Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	114132
Gene name	Sialic acid binding Ig like lectin 11
Gene symbol	SIGLEC11
Synonyms (NCBI Gene)	-
Chromosome	19
Chromosome location	19q13.33
Summary	This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set doma

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miRTarBase ID	miRNA	Experiments	Reference
MIRT643399	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT643398	hsa-miR-6872-3p	HITS-CLIP	23824327
MIRT514955	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT514964	hsa-miR-4438	PAR-CLIP	23446348
MIRT514963	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT514962	hsa-miR-520g-3p	PAR-CLIP	23446348
MIRT514961	hsa-miR-520h	PAR-CLIP	23446348
MIRT514960	hsa-miR-186-3p	PAR-CLIP	23446348
MIRT514959	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT514958	hsa-miR-5186	PAR-CLIP	23446348
MIRT514957	hsa-miR-5095	PAR-CLIP	23446348
MIRT514956	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT514955	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT643399	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT643398	hsa-miR-6872-3p	HITS-CLIP	23824327
MIRT514955	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT514964	hsa-miR-4438	PAR-CLIP	23446348
MIRT514963	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT514962	hsa-miR-520g-3p	PAR-CLIP	23446348
MIRT514961	hsa-miR-520h	PAR-CLIP	23446348
MIRT514960	hsa-miR-186-3p	PAR-CLIP	23446348
MIRT514959	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT514958	hsa-miR-5186	PAR-CLIP	23446348
MIRT514957	hsa-miR-5095	PAR-CLIP	23446348
MIRT514956	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT514955	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT1348499	hsa-miR-122	CLIP-seq
MIRT1348500	hsa-miR-1307	CLIP-seq
MIRT1348501	hsa-miR-4258	CLIP-seq
MIRT1348502	hsa-miR-4284	CLIP-seq
MIRT1348503	hsa-miR-4638-5p	CLIP-seq
MIRT1348504	hsa-miR-4648	CLIP-seq
MIRT1348505	hsa-miR-4707-3p	CLIP-seq
MIRT1348506	hsa-miR-4735-5p	CLIP-seq
MIRT1348507	hsa-miR-4775	CLIP-seq
MIRT1348508	hsa-miR-590-3p	CLIP-seq
MIRT1348509	hsa-miR-10a	CLIP-seq
MIRT1348510	hsa-miR-10b	CLIP-seq
MIRT1348511	hsa-miR-339-5p	CLIP-seq
MIRT1348512	hsa-miR-3919	CLIP-seq
MIRT1348513	hsa-miR-3941	CLIP-seq
MIRT1348514	hsa-miR-4261	CLIP-seq
MIRT1348515	hsa-miR-4421	CLIP-seq
MIRT1348516	hsa-miR-4470	CLIP-seq
MIRT1348517	hsa-miR-4643	CLIP-seq
MIRT1348518	hsa-miR-466	CLIP-seq
MIRT1348519	hsa-miR-4672	CLIP-seq
MIRT1348520	hsa-miR-4786-5p	CLIP-seq
MIRT1348521	hsa-miR-4789-3p	CLIP-seq
MIRT1348522	hsa-miR-494	CLIP-seq
MIRT1348523	hsa-miR-520a-5p	CLIP-seq
MIRT1348524	hsa-miR-525-5p	CLIP-seq
MIRT1348525	hsa-miR-769-5p	CLIP-seq
MIRT2327585	hsa-miR-103a	CLIP-seq
MIRT2327586	hsa-miR-107	CLIP-seq
MIRT2327587	hsa-miR-1207-5p	CLIP-seq
MIRT1348499	hsa-miR-122	CLIP-seq
MIRT2327588	hsa-miR-1301	CLIP-seq
MIRT2327589	hsa-miR-1304	CLIP-seq
MIRT2327590	hsa-miR-139-5p	CLIP-seq
MIRT2327591	hsa-miR-24	CLIP-seq
MIRT2327592	hsa-miR-2467-3p	CLIP-seq
MIRT2327593	hsa-miR-2467-5p	CLIP-seq
MIRT2327594	hsa-miR-3135b	CLIP-seq
MIRT2327595	hsa-miR-3160-3p	CLIP-seq
MIRT2327596	hsa-miR-3182	CLIP-seq
MIRT2327597	hsa-miR-3188	CLIP-seq
MIRT2327598	hsa-miR-34a	CLIP-seq
MIRT2327599	hsa-miR-34c-5p	CLIP-seq
MIRT2327600	hsa-miR-3607-3p	CLIP-seq
MIRT2327601	hsa-miR-3652	CLIP-seq
MIRT2327602	hsa-miR-3686	CLIP-seq
MIRT2327603	hsa-miR-3689a-3p	CLIP-seq
MIRT2327604	hsa-miR-3689c	CLIP-seq
MIRT2327605	hsa-miR-3975	CLIP-seq
MIRT1348502	hsa-miR-4284	CLIP-seq
MIRT2327606	hsa-miR-4430	CLIP-seq
MIRT2327607	hsa-miR-4487	CLIP-seq
MIRT2327608	hsa-miR-449a	CLIP-seq
MIRT2327609	hsa-miR-449b	CLIP-seq
MIRT1348504	hsa-miR-4648	CLIP-seq
MIRT2327610	hsa-miR-4728-5p	CLIP-seq
MIRT2327611	hsa-miR-4736	CLIP-seq
MIRT2327612	hsa-miR-4763-3p	CLIP-seq
MIRT2327613	hsa-miR-485-5p	CLIP-seq
MIRT2327614	hsa-miR-5047	CLIP-seq
MIRT2327615	hsa-miR-545	CLIP-seq
MIRT2327616	hsa-miR-548v	CLIP-seq
MIRT2327617	hsa-miR-558	CLIP-seq
MIRT2327618	hsa-miR-657	CLIP-seq
MIRT2466022	hsa-miR-1273f	CLIP-seq
MIRT2466023	hsa-miR-3149	CLIP-seq
MIRT2466024	hsa-miR-3170	CLIP-seq
MIRT2466025	hsa-miR-411	CLIP-seq
MIRT2466026	hsa-miR-4251	CLIP-seq
MIRT2466027	hsa-miR-4294	CLIP-seq
MIRT2466028	hsa-miR-4329	CLIP-seq
MIRT2466029	hsa-miR-4433	CLIP-seq
MIRT1348506	hsa-miR-4735-5p	CLIP-seq
MIRT1348507	hsa-miR-4775	CLIP-seq
MIRT1348520	hsa-miR-4786-5p	CLIP-seq
MIRT1348508	hsa-miR-590-3p	CLIP-seq
MIRT2466030	hsa-miR-665	CLIP-seq
MIRT1348525	hsa-miR-769-5p	CLIP-seq
MIRT2622653	hsa-miR-1273e	CLIP-seq
MIRT2466022	hsa-miR-1273f	CLIP-seq
MIRT2622654	hsa-miR-1827	CLIP-seq
MIRT2622655	hsa-miR-197	CLIP-seq
MIRT2327592	hsa-miR-2467-3p	CLIP-seq
MIRT2622656	hsa-miR-3122	CLIP-seq
MIRT2466023	hsa-miR-3149	CLIP-seq
MIRT2466024	hsa-miR-3170	CLIP-seq
MIRT2327600	hsa-miR-3607-3p	CLIP-seq
MIRT2622657	hsa-miR-3612	CLIP-seq
MIRT2327602	hsa-miR-3686	CLIP-seq
MIRT2327603	hsa-miR-3689a-3p	CLIP-seq
MIRT2327604	hsa-miR-3689c	CLIP-seq
MIRT2622658	hsa-miR-3913-5p	CLIP-seq
MIRT2466025	hsa-miR-411	CLIP-seq
MIRT1348501	hsa-miR-4258	CLIP-seq
MIRT1348505	hsa-miR-4707-3p	CLIP-seq
MIRT2327610	hsa-miR-4728-5p	CLIP-seq
MIRT1348506	hsa-miR-4735-5p	CLIP-seq
MIRT1348507	hsa-miR-4775	CLIP-seq
MIRT2622659	hsa-miR-5096	CLIP-seq
MIRT1348508	hsa-miR-590-3p	CLIP-seq
MIRT2622660	hsa-miR-650	CLIP-seq
MIRT2622653	hsa-miR-1273e	CLIP-seq
MIRT2466022	hsa-miR-1273f	CLIP-seq
MIRT2622655	hsa-miR-197	CLIP-seq
MIRT2466023	hsa-miR-3149	CLIP-seq
MIRT2466024	hsa-miR-3170	CLIP-seq
MIRT2466025	hsa-miR-411	CLIP-seq
MIRT1348501	hsa-miR-4258	CLIP-seq
MIRT1348505	hsa-miR-4707-3p	CLIP-seq
MIRT1348506	hsa-miR-4735-5p	CLIP-seq
MIRT1348507	hsa-miR-4775	CLIP-seq
MIRT2622659	hsa-miR-5096	CLIP-seq
MIRT1348508	hsa-miR-590-3p	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IBA
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0016020	Component	Membrane	IEA
GO:0019902	Function	Phosphatase binding	IPI	11986327
GO:0030246	Function	Carbohydrate binding	IEA
GO:0033691	Function	Sialic acid binding	IBA
GO:0033691	Function	Sialic acid binding	IDA	11986327

