SCAND3 (SCAN domain containing 3)

Gene

• Entrez ID: 114821
• Gene name: SCAN domain containing 3
• Gene symbol: SCAND3
• Synonyms (NCBI Gene): Buster4, FAM200D, ZBED9, ZFP38-L, ZNF305P2, ZNF452, dJ1186N24.3
• Chromosome: 6
• Chromosome location: 6p22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT708851	hsa-miR-1178-5p	HITS-CLIP	19536157
MIRT708850	hsa-miR-4502	HITS-CLIP	19536157
MIRT708849	hsa-miR-6134	HITS-CLIP	19536157
MIRT708848	hsa-miR-219b-5p	HITS-CLIP	19536157
MIRT708847	hsa-miR-7106-5p	HITS-CLIP	19536157
MIRT708846	hsa-miR-149-3p	HITS-CLIP	19536157
MIRT708845	hsa-miR-4728-5p	HITS-CLIP	19536157
MIRT708844	hsa-miR-6785-5p	HITS-CLIP	19536157
MIRT708843	hsa-miR-6883-5p	HITS-CLIP	19536157
MIRT708842	hsa-miR-6799-5p	HITS-CLIP	19536157
MIRT708841	hsa-miR-1233-5p	HITS-CLIP	19536157
MIRT708840	hsa-miR-6778-5p	HITS-CLIP	19536157
MIRT708839	hsa-miR-452-3p	HITS-CLIP	19536157
MIRT708838	hsa-miR-1273h-5p	HITS-CLIP	19536157
MIRT708837	hsa-miR-30b-3p	HITS-CLIP	19536157
MIRT708836	hsa-miR-3689a-3p	HITS-CLIP	19536157
MIRT708835	hsa-miR-3689b-3p	HITS-CLIP	19536157
MIRT708834	hsa-miR-3689c	HITS-CLIP	19536157
MIRT708833	hsa-miR-6779-5p	HITS-CLIP	19536157
MIRT708832	hsa-miR-6780a-5p	HITS-CLIP	19536157
MIRT740629	hsa-miR-1178-5p	HITS-CLIP	19536157
MIRT740630	hsa-miR-4502	HITS-CLIP	19536157
MIRT740631	hsa-miR-6134	HITS-CLIP	19536157
MIRT740632	hsa-miR-219b-5p	HITS-CLIP	19536157
MIRT740633	hsa-miR-7106-5p	HITS-CLIP	19536157
MIRT740634	hsa-miR-149-3p	HITS-CLIP	19536157
MIRT740635	hsa-miR-4728-5p	HITS-CLIP	19536157
MIRT740636	hsa-miR-6785-5p	HITS-CLIP	19536157
MIRT740637	hsa-miR-6883-5p	HITS-CLIP	19536157
MIRT740638	hsa-miR-6799-5p	HITS-CLIP	19536157
MIRT740639	hsa-miR-1233-5p	HITS-CLIP	19536157
MIRT740640	hsa-miR-6778-5p	HITS-CLIP	19536157
MIRT740641	hsa-miR-452-3p	HITS-CLIP	19536157
MIRT740642	hsa-miR-1273h-5p	HITS-CLIP	19536157
MIRT740643	hsa-miR-30b-3p	HITS-CLIP	19536157
MIRT740644	hsa-miR-3689a-3p	HITS-CLIP	19536157
MIRT740645	hsa-miR-3689b-3p	HITS-CLIP	19536157
MIRT740646	hsa-miR-3689c	HITS-CLIP	19536157
MIRT740647	hsa-miR-6779-5p	HITS-CLIP	19536157
MIRT740648	hsa-miR-6780a-5p	HITS-CLIP	19536157

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	28418919
GO:0015074	Process	DNA integration	IEA
GO:0045787	Process	Positive regulation of cell cycle	IMP	28418919
GO:0050679	Process	Positive regulation of epithelial cell proliferation	IMP	28418919

Other IDs

• MIM: 615254
• HGNC: 13851
• e!Ensembl: ENSG00000232040

Protein

• UniProt ID: Q6R2W3
• Protein name: SCAN domain-containing protein 3 (Transposon-derived Buster4 transposase-like protein) (Zinc finger BED domain-containing protein 9)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02023	SCAN	48 → 137	SCAN domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Weakly expressed in the lung (at protein level). {ECO:0000269|PubMed:28418919}.
• Sequence:

