Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	112724
Gene name	Retinol dehydrogenase 13
Gene symbol	RDH13
Synonyms (NCBI Gene)	SDR7C3
Chromosome	19
Chromosome location	19q13.42
Summary	This gene encodes a mitochondrial short-chain dehydrogenase/reductase, which catalyzes the reduction and oxidation of retinoids. The encoded enzyme may function in retinoic acid production and may also protect the mitochondria against oxidative stress. Al

256

Show/Hide all (256)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020877	hsa-miR-155-5p	Proteomics	18668040
MIRT709169	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT676584	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT709168	hsa-miR-1976	HITS-CLIP	19536157
MIRT709167	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT709166	hsa-miR-7977	HITS-CLIP	19536157
MIRT709165	hsa-miR-4279	HITS-CLIP	19536157
MIRT691051	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT691050	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT691049	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT691048	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT691047	hsa-miR-3143	HITS-CLIP	23313552
MIRT691046	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT691045	hsa-miR-302c-5p	HITS-CLIP	23313552
MIRT679789	hsa-miR-4438	HITS-CLIP	23824327
MIRT679788	hsa-miR-6872-3p	HITS-CLIP	23824327
MIRT679787	hsa-miR-6789-3p	HITS-CLIP	23824327
MIRT676581	hsa-miR-3199	HITS-CLIP	23824327
MIRT676580	hsa-miR-8052	HITS-CLIP	23824327
MIRT676579	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT676578	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT679785	hsa-miR-5095	HITS-CLIP	23824327
MIRT679786	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT676589	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT676588	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT676587	hsa-miR-4324	HITS-CLIP	23824327
MIRT676586	hsa-miR-544b	HITS-CLIP	23824327
MIRT676585	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT676584	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676583	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT676582	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT676581	hsa-miR-3199	HITS-CLIP	23824327
MIRT676580	hsa-miR-8052	HITS-CLIP	23824327
MIRT676579	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT676578	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT676577	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT676576	hsa-miR-1200	HITS-CLIP	23824327
MIRT676575	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT676574	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT643833	hsa-miR-3182	HITS-CLIP	23824327
MIRT643832	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT643831	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT643830	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT643829	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT643828	hsa-miR-5585-3p	HITS-CLIP	23824327
MIRT643833	hsa-miR-3182	HITS-CLIP	23824327
MIRT643832	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT643831	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT643830	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT643829	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT643828	hsa-miR-5585-3p	HITS-CLIP	23824327
MIRT527055	hsa-miR-3691-3p	PAR-CLIP	22012620
MIRT527054	hsa-miR-1292-3p	PAR-CLIP	22012620
MIRT527053	hsa-miR-4539	PAR-CLIP	22012620
MIRT527051	hsa-miR-4480	PAR-CLIP	22012620
MIRT527052	hsa-miR-450b-5p	PAR-CLIP	22012620
MIRT527050	hsa-miR-507	PAR-CLIP	22012620
MIRT527049	hsa-miR-557	PAR-CLIP	22012620
MIRT527048	hsa-miR-3680-3p	PAR-CLIP	22012620
MIRT453570	hsa-miR-495-5p	PAR-CLIP	23592263
MIRT453569	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT453568	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT453567	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT453566	hsa-miR-5186	PAR-CLIP	23592263
