TP53RK (TP53 regulating kinase)

Gene

• Entrez ID: 112858
• Gene name: TP53 regulating kinase
• Gene symbol: TP53RK
• Synonyms (NCBI Gene): BUD32, C20orf64, GAMOS4, Nori-2, Nori-2p, PRPK, TPRKB, dJ101A2
• Chromosome: 20
• Chromosome location: 20q13.12

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs553547069	G>A	Likely-pathogenic	Coding sequence variant, missense variant
rs773814837	C>A,T	Pathogenic	Missense variant, coding sequence variant
rs776588426	C>A,T	Pathogenic	Missense variant, coding sequence variant
rs886913294	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs1431526147	T>-	Pathogenic	Coding sequence variant, frameshift variant
rs1432218739	G>A,C,T	Pathogenic	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT048227	hsa-miR-196a-5p	CLASH	23622248
MIRT037962	hsa-miR-505-5p	CLASH	23622248
MIRT550710	hsa-miR-4311	PAR-CLIP	20371350
MIRT296120	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT550709	hsa-miR-345-3p	PAR-CLIP	20371350
MIRT550708	hsa-miR-4766-5p	PAR-CLIP	20371350
MIRT550707	hsa-miR-3913-3p	PAR-CLIP	20371350
MIRT550706	hsa-miR-4725-5p	PAR-CLIP	20371350
MIRT550705	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT550704	hsa-miR-489-3p	PAR-CLIP	20371350
MIRT550703	hsa-miR-514a-3p	PAR-CLIP	20371350
MIRT550702	hsa-miR-514b-3p	PAR-CLIP	20371350
MIRT550710	hsa-miR-4311	PAR-CLIP	21572407
MIRT296120	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT550709	hsa-miR-345-3p	PAR-CLIP	21572407
MIRT550708	hsa-miR-4766-5p	PAR-CLIP	21572407
MIRT550707	hsa-miR-3913-3p	PAR-CLIP	21572407
MIRT550706	hsa-miR-4725-5p	PAR-CLIP	21572407
MIRT550705	hsa-miR-539-5p	PAR-CLIP	21572407
MIRT550704	hsa-miR-489-3p	PAR-CLIP	21572407
MIRT550703	hsa-miR-514a-3p	PAR-CLIP	21572407
MIRT550702	hsa-miR-514b-3p	PAR-CLIP	21572407
MIRT550710	hsa-miR-4311	PAR-CLIP	20371350
MIRT296120	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT550709	hsa-miR-345-3p	PAR-CLIP	20371350
MIRT550708	hsa-miR-4766-5p	PAR-CLIP	20371350
MIRT550707	hsa-miR-3913-3p	PAR-CLIP	20371350
MIRT550706	hsa-miR-4725-5p	PAR-CLIP	20371350
MIRT550705	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT550704	hsa-miR-489-3p	PAR-CLIP	20371350
MIRT550703	hsa-miR-514a-3p	PAR-CLIP	20371350
MIRT550702	hsa-miR-514b-3p	PAR-CLIP	20371350
MIRT550710	hsa-miR-4311	PAR-CLIP	21572407
MIRT296120	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT550709	hsa-miR-345-3p	PAR-CLIP	21572407
