PIK3IP1 (phosphoinositide-3-kinase interacting protein 1)

Gene

• Entrez ID: 113791
• Gene name: Phosphoinositide-3-kinase interacting protein 1
• Gene symbol: PIK3IP1
• Synonyms (NCBI Gene): HGFL, TrIP, hHGFL(S)
• Chromosome: 22
• Chromosome location: 22q12.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020011	hsa-miR-375	Microarray	20215506
MIRT1234207	hsa-let-7a	CLIP-seq
MIRT1234208	hsa-let-7b	CLIP-seq
MIRT1234209	hsa-let-7c	CLIP-seq
MIRT1234210	hsa-let-7d	CLIP-seq
MIRT1234211	hsa-let-7e	CLIP-seq
MIRT1234212	hsa-let-7f	CLIP-seq
MIRT1234213	hsa-let-7g	CLIP-seq
MIRT1234214	hsa-let-7i	CLIP-seq
MIRT1234215	hsa-miR-105	CLIP-seq
MIRT1234216	hsa-miR-1260	CLIP-seq
MIRT1234217	hsa-miR-1260b	CLIP-seq
MIRT1234218	hsa-miR-128	CLIP-seq
MIRT1234219	hsa-miR-1299	CLIP-seq
MIRT1234220	hsa-miR-1321	CLIP-seq
MIRT1234221	hsa-miR-135a	CLIP-seq
MIRT1234222	hsa-miR-135b	CLIP-seq
MIRT1234223	hsa-miR-145	CLIP-seq
MIRT1234224	hsa-miR-148a	CLIP-seq
MIRT1234225	hsa-miR-148b	CLIP-seq
MIRT1234226	hsa-miR-152	CLIP-seq
MIRT1234227	hsa-miR-188-3p	CLIP-seq
MIRT1234228	hsa-miR-199a-3p	CLIP-seq
MIRT1234229	hsa-miR-199b-3p	CLIP-seq
MIRT1234230	hsa-miR-202	CLIP-seq
MIRT1234231	hsa-miR-224	CLIP-seq
MIRT1234232	hsa-miR-2467-3p	CLIP-seq
MIRT1234233	hsa-miR-3129-5p	CLIP-seq
MIRT1234234	hsa-miR-3156-3p	CLIP-seq
MIRT1234235	hsa-miR-3162-5p	CLIP-seq
MIRT1234236	hsa-miR-3163	CLIP-seq
MIRT1234237	hsa-miR-3180-5p	CLIP-seq
MIRT1234238	hsa-miR-3182	CLIP-seq
MIRT1234239	hsa-miR-3190	CLIP-seq
MIRT1234240	hsa-miR-3202	CLIP-seq
MIRT1234241	hsa-miR-320e	CLIP-seq
MIRT1234242	hsa-miR-34a	CLIP-seq
MIRT1234243	hsa-miR-34c-5p	CLIP-seq
MIRT1234244	hsa-miR-3591-3p	CLIP-seq
MIRT1234245	hsa-miR-3622a-3p	CLIP-seq
MIRT1234246	hsa-miR-3622b-3p	CLIP-seq
MIRT1234247	hsa-miR-3665	CLIP-seq
MIRT1234248	hsa-miR-3678-3p	CLIP-seq
MIRT1234249	hsa-miR-3686	CLIP-seq
MIRT1234250	hsa-miR-378g	CLIP-seq
MIRT1234251	hsa-miR-3934	CLIP-seq
MIRT1234252	hsa-miR-3978	CLIP-seq
MIRT1234253	hsa-miR-410	CLIP-seq
MIRT1234254	hsa-miR-4257	CLIP-seq
MIRT1234255	hsa-miR-4277	CLIP-seq
MIRT1234256	hsa-miR-4330	CLIP-seq
MIRT1234257	hsa-miR-4434	CLIP-seq
MIRT1234258	hsa-miR-4437	CLIP-seq
MIRT1234259	hsa-miR-4458	CLIP-seq
MIRT1234260	hsa-miR-449a	CLIP-seq
MIRT1234261	hsa-miR-449b	CLIP-seq
MIRT1234262	hsa-miR-4500	CLIP-seq
MIRT1234263	hsa-miR-4516	CLIP-seq
MIRT1234264	hsa-miR-4531	CLIP-seq
MIRT1234265	hsa-miR-4533	CLIP-seq
MIRT1234266	hsa-miR-4674	CLIP-seq
MIRT1234267	hsa-miR-4733-5p	CLIP-seq
MIRT1234268	hsa-miR-4739	CLIP-seq
MIRT1234269	hsa-miR-4756-5p	CLIP-seq
MIRT1234270	hsa-miR-4782-5p	CLIP-seq
MIRT1234271	hsa-miR-4786-5p	CLIP-seq
MIRT1234272	hsa-miR-516b	CLIP-seq