  MEAVSRVFPALAGQAPEEQGEIIKVKVKEEDHTWDQESALRRNLSYTRELSRQRFRQFCY
  QETPGPREALSQLRELCRQWLNPEIHTKEQILELLVLEQFLTILPEELQSWVREHNPESG
  EEVVTLLEDLERELDEPRQQVSQGTYGQEVSMEEMIPLDSAKESLGTQLQSMEDRMECES
  PEPHPLQDNGSFLWFSMMSQSMGGDNLSSLDTNEAEIEPENMREKFFRSLARLLENKSNN
  TKIFSKAKYCQLIKEVKEAKAKAKKESVDYRRLARFDVILVQGNEKLIEAVNGETDKIRY
  YLHSEDLFDILHNTHLSIGHGGRTRMEKELQAKYKNITKEVIMLYLTLCKPCQQKNSKLK
  KVLTSKSIKEVSSRCQVDLIDMQLNPDGEYRFILHYQDLCTKLTFLRSLKSKRPTEVAHA
  LLDIFTIIGAPSVLQSDNGREFSSQVVSELSNIWPELKIVHGKSQTCQSQSSAEQTEDIR
  KRIFSWMQTNNSSHWTEFLWFIQMSQNQPYHRSMQQTPCESAFSSEAKLGLSHSQLTEEL
  VASLHTENELDQADKELENTLRAQYEENIETGTDSSDIEENLSVTPKVAEKSPPESRLRF
  LSCVVCEKECTGVNSCISCDGNIHAICGVPSQHGTEGCGRQITCSLCYETSTMKRKHDEI
  QRSLPVKPSKMLKPSGTPFSPDKVGDWMAKQASLDFFVKKRHAFSEHSSSNKRNVNNRSY
  PEEGKTKRVHASFTRKYDPSYIEFGFVAVIDGEVLKPQCIICGDVLANEAMKPSKLKRHL
  YSKHKEISSQPKEFFERKSSELKSQPKQVFNVSHINISALRASYKVALPVAKSKTPYTIA
  ETLVKDCIKEVCLEMLGESAAKKVAQVPLSNDTIARRIQELANDMEDQLIEQIKLAKYFS
  LQLDECRDIANMIILLVYVRFEHDDDIKEEFFFSASLPTNTTSSELYEAVKNYIVNKCGL
  EFKFCVGVCSDGAASMTGKHSEVVTQIKELAPECKTTHCFIHRESLAMKKISAELNSVLN
  DIVKIVNYIKSNSLNSRLFSLLCDNMEADHKQLLLHAEIRWLSRGKVLSRMFEIRNELLV
  FLQGKKPMWSQLFKDVNWTARLAYLSDIFSIFNDLNASMQGKNATYFSMADKVEGQKQKL
  EAWKNRISTDCYDMFHNLTTIINEVGNDLDIAHLRKVISEHLTNLLECFEFYFPSKEDPR
  IGNLWIQNPFLSSKDNLNLTVTLQDKLLKLATDEGLKISFENTASLPSFWIKAKNDYPEL
  AEIALKLLLLFPSTYLCETGFSTLSVIKTKHRNSLNIHYPLRVALSSIQPRLDKLTSKKQ
  AHLSH

• Sequence length: 1325

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DENTAL CARIES	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EOSINOPHILIC ESOPHAGITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POST-TRAUMATIC STRESS DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	GWASCAT_DG	29059683		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cardiovascular Diseases	Cardiovascular disease	Pubtator	34083597	Associate	★☆☆☆☆ Found in Text Mining only
Child Development Disorders, Pervasive	Development Disorder	GWASCAT_DG	28540026		★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	GWASDB_DG	21971053		★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	28493959	Associate	★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	34083597	Associate	★☆☆☆☆ Found in Text Mining only
Hypotension	Hypotension	Pubtator	34083597	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28418919		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	28418919		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	28540026, 30285260		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	28493959		★☆☆☆☆ Found in Text Mining only