MIRT550708	hsa-miR-4766-5p	PAR-CLIP	21572407
MIRT550707	hsa-miR-3913-3p	PAR-CLIP	21572407
MIRT550706	hsa-miR-4725-5p	PAR-CLIP	21572407
MIRT550705	hsa-miR-539-5p	PAR-CLIP	21572407
MIRT550704	hsa-miR-489-3p	PAR-CLIP	21572407
MIRT550703	hsa-miR-514a-3p	PAR-CLIP	21572407
MIRT550702	hsa-miR-514b-3p	PAR-CLIP	21572407
MIRT1448616	hsa-let-7a	CLIP-seq
MIRT1448617	hsa-let-7b	CLIP-seq
MIRT1448618	hsa-let-7c	CLIP-seq
MIRT1448619	hsa-let-7d	CLIP-seq
MIRT1448620	hsa-let-7e	CLIP-seq
MIRT1448621	hsa-let-7f	CLIP-seq
MIRT1448622	hsa-let-7g	CLIP-seq
MIRT1448623	hsa-let-7i	CLIP-seq
MIRT1448624	hsa-miR-103b	CLIP-seq
MIRT1448625	hsa-miR-1183	CLIP-seq
MIRT1448626	hsa-miR-1193	CLIP-seq
MIRT1448627	hsa-miR-1224-3p	CLIP-seq
MIRT1448628	hsa-miR-1260	CLIP-seq
MIRT1448629	hsa-miR-1260b	CLIP-seq
MIRT1448630	hsa-miR-1273f	CLIP-seq
MIRT1448631	hsa-miR-1278	CLIP-seq
MIRT1448632	hsa-miR-128	CLIP-seq
MIRT1448633	hsa-miR-1280	CLIP-seq
MIRT1448634	hsa-miR-1294	CLIP-seq
MIRT1448635	hsa-miR-129-5p	CLIP-seq
MIRT1448636	hsa-miR-1323	CLIP-seq
MIRT1448637	hsa-miR-1343	CLIP-seq
MIRT1448638	hsa-miR-143	CLIP-seq
MIRT1448639	hsa-miR-146a	CLIP-seq
MIRT1448640	hsa-miR-146b-5p	CLIP-seq
MIRT1448641	hsa-miR-147	CLIP-seq
MIRT1448642	hsa-miR-1470	CLIP-seq
MIRT1448643	hsa-miR-1827	CLIP-seq
MIRT1448644	hsa-miR-188-3p	CLIP-seq
MIRT1448645	hsa-miR-1914	CLIP-seq
MIRT1448646	hsa-miR-197	CLIP-seq
MIRT1448647	hsa-miR-2053	CLIP-seq
MIRT1448648	hsa-miR-22	CLIP-seq
MIRT1448649	hsa-miR-224	CLIP-seq
MIRT1448650	hsa-miR-2467-3p	CLIP-seq
MIRT1448651	hsa-miR-27a	CLIP-seq
MIRT1448652	hsa-miR-27b	CLIP-seq
MIRT1448653	hsa-miR-3065-3p	CLIP-seq
MIRT1448654	hsa-miR-3065-5p	CLIP-seq
MIRT1448655	hsa-miR-3156-3p	CLIP-seq
MIRT1448656	hsa-miR-3159	CLIP-seq
MIRT1448657	hsa-miR-3163	CLIP-seq
MIRT1448658	hsa-miR-3187-3p	CLIP-seq
MIRT1448659	hsa-miR-3189-3p	CLIP-seq
MIRT1448660	hsa-miR-3190	CLIP-seq
MIRT1448661	hsa-miR-324-5p	CLIP-seq
MIRT1448662	hsa-miR-330-3p	CLIP-seq
MIRT1448663	hsa-miR-340	CLIP-seq
MIRT1448664	hsa-miR-3607-3p	CLIP-seq
MIRT1448665	hsa-miR-3614-3p	CLIP-seq
MIRT1448666	hsa-miR-362-5p	CLIP-seq
MIRT1448667	hsa-miR-365	CLIP-seq
MIRT1448668	hsa-miR-3652	CLIP-seq
MIRT1448669	hsa-miR-3653	CLIP-seq
MIRT1448670	hsa-miR-3658	CLIP-seq
MIRT1448671	hsa-miR-3678-3p	CLIP-seq
MIRT1448672	hsa-miR-3680	CLIP-seq
MIRT1448673	hsa-miR-376a	CLIP-seq
MIRT1448674	hsa-miR-376b	CLIP-seq
