MBD6 (methyl-CpG binding domain protein 6)

Gene

• Entrez ID: 114785
• Gene name: Methyl-CpG binding domain protein 6
• Gene symbol: MBD6
• Synonyms (NCBI Gene): -
• Chromosome: 12
• Chromosome location: 12q13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022555	hsa-miR-124-3p	Microarray	18668037
MIRT030471	hsa-miR-24-3p	qRT-PCR;Microarray	19748357
MIRT052082	hsa-let-7b-5p	CLASH	23622248
MIRT232511	hsa-miR-532-3p	PAR-CLIP	20371350
MIRT232510	hsa-miR-150-5p	PAR-CLIP	20371350
MIRT566802	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT566801	hsa-miR-4519	PAR-CLIP	20371350
MIRT232512	hsa-miR-2116-3p	PAR-CLIP	20371350
MIRT232513	hsa-miR-4713-5p	PAR-CLIP	20371350
MIRT566800	hsa-miR-5010-3p	PAR-CLIP	20371350
MIRT187980	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT374314	hsa-miR-34c-5p	PAR-CLIP	23592263
MIRT374317	hsa-miR-449b-5p	PAR-CLIP	23592263
MIRT374313	hsa-miR-34a-5p	PAR-CLIP	23592263
MIRT374315	hsa-miR-449a	PAR-CLIP	23592263
MIRT473499	hsa-miR-5088-5p	PAR-CLIP	23592263
MIRT374323	hsa-miR-4688	PAR-CLIP	23592263
MIRT374329	hsa-miR-6743-5p	PAR-CLIP	23592263
MIRT187983	hsa-miR-4280	PAR-CLIP	23592263
MIRT187981	hsa-miR-648	PAR-CLIP	23592263
MIRT187992	hsa-miR-6871-5p	PAR-CLIP	23592263
MIRT187986	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT187988	hsa-miR-4784	PAR-CLIP	23592263
MIRT397652	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT473498	hsa-miR-4721	PAR-CLIP	23592263
MIRT374327	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT187982	hsa-miR-765	PAR-CLIP	23592263
MIRT187993	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT473497	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT473496	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT473495	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT473494	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT473493	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT374316	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT187989	hsa-miR-6073	PAR-CLIP	23592263
MIRT473492	hsa-miR-223-5p	PAR-CLIP	23592263
MIRT187994	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT187979	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT187984	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT187985	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT187987	hsa-miR-3689c	PAR-CLIP	23592263
MIRT187990	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT187991	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT187980	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT374314	hsa-miR-34c-5p	PAR-CLIP	23592263
MIRT374317	hsa-miR-449b-5p	PAR-CLIP	23592263
MIRT374313	hsa-miR-34a-5p	PAR-CLIP	23592263
MIRT374315	hsa-miR-449a	PAR-CLIP	23592263
MIRT473499	hsa-miR-5088-5p	PAR-CLIP	23592263
MIRT374323	hsa-miR-4688	PAR-CLIP	23592263
MIRT374329	hsa-miR-6743-5p	PAR-CLIP	23592263
MIRT187983	hsa-miR-4280	PAR-CLIP	23592263
MIRT187981	hsa-miR-648	PAR-CLIP	23592263
MIRT187992	hsa-miR-6871-5p	PAR-CLIP	23592263