MIRT1234273	hsa-miR-544b	CLIP-seq
MIRT1234274	hsa-miR-558	CLIP-seq
MIRT1234275	hsa-miR-601	CLIP-seq
MIRT1234276	hsa-miR-617	CLIP-seq
MIRT1234277	hsa-miR-621	CLIP-seq
MIRT1234278	hsa-miR-657	CLIP-seq
MIRT1234279	hsa-miR-873	CLIP-seq
MIRT1234280	hsa-miR-875-3p	CLIP-seq
MIRT1234281	hsa-miR-936	CLIP-seq
MIRT1234282	hsa-miR-98	CLIP-seq
MIRT1234215	hsa-miR-105	CLIP-seq
MIRT2068999	hsa-miR-1275	CLIP-seq
MIRT2069000	hsa-miR-129-3p	CLIP-seq
MIRT1234231	hsa-miR-224	CLIP-seq
MIRT1234232	hsa-miR-2467-3p	CLIP-seq
MIRT2069001	hsa-miR-3159	CLIP-seq
MIRT1234248	hsa-miR-3678-3p	CLIP-seq
MIRT2069002	hsa-miR-4300	CLIP-seq
MIRT2069003	hsa-miR-4525	CLIP-seq
MIRT2069004	hsa-miR-4665-5p	CLIP-seq
MIRT2069005	hsa-miR-4723-5p	CLIP-seq
MIRT2069006	hsa-miR-625	CLIP-seq
MIRT2069007	hsa-miR-637	CLIP-seq
MIRT2069008	hsa-miR-661	CLIP-seq
MIRT2069009	hsa-miR-920	CLIP-seq
MIRT2069010	hsa-miR-939	CLIP-seq
MIRT1234207	hsa-let-7a	CLIP-seq
MIRT1234208	hsa-let-7b	CLIP-seq
MIRT1234209	hsa-let-7c	CLIP-seq
MIRT1234210	hsa-let-7d	CLIP-seq
MIRT1234211	hsa-let-7e	CLIP-seq
MIRT1234212	hsa-let-7f	CLIP-seq
MIRT1234213	hsa-let-7g	CLIP-seq
MIRT1234214	hsa-let-7i	CLIP-seq
MIRT2296017	hsa-miR-103a	CLIP-seq
MIRT1234215	hsa-miR-105	CLIP-seq
MIRT2296018	hsa-miR-107	CLIP-seq
MIRT2296019	hsa-miR-1202	CLIP-seq
MIRT2296020	hsa-miR-1208	CLIP-seq
MIRT2296021	hsa-miR-1236	CLIP-seq
MIRT1234216	hsa-miR-1260	CLIP-seq
MIRT1234217	hsa-miR-1260b	CLIP-seq
MIRT2068999	hsa-miR-1275	CLIP-seq
MIRT2069000	hsa-miR-129-3p	CLIP-seq
MIRT1234219	hsa-miR-1299	CLIP-seq
MIRT1234221	hsa-miR-135a	CLIP-seq
MIRT1234222	hsa-miR-135b	CLIP-seq
MIRT2296022	hsa-miR-15a	CLIP-seq
MIRT2296023	hsa-miR-15b	CLIP-seq
MIRT2296024	hsa-miR-16	CLIP-seq
MIRT1234227	hsa-miR-188-3p	CLIP-seq
MIRT2296025	hsa-miR-188-5p	CLIP-seq
MIRT2296026	hsa-miR-1914	CLIP-seq
MIRT2296027	hsa-miR-1915	CLIP-seq
MIRT2296028	hsa-miR-192	CLIP-seq
MIRT2296029	hsa-miR-195	CLIP-seq
MIRT1234230	hsa-miR-202	CLIP-seq
MIRT2296030	hsa-miR-215	CLIP-seq
MIRT1234231	hsa-miR-224	CLIP-seq
MIRT1234232	hsa-miR-2467-3p	CLIP-seq
MIRT2296031	hsa-miR-3123	CLIP-seq
MIRT1234234	hsa-miR-3156-3p	CLIP-seq
MIRT1234236	hsa-miR-3163	CLIP-seq
MIRT1234238	hsa-miR-3182	CLIP-seq
MIRT1234239	hsa-miR-3190	CLIP-seq
MIRT2296032	hsa-miR-3194-5p	CLIP-seq
MIRT1234240	hsa-miR-3202	CLIP-seq
MIRT2296033	hsa-miR-324-5p	CLIP-seq
MIRT2296034	hsa-miR-330-3p	CLIP-seq
MIRT2296035	hsa-miR-338-3p	CLIP-seq
MIRT2296036	hsa-miR-342-5p	CLIP-seq
MIRT2296037	hsa-miR-346	CLIP-seq
MIRT1234242	hsa-miR-34a	CLIP-seq
MIRT2296038	hsa-miR-34c-3p	CLIP-seq
MIRT1234243	hsa-miR-34c-5p	CLIP-seq
MIRT1234244	hsa-miR-3591-3p	CLIP-seq
MIRT1234245	hsa-miR-3622a-3p	CLIP-seq
