CCDC85A (coiled-coil domain containing 85A)

Gene

• Entrez ID: 114800
• Gene name: Coiled-coil domain containing 85A
• Gene symbol: CCDC85A
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2p16.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT869928	hsa-miR-128	CLIP-seq
MIRT869929	hsa-miR-1976	CLIP-seq
MIRT869930	hsa-miR-205	CLIP-seq
MIRT869931	hsa-miR-27a	CLIP-seq
MIRT869932	hsa-miR-27b	CLIP-seq
MIRT869933	hsa-miR-3074-3p	CLIP-seq
MIRT869934	hsa-miR-3175	CLIP-seq
MIRT869935	hsa-miR-3184	CLIP-seq
MIRT869936	hsa-miR-382	CLIP-seq
MIRT869937	hsa-miR-423-5p	CLIP-seq
MIRT869938	hsa-miR-4434	CLIP-seq
MIRT869939	hsa-miR-4516	CLIP-seq
MIRT869940	hsa-miR-4695-3p	CLIP-seq
MIRT869941	hsa-miR-495	CLIP-seq
MIRT869942	hsa-miR-513a-5p	CLIP-seq
MIRT1958128	hsa-miR-219-2-3p	CLIP-seq
MIRT1958129	hsa-miR-3190	CLIP-seq
MIRT1958130	hsa-miR-33a	CLIP-seq
MIRT1958131	hsa-miR-33b	CLIP-seq
MIRT1958132	hsa-miR-4261	CLIP-seq
MIRT1958133	hsa-miR-4464	CLIP-seq
MIRT1958134	hsa-miR-4646-5p	CLIP-seq
MIRT1958135	hsa-miR-4748	CLIP-seq
MIRT1958136	hsa-miR-4752	CLIP-seq
MIRT1958137	hsa-miR-548a-3p	CLIP-seq
MIRT1958138	hsa-miR-548e	CLIP-seq
MIRT1958139	hsa-miR-548f	CLIP-seq
MIRT2195078	hsa-miR-34c-3p	CLIP-seq
MIRT2446428	hsa-miR-3124-3p	CLIP-seq
MIRT2446429	hsa-miR-3143	CLIP-seq
MIRT2446430	hsa-miR-3685	CLIP-seq
MIRT2446431	hsa-miR-384	CLIP-seq
MIRT2446432	hsa-miR-410	CLIP-seq
MIRT2446433	hsa-miR-4300	CLIP-seq
MIRT2446434	hsa-miR-4496	CLIP-seq
MIRT2446435	hsa-miR-543	CLIP-seq
MIRT2446436	hsa-miR-920	CLIP-seq
MIRT2446437	hsa-miR-939	CLIP-seq
MIRT2446428	hsa-miR-3124-3p	CLIP-seq
MIRT2446430	hsa-miR-3685	CLIP-seq
MIRT2446431	hsa-miR-384	CLIP-seq
MIRT2446434	hsa-miR-4496	CLIP-seq
MIRT2498412	hsa-miR-1323	CLIP-seq
MIRT2498413	hsa-miR-508-5p	CLIP-seq
MIRT2498414	hsa-miR-548o	CLIP-seq
MIRT2498412	hsa-miR-1323	CLIP-seq
MIRT2498413	hsa-miR-508-5p	CLIP-seq
MIRT2498414	hsa-miR-548o	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005912	Component	Adherens junction	IDA	25009281
GO:0005912	Component	Adherens junction	IEA
GO:0070161	Component	Anchoring junction	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q96PX6
• Protein name: Coiled-coil domain-containing protein 85A
• Protein function: May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10226	CCDC85	33 → 224	CCDC85 family	Family

• Sequence:

  MSKAAGGAAAAAAAAESCSPAPAGSSAAPPAPVEDLSKVSDEELLQWSKEELIRSLRRAE
  AEKVSAMLDHSNLIREVNRRLQLHLGEIRGLKDINQKLQEDNQELRDLCCFLDDDRQKGK
  RVSREWQRLGRYTAGVMHKEVALYLQKLKDLEVKQEEVVKENMELKELCVLLDEEKGAGC
  AGSRCSIDSQASLCQLTASTAPYVRDVGDGSSTSSTGSTDSPDHHKHHASSGSPEHLQKP
  RSEGSPEHSKHRSASPEHPQKPRACGTPDRPKALKGPSPEHHKPLCKGSPEQQRHPHPGS
  SPETLPKHVLSGSPEHFQKHRSGSSPEHARHSGGSPEHLQKHALGGSLEHLPRARGTSPE
  HLKQHYGGSPDHKHGGGSGGSGGSGGGSREGTLRRQAQEDGSPHHRNVYSGMNESTLSYV
  RQLEARVRQLEEENRMLPQASQNRRQPPTRNSSNMEKGWGSRARRVLQWWQGCRGIGRCL
  PTLPGSFRLSSGADGSNSSPNSAASFSGHATPSQQPEPVVHSLKVVWRKLGDAAGSCPGI
  RQHLSGNQYKGPM

• Sequence length: 553

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTOIMMUNE THROMBOCYTOPENIC PURPURA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL ADENOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR NEGATIVE BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	30822522		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	30822522	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30822522		★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	Pubtator	39344312	Associate	★☆☆☆☆ Found in Text Mining only