MIRT187986	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT187988	hsa-miR-4784	PAR-CLIP	23592263
MIRT397652	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT473498	hsa-miR-4721	PAR-CLIP	23592263
MIRT374327	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT187982	hsa-miR-765	PAR-CLIP	23592263
MIRT187993	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT473497	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT473496	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT473495	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT473494	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT473493	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT374316	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT187989	hsa-miR-6073	PAR-CLIP	23592263
MIRT473492	hsa-miR-223-5p	PAR-CLIP	23592263
MIRT187994	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT187979	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT187984	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT187985	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT187987	hsa-miR-3689c	PAR-CLIP	23592263
MIRT187990	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT187991	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT232511	hsa-miR-532-3p	PAR-CLIP	20371350
MIRT232510	hsa-miR-150-5p	PAR-CLIP	20371350
MIRT566802	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT566801	hsa-miR-4519	PAR-CLIP	20371350
MIRT232512	hsa-miR-2116-3p	PAR-CLIP	20371350
MIRT232513	hsa-miR-4713-5p	PAR-CLIP	20371350
MIRT566800	hsa-miR-5010-3p	PAR-CLIP	20371350
MIRT187980	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT374314	hsa-miR-34c-5p	PAR-CLIP	23592263
MIRT374317	hsa-miR-449b-5p	PAR-CLIP	23592263
MIRT374313	hsa-miR-34a-5p	PAR-CLIP	23592263
MIRT374315	hsa-miR-449a	PAR-CLIP	23592263
MIRT473499	hsa-miR-5088-5p	PAR-CLIP	23592263
MIRT374323	hsa-miR-4688	PAR-CLIP	23592263
MIRT374329	hsa-miR-6743-5p	PAR-CLIP	23592263
MIRT187983	hsa-miR-4280	PAR-CLIP	23592263
MIRT187981	hsa-miR-648	PAR-CLIP	23592263
MIRT187992	hsa-miR-6871-5p	PAR-CLIP	23592263
MIRT187986	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT187988	hsa-miR-4784	PAR-CLIP	23592263
MIRT397652	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT473498	hsa-miR-4721	PAR-CLIP	23592263
MIRT374327	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT187982	hsa-miR-765	PAR-CLIP	23592263
MIRT187993	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT473497	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT473496	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT473495	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT473494	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT473493	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT374316	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT187989	hsa-miR-6073	PAR-CLIP	23592263
MIRT473492	hsa-miR-223-5p	PAR-CLIP	23592263