MIRT453565	hsa-miR-4537	PAR-CLIP	23592263
MIRT453564	hsa-miR-1827	PAR-CLIP	23592263
MIRT453563	hsa-miR-298	PAR-CLIP	23592263
MIRT453562	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT453561	hsa-miR-3612	PAR-CLIP	23592263
MIRT453560	hsa-miR-650	PAR-CLIP	23592263
MIRT453559	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT453558	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT453567	hsa-miR-1247-3p	PAR-CLIP	26701625
MIRT453567	hsa-miR-1247-3p	PAR-CLIP	26701625
MIRT453567	hsa-miR-1247-3p	PAR-CLIP	26701625
MIRT453564	hsa-miR-1827	PAR-CLIP	26701625
MIRT453564	hsa-miR-1827	PAR-CLIP	26701625
MIRT453564	hsa-miR-1827	PAR-CLIP	26701625
MIRT453569	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT453569	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT453569	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT453563	hsa-miR-298	PAR-CLIP	26701625
MIRT453563	hsa-miR-298	PAR-CLIP	26701625
MIRT453563	hsa-miR-298	PAR-CLIP	26701625
MIRT453561	hsa-miR-3612	PAR-CLIP	26701625
MIRT453561	hsa-miR-3612	PAR-CLIP	26701625
MIRT453561	hsa-miR-3612	PAR-CLIP	26701625
MIRT453565	hsa-miR-4537	PAR-CLIP	26701625
MIRT453565	hsa-miR-4537	PAR-CLIP	26701625
MIRT453559	hsa-miR-455-3p	PAR-CLIP	26701625
MIRT453559	hsa-miR-455-3p	PAR-CLIP	26701625
MIRT453559	hsa-miR-455-3p	PAR-CLIP	26701625
MIRT453570	hsa-miR-495-5p	PAR-CLIP	26701625
MIRT453570	hsa-miR-495-5p	PAR-CLIP	26701625
MIRT453566	hsa-miR-5186	PAR-CLIP	26701625
MIRT453562	hsa-miR-6499-3p	PAR-CLIP	26701625
MIRT453562	hsa-miR-6499-3p	PAR-CLIP	26701625
MIRT453562	hsa-miR-6499-3p	PAR-CLIP	26701625
MIRT453560	hsa-miR-650	PAR-CLIP	26701625
MIRT453560	hsa-miR-650	PAR-CLIP	26701625
MIRT453560	hsa-miR-650	PAR-CLIP	26701625
MIRT453568	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT453568	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT453568	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT453558	hsa-miR-6516-5p	PAR-CLIP	26701625
MIRT453558	hsa-miR-6516-5p	PAR-CLIP	26701625
MIRT453558	hsa-miR-6516-5p	PAR-CLIP	26701625
MIRT453567	hsa-miR-1247-3p	PAR-CLIP	27292025
MIRT453567	hsa-miR-1247-3p	PAR-CLIP	27292025
MIRT453567	hsa-miR-1247-3p	PAR-CLIP	27292025
MIRT453564	hsa-miR-1827	PAR-CLIP	27292025
MIRT453564	hsa-miR-1827	PAR-CLIP	27292025
MIRT453564	hsa-miR-1827	PAR-CLIP	27292025
MIRT453569	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT453569	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT453563	hsa-miR-298	PAR-CLIP	27292025
MIRT453563	hsa-miR-298	PAR-CLIP	27292025
MIRT453563	hsa-miR-298	PAR-CLIP	27292025
MIRT453561	hsa-miR-3612	PAR-CLIP	27292025
MIRT453561	hsa-miR-3612	PAR-CLIP	27292025
MIRT453561	hsa-miR-3612	PAR-CLIP	27292025
MIRT453565	hsa-miR-4537	PAR-CLIP	27292025
MIRT453565	hsa-miR-4537	PAR-CLIP	27292025
MIRT453565	hsa-miR-4537	PAR-CLIP	27292025
MIRT453559	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT453559	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT453559	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT453570	hsa-miR-495-5p	PAR-CLIP	27292025
MIRT453570	hsa-miR-495-5p	PAR-CLIP	27292025
MIRT453570	hsa-miR-495-5p	PAR-CLIP	27292025
MIRT453566	hsa-miR-5186	PAR-CLIP	27292025
MIRT453566	hsa-miR-5186	PAR-CLIP	27292025
MIRT453562	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT453562	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT453562	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT453560	hsa-miR-650	PAR-CLIP	27292025
MIRT453560	hsa-miR-650	PAR-CLIP	27292025
MIRT453560	hsa-miR-650	PAR-CLIP	27292025
