ELFN2 (extracellular leucine rich repeat and fibronectin type III domain containing 2)

Gene

• Entrez ID: 114794
• Gene name: Extracellular leucine rich repeat and fibronectin type III domain containing 2
• Gene symbol: ELFN2
• Synonyms (NCBI Gene): LRRC62, PPP1R29
• Chromosome: 22
• Chromosome location: 22q13.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT960190	hsa-miR-1236	CLIP-seq
MIRT960191	hsa-miR-1247	CLIP-seq
MIRT960192	hsa-miR-1250	CLIP-seq
MIRT960193	hsa-miR-1275	CLIP-seq
MIRT960194	hsa-miR-1324	CLIP-seq
MIRT960195	hsa-miR-1470	CLIP-seq
MIRT960196	hsa-miR-183	CLIP-seq
MIRT960197	hsa-miR-1915	CLIP-seq
MIRT960198	hsa-miR-2355-5p	CLIP-seq
MIRT960199	hsa-miR-299-3p	CLIP-seq
MIRT960200	hsa-miR-3074-5p	CLIP-seq
MIRT960201	hsa-miR-3124-3p	CLIP-seq
MIRT960202	hsa-miR-3153	CLIP-seq
MIRT960203	hsa-miR-3194-3p	CLIP-seq
MIRT960204	hsa-miR-320e	CLIP-seq
MIRT960205	hsa-miR-339-5p	CLIP-seq
MIRT960206	hsa-miR-3648	CLIP-seq
MIRT960207	hsa-miR-3675-5p	CLIP-seq
MIRT960208	hsa-miR-3688-3p	CLIP-seq
MIRT960209	hsa-miR-3688-5p	CLIP-seq
MIRT960210	hsa-miR-3919	CLIP-seq
MIRT960211	hsa-miR-3978	CLIP-seq
MIRT960212	hsa-miR-421	CLIP-seq
MIRT960213	hsa-miR-4283	CLIP-seq
MIRT960214	hsa-miR-4287	CLIP-seq
MIRT960215	hsa-miR-4292	CLIP-seq
MIRT960216	hsa-miR-4469	CLIP-seq
MIRT960217	hsa-miR-4514	CLIP-seq
MIRT960218	hsa-miR-4525	CLIP-seq
MIRT960219	hsa-miR-4648	CLIP-seq
MIRT960220	hsa-miR-4654	CLIP-seq
MIRT960221	hsa-miR-4661-5p	CLIP-seq
MIRT960222	hsa-miR-4665-5p	CLIP-seq
MIRT960223	hsa-miR-4667-3p	CLIP-seq
MIRT960224	hsa-miR-4668-5p	CLIP-seq
MIRT960225	hsa-miR-4685-3p	CLIP-seq
MIRT960226	hsa-miR-4691-3p	CLIP-seq
MIRT960227	hsa-miR-4692	CLIP-seq
MIRT960228	hsa-miR-4700-3p	CLIP-seq
MIRT960229	hsa-miR-4709-5p	CLIP-seq
MIRT960230	hsa-miR-4711-5p	CLIP-seq
MIRT960231	hsa-miR-4722-3p	CLIP-seq
MIRT960232	hsa-miR-4723-5p	CLIP-seq
MIRT960233	hsa-miR-4725-5p	CLIP-seq
MIRT960234	hsa-miR-4731-5p	CLIP-seq
MIRT960235	hsa-miR-4756-3p	CLIP-seq
MIRT960236	hsa-miR-4761-3p	CLIP-seq
MIRT960237	hsa-miR-4768-3p	CLIP-seq
MIRT960238	hsa-miR-4769-5p	CLIP-seq
MIRT960239	hsa-miR-490-5p	CLIP-seq
MIRT960240	hsa-miR-504	CLIP-seq
MIRT960241	hsa-miR-505	CLIP-seq
MIRT960242	hsa-miR-625	CLIP-seq
MIRT960243	hsa-miR-760	CLIP-seq
MIRT1984416	hsa-miR-1178	CLIP-seq
MIRT1984417	hsa-miR-1228	CLIP-seq
MIRT1984418	hsa-miR-1233	CLIP-seq
MIRT1984419	hsa-miR-1252	CLIP-seq
MIRT1984420	hsa-miR-1268	CLIP-seq
MIRT1984421	hsa-miR-1268b	CLIP-seq
MIRT1984422	hsa-miR-1291	CLIP-seq
MIRT1984423	hsa-miR-1909	CLIP-seq
MIRT1984424	hsa-miR-1913	CLIP-seq
MIRT1984425	hsa-miR-197	CLIP-seq
MIRT1984426	hsa-miR-2115	CLIP-seq
MIRT1984427	hsa-miR-27a	CLIP-seq
MIRT1984428	hsa-miR-27b	CLIP-seq
MIRT1984429	hsa-miR-28-5p	CLIP-seq
MIRT1984430	hsa-miR-3128	CLIP-seq
MIRT1984431	hsa-miR-3139	CLIP-seq
MIRT1984432	hsa-miR-3144-5p	CLIP-seq
MIRT1984433	hsa-miR-3150b-3p	CLIP-seq
MIRT1984434	hsa-miR-3173-5p	CLIP-seq
MIRT1984435	hsa-miR-3176	CLIP-seq
MIRT1984436	hsa-miR-3189-5p	CLIP-seq
MIRT1984437	hsa-miR-3191	CLIP-seq
MIRT1984438	hsa-miR-3192	CLIP-seq
MIRT1984439	hsa-miR-3194-5p	CLIP-seq
MIRT1984440	hsa-miR-324-3p	CLIP-seq
MIRT1984441	hsa-miR-326	CLIP-seq
MIRT1984442	hsa-miR-328	CLIP-seq
MIRT1984443	hsa-miR-330-5p	CLIP-seq
MIRT960205	hsa-miR-339-5p	CLIP-seq
MIRT1984444	hsa-miR-370	CLIP-seq
MIRT1984445	hsa-miR-377	CLIP-seq
MIRT1984446	hsa-miR-3922-3p	CLIP-seq
MIRT1984447	hsa-miR-3943	CLIP-seq
MIRT1984448	hsa-miR-412	CLIP-seq
MIRT1984449	hsa-miR-4257	CLIP-seq
MIRT1984450	hsa-miR-4258	CLIP-seq
MIRT1984451	hsa-miR-4270	CLIP-seq
MIRT1984452	hsa-miR-4290	CLIP-seq
MIRT960215	hsa-miR-4292	CLIP-seq
MIRT1984453	hsa-miR-4441	CLIP-seq
