-seq
MIRT1306238	hsa-miR-4507	CLIP-seq
MIRT1306239	hsa-miR-4514	CLIP-seq
MIRT1306240	hsa-miR-4515	CLIP-seq
MIRT1306241	hsa-miR-4518	CLIP-seq
MIRT1306242	hsa-miR-4520a-3p	CLIP-seq
MIRT1306243	hsa-miR-4526	CLIP-seq
MIRT1306244	hsa-miR-4530	CLIP-seq
MIRT1306245	hsa-miR-4532	CLIP-seq
MIRT1306246	hsa-miR-4642	CLIP-seq
MIRT1306247	hsa-miR-4645-5p	CLIP-seq
MIRT1306248	hsa-miR-4663	CLIP-seq
MIRT1306249	hsa-miR-4667-5p	CLIP-seq
MIRT1306250	hsa-miR-4673	CLIP-seq
MIRT1306251	hsa-miR-4677-3p	CLIP-seq
MIRT1306252	hsa-miR-4685-5p	CLIP-seq
MIRT1306253	hsa-miR-4687-3p	CLIP-seq
MIRT1306254	hsa-miR-4687-5p	CLIP-seq
MIRT1306255	hsa-miR-4689	CLIP-seq
MIRT1306256	hsa-miR-4690-5p	CLIP-seq
MIRT1306257	hsa-miR-4692	CLIP-seq
MIRT1306258	hsa-miR-4700-5p	CLIP-seq
MIRT1306259	hsa-miR-4720-5p	CLIP-seq
MIRT1306260	hsa-miR-4721	CLIP-seq
MIRT1306261	hsa-miR-4728-5p	CLIP-seq
MIRT1306262	hsa-miR-4731-5p	CLIP-seq
MIRT1306263	hsa-miR-4733-3p	CLIP-seq
MIRT1306264	hsa-miR-4736	CLIP-seq
MIRT1306265	hsa-miR-4784	CLIP-seq
MIRT1306266	hsa-miR-4786-5p	CLIP-seq
MIRT1306267	hsa-miR-4787-5p	CLIP-seq
MIRT1306268	hsa-miR-4799-3p	CLIP-seq
MIRT1306269	hsa-miR-486-3p	CLIP-seq
MIRT1306270	hsa-miR-497	CLIP-seq
MIRT1306271	hsa-miR-563	CLIP-seq
MIRT1306272	hsa-miR-612	CLIP-seq
MIRT1306273	hsa-miR-634	CLIP-seq
MIRT1306274	hsa-miR-665	CLIP-seq
MIRT1306275	hsa-miR-708	CLIP-seq
MIRT1306276	hsa-miR-761	CLIP-seq
MIRT1306277	hsa-miR-762	CLIP-seq
MIRT1306278	hsa-miR-764	CLIP-seq
MIRT1306279	hsa-miR-766	CLIP-seq
MIRT1306280	hsa-miR-769-5p	CLIP-seq
MIRT1306281	hsa-miR-939	CLIP-seq
MIRT1306282	hsa-miR-940	CLIP-seq
MIRT2090735	hsa-miR-1207-5p	CLIP-seq
MIRT1306195	hsa-miR-1909	CLIP-seq
MIRT1306198	hsa-miR-214	CLIP-seq
MIRT1306202	hsa-miR-3135b	CLIP-seq
MIRT1306213	hsa-miR-3197	CLIP-seq
MIRT2090736	hsa-miR-3616-3p	CLIP-seq
MIRT1306217	hsa-miR-3619-5p	CLIP-seq
MIRT2090737	hsa-miR-4327	CLIP-seq
MIRT1306230	hsa-miR-4436b-3p	CLIP-seq
MIRT1306231	hsa-miR-4446-3p	CLIP-seq
MIRT1306233	hsa-miR-4487	CLIP-seq
MIRT1306252	hsa-miR-4685-5p	CLIP-seq
MIRT2090738	hsa-miR-4763-3p	CLIP-seq
MIRT2090739	hsa-miR-636	CLIP-seq
MIRT1306276	hsa-miR-761	CLIP-seq
MIRT1306181	hsa-miR-1182	CLIP-seq
MIRT2090735	hsa-miR-1207-5p	CLIP-seq
MIRT1306185	hsa-miR-1266	CLIP-seq
MIRT2315396	hsa-miR-1272	CLIP-seq
MIRT2315397	hsa-miR-1286	CLIP-seq
MIRT2315398	hsa-miR-1296	CLIP-seq
MIRT1306191	hsa-miR-15a	CLIP-seq
MIRT1306192	hsa-miR-15b	CLIP-seq
MIRT1306193	hsa-miR-16	CLIP-seq
MIRT1306194	hsa-miR-1827	CLIP-seq
MIRT1306196	hsa-miR-1915	CLIP-seq
MIRT1306197	hsa-miR-195	CLIP-seq
MIRT1306198	hsa-miR-214	CLIP-seq
MIRT2315399	hsa-miR-2278	CLIP-seq
MIRT2315400	hsa-miR-2909	CLIP-seq
MIRT2315401	hsa-miR-3120-3p	CLIP-seq
MIRT1306204	hsa-miR-3138	CLIP-seq
MIRT1306206	hsa-miR-3150a-3p	CLIP-seq
MIRT2315402	hsa-miR-3169	CLIP-seq
MIRT1306210	hsa-miR-3175	CLIP-seq
MIRT1306213	hsa-miR-3197	CLIP-seq
MIRT1306216	hsa-miR-338-3p	CLIP-seq
MIRT2315403	hsa-miR-34b	CLIP-seq
MIRT1306217	hsa-miR-3619-5p	CLIP-seq
MIRT1306225	hsa-miR-424	CLIP-seq
MIRT2315404	hsa-miR-4436a	CLIP-seq
MIRT1306230	hsa-miR-4436b-3p	CLIP-seq
MIRT1306231	hsa-miR-4446-3p	CLIP-seq
MIRT1306234	hsa-miR-4492	CLIP-seq
MIRT1306235	hsa-miR-4498	CLIP-seq
MIRT2315405	hsa-miR-4512	CLIP-seq
MIRT1306241	hsa-miR-4518	CLIP-seq
MIRT1306242	hsa-miR-4520a-3p	CLIP-seq
MIRT1306244	hsa-miR-4530	CLIP-seq
MIRT2315406	hsa-miR-4641	CLIP-seq
MIRT1306249	hsa-miR-4667-5p	CLIP-seq
MIRT1306252	hsa-miR-4685-5p	CLIP-seq
MIRT1306258	hsa-miR-4700-5p	CLIP-seq
MIRT2315407	hsa-miR-4708-3p	CLIP-seq
MIRT1306262	hsa-miR-4731-5p	CLIP-seq
MIRT1306264	hsa-miR-4736	CLIP-seq
MIRT2090738	hsa-miR-4763-3p	CLIP-seq
MIRT1306266	hsa-miR-4786-5p	CLIP-seq
MIRT1306269	hsa-miR-486-3p	CLIP-seq
MIRT1306270	hsa-miR-497	CLIP-seq
MIRT1306271	hsa-miR-563	CLIP-seq
MIRT1306273	hsa-miR-634	CLIP-seq
MIRT2315408	hsa-miR-647	CLIP-seq
MIRT1306276	hsa-miR-761	CLIP-seq
MIRT1306277	hsa-miR-762	CLIP-seq
MIRT1306279	hsa-miR-766	CLIP-seq
MIRT1306280	hsa-miR-769-5p	CLIP-seq
MIRT1306281	hsa-miR-939	CLIP-seq
MIRT1306282	hsa-miR-940	CLIP-seq
MIRT1306195	hsa-miR-1909	CLIP-seq

