PTGDR2 (prostaglandin D2 receptor 2)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 11251
Gene name Prostaglandin D2 receptor 2
Gene symbol PTGDR2
Synonyms (NCBI Gene)
CD294CRTH2DL1RDP2GPR44
Chromosome 11
Chromosome location 11q12.2
Summary This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocyt
miRNA miRNA information provided by mirtarbase database.
60
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (60)
miRTarBase ID miRNA Experiments Reference
MIRT647268 hsa-miR-302c-3p HITS-CLIP 23824327
MIRT647267 hsa-miR-520f-3p HITS-CLIP 23824327
MIRT647266 hsa-miR-6715a-3p HITS-CLIP 23824327
MIRT647265 hsa-miR-3183 HITS-CLIP 23824327
MIRT647264 hsa-miR-4723-3p HITS-CLIP 23824327
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (1)
Transcription factor Regulation Reference
TBX21 Repression 14500650
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (30)
GO ID Ontology Definition Evidence Reference
GO:0001785 Function Prostaglandin J receptor activity IEA
GO:0004930 Function G protein-coupled receptor activity IDA 11208866
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004930 Function G protein-coupled receptor activity TAS 9973380
GO:0004953 Function Icosanoid receptor activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604837 4502 ENSG00000183134
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y5Y4
Protein name Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294)
Protein function Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2
PDB 6D26 , 6D27 , 7M8W , 8XXU , 8XXV , 9IYB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 49 → 304 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- an
Sequence
Sequence length 395
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Prostanoid ligand receptors
G alpha (i) signalling events
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (2)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTHMA — CTD, Disgenet
CTD, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTHMA, ASPIRIN-INDUCED — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (67)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 28928446
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma of large intestine Colorectal adenoma BEFREE 15172124
★★★★★
★☆☆☆☆
Found in Text Mining only
Allergic rhinitis (disorder) Allergic rhinitis BEFREE 28222358, 28612233, 31267527
★★★★★
★☆☆☆☆
Found in Text Mining only
Allergic sensitization Allergic Sensitization BEFREE 19392992
★★★★★
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 15345705, 15986064, 17016057, 18757520, 18777142, 18946232, 19392992, 19796209, 22442685, 23506843, 25312757, 27103662, 28099820, 28234053, 28609567
View all (12 more)
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Asthma Asthma LHGDN 15345705
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Asthma Asthma Pubtator 19010788, 23506843, 25312757, 37231900 Associate
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Asthma Asthma CTD_human_DG 27103662
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Asthma, Aspirin-Induced Asthma CTD_human_DG 20485159
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Ataxia Telangiectasia Ataxia Telangiectasia BEFREE 19796209
★★★★★
★☆☆☆☆
Found in Text Mining only