PGLYRP3 (peptidoglycan recognition protein 3)

Gene

• Entrez ID: 114771
• Gene name: Peptidoglycan recognition protein 3
• Gene symbol: PGLYRP3
• Synonyms (NCBI Gene): PGLYRPIalpha, PGRP-Ialpha, PGRPIA
• Chromosome: 1
• Chromosome location: 1q21.3
• Summary: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 32814053, 33961781
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0006955	Process	Immune response	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008745	Function	N-acetylmuramoyl-L-alanine amidase activity	IEA
GO:0009253	Process	Peptidoglycan catabolic process	IEA
GO:0016019	Function	Peptidoglycan immune receptor activity	IDA	11461926
GO:0016019	Function	Peptidoglycan immune receptor activity	IEA
GO:0016020	Component	Membrane	NAS	11461926
GO:0016045	Process	Detection of bacterium	IDA	11461926
GO:0016045	Process	Detection of bacterium	IEA
GO:0031640	Process	Killing of cells of another organism	IDA	16354652
GO:0031640	Process	Killing of cells of another organism	IEA
GO:0032689	Process	Negative regulation of type II interferon production	IEA
GO:0032827	Process	Negative regulation of natural killer cell differentiation involved in immune response	IEA
GO:0032991	Component	Protein-containing complex	IDA	16354652
GO:0042742	Process	Defense response to bacterium	IBA
GO:0042742	Process	Defense response to bacterium	IEA
GO:0042834	Function	Peptidoglycan binding	IDA	11461926, 16354652, 17502600
GO:0042834	Function	Peptidoglycan binding	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0045087	Process	Innate immune response	NAS	11461926
GO:0046982	Function	Protein heterodimerization activity	IPI	16354652
GO:0050830	Process	Defense response to Gram-positive bacterium	IDA	11461926, 16354652
GO:0050830	Process	Defense response to Gram-positive bacterium	IEA
GO:0051701	Process	Biological process involved in interaction with host	IEA
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	16354652
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IEA

Other IDs

• MIM: 608197
• HGNC: 30014
• e!Ensembl: ENSG00000159527

Protein

• UniProt ID: Q96LB9
• Protein name: Peptidoglycan recognition protein 3 (Peptidoglycan recognition protein I-alpha) (PGLYRPIalpha) (PGRP-I-alpha) (Peptidoglycan recognition protein intermediate alpha)
• Protein function: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Also binds to Gram-ne
• PDB: 1SK3, 1SK4, 1TWQ, 2APH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01510	Amidase_2	46 → 181	N-acetylmuramoyl-L-alanine amidase	Domain
  PF01510	Amidase_2	197 → 327	N-acetylmuramoyl-L-alanine amidase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in skin epidermis, eccrine sweat glands and ducts, ciliary body epithelial cells of the eye, in small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). Highly expressed in skin and esop
• Sequence:

  MGTLPWLLAFFILGLQAWDTPTIVSRKEWGARPLACRALLTLPVAYIITDQLPGMQCQQQ
  SVCSQMLRGLQSHSVYTIGWCDVAYNFLVGDDGRVYEGVGWNIQGLHTQGYNNISLGIAF
  FGNKIGSSPSPAALSAAEGLISYAIQKGHLSPRYIQPLLLKEETCLDPQHPVMPRKVCPN
  IIKRSAWEARETHCPKMNLPAKYVIIIHTAGTSCTVSTDCQTVVRNIQSFHMDTRNFCDI
  GYHFLVGQDGGVYEGVGWHIQGSHTYGFNDIALGIAFIGYFVEKPPNAAALEAAQDLIQC
  AVVEGYLTPNYLLMGHSDVVNILSPGQALYNIISTWPHFKH

• Sequence length: 341

Pathways

Reactome:

Antimicrobial peptides

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATOPIC ECZEMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PGLYRP3-associated inflamatory bowel disease	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Colitis	Colitis	BEFREE	30530168		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	23840689		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	36588538	Associate	★☆☆☆☆ Found in Text Mining only
Gastroenteritis	Gastroenteritis	BEFREE	22099350		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	24838182		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	24838182	Associate	★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	BEFREE	16362825		★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	35909123	Associate	★☆☆☆☆ Found in Text Mining only