MIRT187994	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT187979	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT187984	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT187985	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT187987	hsa-miR-3689c	PAR-CLIP	23592263
MIRT187990	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT187991	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT187980	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT374314	hsa-miR-34c-5p	PAR-CLIP	23592263
MIRT374317	hsa-miR-449b-5p	PAR-CLIP	23592263
MIRT374313	hsa-miR-34a-5p	PAR-CLIP	23592263
MIRT374315	hsa-miR-449a	PAR-CLIP	23592263
MIRT473499	hsa-miR-5088-5p	PAR-CLIP	23592263
MIRT374323	hsa-miR-4688	PAR-CLIP	23592263
MIRT374329	hsa-miR-6743-5p	PAR-CLIP	23592263
MIRT187983	hsa-miR-4280	PAR-CLIP	23592263
MIRT187981	hsa-miR-648	PAR-CLIP	23592263
MIRT187992	hsa-miR-6871-5p	PAR-CLIP	23592263
MIRT187986	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT187988	hsa-miR-4784	PAR-CLIP	23592263
MIRT397652	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT473498	hsa-miR-4721	PAR-CLIP	23592263
MIRT374327	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT187982	hsa-miR-765	PAR-CLIP	23592263
MIRT187993	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT473497	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT473496	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT473495	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT473494	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT473493	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT374316	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT187989	hsa-miR-6073	PAR-CLIP	23592263
MIRT473492	hsa-miR-223-5p	PAR-CLIP	23592263
MIRT187994	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT187979	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT187984	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT187985	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT187987	hsa-miR-3689c	PAR-CLIP	23592263
MIRT187990	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT187991	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT1135118	hsa-miR-1182	CLIP-seq
MIRT1135119	hsa-miR-1207-3p	CLIP-seq
MIRT1135120	hsa-miR-150	CLIP-seq
MIRT1135121	hsa-miR-1827	CLIP-seq
MIRT1135122	hsa-miR-193a-5p	CLIP-seq
MIRT1135123	hsa-miR-19a	CLIP-seq
MIRT1135124	hsa-miR-19b	CLIP-seq
MIRT1135125	hsa-miR-203	CLIP-seq
MIRT1135126	hsa-miR-2113	CLIP-seq
MIRT1135127	hsa-miR-2467-3p	CLIP-seq
MIRT1135128	hsa-miR-2467-5p	CLIP-seq
MIRT1135129	hsa-miR-3125	CLIP-seq
MIRT1135130	hsa-miR-3154	CLIP-seq
MIRT1135131	hsa-miR-3163	CLIP-seq
MIRT1135132	hsa-miR-3173-3p	CLIP-seq
MIRT1135133	hsa-miR-3175	CLIP-seq
MIRT1135134	hsa-miR-3179	CLIP-seq
MIRT1135135	hsa-miR-3188	CLIP-seq
MIRT1135136	hsa-miR-331-3p	CLIP-seq
MIRT1135137	hsa-miR-34a	CLIP-seq
MIRT1135138	hsa-miR-3605-5p	CLIP-seq
MIRT1135139	hsa-miR-3612	CLIP-seq
MIRT1135140	hsa-miR-3655	CLIP-seq
MIRT1135141	hsa-miR-3690	CLIP-seq
MIRT1135142	hsa-miR-3714	CLIP-seq
MIRT1135143	hsa-miR-3916	CLIP-seq
MIRT1135144	hsa-miR-3936	CLIP-seq