MIRT453568	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT453568	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT453558	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT453558	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT453558	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT709169	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT676584	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT709168	hsa-miR-1976	HITS-CLIP	19536157
MIRT709167	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT709166	hsa-miR-7977	HITS-CLIP	19536157
MIRT709165	hsa-miR-4279	HITS-CLIP	19536157
MIRT691051	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT691050	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT691049	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT691048	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT691047	hsa-miR-3143	HITS-CLIP	23313552
MIRT691046	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT691045	hsa-miR-302c-5p	HITS-CLIP	23313552
MIRT679789	hsa-miR-4438	HITS-CLIP	23824327
MIRT679788	hsa-miR-6872-3p	HITS-CLIP	23824327
MIRT679787	hsa-miR-6789-3p	HITS-CLIP	23824327
MIRT676581	hsa-miR-3199	HITS-CLIP	23824327
MIRT676580	hsa-miR-8052	HITS-CLIP	23824327
MIRT676579	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT676578	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT679785	hsa-miR-5095	HITS-CLIP	23824327
MIRT679786	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT676589	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT676588	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT676587	hsa-miR-4324	HITS-CLIP	23824327
MIRT676586	hsa-miR-544b	HITS-CLIP	23824327
MIRT676585	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT676584	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676583	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT676582	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT676581	hsa-miR-3199	HITS-CLIP	23824327
MIRT676580	hsa-miR-8052	HITS-CLIP	23824327
MIRT676579	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT676578	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT676577	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT676576	hsa-miR-1200	HITS-CLIP	23824327
MIRT676575	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT676574	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT643833	hsa-miR-3182	HITS-CLIP	23824327
MIRT643832	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT643831	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT643830	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT643829	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT643828	hsa-miR-5585-3p	HITS-CLIP	23824327
MIRT643833	hsa-miR-3182	HITS-CLIP	23824327
MIRT643832	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT643831	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT643830	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT643829	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT643828	hsa-miR-5585-3p	HITS-CLIP	23824327
MIRT527055	hsa-miR-3691-3p	PAR-CLIP	22012620
MIRT527054	hsa-miR-1292-3p	PAR-CLIP	22012620
MIRT527053	hsa-miR-4539	PAR-CLIP	22012620
MIRT527051	hsa-miR-4480	PAR-CLIP	22012620
MIRT527052	hsa-miR-450b-5p	PAR-CLIP	22012620
MIRT527050	hsa-miR-507	PAR-CLIP	22012620
MIRT527049	hsa-miR-557	PAR-CLIP	22012620
MIRT527048	hsa-miR-3680-3p	PAR-CLIP	22012620
MIRT453570	hsa-miR-495-5p	PAR-CLIP	23592263
MIRT453569	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT453568	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT453567	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT453566	hsa-miR-5186	PAR-CLIP	23592263
MIRT453565	hsa-miR-4537	PAR-CLIP	23592263
MIRT453564	hsa-miR-1827	PAR-CLIP	23592263
MIRT453563	hsa-miR-298	PAR-CLIP	23592263
MIRT453562	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT453561	hsa-miR-3612	PAR-CLIP	23592263
MIRT453560	hsa-miR-650	PAR-CLIP	23592263
MIRT453559	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT453558	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT1299072	hsa-miR-1245b-3p	CLIP-seq