MIRT1448675	hsa-miR-3911	CLIP-seq
MIRT1448676	hsa-miR-3915	CLIP-seq
MIRT1448677	hsa-miR-3928	CLIP-seq
MIRT1448678	hsa-miR-3936	CLIP-seq
MIRT1448679	hsa-miR-3944-5p	CLIP-seq
MIRT1448680	hsa-miR-412	CLIP-seq
MIRT1448681	hsa-miR-4260	CLIP-seq
MIRT1448682	hsa-miR-4263	CLIP-seq
MIRT1448683	hsa-miR-4291	CLIP-seq
MIRT1448684	hsa-miR-4301	CLIP-seq
MIRT1448685	hsa-miR-4302	CLIP-seq
MIRT1448686	hsa-miR-4310	CLIP-seq
MIRT1448687	hsa-miR-4316	CLIP-seq
MIRT1448688	hsa-miR-432	CLIP-seq
MIRT1448689	hsa-miR-4328	CLIP-seq
MIRT1448690	hsa-miR-4430	CLIP-seq
MIRT1448691	hsa-miR-4450	CLIP-seq
MIRT1448692	hsa-miR-4455	CLIP-seq
MIRT1448693	hsa-miR-4457	CLIP-seq
MIRT1448694	hsa-miR-4458	CLIP-seq
MIRT1448695	hsa-miR-4477a	CLIP-seq
MIRT1448696	hsa-miR-4496	CLIP-seq
MIRT1448697	hsa-miR-4500	CLIP-seq
MIRT1448698	hsa-miR-4501	CLIP-seq
MIRT1448699	hsa-miR-4505	CLIP-seq
MIRT1448700	hsa-miR-450b-5p	CLIP-seq
MIRT1448701	hsa-miR-4520a-3p	CLIP-seq
MIRT1448702	hsa-miR-4520b-3p	CLIP-seq
MIRT1448703	hsa-miR-4529-5p	CLIP-seq
MIRT1448704	hsa-miR-4632	CLIP-seq
MIRT1448705	hsa-miR-4640-5p	CLIP-seq
MIRT1448706	hsa-miR-4645-3p	CLIP-seq
MIRT1448707	hsa-miR-4661-5p	CLIP-seq
MIRT1448708	hsa-miR-4667-3p	CLIP-seq
MIRT1448709	hsa-miR-4667-5p	CLIP-seq
MIRT1448710	hsa-miR-4681	CLIP-seq
MIRT1448711	hsa-miR-4693-3p	CLIP-seq
MIRT1448712	hsa-miR-4694-5p	CLIP-seq
MIRT1448713	hsa-miR-4700-5p	CLIP-seq
MIRT1448714	hsa-miR-4708-5p	CLIP-seq
MIRT1448715	hsa-miR-4709-5p	CLIP-seq
MIRT1448716	hsa-miR-4726-5p	CLIP-seq
MIRT1448717	hsa-miR-4731-5p	CLIP-seq
MIRT1448718	hsa-miR-4738-3p	CLIP-seq
MIRT1448719	hsa-miR-4760-3p	CLIP-seq
MIRT1448720	hsa-miR-4770	CLIP-seq
MIRT1448721	hsa-miR-4773	CLIP-seq
MIRT1448722	hsa-miR-4777-3p	CLIP-seq
MIRT1448723	hsa-miR-4789-5p	CLIP-seq
MIRT1448724	hsa-miR-4795-3p	CLIP-seq
MIRT1448725	hsa-miR-4796-5p	CLIP-seq
MIRT1448726	hsa-miR-4799-5p	CLIP-seq
MIRT1448727	hsa-miR-489	CLIP-seq
MIRT1448728	hsa-miR-499a-5p	CLIP-seq
MIRT1448729	hsa-miR-500b	CLIP-seq
MIRT1448730	hsa-miR-501-5p	CLIP-seq
MIRT1448731	hsa-miR-507	CLIP-seq
MIRT1448732	hsa-miR-512-5p	CLIP-seq
MIRT1448733	hsa-miR-513b	CLIP-seq
MIRT1448734	hsa-miR-514	CLIP-seq
MIRT1448735	hsa-miR-515-5p	CLIP-seq
MIRT1448736	hsa-miR-532-3p	CLIP-seq
MIRT1448737	hsa-miR-548a-3p	CLIP-seq
MIRT1448738	hsa-miR-548aa	CLIP-seq
MIRT1448739	hsa-miR-548e	CLIP-seq
MIRT1448740	hsa-miR-548f	CLIP-seq