MIRT1135145	hsa-miR-3975	CLIP-seq
MIRT1135146	hsa-miR-4308	CLIP-seq
MIRT1135147	hsa-miR-4420	CLIP-seq
MIRT1135148	hsa-miR-4434	CLIP-seq
MIRT1135149	hsa-miR-4443	CLIP-seq
MIRT1135150	hsa-miR-4459	CLIP-seq
MIRT1135151	hsa-miR-449b	CLIP-seq
MIRT1135152	hsa-miR-4516	CLIP-seq
MIRT1135153	hsa-miR-4520a-3p	CLIP-seq
MIRT1135154	hsa-miR-4533	CLIP-seq
MIRT1135155	hsa-miR-4638-3p	CLIP-seq
MIRT1135156	hsa-miR-4646-5p	CLIP-seq
MIRT1135157	hsa-miR-4695-5p	CLIP-seq
MIRT1135158	hsa-miR-4722-5p	CLIP-seq
MIRT1135159	hsa-miR-4723-5p	CLIP-seq
MIRT1135160	hsa-miR-4733-5p	CLIP-seq
MIRT1135161	hsa-miR-4747-5p	CLIP-seq
MIRT1135162	hsa-miR-4758-3p	CLIP-seq
MIRT1135163	hsa-miR-4779	CLIP-seq
MIRT1135164	hsa-miR-4787-5p	CLIP-seq
MIRT1135165	hsa-miR-4794	CLIP-seq
MIRT1135166	hsa-miR-485-5p	CLIP-seq
MIRT1135167	hsa-miR-490-3p	CLIP-seq
MIRT1135168	hsa-miR-511	CLIP-seq
MIRT1135169	hsa-miR-520d-5p	CLIP-seq
MIRT1135170	hsa-miR-524-5p	CLIP-seq
MIRT1135171	hsa-miR-548a-3p	CLIP-seq
MIRT1135172	hsa-miR-548e	CLIP-seq
MIRT1135173	hsa-miR-548f	CLIP-seq
MIRT1135174	hsa-miR-555	CLIP-seq
MIRT1135175	hsa-miR-579	CLIP-seq
MIRT1135176	hsa-miR-607	CLIP-seq
MIRT1135177	hsa-miR-609	CLIP-seq
MIRT1135178	hsa-miR-625	CLIP-seq
MIRT1135179	hsa-miR-650	CLIP-seq
MIRT1135180	hsa-miR-940	CLIP-seq
MIRT1135149	hsa-miR-4443	CLIP-seq
MIRT2038409	hsa-miR-137	CLIP-seq
MIRT1135120	hsa-miR-150	CLIP-seq
MIRT2038410	hsa-miR-153	CLIP-seq
MIRT1135121	hsa-miR-1827	CLIP-seq
MIRT2038411	hsa-miR-1913	CLIP-seq
MIRT1135125	hsa-miR-203	CLIP-seq
MIRT2038412	hsa-miR-2052	CLIP-seq
MIRT2038413	hsa-miR-2392	CLIP-seq
MIRT2038414	hsa-miR-24	CLIP-seq
MIRT1135128	hsa-miR-2467-5p	CLIP-seq
MIRT2038415	hsa-miR-3065-3p	CLIP-seq
MIRT1135130	hsa-miR-3154	CLIP-seq
MIRT1135132	hsa-miR-3173-3p	CLIP-seq
MIRT1135133	hsa-miR-3175	CLIP-seq
MIRT1135134	hsa-miR-3179	CLIP-seq
MIRT1135135	hsa-miR-3188	CLIP-seq
MIRT2038416	hsa-miR-324-3p	CLIP-seq
MIRT2038417	hsa-miR-33a	CLIP-seq
MIRT2038418	hsa-miR-33b	CLIP-seq
MIRT1135137	hsa-miR-34a	CLIP-seq
MIRT1135139	hsa-miR-3612	CLIP-seq
MIRT2038419	hsa-miR-3616-3p	CLIP-seq
MIRT2038420	hsa-miR-3619-3p	CLIP-seq
MIRT2038421	hsa-miR-3664-3p	CLIP-seq
MIRT1135142	hsa-miR-3714	CLIP-seq
MIRT1135145	hsa-miR-3975	CLIP-seq
MIRT2038422	hsa-miR-4264	CLIP-seq
MIRT2038423	hsa-miR-4271	CLIP-seq
MIRT2038424	hsa-miR-4284	CLIP-seq
MIRT2038425	hsa-miR-4313	CLIP-seq
MIRT1135147	hsa-miR-4420	CLIP-seq
MIRT1135148	hsa-miR-4434	CLIP-seq
MIRT2038426	hsa-miR-4436b-3p	CLIP-seq
MIRT1135149	hsa-miR-4443	CLIP-seq
MIRT1135150	hsa-miR-4459	CLIP-seq
MIRT2038427	hsa-miR-448	CLIP-seq
MIRT1135151	hsa-miR-449b	CLIP-seq
MIRT1135152	hsa-miR-4516	CLIP-seq
MIRT1135154	hsa-miR-4533	CLIP-seq
MIRT2038428	hsa-miR-4535	CLIP-seq
MIRT1135156	hsa-miR-4646-5p	CLIP-seq
MIRT1135157	hsa-miR-4695-5p	CLIP-seq
MIRT2038429	hsa-miR-4709-5p	CLIP-seq
MIRT1135158	hsa-miR-4722-5p	CLIP-seq
MIRT1135159	hsa-miR-4723-5p	CLIP-seq
MIRT2038430	hsa-miR-4725-3p	CLIP-seq
MIRT1135161	hsa-miR-4747-5p	CLIP-seq
MIRT2038431	hsa-miR-4776-5p	CLIP-seq
