NXPH2 (neurexophilin 2)

Gene

• Entrez ID: 11249
• Gene name: Neurexophilin 2
• Gene symbol: NXPH2
• Synonyms (NCBI Gene): NPH2
• Chromosome: 2
• Chromosome location: 2q22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023595	hsa-miR-1-3p	Microarray	18668037
MIRT051108	hsa-miR-16-5p	CLASH	23622248
MIRT1200587	hsa-miR-1236	CLIP-seq
MIRT1200588	hsa-miR-3117-3p	CLIP-seq
MIRT1200589	hsa-miR-3123	CLIP-seq
MIRT1200590	hsa-miR-3169	CLIP-seq
MIRT1200591	hsa-miR-361-5p	CLIP-seq
MIRT1200592	hsa-miR-3646	CLIP-seq
MIRT1200593	hsa-miR-3692	CLIP-seq
MIRT1200594	hsa-miR-3925-5p	CLIP-seq
MIRT1200595	hsa-miR-3976	CLIP-seq
MIRT1200596	hsa-miR-4310	CLIP-seq
MIRT1200597	hsa-miR-433	CLIP-seq
MIRT1200598	hsa-miR-4452	CLIP-seq
MIRT1200599	hsa-miR-4511	CLIP-seq
MIRT1200600	hsa-miR-451b	CLIP-seq
MIRT1200601	hsa-miR-4662a-3p	CLIP-seq
MIRT1200602	hsa-miR-4699-5p	CLIP-seq
MIRT1200603	hsa-miR-4753-3p	CLIP-seq
MIRT1200604	hsa-miR-4759	CLIP-seq
MIRT1200605	hsa-miR-486-5p	CLIP-seq
MIRT1200606	hsa-miR-498	CLIP-seq
MIRT1200607	hsa-miR-548ac	CLIP-seq
MIRT1200608	hsa-miR-548ae	CLIP-seq
MIRT1200609	hsa-miR-548aj	CLIP-seq
MIRT1200610	hsa-miR-548am	CLIP-seq
MIRT1200611	hsa-miR-548d-3p	CLIP-seq
MIRT1200612	hsa-miR-548x	CLIP-seq
MIRT1200613	hsa-miR-548z	CLIP-seq
MIRT1200614	hsa-miR-578	CLIP-seq
MIRT1200615	hsa-miR-651	CLIP-seq
MIRT1200616	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005576	Component	Extracellular region	IEA
GO:0007218	Process	Neuropeptide signaling pathway	NAS	9570794

Other IDs

• MIM: 604635
• HGNC: 8076
• e!Ensembl: ENSG00000144227

Protein

• UniProt ID: O95156
• Protein name: Neurexophilin-2
• Protein function: May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06312	Neurexophilin	52 → 264	Neurexophilin	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain and kidney.
• Sequence:

  MRLRPLPLVVVPGLLQLLFCDSKEVVHATEGLDWEDKDAPGTLVGNVVHSRIISPLRLFV
  KQSPVPKPGPMAYADSMENFWDWLANITEIQEPLARTKRRPIVKTGKFKKMFGWGDFHSN
  IKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGLGNVSVSLVPPSKVVEFEVSPQSTLETK
  ESKSFNCRIEYEKTDRAKKTALCNFDPSKICYQEQTQSHVSWLCSKPFKVICIYIAFYSV
  DYKLVQKVCPDYNYHSETPYLSSG

• Sequence length: 264

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
OVARIAN CYSTS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	19304784		★☆☆☆☆ Found in Text Mining only
Corpus Luteum Cyst	Corpus Luteum Cyst	CTD_human_DG	21239663		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	19304784		★☆☆☆☆ Found in Text Mining only
NEPHRONOPHTHISIS 2	Nephronophthisis	GENOMICS_ENGLAND_DG			★☆☆☆☆ Found in Text Mining only
Ovarian Cysts	Ovarian Cysts	CTD_human_DG	21239663		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ovarian neoplasm	Ovarian neoplasm	BEFREE	19304784		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	19304784	Associate	★☆☆☆☆ Found in Text Mining only