MIM	HGNC	e!Ensembl
607157	15622	ENSG00000161640

Q96RL6

Protein name

Sialic acid-binding Ig-like lectin 11 (Sialic acid-binding lectin 11) (Siglec-11)

Protein function

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	37 → 153	Immunoglobulin V-set domain	Domain
PF07679	I-set	267 → 351	Immunoglobulin I-set domain	Domain
PF13927	Ig_3	373 → 440		Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.

Sequence

MVPGQAQPQSPEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPR
DGWDESTAAYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRD
AQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTVICVFN
WAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQ
RTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWV
LQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRV
MVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGV
LELPPIQMEHEGEFTCHAQHPLGSQHVSLSLSVHYPPQLLGPSCSWEAEGLHCSCSSQAS
PAPSLRWWLGEELLEGNSSQGSFEVTPSSAGPWANSSLSLHGGLSSGLRLRCKAWNVHGA
QSGSVFQLLPGKLEHGGGLGLGAALGAGVAALLAFCSCLVVFRVKICRKEARKRAAAEQD
VPSTLGPISQGHQHECSAGSSQDHPPPGAATYTPGKGEEQELHYASLSFQGLRLWEPADQ
EAPSTTEYSEIKIHTGQPLRGPGFGLQLEREMSGMVPK

Sequence length

698

Interactions

View interactions

	Reactome
			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Glioma	Glioma	Pubtator	33670244	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SIGLEC11 (sialic acid binding Ig like lectin 11)