MIRT1135163	hsa-miR-4779	CLIP-seq
MIRT1135164	hsa-miR-4787-5p	CLIP-seq
MIRT1135165	hsa-miR-4794	CLIP-seq
MIRT1135166	hsa-miR-485-5p	CLIP-seq
MIRT1135167	hsa-miR-490-3p	CLIP-seq
MIRT2038432	hsa-miR-500a	CLIP-seq
MIRT2038433	hsa-miR-508-3p	CLIP-seq
MIRT2038434	hsa-miR-512-5p	CLIP-seq
MIRT2038435	hsa-miR-548an	CLIP-seq
MIRT1135176	hsa-miR-607	CLIP-seq
MIRT1135178	hsa-miR-625	CLIP-seq
MIRT1135179	hsa-miR-650	CLIP-seq
MIRT2038436	hsa-miR-670	CLIP-seq
MIRT2038437	hsa-miR-671-3p	CLIP-seq
MIRT1135180	hsa-miR-940	CLIP-seq
MIRT1135119	hsa-miR-1207-3p	CLIP-seq
MIRT1135120	hsa-miR-150	CLIP-seq
MIRT1135121	hsa-miR-1827	CLIP-seq
MIRT2038412	hsa-miR-2052	CLIP-seq
MIRT1135126	hsa-miR-2113	CLIP-seq
MIRT2268261	hsa-miR-218	CLIP-seq
MIRT2268262	hsa-miR-3150a-3p	CLIP-seq
MIRT1135132	hsa-miR-3173-3p	CLIP-seq
MIRT1135133	hsa-miR-3175	CLIP-seq
MIRT2268263	hsa-miR-3194-3p	CLIP-seq
MIRT1135136	hsa-miR-331-3p	CLIP-seq
MIRT2038417	hsa-miR-33a	CLIP-seq
MIRT2038418	hsa-miR-33b	CLIP-seq
MIRT1135139	hsa-miR-3612	CLIP-seq
MIRT2038419	hsa-miR-3616-3p	CLIP-seq
MIRT1135141	hsa-miR-3690	CLIP-seq
MIRT2268264	hsa-miR-371-3p	CLIP-seq
MIRT1135142	hsa-miR-3714	CLIP-seq
MIRT2268265	hsa-miR-371b-3p	CLIP-seq
MIRT2268266	hsa-miR-3921	CLIP-seq
MIRT2268267	hsa-miR-4267	CLIP-seq
MIRT2038423	hsa-miR-4271	CLIP-seq
MIRT2268268	hsa-miR-4303	CLIP-seq
MIRT1135146	hsa-miR-4308	CLIP-seq
MIRT1135147	hsa-miR-4420	CLIP-seq
MIRT2038426	hsa-miR-4436b-3p	CLIP-seq
MIRT1135149	hsa-miR-4443	CLIP-seq
MIRT1135150	hsa-miR-4459	CLIP-seq
MIRT2268269	hsa-miR-4481	CLIP-seq
MIRT1135153	hsa-miR-4520a-3p	CLIP-seq
MIRT1135154	hsa-miR-4533	CLIP-seq
MIRT1135155	hsa-miR-4638-3p	CLIP-seq
MIRT1135156	hsa-miR-4646-5p	CLIP-seq
MIRT2268270	hsa-miR-4653-5p	CLIP-seq
MIRT2268271	hsa-miR-4682	CLIP-seq
MIRT1135157	hsa-miR-4695-5p	CLIP-seq
MIRT2038429	hsa-miR-4709-5p	CLIP-seq
MIRT1135158	hsa-miR-4722-5p	CLIP-seq
MIRT2038430	hsa-miR-4725-3p	CLIP-seq
MIRT2268272	hsa-miR-4745-5p	CLIP-seq
MIRT1135161	hsa-miR-4747-5p	CLIP-seq
MIRT2268273	hsa-miR-4758-5p	CLIP-seq
MIRT1135163	hsa-miR-4779	CLIP-seq
MIRT2268274	hsa-miR-491-5p	CLIP-seq
MIRT2038433	hsa-miR-508-3p	CLIP-seq
MIRT2268275	hsa-miR-515-3p	CLIP-seq
MIRT2268276	hsa-miR-519e	CLIP-seq
MIRT2038435	hsa-miR-548an	CLIP-seq
MIRT2268277	hsa-miR-593	CLIP-seq
MIRT1135179	hsa-miR-650	CLIP-seq
MIRT2268278	hsa-miR-939	CLIP-seq
MIRT1135180	hsa-miR-940	CLIP-seq
MIRT1135139	hsa-miR-3612	CLIP-seq
MIRT1135149	hsa-miR-4443	CLIP-seq
MIRT1135179	hsa-miR-650	CLIP-seq
MIRT1135139	hsa-miR-3612	CLIP-seq
MIRT1135149	hsa-miR-4443	CLIP-seq
MIRT1135179	hsa-miR-650	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IDA
GO:0003677	Function	DNA binding	IDA	20700456
GO:0003682	Function	Chromatin binding	IBA
GO:0003682	Function	Chromatin binding	IDA	20700456
GO:0005515	Function	Protein binding	IPI	28514442, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	20700456
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0010369	Component	Chromocenter	IBA
GO:0010369	Component	Chromocenter	IDA	20700456