MIRT1448741	hsa-miR-548k	CLIP-seq
MIRT1448742	hsa-miR-548o	CLIP-seq
MIRT1448743	hsa-miR-549	CLIP-seq
MIRT1448744	hsa-miR-550a	CLIP-seq
MIRT1448745	hsa-miR-557	CLIP-seq
MIRT1448746	hsa-miR-569	CLIP-seq
MIRT1448747	hsa-miR-570	CLIP-seq
MIRT1448748	hsa-miR-574-5p	CLIP-seq
MIRT1448749	hsa-miR-576-5p	CLIP-seq
MIRT1448750	hsa-miR-589	CLIP-seq
MIRT1448751	hsa-miR-601	CLIP-seq
MIRT1448752	hsa-miR-609	CLIP-seq
MIRT1448753	hsa-miR-622	CLIP-seq
MIRT1448754	hsa-miR-644	CLIP-seq
MIRT1448755	hsa-miR-648	CLIP-seq
MIRT1448756	hsa-miR-98	CLIP-seq
MIRT1448627	hsa-miR-1224-3p	CLIP-seq
MIRT2134285	hsa-miR-1254	CLIP-seq
MIRT1448628	hsa-miR-1260	CLIP-seq
MIRT1448629	hsa-miR-1260b	CLIP-seq
MIRT1448632	hsa-miR-128	CLIP-seq
MIRT1448633	hsa-miR-1280	CLIP-seq
MIRT1448634	hsa-miR-1294	CLIP-seq
MIRT2134286	hsa-miR-138	CLIP-seq
MIRT1448639	hsa-miR-146a	CLIP-seq
MIRT1448640	hsa-miR-146b-5p	CLIP-seq
MIRT1448651	hsa-miR-27a	CLIP-seq
MIRT1448652	hsa-miR-27b	CLIP-seq
MIRT1448654	hsa-miR-3065-5p	CLIP-seq
MIRT2134287	hsa-miR-3116	CLIP-seq
MIRT2134288	hsa-miR-3133	CLIP-seq
MIRT2134289	hsa-miR-3192	CLIP-seq
MIRT2134290	hsa-miR-3202	CLIP-seq
MIRT2134291	hsa-miR-323b-5p	CLIP-seq
MIRT1448662	hsa-miR-330-3p	CLIP-seq
MIRT2134292	hsa-miR-34b	CLIP-seq
MIRT1448665	hsa-miR-3614-3p	CLIP-seq
MIRT2134293	hsa-miR-3614-5p	CLIP-seq
MIRT2134294	hsa-miR-3622b-5p	CLIP-seq
MIRT1448668	hsa-miR-3652	CLIP-seq
MIRT2134295	hsa-miR-3662	CLIP-seq
MIRT1448672	hsa-miR-3680	CLIP-seq
MIRT2134296	hsa-miR-3713	CLIP-seq
MIRT2134297	hsa-miR-3908	CLIP-seq
MIRT2134298	hsa-miR-3909	CLIP-seq
MIRT2134299	hsa-miR-3942-5p	CLIP-seq
MIRT2134300	hsa-miR-3978	CLIP-seq
MIRT1448681	hsa-miR-4260	CLIP-seq
MIRT1448683	hsa-miR-4291	CLIP-seq
MIRT2134301	hsa-miR-4307	CLIP-seq
MIRT1448686	hsa-miR-4310	CLIP-seq
MIRT2134302	hsa-miR-4314	CLIP-seq
MIRT1448687	hsa-miR-4316	CLIP-seq
MIRT1448690	hsa-miR-4430	CLIP-seq
MIRT2134303	hsa-miR-4434	CLIP-seq
MIRT1448691	hsa-miR-4450	CLIP-seq
MIRT2134304	hsa-miR-4476	CLIP-seq
MIRT1448698	hsa-miR-4501	CLIP-seq
MIRT1448699	hsa-miR-4505	CLIP-seq
MIRT2134305	hsa-miR-4516	CLIP-seq
MIRT1448705	hsa-miR-4640-5p	CLIP-seq
MIRT1448706	hsa-miR-4645-3p	CLIP-seq
MIRT2134306	hsa-miR-4646-5p	CLIP-seq
MIRT2134307	hsa-miR-4653-3p	CLIP-seq
MIRT1448707	hsa-miR-4661-5p	CLIP-seq
MIRT1448709	hsa-miR-4667-5p	CLIP-seq
MIRT2134308	hsa-miR-4690-3p	CLIP-seq
MIRT2134309	hsa-miR-4697-3p	CLIP-seq