MIRT1234246	hsa-miR-3622b-3p	CLIP-seq
MIRT2296039	hsa-miR-3646	CLIP-seq
MIRT2296040	hsa-miR-3661	CLIP-seq
MIRT2296041	hsa-miR-3662	CLIP-seq
MIRT1234247	hsa-miR-3665	CLIP-seq
MIRT1234248	hsa-miR-3678-3p	CLIP-seq
MIRT2296042	hsa-miR-3925-3p	CLIP-seq
MIRT2296043	hsa-miR-3925-5p	CLIP-seq
MIRT1234251	hsa-miR-3934	CLIP-seq
MIRT2296044	hsa-miR-3972	CLIP-seq
MIRT2296045	hsa-miR-3976	CLIP-seq
MIRT1234252	hsa-miR-3978	CLIP-seq
MIRT2296046	hsa-miR-409-3p	CLIP-seq
MIRT1234253	hsa-miR-410	CLIP-seq
MIRT2296047	hsa-miR-424	CLIP-seq
MIRT2296048	hsa-miR-4268	CLIP-seq
MIRT1234255	hsa-miR-4277	CLIP-seq
MIRT2069002	hsa-miR-4300	CLIP-seq
MIRT2296049	hsa-miR-4317	CLIP-seq
MIRT2296050	hsa-miR-4422	CLIP-seq
MIRT1234258	hsa-miR-4437	CLIP-seq
MIRT2296051	hsa-miR-4448	CLIP-seq
MIRT2296052	hsa-miR-4453	CLIP-seq
MIRT1234259	hsa-miR-4458	CLIP-seq
MIRT1234260	hsa-miR-449a	CLIP-seq
MIRT1234261	hsa-miR-449b	CLIP-seq
MIRT1234262	hsa-miR-4500	CLIP-seq
MIRT2296053	hsa-miR-4524	CLIP-seq
MIRT2069003	hsa-miR-4525	CLIP-seq
MIRT2296054	hsa-miR-4527	CLIP-seq
MIRT2296055	hsa-miR-4530	CLIP-seq
MIRT1234265	hsa-miR-4533	CLIP-seq
MIRT2296056	hsa-miR-4538	CLIP-seq
MIRT2296057	hsa-miR-4639-3p	CLIP-seq
MIRT2296058	hsa-miR-4664-5p	CLIP-seq
MIRT2069004	hsa-miR-4665-5p	CLIP-seq
MIRT1234266	hsa-miR-4674	CLIP-seq
MIRT2296059	hsa-miR-4685-5p	CLIP-seq
MIRT2296060	hsa-miR-4691-3p	CLIP-seq
MIRT2296061	hsa-miR-4695-3p	CLIP-seq
MIRT2296062	hsa-miR-4698	CLIP-seq
MIRT2296063	hsa-miR-4714-3p	CLIP-seq
MIRT2069005	hsa-miR-4723-5p	CLIP-seq
MIRT2296064	hsa-miR-4726-3p	CLIP-seq
MIRT2296065	hsa-miR-4742-5p	CLIP-seq
MIRT2296066	hsa-miR-4753-3p	CLIP-seq
MIRT1234270	hsa-miR-4782-5p	CLIP-seq
MIRT1234271	hsa-miR-4786-5p	CLIP-seq
MIRT2296067	hsa-miR-497	CLIP-seq
MIRT2296068	hsa-miR-499-3p	CLIP-seq
MIRT2296069	hsa-miR-499a-3p	CLIP-seq
MIRT2296070	hsa-miR-503	CLIP-seq
MIRT2296071	hsa-miR-515-5p	CLIP-seq
MIRT1234272	hsa-miR-516b	CLIP-seq
MIRT2296072	hsa-miR-532-5p	CLIP-seq
MIRT2296073	hsa-miR-539	CLIP-seq
MIRT1234273	hsa-miR-544b	CLIP-seq
MIRT1234275	hsa-miR-601	CLIP-seq
MIRT2069006	hsa-miR-625	CLIP-seq
MIRT2296074	hsa-miR-631	CLIP-seq
MIRT2296075	hsa-miR-634	CLIP-seq
MIRT2069007	hsa-miR-637	CLIP-seq
MIRT2296076	hsa-miR-646	CLIP-seq
MIRT1234278	hsa-miR-657	CLIP-seq
MIRT2069008	hsa-miR-661	CLIP-seq
MIRT2296077	hsa-miR-668	CLIP-seq
MIRT2296078	hsa-miR-671-5p	CLIP-seq
MIRT2296079	hsa-miR-766	CLIP-seq
MIRT2296080	hsa-miR-767-3p	CLIP-seq
MIRT1234280	hsa-miR-875-3p	CLIP-seq
MIRT2069009	hsa-miR-920	CLIP-seq
MIRT2296081	hsa-miR-938	CLIP-seq
MIRT2069010	hsa-miR-939	CLIP-seq
MIRT2296082	hsa-miR-942	CLIP-seq
MIRT1234282	hsa-miR-98	CLIP-seq
MIRT2456501	hsa-miR-18a	CLIP-seq
MIRT2456502	hsa-miR-18b	CLIP-seq