Other IDs

• MIM: 619458
• HGNC: 20445
• e!Ensembl: ENSG00000166987

Protein

• UniProt ID: Q96DN6
• Protein name: Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6)
• Protein function: Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:24634419). Important for stability of PR
• Sequence:

  MNGGNESSGADRAGGPVATSVPIGWQRCVREGAVLYISPSGTELSSLEQTRSYLLSDGTC
  KCGLECPLNVPKVFNFDPLAPVTPGGAGVGPASEEDMTKLCNHRRKAVAMATLYRSMETT
  CSHSSPGEGASPQMFHTVSPGPPSARPPCRVPPTTPLNGGPGSLPPEPPSVSQAFPTLAG
  PGGLFPPRLADPVPSGGSSSPRFLPRGNAPSPAPPPPPAISLNAPSYNWGAALRSSLVPS
  DLGSPPAPHASSSPPSDPPLFHCSDALTPPPLPPSNNLPAHPGPASQPPVSSATMHLPLV
  LGPLGGAPTVEGPGAPPFLASSLLSAAAKAQHPPLPPPSTLQGRRPRAQAPSASHSSSLR
  PSQRRPRRPPTVFRLLEGRGPQTPRRSRPRAPAPVPQPFSLPEPSQPILPSVLSLLGLPT
  PGPSHSDGSFNLLGSDAHLPPPPTLSSGSPPQPRHPIQPSLPGTTSGSLSSVPGAPAPPA
  ASKAPVVPSPVLQSPSEGLGMGAGPACPLPPLAGGEAFPFPSPEQGLALSGAGFPGMLGA
  LPLPLSLGQPPPSPLLNHSLFGVLTGGGGQPPPEPLLPPPGGPGPPLAPGEPEGPSLLVA
  SLLPPPPSDLLPPPSAPPSNLLASFLPLLALGPTAGDGEGSAEGAGGPSGEPFSGLGDLS
  PLLFPPLSAPPTLIALNSALLAATLDPPSGTPPQPCVLSAPQPGPPTSSVTTATTDPGAS
  SLGKAPSNSGRPPQLLSPLLGASLLGDLSSLTSSPGALPSLLQPPGPLLSGQLGLQLLPG
  GGAPPPLSEASSPLACLLQSLQIPPEQPEAPCLPPESPASALEPEPARPPLSALAPPHGS
  PDPPVPELLTGRGSGKRGRRGGGGLRGINGEARPARGRKPGSRREPGRLALKWGTRGGFN
  GQMERSPRRTHHWQHNGELAEGGAEPKDPPPPGPHSEDLKVPPGVVRKSRRGRRRKYNPT
  RNSNSSRQDITLEPSPTARAAVPLPPRARPGRPAKNKRRKLAP

• Sequence length: 1003

Pathways

KEGG:

Polycomb repressive complex

Reactome:

UCH proteinases

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MBD6-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autistic Disorder	Autism	BEFREE	23055267		★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	23055267	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	23055267	Associate	★☆☆☆☆ Found in Text Mining only
Heart Diseases	Heart disease	Pubtator	27744583	Associate	★☆☆☆☆ Found in Text Mining only
Hepatolenticular Degeneration	Hepatolenticular Degeneration	BEFREE	27744583, 30230192, 31321400		★☆☆☆☆ Found in Text Mining only
Hepatolenticular Degeneration	Hepatolenticular degeneration	Pubtator	27744583	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31313936		★☆☆☆☆ Found in Text Mining only
Uterine Fibroids	Uterine Fibroids	BEFREE	31313936		★☆☆☆☆ Found in Text Mining only