MIRT2134310	hsa-miR-4698	CLIP-seq
MIRT2134311	hsa-miR-4699-3p	CLIP-seq
MIRT1448713	hsa-miR-4700-5p	CLIP-seq
MIRT2134312	hsa-miR-4703-5p	CLIP-seq
MIRT2134313	hsa-miR-4705	CLIP-seq
MIRT2134314	hsa-miR-4718	CLIP-seq
MIRT2134315	hsa-miR-4720-5p	CLIP-seq
MIRT1448716	hsa-miR-4726-5p	CLIP-seq
MIRT1448717	hsa-miR-4731-5p	CLIP-seq
MIRT2134316	hsa-miR-4733-5p	CLIP-seq
MIRT2134317	hsa-miR-4742-3p	CLIP-seq
MIRT2134318	hsa-miR-4760-5p	CLIP-seq
MIRT2134319	hsa-miR-4766-3p	CLIP-seq
MIRT1448722	hsa-miR-4777-3p	CLIP-seq
MIRT2134320	hsa-miR-4799-3p	CLIP-seq
MIRT2134321	hsa-miR-5096	CLIP-seq
MIRT2134322	hsa-miR-511	CLIP-seq
MIRT1448735	hsa-miR-515-5p	CLIP-seq
MIRT2134323	hsa-miR-548g	CLIP-seq
MIRT2134324	hsa-miR-579	CLIP-seq
MIRT2134325	hsa-miR-587	CLIP-seq
MIRT1448750	hsa-miR-589	CLIP-seq
MIRT2134326	hsa-miR-607	CLIP-seq
MIRT2134327	hsa-miR-661	CLIP-seq
MIRT2134328	hsa-miR-943	CLIP-seq
MIRT2355498	hsa-miR-124	CLIP-seq
MIRT2355499	hsa-miR-1245b-3p	CLIP-seq
MIRT1448632	hsa-miR-128	CLIP-seq
MIRT1448634	hsa-miR-1294	CLIP-seq
MIRT1448647	hsa-miR-2053	CLIP-seq
MIRT1448649	hsa-miR-224	CLIP-seq
MIRT1448651	hsa-miR-27a	CLIP-seq
MIRT1448652	hsa-miR-27b	CLIP-seq
MIRT1448654	hsa-miR-3065-5p	CLIP-seq
MIRT1448655	hsa-miR-3156-3p	CLIP-seq
MIRT1448657	hsa-miR-3163	CLIP-seq
MIRT2355500	hsa-miR-3200-5p	CLIP-seq
MIRT2355501	hsa-miR-323b-3p	CLIP-seq
MIRT2355502	hsa-miR-3616-5p	CLIP-seq
MIRT1448666	hsa-miR-362-5p	CLIP-seq
MIRT2355503	hsa-miR-3647-5p	CLIP-seq
MIRT1448668	hsa-miR-3652	CLIP-seq
MIRT2355504	hsa-miR-3682-3p	CLIP-seq
MIRT2355505	hsa-miR-371b-5p	CLIP-seq
MIRT1448680	hsa-miR-412	CLIP-seq
MIRT2355506	hsa-miR-4251	CLIP-seq
MIRT1448683	hsa-miR-4291	CLIP-seq
MIRT1448684	hsa-miR-4301	CLIP-seq
MIRT1448686	hsa-miR-4310	CLIP-seq
MIRT1448687	hsa-miR-4316	CLIP-seq
MIRT2355507	hsa-miR-4329	CLIP-seq
MIRT1448690	hsa-miR-4430	CLIP-seq
MIRT1448691	hsa-miR-4450	CLIP-seq
MIRT1448692	hsa-miR-4455	CLIP-seq
MIRT1448693	hsa-miR-4457	CLIP-seq
MIRT1448698	hsa-miR-4501	CLIP-seq
MIRT1448699	hsa-miR-4505	CLIP-seq
MIRT1448706	hsa-miR-4645-3p	CLIP-seq
MIRT2355508	hsa-miR-4658	CLIP-seq
MIRT1448709	hsa-miR-4667-5p	CLIP-seq
MIRT1448712	hsa-miR-4694-5p	CLIP-seq
MIRT2134310	hsa-miR-4698	CLIP-seq
MIRT1448713	hsa-miR-4700-5p	CLIP-seq
MIRT1448717	hsa-miR-4731-5p	CLIP-seq
MIRT2355509	hsa-miR-4758-5p	CLIP-seq
MIRT2355510	hsa-miR-4765	CLIP-seq
MIRT1448721	hsa-miR-4773	CLIP-seq