MIRT1299073	hsa-miR-2278	CLIP-seq
MIRT1299074	hsa-miR-2681	CLIP-seq
MIRT1299075	hsa-miR-331-3p	CLIP-seq
MIRT1299076	hsa-miR-370	CLIP-seq
MIRT1299077	hsa-miR-4468	CLIP-seq
MIRT1299078	hsa-miR-4711-5p	CLIP-seq
MIRT1299079	hsa-miR-4749-3p	CLIP-seq
MIRT1299080	hsa-miR-885-3p	CLIP-seq
MIRT1299081	hsa-miR-922	CLIP-seq
MIRT2088942	hsa-miR-3646	CLIP-seq
MIRT2313870	hsa-miR-140-3p	CLIP-seq
MIRT1299074	hsa-miR-2681	CLIP-seq
MIRT2313871	hsa-miR-3130-3p	CLIP-seq
MIRT2313872	hsa-miR-326	CLIP-seq
MIRT2313873	hsa-miR-330-5p	CLIP-seq
MIRT2313874	hsa-miR-3909	CLIP-seq
MIRT2313875	hsa-miR-425	CLIP-seq
MIRT2313876	hsa-miR-4730	CLIP-seq
MIRT2393601	hsa-miR-4687-5p	CLIP-seq
MIRT2393602	hsa-miR-545	CLIP-seq
MIRT2393603	hsa-miR-671-5p	CLIP-seq
MIRT2689621	hsa-miR-149	CLIP-seq
MIRT2689622	hsa-miR-3064-5p	CLIP-seq
MIRT2689623	hsa-miR-3128	CLIP-seq
MIRT2313871	hsa-miR-3130-3p	CLIP-seq
MIRT2313872	hsa-miR-326	CLIP-seq
MIRT2313873	hsa-miR-330-5p	CLIP-seq
MIRT2689624	hsa-miR-3652	CLIP-seq
MIRT2689625	hsa-miR-378g	CLIP-seq
MIRT2689626	hsa-miR-4430	CLIP-seq
MIRT2689627	hsa-miR-4437	CLIP-seq
MIRT2689628	hsa-miR-4505	CLIP-seq
MIRT2689629	hsa-miR-4674	CLIP-seq
MIRT2393601	hsa-miR-4687-5p	CLIP-seq
MIRT2689630	hsa-miR-4707-5p	CLIP-seq
MIRT2689631	hsa-miR-4720-5p	CLIP-seq
MIRT2689632	hsa-miR-4794	CLIP-seq
MIRT2689633	hsa-miR-4799-3p	CLIP-seq
MIRT2393602	hsa-miR-545	CLIP-seq
MIRT2393603	hsa-miR-671-5p	CLIP-seq
MIRT2689634	hsa-miR-760	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IBA
GO:0005743	Component	Mitochondrial inner membrane	IDA	18039331
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0009644	Process	Response to high light intensity	IEA
GO:0010842	Process	Retina layer formation	IEA
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0042462	Process	Eye photoreceptor cell development	IEA
GO:0042572	Process	Retinol metabolic process	IEA
GO:0042574	Process	Retinal metabolic process	IBA
GO:0042574	Process	Retinal metabolic process	IDA	18039331
GO:0052650	Function	All-trans-retinol dehydrogenase (NADP+) activity	IBA
GO:0052650	Function	All-trans-retinol dehydrogenase (NADP+) activity	IDA	18039331
GO:0052650	Function	All-trans-retinol dehydrogenase (NADP+) activity	IEA
GO:0052650	Function	All-trans-retinol dehydrogenase (NADP+) activity	TAS

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q8NBN7

Protein name

Retinol dehydrogenase 13 (EC 1.1.1.300) (Short chain dehydrogenase/reductase family 7C member 3)

Protein function

Retinol dehydrogenase with a clear preference for NADP. Oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiency (PubMed:18039331). Has no activity toward steroids (PubMed:18039331). {ECO:0000269|PubMed:18039

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00106	adh_short	39 → 242	short chain dehydrogenase	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed (PubMed:18039331). In the retina, detected in the inner segment of the photoreceptor cells. Weak signals are observed in a small population of inner nuclear neurons and the inner plexiform layer (PubMed:12226107). {ECO

Sequence

MSRYLLPLSALGTVAGAAVLLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELAR
RGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDI
LINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAG
HIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRH
TGIHGSTFSSTTLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEA
EDEEVARRLWAESARLVGLEAPSVREQPLPR

Sequence length

331

Interactions

View interactions

	KEGG		Reactome
	Retinol metabolism Metabolic pathways Biosynthesis of cofactors		RA biosynthesis pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AORTIC DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NECROSIS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

RDH13 (retinol dehydrogenase 13)