Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	11245
Gene name	G protein-coupled receptor 176
Gene symbol	GPR176
Synonyms (NCBI Gene)	HB-954
Chromosome	15
Chromosome location	15q14-q15.1
Summary	Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995 [PubMed 7893747]).[supplied by OMIM, Jul 2008]

Show/Hide all (48)

miRTarBase ID	miRNA	Experiments	Reference
MIRT537076	hsa-miR-382-5p	PAR-CLIP	22012620
MIRT537075	hsa-miR-548n	PAR-CLIP	22012620
MIRT537074	hsa-miR-548az-5p	PAR-CLIP	22012620
MIRT537073	hsa-miR-548t-5p	PAR-CLIP	22012620
MIRT537072	hsa-miR-580-5p	PAR-CLIP	22012620
MIRT537071	hsa-miR-3938	PAR-CLIP	22012620
MIRT537070	hsa-miR-3127-3p	PAR-CLIP	22012620
MIRT537069	hsa-miR-6756-3p	PAR-CLIP	22012620
MIRT537068	hsa-miR-4780	PAR-CLIP	22012620
MIRT537067	hsa-miR-508-3p	PAR-CLIP	22012620
MIRT537066	hsa-miR-219a-5p	PAR-CLIP	22012620
MIRT537065	hsa-miR-4782-3p	PAR-CLIP	22012620
MIRT537064	hsa-miR-6766-3p	PAR-CLIP	22012620
MIRT537063	hsa-miR-4445-5p	PAR-CLIP	22012620
MIRT537062	hsa-miR-6826-3p	PAR-CLIP	22012620
MIRT537061	hsa-miR-3161	PAR-CLIP	22012620
MIRT537060	hsa-miR-2054	PAR-CLIP	22012620
MIRT537059	hsa-miR-599	PAR-CLIP	22012620
MIRT537076	hsa-miR-382-5p	PAR-CLIP	22012620
MIRT537075	hsa-miR-548n	PAR-CLIP	22012620
MIRT537074	hsa-miR-548az-5p	PAR-CLIP	22012620
MIRT537073	hsa-miR-548t-5p	PAR-CLIP	22012620
MIRT537072	hsa-miR-580-5p	PAR-CLIP	22012620
MIRT537071	hsa-miR-3938	PAR-CLIP	22012620
MIRT537070	hsa-miR-3127-3p	PAR-CLIP	22012620
MIRT537069	hsa-miR-6756-3p	PAR-CLIP	22012620
MIRT537068	hsa-miR-4780	PAR-CLIP	22012620
MIRT537067	hsa-miR-508-3p	PAR-CLIP	22012620
MIRT537066	hsa-miR-219a-5p	PAR-CLIP	22012620
MIRT537065	hsa-miR-4782-3p	PAR-CLIP	22012620
MIRT537064	hsa-miR-6766-3p	PAR-CLIP	22012620
MIRT537063	hsa-miR-4445-5p	PAR-CLIP	22012620
MIRT537062	hsa-miR-6826-3p	PAR-CLIP	22012620
MIRT537061	hsa-miR-3161	PAR-CLIP	22012620
MIRT537060	hsa-miR-2054	PAR-CLIP	22012620
MIRT537059	hsa-miR-599	PAR-CLIP	22012620
MIRT1030966	hsa-miR-3123	CLIP-seq
MIRT1030967	hsa-miR-3655	CLIP-seq
MIRT1030968	hsa-miR-3919	CLIP-seq
MIRT1030969	hsa-miR-4286	CLIP-seq
MIRT1030970	hsa-miR-4491	CLIP-seq
MIRT1030971	hsa-miR-4646-3p	CLIP-seq
MIRT1030972	hsa-miR-4657	CLIP-seq
MIRT2465390	hsa-miR-1197	CLIP-seq
MIRT2465391	hsa-miR-1276	CLIP-seq
MIRT2465392	hsa-miR-4311	CLIP-seq
MIRT2465393	hsa-miR-4469	CLIP-seq
MIRT2465394	hsa-miR-583	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	ISS
GO:0004930	Function	G protein-coupled receptor activity	TAS	7893747
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS	7893747
GO:0007154	Process	Cell communication	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	ISS
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	7893747
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA
GO:0007268	Process	Chemical synaptic transmission	TAS	7893747
GO:0016020	Component	Membrane	IEA
GO:0023052	Process	Signaling	IEA
GO:0045202	Component	Synapse	IEA
GO:0048511	Process	Rhythmic process	IEA
GO:0048512	Process	Circadian behavior	IEA
GO:0048512	Process	Circadian behavior	ISS

MIM	HGNC	e!Ensembl
612183	32370	ENSG00000166073

Q14439

Protein name

G-protein coupled receptor 176 (HB-954)

Protein function

Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	58 → 320	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MGHNGSWISPNASEPHNASGAEAAGVNRSALGEFGEAQLYRQFTTTVQVVIFIGSLLGNF
MVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHCCWWIYTMLFCKVV
KFLHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAV
TNVADIYATSTCTEVWSNSLGHLVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKV
IIAALRTPQNTISIPYASQREAELHATLLSMVMVFILCSVPYATLVVYQTVLNVPDTSVF
LLLTAVWLPKVSLLANPVLFLTVNKSVRKCLIGTLVQLHHRYSRRNVVSTGSGMAEASLE
PSIRSGSQLLEMFHIGQQQIFKPTEDEEESEAKYIGSADFQAKEIFSTCLEGEQGPQFAP
SAPPLSTVDSVSQVAPAAPVEPETFPDKYSLQFGFGPFELPPQWLSETRNSKKRLLPPLG
NTPEELIQTKVPKVGRVERKMSRNNKVSIFPKVDS

Sequence length

515

Interactions

View interactions

	Reactome
			G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DIVERTICULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinogenesis	Carcinogenesis	Pubtator	37584712	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	37124060	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	37291181	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GPR176 (G protein-coupled receptor 176)