MIRT2355511	hsa-miR-4789-3p	CLIP-seq
MIRT2355512	hsa-miR-4795-5p	CLIP-seq
MIRT1448729	hsa-miR-500b	CLIP-seq
MIRT2355513	hsa-miR-506	CLIP-seq
MIRT1448733	hsa-miR-513b	CLIP-seq
MIRT2355514	hsa-miR-519a	CLIP-seq
MIRT2355515	hsa-miR-519b-3p	CLIP-seq
MIRT2355516	hsa-miR-519c-3p	CLIP-seq
MIRT2355517	hsa-miR-526b	CLIP-seq
MIRT2355518	hsa-miR-545	CLIP-seq
MIRT2355519	hsa-miR-548an	CLIP-seq
MIRT1448743	hsa-miR-549	CLIP-seq
MIRT1448746	hsa-miR-569	CLIP-seq
MIRT2355520	hsa-miR-573	CLIP-seq
MIRT1448752	hsa-miR-609	CLIP-seq
MIRT2355521	hsa-miR-642b	CLIP-seq
MIRT2355522	hsa-miR-888	CLIP-seq
MIRT1448626	hsa-miR-1193	CLIP-seq
MIRT2396234	hsa-miR-3144-5p	CLIP-seq
MIRT2396235	hsa-miR-3191	CLIP-seq
MIRT2396236	hsa-miR-4652-5p	CLIP-seq
MIRT1448632	hsa-miR-128	CLIP-seq
MIRT2462185	hsa-miR-136	CLIP-seq
MIRT1448651	hsa-miR-27a	CLIP-seq
MIRT1448652	hsa-miR-27b	CLIP-seq
MIRT1448657	hsa-miR-3163	CLIP-seq
MIRT1448668	hsa-miR-3652	CLIP-seq
MIRT2134295	hsa-miR-3662	CLIP-seq
MIRT1448683	hsa-miR-4291	CLIP-seq
MIRT1448686	hsa-miR-4310	CLIP-seq
MIRT1448690	hsa-miR-4430	CLIP-seq
MIRT1448691	hsa-miR-4450	CLIP-seq
MIRT1448699	hsa-miR-4505	CLIP-seq
MIRT1448709	hsa-miR-4667-5p	CLIP-seq
MIRT1448713	hsa-miR-4700-5p	CLIP-seq
MIRT1448717	hsa-miR-4731-5p	CLIP-seq
MIRT1448735	hsa-miR-515-5p	CLIP-seq
MIRT1448632	hsa-miR-128	CLIP-seq
MIRT1448651	hsa-miR-27a	CLIP-seq
MIRT1448652	hsa-miR-27b	CLIP-seq
MIRT1448668	hsa-miR-3652	CLIP-seq
MIRT1448683	hsa-miR-4291	CLIP-seq
MIRT1448686	hsa-miR-4310	CLIP-seq
MIRT1448690	hsa-miR-4430	CLIP-seq
MIRT1448691	hsa-miR-4450	CLIP-seq
MIRT1448699	hsa-miR-4505	CLIP-seq
MIRT1448709	hsa-miR-4667-5p	CLIP-seq
MIRT1448713	hsa-miR-4700-5p	CLIP-seq
MIRT1448717	hsa-miR-4731-5p	CLIP-seq
MIRT1448632	hsa-miR-128	CLIP-seq
MIRT2649123	hsa-miR-1324	CLIP-seq
MIRT1448651	hsa-miR-27a	CLIP-seq
MIRT1448652	hsa-miR-27b	CLIP-seq
MIRT2649124	hsa-miR-3123	CLIP-seq
MIRT2649125	hsa-miR-342-3p	CLIP-seq
MIRT1448666	hsa-miR-362-5p	CLIP-seq
MIRT1448668	hsa-miR-3652	CLIP-seq
MIRT2649126	hsa-miR-3672	CLIP-seq
MIRT1448683	hsa-miR-4291	CLIP-seq
MIRT1448686	hsa-miR-4310	CLIP-seq
MIRT1448690	hsa-miR-4430	CLIP-seq
MIRT1448691	hsa-miR-4450	CLIP-seq
MIRT1448693	hsa-miR-4457	CLIP-seq
MIRT1448699	hsa-miR-4505	CLIP-seq
MIRT1448709	hsa-miR-4667-5p	CLIP-seq
MIRT1448713	hsa-miR-4700-5p	CLIP-seq
MIRT1448717	hsa-miR-4731-5p	CLIP-seq
MIRT2649127	hsa-miR-4759	CLIP-seq
MIRT2649128	hsa-miR-4793-5p	CLIP-seq