MIRT960216	hsa-miR-4469	CLIP-seq
MIRT1984454	hsa-miR-4474-5p	CLIP-seq
MIRT1984455	hsa-miR-4487	CLIP-seq
MIRT1984456	hsa-miR-4645-5p	CLIP-seq
MIRT1984457	hsa-miR-4652-5p	CLIP-seq
MIRT960223	hsa-miR-4667-3p	CLIP-seq
MIRT1984458	hsa-miR-4667-5p	CLIP-seq
MIRT1984459	hsa-miR-4673	CLIP-seq
MIRT1984460	hsa-miR-4700-5p	CLIP-seq
MIRT1984461	hsa-miR-4707-5p	CLIP-seq
MIRT1984462	hsa-miR-4720-5p	CLIP-seq
MIRT1984463	hsa-miR-4736	CLIP-seq
MIRT1984464	hsa-miR-4755-3p	CLIP-seq
MIRT1984465	hsa-miR-4758-3p	CLIP-seq
MIRT1984466	hsa-miR-4763-5p	CLIP-seq
MIRT1984467	hsa-miR-4784	CLIP-seq
MIRT1984468	hsa-miR-4799-3p	CLIP-seq
MIRT1984469	hsa-miR-513a-5p	CLIP-seq
MIRT1984470	hsa-miR-516a-3p	CLIP-seq
MIRT1984471	hsa-miR-518a-5p	CLIP-seq
MIRT1984472	hsa-miR-527	CLIP-seq
MIRT1984473	hsa-miR-593	CLIP-seq
MIRT1984474	hsa-miR-637	CLIP-seq
MIRT1984475	hsa-miR-665	CLIP-seq
MIRT1984476	hsa-miR-708	CLIP-seq
MIRT2219535	hsa-miR-1227	CLIP-seq
MIRT2219536	hsa-miR-1254	CLIP-seq
MIRT2219537	hsa-miR-1255a	CLIP-seq
MIRT2219538	hsa-miR-1255b	CLIP-seq
MIRT960194	hsa-miR-1324	CLIP-seq
MIRT960197	hsa-miR-1915	CLIP-seq
MIRT2219539	hsa-miR-1972	CLIP-seq
MIRT2219540	hsa-miR-1976	CLIP-seq
MIRT2219541	hsa-miR-210	CLIP-seq
MIRT2219542	hsa-miR-22	CLIP-seq
MIRT2219543	hsa-miR-3116	CLIP-seq
MIRT2219544	hsa-miR-3130-3p	CLIP-seq
MIRT1984432	hsa-miR-3144-5p	CLIP-seq
MIRT960202	hsa-miR-3153	CLIP-seq
MIRT2219545	hsa-miR-3179	CLIP-seq
MIRT1984437	hsa-miR-3191	CLIP-seq
MIRT1984441	hsa-miR-326	CLIP-seq
MIRT1984443	hsa-miR-330-5p	CLIP-seq
MIRT1984444	hsa-miR-370	CLIP-seq
MIRT2219546	hsa-miR-3928	CLIP-seq
MIRT2219547	hsa-miR-4267	CLIP-seq
MIRT1984451	hsa-miR-4270	CLIP-seq
MIRT1984452	hsa-miR-4290	CLIP-seq
MIRT2219548	hsa-miR-4435	CLIP-seq
MIRT1984453	hsa-miR-4441	CLIP-seq
MIRT2219549	hsa-miR-4468	CLIP-seq
MIRT2219550	hsa-miR-4480	CLIP-seq
MIRT960217	hsa-miR-4514	CLIP-seq
MIRT2219551	hsa-miR-4533	CLIP-seq
MIRT2219552	hsa-miR-4640-5p	CLIP-seq
MIRT2219553	hsa-miR-4650-5p	CLIP-seq
MIRT1984457	hsa-miR-4652-5p	CLIP-seq
MIRT960227	hsa-miR-4692	CLIP-seq
MIRT2219554	hsa-miR-4726-5p	CLIP-seq
MIRT1984464	hsa-miR-4755-3p	CLIP-seq
MIRT1984473	hsa-miR-593	CLIP-seq
MIRT2219555	hsa-miR-940	CLIP-seq
MIRT2387328	hsa-miR-1285	CLIP-seq
MIRT1984422	hsa-miR-1291	CLIP-seq
MIRT2219541	hsa-miR-210	CLIP-seq
MIRT2387329	hsa-miR-2861	CLIP-seq
MIRT2387330	hsa-miR-3187-5p	CLIP-seq
MIRT1984439	hsa-miR-3194-5p	CLIP-seq
MIRT1984441	hsa-miR-326	CLIP-seq
MIRT1984443	hsa-miR-330-5p	CLIP-seq
MIRT2387331	hsa-miR-378g	CLIP-seq
MIRT960214	hsa-miR-4287	CLIP-seq
MIRT2387332	hsa-miR-4486	CLIP-seq
MIRT960223	hsa-miR-4667-3p	CLIP-seq
MIRT960225	hsa-miR-4685-3p	CLIP-seq
MIRT1984461	hsa-miR-4707-5p	CLIP-seq
MIRT960241	hsa-miR-505	CLIP-seq
MIRT2387333	hsa-miR-612	CLIP-seq
MIRT2387334	hsa-miR-942	CLIP-seq
MIRT960202	hsa-miR-3153	CLIP-seq
MIRT960210	hsa-miR-3919	CLIP-seq
MIRT960224	hsa-miR-4668-5p	CLIP-seq
MIRT960230	hsa-miR-4711-5p	CLIP-seq
MIRT960235	hsa-miR-4756-3p	CLIP-seq
MIRT960236	hsa-miR-4761-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004864	Function	Protein phosphatase inhibitor activity	IEA
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005886	Component	Plasma membrane	IBA
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0010467	Process	Gene expression	IEA
GO:0016020	Component	Membrane	IEA
GO:0038023	Function	Signaling receptor activity	IBA
GO:0045184	Process	Establishment of protein localization	IEA
GO:0045184	Process	Establishment of protein localization	IEA
GO:0045202	Component	Synapse	IEA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0099560	Process	Synaptic membrane adhesion	IEA