Show/Hide all (4)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0051497	Process	Negative regulation of stress fiber assembly	IBA

MIM	HGNC	e!Ensembl
601031	19973	ENSG00000158106

Q8TCX5

Protein name

Rhophilin-1 (GTP-Rho-binding protein 1)

Protein function

Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02185	HR1	36 → 97	Hr1 repeat	Family
PF03097	BRO1	109 → 510	BRO1-like domain	Domain
PF00595	PDZ	513 → 590	PDZ domain	Domain

Sequence

MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA
TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL
DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA
RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR
RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP
QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA
MALCDGSPATEGELPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAHLKRAILGQEEA
LRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPKTHQKPEAR
MPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIP
GSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLG
DRRPVLLGPRGLLRSQREHGCKTPASTWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAP
PSSLKHPGWP

Sequence length

670

Interactions

View interactions

	Reactome
			RHO GTPases Activate Rhotekin and Rhophilins

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERALDOSTERONISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POLYCYSTIC OVARY SYNDROME	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (21)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	31089812		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	31285391	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32910747, 34095306, 37478241	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	32163372	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	32910747	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	39233606	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	31089812		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31285391		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28124977, 31417644		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Diseases	Ovarian diseases	Pubtator	33907841, 34414458	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	32163372, 33907841, 34414458	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	31285391	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	CTD_human_DG	21411543		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	32953881	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	Pubtator	33426053	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sclerocystic Ovaries	Sclerocystic Ovaries	CTD_human_DG	21411543		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	31417644		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	31982726	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	39233606	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal Melanoma	BEFREE	28124977		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal melanoma	Pubtator	28124977	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

RHPN1 (rhophilin Rho GTPase binding protein 1)