MIRT2649129	hsa-miR-494	CLIP-seq
MIRT1448729	hsa-miR-500b	CLIP-seq
MIRT1448733	hsa-miR-513b	CLIP-seq
MIRT1448632	hsa-miR-128	CLIP-seq
MIRT1448651	hsa-miR-27a	CLIP-seq
MIRT1448652	hsa-miR-27b	CLIP-seq
MIRT2649124	hsa-miR-3123	CLIP-seq
MIRT2649125	hsa-miR-342-3p	CLIP-seq
MIRT1448666	hsa-miR-362-5p	CLIP-seq
MIRT1448668	hsa-miR-3652	CLIP-seq
MIRT2649126	hsa-miR-3672	CLIP-seq
MIRT1448683	hsa-miR-4291	CLIP-seq
MIRT1448686	hsa-miR-4310	CLIP-seq
MIRT1448690	hsa-miR-4430	CLIP-seq
MIRT1448691	hsa-miR-4450	CLIP-seq
MIRT1448693	hsa-miR-4457	CLIP-seq
MIRT1448699	hsa-miR-4505	CLIP-seq
MIRT1448709	hsa-miR-4667-5p	CLIP-seq
MIRT1448713	hsa-miR-4700-5p	CLIP-seq
MIRT1448717	hsa-miR-4731-5p	CLIP-seq
MIRT2649127	hsa-miR-4759	CLIP-seq
MIRT2649128	hsa-miR-4793-5p	CLIP-seq
MIRT1448729	hsa-miR-500b	CLIP-seq
MIRT1448733	hsa-miR-513b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000408	Component	EKC/KEOPS complex	IBA
GO:0000408	Component	EKC/KEOPS complex	IDA	27903914, 28805828
GO:0000408	Component	EKC/KEOPS complex	IEA
GO:0002039	Function	P53 binding	IDA	11546806
GO:0003824	Function	Catalytic activity	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	11546806
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0005515	Function	Protein binding	IPI	11546806, 12659830, 16189514, 23414517, 23455922, 25416956, 27903914, 28514442, 28805828, 31515488, 32296183, 32707033, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	11546806, 27903914, 28805828
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	28805828
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0006468	Process	Protein phosphorylation	IDA	11546806
GO:0008033	Process	TRNA processing	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0070525	Process	TRNA threonylcarbamoyladenosine metabolic process	IBA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	TAS

Other IDs

• MIM: 608679
• HGNC: 16197
• e!Ensembl: ENSG00000172315

Protein

• UniProt ID: Q96S44
• Protein name: EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase)
• Protein function: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably
• PDB: 6WQX, 7SZA, 7SZB, 7SZC, 7SZD
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06293	Kdo	49 → 225		Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in testis. Weakly expressed in heart kidney and spleen. {ECO:0000269|PubMed:11546806}.
