Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	11221
Gene name	Dual specificity phosphatase 10
Gene symbol	DUSP10
Synonyms (NCBI Gene)	MKP-5MKP5
Chromosome	1
Chromosome location	1q41
Summary	Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT006323	hsa-miR-21-5p	Luciferase reporter assayqRT-PCRWestern blot	22387553
MIRT006323	hsa-miR-21-5p	Luciferase reporter assayqRT-PCRWestern blot	22387553
MIRT006323	hsa-miR-21-5p	Luciferase reporter assayqRT-PCRWestern blot	22387553
MIRT006323	hsa-miR-21-5p	Luciferase reporter assayqRT-PCRWestern blot	22387553
MIRT006323	hsa-miR-21-5p	Luciferase reporter assayqRT-PCRWestern blot	22387553
MIRT006323	hsa-miR-21-5p	Luciferase reporter assayqRT-PCRWestern blot	22387553
MIRT027621	hsa-miR-98-5p	Microarray	19088304
MIRT438170	hsa-miR-92a-3p	ELISALuciferase reporter assayqRT-PCRWestern blot	24332650
MIRT438170	hsa-miR-92a-3p	ELISALuciferase reporter assayqRT-PCRWestern blot	24332650
MIRT646225	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT646224	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT646223	hsa-miR-4289	HITS-CLIP	23824327
MIRT646222	hsa-miR-6072	HITS-CLIP	23824327
MIRT646221	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT646220	hsa-miR-5193	HITS-CLIP	23824327
MIRT646219	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT646218	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT646217	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT646216	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT646215	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT646214	hsa-miR-3163	HITS-CLIP	23824327
MIRT646213	hsa-miR-410-3p	HITS-CLIP	23824327
MIRT646212	hsa-miR-454-5p	HITS-CLIP	23824327
MIRT646211	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT646210	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT646209	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT646208	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT646207	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT646206	hsa-miR-190a-5p	HITS-CLIP	23824327
MIRT646205	hsa-miR-190b	HITS-CLIP	23824327
MIRT646204	hsa-miR-3201	HITS-CLIP	23824327
MIRT646203	hsa-miR-4791	HITS-CLIP	23824327
MIRT646202	hsa-miR-642b-5p	HITS-CLIP	23824327
MIRT646201	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT646200	hsa-miR-623	HITS-CLIP	23824327
MIRT646199	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT646198	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT646197	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT646196	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT646195	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT646194	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT615029	hsa-miR-450a-5p	HITS-CLIP	23824327
MIRT615028	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT438170	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT727844	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT727843	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT734965	hsa-miR-363-3p	Luciferase reporter assayWestern blottingqRT-PCRFlow cytometry	33208005
MIRT646225	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT646224	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT646223	hsa-miR-4289	HITS-CLIP	23824327
MIRT646222	hsa-miR-6072	HITS-CLIP	23824327
MIRT646221	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT646220	hsa-miR-5193	HITS-CLIP	23824327
MIRT646219	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT646218	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT646217	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT646216	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT646215	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT646214	hsa-miR-3163	HITS-CLIP	23824327
MIRT646213	hsa-miR-410-3p	HITS-CLIP	23824327
MIRT646212	hsa-miR-454-5p	HITS-CLIP	23824327
MIRT646211	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT646210	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT646209	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT646208	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT646207	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT646206	hsa-miR-190a-5p	HITS-CLIP	23824327
MIRT646205	hsa-miR-190b	HITS-CLIP	23824327
MIRT646204	hsa-miR-3201	HITS-CLIP	23824327
MIRT646203	hsa-miR-4791	HITS-CLIP	23824327
MIRT646202	hsa-miR-642b-5p	HITS-CLIP	23824327
MIRT646201	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT646200	hsa-miR-623	HITS-CLIP	23824327
MIRT646199	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT646198	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT646197	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT646196	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT646195	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT646194	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT615029	hsa-miR-450a-5p	HITS-CLIP	23824327
MIRT615028	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT947345	hsa-miR-3158-3p	CLIP-seq
MIRT947346	hsa-miR-3940-5p	CLIP-seq
MIRT947347	hsa-miR-4507	CLIP-seq
MIRT947348	hsa-miR-629	CLIP-seq
MIRT947349	hsa-miR-659	CLIP-seq
MIRT2215611	hsa-miR-1279	CLIP-seq
MIRT2215612	hsa-miR-1283	CLIP-seq
MIRT2215613	hsa-miR-137	CLIP-seq
MIRT2215614	hsa-miR-185	CLIP-seq
MIRT2215615	hsa-miR-223	CLIP-seq
MIRT2215616	hsa-miR-2278	CLIP-seq
MIRT2215617	hsa-miR-25	CLIP-seq
MIRT2215618	hsa-miR-32	CLIP-seq
MIRT2215619	hsa-miR-329	CLIP-seq
MIRT2215620	hsa-miR-362-3p	CLIP-seq
MIRT2215621	hsa-miR-363	CLIP-seq
MIRT2215622	hsa-miR-367	CLIP-seq
MIRT2215623	hsa-miR-3910	CLIP-seq
MIRT2215624	hsa-miR-3941	CLIP-seq
MIRT2215625	hsa-miR-421	CLIP-seq
MIRT2215626	hsa-miR-4277	CLIP-seq
MIRT2215627	hsa-miR-4306	CLIP-seq
MIRT2215628	hsa-miR-4493	CLIP-seq
MIRT2215629	hsa-miR-4644	CLIP-seq
MIRT2215630	hsa-miR-466	CLIP-seq
MIRT2215631	hsa-miR-4672	CLIP-seq
MIRT2215632	hsa-miR-4676-5p	CLIP-seq
MIRT2215633	hsa-miR-4709-5p	CLIP-seq
MIRT2215634	hsa-miR-4731-3p	CLIP-seq
MIRT2215635	hsa-miR-4786-3p	CLIP-seq
MIRT2215636	hsa-miR-4795-3p	CLIP-seq
MIRT2215637	hsa-miR-4801	CLIP-seq
MIRT2215638	hsa-miR-507	CLIP-seq
MIRT2215639	hsa-miR-557	CLIP-seq
MIRT2215640	hsa-miR-575	CLIP-seq
MIRT2215641	hsa-miR-656	CLIP-seq
MIRT2215642	hsa-miR-767-5p	CLIP-seq
MIRT2215643	hsa-miR-92a	CLIP-seq
MIRT2215644	hsa-miR-92b	CLIP-seq
MIRT2215645	hsa-miR-942	CLIP-seq

