Gene Gene information from NCBI Gene database.
Entrez ID 11334
Gene name Tumor suppressor 2, mitochondrial calcium regulator
Gene symbol TUSC2
Synonyms (NCBI Gene)
C3orf11FUS1PAPPDAP2
Chromosome 3
Chromosome location 3p21.31
Summary This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
508
miRTarBase ID miRNA Experiments Reference
MIRT003753 hsa-miR-378a-5p Luciferase reporter assayWestern blotqRT-PCR 18077375
MIRT003753 hsa-miR-378a-5p Luciferase reporter assayWestern blotqRT-PCR 18077375
MIRT004410 hsa-miR-93-5p Luciferase reporter assayWestern blot 19671678
MIRT004411 hsa-miR-98-5p Luciferase reporter assayWestern blot 19671678
MIRT004412 hsa-miR-197-3p Luciferase reporter assayWestern blot 19671678
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0001779 Process Natural killer cell differentiation IEA
GO:0005515 Function Protein binding IPI 25416956, 29892012, 32296183
GO:0005739 Component Mitochondrion IBA
GO:0005739 Component Mitochondrion IEA
GO:0006909 Process Phagocytosis IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607052 17034 ENSG00000114383
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75896
Protein name Tumor suppressor candidate 2 (Fusion 1 protein) (Fus-1 protein) (PDGFA-associated protein 2)
Protein function May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15000 TUSC2 1 109 Tumour suppressor candidate 2 Family
Tissue specificity TISSUE SPECIFICITY: Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta.
Sequence
Sequence length 110
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PEPTIC ULCER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 26112163
★☆☆☆☆
Found in Text Mining only
Amnesia Amnesia BEFREE 28351997
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 23867462, 25457557, 29982879, 30050497, 31383794
★☆☆☆☆
Found in Text Mining only
Anaplastic thyroid carcinoma Anaplastic thyroid cancer BEFREE 27661106
★☆☆☆☆
Found in Text Mining only
Androgen-Insensitivity Syndrome Androgen-Insensitivity Syndrome BEFREE 17481701
★☆☆☆☆
Found in Text Mining only
Atrial Fibrillation Atrial Fibrillation BEFREE 30373693
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases of the Nervous System Autoimmune nervous system disorder Pubtator 19852844 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 11593436
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 31973107 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma in situ of uterine cervix Cervical Intraepithelial Neoplasia BEFREE 11042905
★☆☆☆☆
Found in Text Mining only