Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	11230
Gene name	PRA1 domain family member 2
Gene symbol	PRAF2
Synonyms (NCBI Gene)	JM4Yip6a
Chromosome	X
Chromosome location	Xp11.23

138

Show/Hide all (138)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001516	hsa-miR-155-5p	pSILAC	18668040
MIRT052307	hsa-let-7b-5p	CLASH	23622248
MIRT051851	hsa-let-7c-5p	CLASH	23622248
MIRT1259535	hsa-miR-103a	CLIP-seq
MIRT1259536	hsa-miR-107	CLIP-seq
MIRT1259537	hsa-miR-1299	CLIP-seq
MIRT1259538	hsa-miR-1301	CLIP-seq
MIRT1259539	hsa-miR-192	CLIP-seq
MIRT1259540	hsa-miR-215	CLIP-seq
MIRT1259541	hsa-miR-3148	CLIP-seq
MIRT1259542	hsa-miR-3202	CLIP-seq
MIRT1259543	hsa-miR-3661	CLIP-seq
MIRT1259544	hsa-miR-3940-5p	CLIP-seq
MIRT1259545	hsa-miR-4438	CLIP-seq
MIRT1259546	hsa-miR-4507	CLIP-seq
MIRT1259547	hsa-miR-4533	CLIP-seq
MIRT1259548	hsa-miR-4684-3p	CLIP-seq
MIRT1259549	hsa-miR-4708-5p	CLIP-seq
MIRT1259550	hsa-miR-4712-3p	CLIP-seq
MIRT1259551	hsa-miR-5047	CLIP-seq
MIRT1259552	hsa-miR-615-5p	CLIP-seq
MIRT1259553	hsa-miR-631	CLIP-seq
MIRT1259554	hsa-miR-875-3p	CLIP-seq
MIRT1556838	hsa-miR-1193	CLIP-seq
MIRT1556839	hsa-miR-122	CLIP-seq
MIRT1556840	hsa-miR-3165	CLIP-seq
MIRT1556841	hsa-miR-326	CLIP-seq
MIRT1556842	hsa-miR-330-5p	CLIP-seq
MIRT1556843	hsa-miR-3691-5p	CLIP-seq
MIRT1556844	hsa-miR-593	CLIP-seq
MIRT2076476	hsa-miR-133a	CLIP-seq
MIRT2076477	hsa-miR-133b	CLIP-seq
MIRT2076478	hsa-miR-302a	CLIP-seq
MIRT2076479	hsa-miR-302b	CLIP-seq
MIRT2076480	hsa-miR-302c	CLIP-seq
MIRT2076481	hsa-miR-302d	CLIP-seq
MIRT2076482	hsa-miR-302e	CLIP-seq
MIRT2076483	hsa-miR-3153	CLIP-seq
MIRT2076484	hsa-miR-372	CLIP-seq
MIRT2076485	hsa-miR-373	CLIP-seq
MIRT2076486	hsa-miR-4312	CLIP-seq
MIRT2076487	hsa-miR-4506	CLIP-seq
MIRT2076488	hsa-miR-4646-5p	CLIP-seq
MIRT2076489	hsa-miR-4668-5p	CLIP-seq
MIRT2076490	hsa-miR-4685-5p	CLIP-seq
MIRT2076491	hsa-miR-4693-3p	CLIP-seq
MIRT2076492	hsa-miR-4731-5p	CLIP-seq
MIRT2076493	hsa-miR-512-3p	CLIP-seq
MIRT2076494	hsa-miR-515-3p	CLIP-seq
MIRT2076495	hsa-miR-519a	CLIP-seq
MIRT2076496	hsa-miR-519b-3p	CLIP-seq
MIRT2076497	hsa-miR-519c-3p	CLIP-seq
MIRT2076498	hsa-miR-519e	CLIP-seq
MIRT2076499	hsa-miR-520a-3p	CLIP-seq
MIRT2076500	hsa-miR-520b	CLIP-seq
MIRT2076501	hsa-miR-520c-3p	CLIP-seq
MIRT2076502	hsa-miR-520d-3p	CLIP-seq
MIRT2076503	hsa-miR-520e	CLIP-seq
MIRT2076504	hsa-miR-9	CLIP-seq
MIRT2303122	hsa-miR-3170	CLIP-seq
MIRT2303123	hsa-miR-3184	CLIP-seq
MIRT1556841	hsa-miR-326	CLIP-seq
MIRT1556842	hsa-miR-330-5p	CLIP-seq
MIRT2303124	hsa-miR-342-5p	CLIP-seq
MIRT2303125	hsa-miR-423-5p	CLIP-seq
MIRT2076487	hsa-miR-4506	CLIP-seq
MIRT2303126	hsa-miR-4651	CLIP-seq
MIRT2303127	hsa-miR-4664-5p	CLIP-seq
MIRT2303128	hsa-miR-4688	CLIP-seq
MIRT2303129	hsa-miR-4698	CLIP-seq
MIRT2303130	hsa-miR-4710	CLIP-seq
MIRT2303131	hsa-miR-608	CLIP-seq
MIRT1259552	hsa-miR-615-5p	CLIP-seq
MIRT1259542	hsa-miR-3202	CLIP-seq
MIRT1259547	hsa-miR-4533	CLIP-seq
MIRT2599800	hsa-miR-1224-3p	CLIP-seq
MIRT2599801	hsa-miR-1321	CLIP-seq
MIRT2599802	hsa-miR-3135b	CLIP-seq
MIRT2303122	hsa-miR-3170	CLIP-seq
MIRT2303123	hsa-miR-3184	CLIP-seq
MIRT2599803	hsa-miR-3189-5p	CLIP-seq
MIRT2599804	hsa-miR-3190	CLIP-seq
MIRT2599805	hsa-miR-3199	CLIP-seq
MIRT2599806	hsa-miR-323b-5p	CLIP-seq
MIRT2303124	hsa-miR-342-5p	CLIP-seq
MIRT2599807	hsa-miR-3612	CLIP-seq
MIRT2599808	hsa-miR-3622a-3p	CLIP-seq
MIRT2599809	hsa-miR-3622b-3p	CLIP-seq
MIRT2599810	hsa-miR-3650	CLIP-seq
MIRT2599811	hsa-miR-370	CLIP-seq
MIRT2599812	hsa-miR-3911	CLIP-seq
MIRT2599813	hsa-miR-3938	CLIP-seq
MIRT2303125	hsa-miR-423-5p	CLIP-seq
MIRT2599814	hsa-miR-4286	CLIP-seq
MIRT2599815	hsa-miR-4299	CLIP-seq