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Transcription factor	Regulation	Reference
ATF2	Unknown	17681939

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002682	Process	Regulation of immune system process	IEA
GO:0002819	Process	Regulation of adaptive immune response	IEA
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	16288922, 27880917, 32296183, 32814053
GO:0005634	Component	Nucleus	IDA	10391943
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10391943
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0007165	Process	Signal transduction	IBA
GO:0008330	Function	Protein tyrosine/threonine phosphatase activity	IBA
GO:0008330	Function	Protein tyrosine/threonine phosphatase activity	IDA	10391943
GO:0008432	Function	JUN kinase binding	IDA	10391943
GO:0010633	Process	Negative regulation of epithelial cell migration	IEA
GO:0010633	Process	Negative regulation of epithelial cell migration	ISS
GO:0016311	Process	Dephosphorylation	IDA	24531476
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IDA	16806267, 24531476
GO:0017017	Function	MAP kinase tyrosine/serine/threonine phosphatase activity	IBA
GO:0017017	Function	MAP kinase tyrosine/serine/threonine phosphatase activity	IEA
GO:0030336	Process	Negative regulation of cell migration	NAS	23993976
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0032873	Process	Negative regulation of stress-activated MAPK cascade	IEA
GO:0033549	Function	MAP kinase phosphatase activity	IDA	22375048
GO:0033549	Function	MAP kinase phosphatase activity	IEA
GO:0033549	Function	MAP kinase phosphatase activity	ISS
GO:0033550	Function	MAP kinase tyrosine phosphatase activity	IBA
GO:0045088	Process	Regulation of innate immune response	IEA
GO:0045591	Process	Positive regulation of regulatory T cell differentiation	IMP	22387553
GO:0046329	Process	Negative regulation of JNK cascade	IBA
GO:0046329	Process	Negative regulation of JNK cascade	IDA	10391943
GO:0046329	Process	Negative regulation of JNK cascade	IEA
GO:0046329	Process	Negative regulation of JNK cascade	IEA
GO:0048273	Function	Mitogen-activated protein kinase p38 binding	IPI	10391943
GO:0048709	Process	Oligodendrocyte differentiation	IEA
GO:0048715	Process	Negative regulation of oligodendrocyte differentiation	IEA
GO:0050680	Process	Negative regulation of epithelial cell proliferation	IEA
GO:0050680	Process	Negative regulation of epithelial cell proliferation	ISS
GO:0051239	Process	Regulation of multicellular organismal process	IEA
GO:0051403	Process	Stress-activated MAPK cascade	IEA
GO:0060266	Process	Negative regulation of respiratory burst involved in inflammatory response	IEA
GO:0060284	Process	Regulation of cell development	IEA
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IEA
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	ISS
GO:0090335	Process	Regulation of brown fat cell differentiation	IEA
GO:1903753	Process	Negative regulation of p38MAPK cascade	IDA	10391943
GO:1903753	Process	Negative regulation of p38MAPK cascade	NAS	23993976
GO:1905042	Process	Negative regulation of epithelium regeneration	IEA
GO:1905042	Process	Negative regulation of epithelium regeneration	ISS