• Sequence:

  MAAARATTPADGEEPAPEAEALAAARERSSRFLSGLELVKQGAEARVFRGRFQGRAAVIK
  HRFPKGYRHPALEARLGRRRTVQEARALLRCRRAGISAPVVFFVDYASNCLYMEEIEGSV
  TVRDYIQSTMETEKTPQGLSNLAKTIGQVLARMHDEDLIHGDLTTSNMLLKPPLEQLNIV
  LIDFGLSFISALPEDKGVDLYVLEKAFLSTHPNTETVFEAFLKSYSTSSKKARPVLKKLD
  EVRLRGRKRSMVG

• Sequence length: 253

Pathways

Reactome:

Regulation of TP53 Activity through Phosphorylation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Galloway-Mowat syndrome 4	Likely pathogenic; Pathogenic	rs1568972559, rs1431526147, rs1432218739, rs773814837, rs774069989	RCV001580607 RCV000513210 RCV000513568 RCV000513023 RCV002489515	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Microcephaly	Pathogenic	rs774069989	RCV001252762	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
GALLOWAY MOWAT SYNDROME	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GALLOWAY-MOWAT SYNDROME	—	GWAS catalog, Orphanet GWAS catalog, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Global developmental delay	Conflicting classifications of pathogenicity; Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Seizure	Conflicting classifications of pathogenicity; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TP53RK-related disorder	Conflicting classifications of pathogenicity; Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Aqueductal Stenosis	Aqueductal Stenosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Brain atrophy	Brain atrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	40352177	Associate	★☆☆☆☆ Found in Text Mining only
Cerebellar Hypoplasia	Cerebellar Hypoplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cerebral atrophy	Cerebral Atrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Chronic kidney disease stage 5	Kidney Disease	HPO_DG			★☆☆☆☆ Found in Text Mining only
Class III malocclusion	Malocclusion	HPO_DG			★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	29483219		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	26263387		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	26263387, 33547416	Associate	★☆☆☆☆ Found in Text Mining only
Congenital Epicanthus	Congenital Epicanthus	HPO_DG			★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	GWASCAT_DG	31451708		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	GWASCAT_DG	31451708		★☆☆☆☆ Found in Text Mining only
Diffuse mesangial sclerosis (disorder)	Mesangial sclerosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Galloway Mowat syndrome	Galloway-Mowat Syndrome	CTD_human_DG	28805828		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Galloway Mowat syndrome	Galloway-Mowat Syndrome	ORPHANET_DG	28805828		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Galloway Mowat syndrome	Galloway-Mowat Syndrome	BEFREE	30053862, 30141175, 30975089		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Galloway Mowat syndrome	Galloway-mowat syndrome	Pubtator	30053862, 33547416, 36755238	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Galloway-Mowat syndrome	Galloway-Mowat Syndrome	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GALLOWAY-MOWAT SYNDROME 4	Galloway-Mowat Syndrome	GENOMICS_ENGLAND_DG	28805828		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
GALLOWAY-MOWAT SYNDROME 4	Galloway-Mowat Syndrome	UNIPROT_DG	28805828		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
GALLOWAY-MOWAT SYNDROME 4	Galloway-Mowat Syndrome	CLINVAR_DG			★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
GALLOWAY-MOWAT SYNDROME 5	Galloway-Mowat Syndrome	GENOMICS_ENGLAND_DG	28805828, 30053862		★☆☆☆☆ Found in Text Mining only
GALLOWAY-MOWAT SYNDROME 5	Galloway-Mowat Syndrome	UNIPROT_DG	28805828		★☆☆☆☆ Found in Text Mining only
GALLOWAY-MOWAT SYNDROME 5	Galloway-Mowat Syndrome	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Glomerulonephritis	Glomerulonephritis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Glomerulosclerosis (disorder)	Glomerulosclerosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hemiplegia/hemiparesis	Hemiplegia/hemiparesis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hiatal Hernia	Hiatal Hernia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	HPO_DG			★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney Disease	HPO_DG			★☆☆☆☆ Found in Text Mining only
Macrotia	Macrotia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of skin	Skin cancer	BEFREE	29904102		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31110156		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	29483219		★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	BEFREE	30141175		★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Microcephaly	Microcephaly	Pubtator	36755238	Associate	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Microcephaly	Microcephaly	HPO_DG			★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Micrognathism	Micrognathism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	28082445		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	28082445	Associate	★☆☆☆☆ Found in Text Mining only
Nephrotic Syndrome	Nephrotic Syndrome	BEFREE	28805828		★☆☆☆☆ Found in Text Mining only
Nephrotic Syndrome	Nephrotic Syndrome	HPO_DG			★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	32944406	Associate	★☆☆☆☆ Found in Text Mining only
Pachygyria	Pachygyria	HPO_DG			★☆☆☆☆ Found in Text Mining only
Polymicrogyria	Polymicrogyria	HPO_DG			★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of skin	Skin carcinoma	BEFREE	29904102		★☆☆☆☆ Found in Text Mining only
Steroid resistant nephrotic syndrome of childhood	Steroid resistant nephrotic syndrome	BEFREE	30141175		★☆☆☆☆ Found in Text Mining only