MIRT2599816	hsa-miR-4419a	CLIP-seq
MIRT2599817	hsa-miR-4487	CLIP-seq
MIRT2599818	hsa-miR-4510	CLIP-seq
MIRT2599819	hsa-miR-4515	CLIP-seq
MIRT2599820	hsa-miR-4649-3p	CLIP-seq
MIRT2303126	hsa-miR-4651	CLIP-seq
MIRT2599821	hsa-miR-4663	CLIP-seq
MIRT2303127	hsa-miR-4664-5p	CLIP-seq
MIRT2303128	hsa-miR-4688	CLIP-seq
MIRT2303129	hsa-miR-4698	CLIP-seq
MIRT2303130	hsa-miR-4710	CLIP-seq
MIRT2599822	hsa-miR-4739	CLIP-seq
MIRT2599823	hsa-miR-4756-5p	CLIP-seq
MIRT2599824	hsa-miR-4792	CLIP-seq
MIRT2599825	hsa-miR-4803	CLIP-seq
MIRT2303131	hsa-miR-608	CLIP-seq
MIRT2599826	hsa-miR-650	CLIP-seq
MIRT2599827	hsa-miR-670	CLIP-seq
MIRT2599800	hsa-miR-1224-3p	CLIP-seq
MIRT2599802	hsa-miR-3135b	CLIP-seq
MIRT2303122	hsa-miR-3170	CLIP-seq
MIRT2303123	hsa-miR-3184	CLIP-seq
MIRT2599803	hsa-miR-3189-5p	CLIP-seq
MIRT2599804	hsa-miR-3190	CLIP-seq
MIRT2599806	hsa-miR-323b-5p	CLIP-seq
MIRT2303124	hsa-miR-342-5p	CLIP-seq
MIRT2599810	hsa-miR-3650	CLIP-seq
MIRT2599811	hsa-miR-370	CLIP-seq
MIRT2599812	hsa-miR-3911	CLIP-seq
MIRT2599813	hsa-miR-3938	CLIP-seq
MIRT2303125	hsa-miR-423-5p	CLIP-seq
MIRT2599814	hsa-miR-4286	CLIP-seq
MIRT2599817	hsa-miR-4487	CLIP-seq
MIRT2599820	hsa-miR-4649-3p	CLIP-seq
MIRT2303126	hsa-miR-4651	CLIP-seq
MIRT2599821	hsa-miR-4663	CLIP-seq
MIRT2303127	hsa-miR-4664-5p	CLIP-seq
MIRT2303128	hsa-miR-4688	CLIP-seq
MIRT2303129	hsa-miR-4698	CLIP-seq
MIRT2303130	hsa-miR-4710	CLIP-seq
MIRT2599825	hsa-miR-4803	CLIP-seq
MIRT2303131	hsa-miR-608	CLIP-seq
MIRT2599827	hsa-miR-670	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 35156780
GO:0005768	Component	Endosome	IEA
GO:0010008	Component	Endosome membrane	IEA
GO:0015031	Process	Protein transport	IEA
GO:0015813	Process	L-glutamate transmembrane transport	ISS
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0098793	Component	Presynapse	IEA
GO:0098794	Component	Postsynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098982	Component	GABA-ergic synapse	IEA

MIM	HGNC	e!Ensembl
300840	28911	ENSG00000243279

O60831

Protein name

PRA1 family protein 2

Protein function

May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03208	PRA1	4 → 151	PRA1 family protein	Family

Tissue specificity

TISSUE SPECIFICITY: Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in tumor tissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same patient. High expression in neuroblast

Sequence

MSEVRLPPLRALDDFVLGSARLAAPDPCDPQRWCHRVINNLLYYQTNYLLCFGIGLALAG
YVRPLHTLLSALVVAVALGVLVWAAETRAAVRRCRRSHPAACLAAVLAVGLLVLWVAGGA
CTFLFSIAGPVLLILVHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQEAGS

Sequence length

178

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Cystic Fibrosis	Cystic fibrosis	Pubtator	36167862	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	31200670	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	20412121	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Idiopathic pulmonary fibrosis	Pubtator	38203769	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30100755		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Glioma	Glioma	BEFREE	20412121		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	20412121		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23440329, 30100755		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	20412121, 23440329		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	20412121	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	31200670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of skin	Skin carcinoma	BEFREE	31649487		★★★★★ ★☆☆☆☆ Found in Text Mining only

PRAF2 (PRA1 domain family member 2)