Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	114792
Gene name	Kelch like family member 32
Gene symbol	KLHL32
Synonyms (NCBI Gene)	BKLHD5KIAA1900UG0030H05dJ21F7.1
Chromosome	6
Chromosome location	6q16.1

Show/Hide all (53)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018022	hsa-miR-335-5p	Microarray	18185580
MIRT445939	hsa-miR-3200-5p	PAR-CLIP	22100165
MIRT445938	hsa-miR-4251	PAR-CLIP	22100165
MIRT445937	hsa-miR-4329	PAR-CLIP	22100165
MIRT445936	hsa-miR-6761-5p	PAR-CLIP	22100165
MIRT445935	hsa-miR-4693-3p	PAR-CLIP	22100165
MIRT445934	hsa-miR-1827	PAR-CLIP	22100165
MIRT445932	hsa-miR-6765-5p	PAR-CLIP	22100165
MIRT445933	hsa-miR-1304-5p	PAR-CLIP	22100165
MIRT445941	hsa-miR-3617-5p	PAR-CLIP	22100165
MIRT445940	hsa-miR-641	PAR-CLIP	22100165
MIRT445939	hsa-miR-3200-5p	PAR-CLIP	22100165
MIRT445938	hsa-miR-4251	PAR-CLIP	22100165
MIRT445937	hsa-miR-4329	PAR-CLIP	22100165
MIRT445936	hsa-miR-6761-5p	PAR-CLIP	22100165
MIRT445935	hsa-miR-4693-3p	PAR-CLIP	22100165
MIRT445934	hsa-miR-1827	PAR-CLIP	22100165
MIRT445932	hsa-miR-6765-5p	PAR-CLIP	22100165
MIRT445933	hsa-miR-1304-5p	PAR-CLIP	22100165
MIRT445939	hsa-miR-3200-5p	PAR-CLIP	22100165
MIRT445938	hsa-miR-4251	PAR-CLIP	22100165
MIRT445937	hsa-miR-4329	PAR-CLIP	22100165
MIRT445936	hsa-miR-6761-5p	PAR-CLIP	22100165
MIRT445935	hsa-miR-4693-3p	PAR-CLIP	22100165
MIRT445934	hsa-miR-1827	PAR-CLIP	22100165
MIRT445932	hsa-miR-6765-5p	PAR-CLIP	22100165
MIRT445933	hsa-miR-1304-5p	PAR-CLIP	22100165
MIRT445941	hsa-miR-3617-5p	PAR-CLIP	22100165
MIRT445940	hsa-miR-641	PAR-CLIP	22100165
MIRT445939	hsa-miR-3200-5p	PAR-CLIP	22100165
MIRT445938	hsa-miR-4251	PAR-CLIP	22100165
MIRT445937	hsa-miR-4329	PAR-CLIP	22100165
MIRT445936	hsa-miR-6761-5p	PAR-CLIP	22100165
MIRT445935	hsa-miR-4693-3p	PAR-CLIP	22100165
MIRT445934	hsa-miR-1827	PAR-CLIP	22100165
MIRT445932	hsa-miR-6765-5p	PAR-CLIP	22100165
MIRT445933	hsa-miR-1304-5p	PAR-CLIP	22100165
MIRT1098514	hsa-miR-1206	CLIP-seq
MIRT1098515	hsa-miR-1238	CLIP-seq
MIRT1098516	hsa-miR-1258	CLIP-seq
MIRT1098517	hsa-miR-3148	CLIP-seq
MIRT1098518	hsa-miR-3646	CLIP-seq
MIRT1098519	hsa-miR-4307	CLIP-seq
MIRT1098520	hsa-miR-433	CLIP-seq
MIRT1098521	hsa-miR-4496	CLIP-seq
MIRT1098522	hsa-miR-4670-3p	CLIP-seq
MIRT1098523	hsa-miR-4691-5p	CLIP-seq
MIRT1098524	hsa-miR-5096	CLIP-seq
MIRT1098525	hsa-miR-548ae	CLIP-seq
MIRT1098526	hsa-miR-548aj	CLIP-seq
MIRT1098527	hsa-miR-548am	CLIP-seq
MIRT1098528	hsa-miR-548x	CLIP-seq
MIRT2026779	hsa-miR-4477a	CLIP-seq

Show/Hide all (1)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32814053

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q96NJ5

Protein name

Kelch-like protein 32 (BTB and kelch domain-containing protein 5)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00651	BTB	32 → 139	BTB/POZ domain	Domain
PF07707	BACK	144 → 245	BTB And C-terminal Kelch	Domain
PF01344	Kelch_1	335 → 385	Kelch motif	Repeat
PF01344	Kelch_1	387 → 432	Kelch motif	Repeat
PF01344	Kelch_1	483 → 530	Kelch motif	Repeat

Sequence

MPSERCLSIQEMLTGQRLCHSESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVL
AACSDYFRAMFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGS
HLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPE
EVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMDELLQYIRFGLMDVDT
LHTVALSHPLVQASETATALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKRE
VCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASG
RTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYC
PKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPM
LQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNES
GVAVHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAP
YFTCPNLQTLQVPHHRIGTI

Sequence length

620

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autistic Disorder	Autism	Pubtator	23253088	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	GWASCAT_DG	26634245		★★★★★ ★☆☆☆☆ Found in Text Mining only
Language Development Disorders	Language development disorders	Pubtator	23253088	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Speech Delay	Speech Delay	BEFREE	23253088		★★★★★ ★☆☆☆☆ Found in Text Mining only
Tourette Syndrome	Tourette syndrome	Pubtator	23253088	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

KLHL32 (kelch like family member 32)