MIM	HGNC	e!Ensembl
608867	3065	ENSG00000143507

Q9Y6W6

Protein name

Dual specificity protein phosphatase 10 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5)

Protein function

Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. {ECO:0000269|PubMed:10391943, ECO:0000269|PubMed:10597297, ECO:0000269|PubMed:2

PDB

1ZZW , 2OUC , 2OUD , 3TG1 , 6MC1 , 7U4O , 7U4R , 7UMU , 7UMV , 7UN0 , 7UN4 , 7Y4B , 7Y4C , 7Y4D , 7Y4E

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00581	Rhodanese	154 → 279	Rhodanese-like domain	Domain
PF00782	DSPc	329 → 461	Dual specificity phosphatase, catalytic domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in keratinocytes (at protein level) (PubMed:29043977). Detected in brain (PubMed:16806267). {ECO:0000269|PubMed:16806267, ECO:0000269|PubMed:29043977}.

Sequence

MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTY
MPSSSGSARSLNCGCSSASCCTVATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNN
NENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPF
MEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENT
NEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSLQLQECREVGGGA
SAASSLLPQPIPTTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPL
YHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVI
AYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGVET
VV

Sequence length

482

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (12)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARCINOMA, BASAL CELL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DRY EYE SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DUPUYTREN CONTRACTURE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPEROPIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALIGNANT EPITHELIAL TUMOR OF OVARY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATIC FEVER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (30)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma	Adenocarcinoma	BEFREE	16618780		★★★★★ ★☆☆☆☆ Found in Text Mining only
Antiphospholipid Syndrome	Antiphospholipid syndrome	Pubtator	38155384	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Aortic Aneurysm Abdominal	Aortic aneurysm	Pubtator	25993293	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	31122150		★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	31122150	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	22711061		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	20413845, 25201346	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	22711061		★★★★★ ★☆☆☆☆ Found in Text Mining only
Celiac Disease	Celiac disease	BEFREE	23936387		★★★★★ ★☆☆☆☆ Found in Text Mining only
Celiac Disease	Celiac disease	Pubtator	23936387	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	25772234		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	22711061		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	BEFREE	25772234		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	23872954, 25772234, 25973098, 31717606		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	25973098, 35812248	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dejerine-Sottas Disease (disorder)	Charcot-Marie-Tooth disease	BEFREE	25772234		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	37387540	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Idiopathic Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	31483681		★★★★★ ★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune System Diseases	BEFREE	15306813		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	22711061		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	16618780		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	14767517, 16618780, 30939861		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	22711061		★★★★★ ★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy	Muscular dystrophy	BEFREE	31483681		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	16618780		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	24361742	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Progressive supranuclear palsy	Progressive Supranuclear Palsy	BEFREE	29986742		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	16618780		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	31483681		★★★★★ ★☆☆☆☆ Found in Text Mining only
Supranuclear Palsy Progressive	Progressive supranuclear palsy	Pubtator	29986742, 35842134	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

DUSP10 (dual specificity phosphatase 10)