Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	11224
Gene name	Ribosomal protein L35
Gene symbol	RPL35
Synonyms (NCBI Gene)	DBA19L35uL29
Chromosome	9
Chromosome location	9q33.3
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

Show/Hide all (41)

miRTarBase ID	miRNA	Experiments	Reference
MIRT037236	hsa-miR-877-5p	CLASH	23622248
MIRT036416	hsa-miR-1226-3p	CLASH	23622248
MIRT035932	hsa-miR-1180-3p	CLASH	23622248
MIRT687016	hsa-miR-6856-3p	HITS-CLIP	23313552
MIRT687015	hsa-miR-4274	HITS-CLIP	23313552
MIRT687014	hsa-miR-6858-3p	HITS-CLIP	23313552
MIRT687013	hsa-miR-1245b-5p	HITS-CLIP	23313552
MIRT687012	hsa-miR-3142	HITS-CLIP	23313552
MIRT687011	hsa-miR-4787-3p	HITS-CLIP	23313552
MIRT687010	hsa-miR-4691-3p	HITS-CLIP	23313552
MIRT687009	hsa-miR-1972	HITS-CLIP	23313552
MIRT687008	hsa-miR-4650-5p	HITS-CLIP	23313552
MIRT687007	hsa-miR-6787-3p	HITS-CLIP	23313552
MIRT687006	hsa-miR-5008-3p	HITS-CLIP	23313552
MIRT687005	hsa-miR-6737-3p	HITS-CLIP	23313552
MIRT687004	hsa-miR-7157-3p	HITS-CLIP	23313552
MIRT687003	hsa-miR-4749-3p	HITS-CLIP	23313552
MIRT687002	hsa-miR-6743-3p	HITS-CLIP	23313552
MIRT687001	hsa-miR-3157-5p	HITS-CLIP	23313552
MIRT687000	hsa-miR-218-5p	HITS-CLIP	23313552
MIRT687016	hsa-miR-6856-3p	HITS-CLIP	23313552
MIRT687015	hsa-miR-4274	HITS-CLIP	23313552
MIRT687014	hsa-miR-6858-3p	HITS-CLIP	23313552
MIRT687013	hsa-miR-1245b-5p	HITS-CLIP	23313552
MIRT687012	hsa-miR-3142	HITS-CLIP	23313552
MIRT687011	hsa-miR-4787-3p	HITS-CLIP	23313552
MIRT687010	hsa-miR-4691-3p	HITS-CLIP	23313552
MIRT687009	hsa-miR-1972	HITS-CLIP	23313552
MIRT687008	hsa-miR-4650-5p	HITS-CLIP	23313552
MIRT687007	hsa-miR-6787-3p	HITS-CLIP	23313552
MIRT687006	hsa-miR-5008-3p	HITS-CLIP	23313552
MIRT687005	hsa-miR-6737-3p	HITS-CLIP	23313552
MIRT687004	hsa-miR-7157-3p	HITS-CLIP	23313552
MIRT687003	hsa-miR-4749-3p	HITS-CLIP	23313552
MIRT687002	hsa-miR-6743-3p	HITS-CLIP	23313552
MIRT687001	hsa-miR-3157-5p	HITS-CLIP	23313552
MIRT687000	hsa-miR-218-5p	HITS-CLIP	23313552
MIRT1316752	hsa-miR-218	CLIP-seq
MIRT1316753	hsa-miR-636	CLIP-seq
MIRT1316752	hsa-miR-218	CLIP-seq
MIRT1316753	hsa-miR-636	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003729	Function	MRNA binding	IBA
GO:0003729	Function	MRNA binding	TAS
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS
GO:0005730	Component	Nucleolus	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS
GO:0015934	Component	Large ribosomal subunit	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
618315	10344	ENSG00000136942

P42766

Protein name

Large ribosomal subunit protein uL29 (60S ribosomal protein L35)

Protein function

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6SXO , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00831	Ribosomal_L29	7 → 63	Ribosomal L29 protein	Family

Sequence

MAKIKARDLRGKKKEELLKQLDDLKVELSQLRVAKVTGGAASKLSKIRVVRKSIARVLTV
INQTQKENLRKFYKGKKYKPLDLRPKKTRAMRRRLNKHEENLKTKKQQRKERLYPLRKYA
VKA

Sequence length

123

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Diamond-Blackfan anemia 19	Pathogenic	rs1564307664	RCV000754834	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANEMIA, DIAMOND-BLACKFAN	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIAMOND-BLACKFAN ANEMIA	—	GWAS catalog, Orphanet GWAS catalog, Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RPL35-related disorder	Benign; Likely benign; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Aase Smith syndrome 2	Aase-Smith syndrome	ORPHANET_DG	28280134		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute leukemia	Leukemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	BEFREE	25107436		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	38176923	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia, Diamond-Blackfan	Anemia	ORPHANET_DG	28280134		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia, Diamond-Blackfan	Anemia	GENOMICS_ENGLAND_DG	28280134		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia, Macrocytic	Anemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Blackfan-Diamond anemia	Blackfan-Diamond Anemia	Orphanet			★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	25107436	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperlipoproteinemia Type II	Hyperlipoproteinemia	Pubtator	27173180	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	21319141	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Migraine Disorders	Migraine	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	21319141	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

RPL35 (ribosomal protein L35)