Gene Gene information from NCBI Gene database.
Entrez ID 11343
Gene name Monoglyceride lipase
Gene symbol MGLL
Synonyms (NCBI Gene)
HU-K5HUK5MAGLMGL
Chromosome 3
Chromosome location 3q21.3
Summary This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and noci
miRNA miRNA information provided by mirtarbase database.
598
miRTarBase ID miRNA Experiments Reference
MIRT025844 hsa-miR-7-5p Microarray 19073608
MIRT047880 hsa-miR-30c-5p CLASH 23622248
MIRT437600 hsa-miR-142-3p MicroarrayqRT-PCR 22815788
MIRT437751 hsa-miR-93-5p MicroarrayqRT-PCR 22815788
MIRT702025 hsa-miR-624-3p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
35
GO ID Ontology Definition Evidence Reference
GO:0004622 Function Phosphatidylcholine lysophospholipase activity TAS 9495531
GO:0005515 Function Protein binding IPI 28298427, 28514442, 33961781
GO:0005737 Component Cytoplasm IEA
GO:0005789 Component Endoplasmic reticulum membrane TAS
GO:0005829 Component Cytosol IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609699 17038 ENSG00000074416
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q99685
Protein name Monoglyceride lipase (MGL) (EC 3.1.1.23) (HU-K5) (Lysophospholipase homolog) (Lysophospholipase-like) (Monoacylglycerol lipase) (MAGL)
Protein function Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation
PDB 3HJU , 3JW8 , 3JWE , 3PE6 , 4UUQ , 5ZUN , 6AX1 , 6BQ0 , 7L4T , 7L4U , 7L4W , 7L50 , 7PRM , 7ZPG , 8AQF , 8PTC , 8PTQ , 8PTR , 8RVF , 9F8A , 9F8B , 9F8C , 9F8D , 9FY5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12146 Hydrolase_4 39 276 Serine aminopeptidase, S33 Family
Tissue specificity TISSUE SPECIFICITY: Detected in adipose tissue, lung, liver, kidney, brain and heart. {ECO:0000269|PubMed:11470505}.
Sequence
Sequence length 303
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Glycerolipid metabolism
Metabolic pathways
Thermogenesis
Retrograde endocannabinoid signaling
Regulation of lipolysis in adipocytes
  Acyl chain remodeling of DAG and TAG
Arachidonate production from DAG
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
14
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 29348400
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 29348400
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 23873026
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 28373073
★☆☆☆☆
Found in Text Mining only
Anxiety Anxiety Disorder BEFREE 29695817, 30481332
★☆☆☆☆
Found in Text Mining only
Anxiety Disorders Anxiety Disorder BEFREE 29695817, 30481332
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm Abdominal Aortic aneurysm Pubtator 19233690 Associate
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 28380440
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 28380440
★☆☆☆☆
Found in Text Mining only
Azoospermia Azoospermia Pubtator 36733803 Associate
★☆☆☆☆
Found in Text Mining only