Other IDs

• MIM: 620223
• HGNC: 29396
• e!Ensembl: ENSG00000166897

Protein

• UniProt ID: Q5R3F8
• Protein name: Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62)
• Protein function: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	79 → 139	Leucine rich repeat	Repeat
  PF13855	LRR_8	132 → 187	Leucine rich repeat	Repeat

• Sequence:

  MLRLGLCAAALLCVCRPGAVRADCWLIEGDKGYVWLAICSQNQPPYETIPQHINSTVHDL
  RLNENKLKAVLYSSLNRFGNLTDLNLTKNEISYIEDGAFLGQSSLQVLQLGYNKLSNLTE
  GMLRGMSRLQFLFVQHNLIEVVTPTAFSECPSLISIDLSSNRLSRLDGATFASLASLMVC
  ELAGNPFNCECDLFGFLAWLVVFNNVTKNYDRLQCESPREFAGYPLLVPRPYHSLNAITV
  LQAKCRNGSLPARPVSHPTPYSTDAQREPDENSGFNPDEILSVEPPASSTTDASAGPAIK
  LHHVTFTSATLVVIIPHPYSKMYILVQYNNSYFSDVMTLKNKKEIVTLDKLRAHTEYTFC
  VTSLRNSRRFNHTCLTFTTRDPVPGDLAPSTSTTTHYIMTILGCLFGMVIVLGAVYYCLR
  KRRMQEEKQKSVNVKKTILEMRYGADVDAGSIVHAAQKLGEPPVLPVSRMASIPSMIGEK
  LPTAKGLEAGLDTPKVATKGNYIEVRTGAGGDGLARPEDDLPDLENGQGSAAEISTIAKE
  VDKVNQIINNCIDALKLDSASFLGGGSSSGDPELAFECQSLPAAAAASSATGPGALERPS
  FLSPPYKESSHHPLQRQLSADAAVTRKTCSVSSSGSIKSAKVFSLDVPDHPAATGLAKGD
  SKYIEKGSPLNSPLDRLPLVPAGSGGGSGGGGGIHHLEVKPAYHCSEHRHSFPALYYEEG
  ADSLSQRVSFLKPLTRSKRDSTYSQLSPRHYYSGYSSSPEYSSESTHKIWERFRPYKKHH
  REEVYMAAGHALRKKVQFAKDEDLHDILDYWKGVSAQQKL

• Sequence length: 820

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Clear cell carcinoma of kidney	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEPROSY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Astrocytoma	Astrocytoma	BEFREE	30037656		★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	Pubtator	30037656	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	30037656		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	30037656	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	30037656		★☆☆☆☆ Found in Text Mining only