MIRT2456503	hsa-miR-3157-3p	CLIP-seq
MIRT2296040	hsa-miR-3661	CLIP-seq
MIRT2456504	hsa-miR-371b-3p	CLIP-seq
MIRT2456505	hsa-miR-4476	CLIP-seq
MIRT2456506	hsa-miR-4700-3p	CLIP-seq
MIRT2456507	hsa-miR-4735-3p	CLIP-seq
MIRT2456508	hsa-miR-628-5p	CLIP-seq
MIRT2296074	hsa-miR-631	CLIP-seq
MIRT2456501	hsa-miR-18a	CLIP-seq
MIRT2456502	hsa-miR-18b	CLIP-seq
MIRT2456503	hsa-miR-3157-3p	CLIP-seq
MIRT2296040	hsa-miR-3661	CLIP-seq
MIRT2456504	hsa-miR-371b-3p	CLIP-seq
MIRT2456505	hsa-miR-4476	CLIP-seq
MIRT2456506	hsa-miR-4700-3p	CLIP-seq
MIRT2456507	hsa-miR-4735-3p	CLIP-seq
MIRT2456508	hsa-miR-628-5p	CLIP-seq
MIRT2296074	hsa-miR-631	CLIP-seq
MIRT1234218	hsa-miR-128	CLIP-seq
MIRT2593964	hsa-miR-1291	CLIP-seq
MIRT1234224	hsa-miR-148a	CLIP-seq
MIRT1234225	hsa-miR-148b	CLIP-seq
MIRT1234226	hsa-miR-152	CLIP-seq
MIRT2593965	hsa-miR-3160-3p	CLIP-seq
MIRT2593966	hsa-miR-3173-5p	CLIP-seq
MIRT1234241	hsa-miR-320e	CLIP-seq
MIRT2593967	hsa-miR-370	CLIP-seq
MIRT1234250	hsa-miR-378g	CLIP-seq
MIRT2593968	hsa-miR-3913-3p	CLIP-seq
MIRT2296046	hsa-miR-409-3p	CLIP-seq
MIRT1234257	hsa-miR-4434	CLIP-seq
MIRT1234258	hsa-miR-4437	CLIP-seq
MIRT2593969	hsa-miR-4487	CLIP-seq
MIRT1234263	hsa-miR-4516	CLIP-seq
MIRT1234264	hsa-miR-4531	CLIP-seq
MIRT2593970	hsa-miR-4663	CLIP-seq
MIRT1234266	hsa-miR-4674	CLIP-seq
MIRT2593971	hsa-miR-489	CLIP-seq
MIRT2296068	hsa-miR-499-3p	CLIP-seq
MIRT2296069	hsa-miR-499a-3p	CLIP-seq
MIRT2593972	hsa-miR-513a-5p	CLIP-seq
MIRT2296073	hsa-miR-539	CLIP-seq
MIRT1234274	hsa-miR-558	CLIP-seq
MIRT1234277	hsa-miR-621	CLIP-seq
MIRT1234279	hsa-miR-873	CLIP-seq
MIRT2593973	hsa-miR-877	CLIP-seq
MIRT1234218	hsa-miR-128	CLIP-seq
MIRT2593964	hsa-miR-1291	CLIP-seq
MIRT1234224	hsa-miR-148a	CLIP-seq
MIRT1234225	hsa-miR-148b	CLIP-seq
MIRT1234226	hsa-miR-152	CLIP-seq
MIRT2593965	hsa-miR-3160-3p	CLIP-seq
MIRT2593966	hsa-miR-3173-5p	CLIP-seq
MIRT2593967	hsa-miR-370	CLIP-seq
MIRT2593969	hsa-miR-4487	CLIP-seq
MIRT2593970	hsa-miR-4663	CLIP-seq
MIRT1234274	hsa-miR-558	CLIP-seq
MIRT1234277	hsa-miR-621	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004175	Function	Endopeptidase activity	IBA
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005615	Component	Extracellular space	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0051898	Process	Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA
GO:0051898	Process	Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA	17475214
GO:0141039	Function	Phosphatidylinositol 3-kinase inhibitor activity	IEA
GO:0141039	Function	Phosphatidylinositol 3-kinase inhibitor activity	IPI	17475214
GO:0141039	Function	Phosphatidylinositol 3-kinase inhibitor activity	ISS

Other IDs

• MIM: 619158
• HGNC: 24942
• e!Ensembl: ENSG00000100100

Protein

• UniProt ID: Q96FE7
• Protein name: Phosphoinositide-3-kinase-interacting protein 1 (PI3K-interacting protein 1) (Kringle domain-containing protein HGFL)
• Protein function: Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00051	Kringle	25 → 101	Kringle domain	Domain

• Sequence:

  MLLAWVQAFLVSNMLLAEAYGSGGCFWDNGHLYREDQTSPAPGLRCLNWLDAQSGLASAP
  VSGAGNHSYCRNPDEDPRGPWCYVSGEAGVPEKRPCEDLRCPETTSQALPAFTTEIQEAS
  EGPGADEVQVFAPANALPARSEAAAVQPVIGISQRVRMNSKEKKDLGTLGYVLGITMMVI
  IIAIGAGIILGYSYKRGKDLKEQHDQKVCEREMQRITLPLSAFTNPTCEIVDEKTVVVHT
  SQTPVDPQEGTTPLMGQAGTPGA

• Sequence length: 263

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART FAILURE, DIASTOLIC	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Brain Edema	Brain edema	Pubtator	24056404	Associate	★☆☆☆☆ Found in Text Mining only
Brain Ischemia	Brain ischemia	Pubtator	36077416	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	28938607		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	36549768	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	36701842	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	38049860	Associate	★☆☆☆☆ Found in Text Mining only
Hashimoto Disease	Hashimoto disease	Pubtator	34867951	Stimulate	★☆☆☆☆ Found in Text Mining only
Heart Failure, Diastolic	Heart Failure	CTD_human_DG	29556499		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	36232694	Associate	★☆☆☆☆ Found in Text Mining only
Liver Failure, Acute	Liver failure	BEFREE	7912298		★☆☆☆☆ Found in Text Mining only
Lung Diseases, Interstitial	Lung Diseases	BEFREE	30886067		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	23676220	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	28938607		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29259156		★☆☆☆☆ Found in Text Mining only
Mantle cell lymphoma	Mantle Cell Lymphoma	BEFREE	23676220		★☆☆☆☆ Found in Text Mining only
Microvascular Angina	Microvascular angina	Pubtator	38049860	Associate	★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	GWASDB_DG	19629137		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19389625, 28938607, 29590609, 31350312		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	28549102	Associate	★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	BEFREE	27271164		★☆☆☆☆ Found in Text Mining only
Small cell carcinoma of lung	Lung carcinoma	BEFREE	9185522		★☆☆☆☆ Found in Text Mining only