Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	11216
Gene name	A-kinase anchoring protein 10
Gene symbol	AKAP10
Synonyms (NCBI Gene)	AKAP-10D-AKAP-2D-AKAP2PRKA10
Chromosome	17
Chromosome location	17p11.2
Summary	This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mito

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SNP ID	Visualize variation	Clinical significance	Consequence
rs203462	T>C	Risk-factor	Coding sequence variant, genic downstream transcript variant, missense variant, non coding transcript variant

335

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miRTarBase ID	miRNA	Experiments	Reference
MIRT043412	hsa-miR-331-3p	CLASH	23622248
MIRT042793	hsa-miR-339-5p	CLASH	23622248
MIRT568562	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT524946	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT524945	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT568561	hsa-miR-548aw	PAR-CLIP	20371350
MIRT568560	hsa-miR-518a-5p	PAR-CLIP	20371350
MIRT568559	hsa-miR-527	PAR-CLIP	20371350
MIRT568558	hsa-miR-450b-5p	PAR-CLIP	20371350
MIRT568557	hsa-miR-507	PAR-CLIP	20371350
MIRT568556	hsa-miR-557	PAR-CLIP	20371350
MIRT568555	hsa-miR-3680-3p	PAR-CLIP	20371350
MIRT559644	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT559643	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT559642	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT559641	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT559640	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT559639	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT559638	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT559636	hsa-miR-5571-5p	PAR-CLIP	21572407
MIRT559637	hsa-miR-3671	PAR-CLIP	21572407
MIRT559635	hsa-miR-3191-5p	PAR-CLIP	21572407
MIRT559634	hsa-miR-106a-3p	PAR-CLIP	21572407
MIRT559633	hsa-miR-6505-5p	PAR-CLIP	21572407
MIRT524946	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT524945	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT441244	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT441244	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT568562	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT524946	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT524945	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT568561	hsa-miR-548aw	PAR-CLIP	20371350
MIRT568560	hsa-miR-518a-5p	PAR-CLIP	20371350
MIRT568559	hsa-miR-527	PAR-CLIP	20371350
MIRT568558	hsa-miR-450b-5p	PAR-CLIP	20371350
MIRT568557	hsa-miR-507	PAR-CLIP	20371350
MIRT568556	hsa-miR-557	PAR-CLIP	20371350
MIRT568555	hsa-miR-3680-3p	PAR-CLIP	20371350
MIRT559644	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT559643	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT559642	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT559641	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT559640	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT559639	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT559638	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT559636	hsa-miR-5571-5p	PAR-CLIP	21572407
MIRT559637	hsa-miR-3671	PAR-CLIP	21572407
MIRT559635	hsa-miR-3191-5p	PAR-CLIP	21572407
MIRT559634	hsa-miR-106a-3p	PAR-CLIP	21572407
MIRT559633	hsa-miR-6505-5p	PAR-CLIP	21572407
MIRT524946	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT524945	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT775198	hsa-miR-1208	CLIP-seq
MIRT775199	hsa-miR-1255a	CLIP-seq
MIRT775200	hsa-miR-1255b	CLIP-seq
MIRT775201	hsa-miR-1297	CLIP-seq
MIRT775202	hsa-miR-137	CLIP-seq
MIRT775203	hsa-miR-224	CLIP-seq
MIRT775204	hsa-miR-26a	CLIP-seq
MIRT775205	hsa-miR-26b	CLIP-seq
MIRT775206	hsa-miR-30a	CLIP-seq
MIRT775207	hsa-miR-30b	CLIP-seq
MIRT775208	hsa-miR-30c	CLIP-seq
MIRT775209	hsa-miR-30d	CLIP-seq
MIRT775210	hsa-miR-30e	CLIP-seq
MIRT775211	hsa-miR-3129-3p	CLIP-seq
MIRT775212	hsa-miR-3148	CLIP-seq
MIRT775213	hsa-miR-3149	CLIP-seq
MIRT775214	hsa-miR-3162-5p	CLIP-seq
MIRT775215	hsa-miR-3168	CLIP-seq
MIRT775216	hsa-miR-3173-3p	CLIP-seq
MIRT775217	hsa-miR-325	CLIP-seq
MIRT775218	hsa-miR-3607-5p	CLIP-seq
MIRT775219	hsa-miR-383	CLIP-seq
MIRT775220	hsa-miR-3920	CLIP-seq
MIRT775221	hsa-miR-3978	CLIP-seq
MIRT775222	hsa-miR-4275	CLIP-seq
MIRT775223	hsa-miR-4277	CLIP-seq
MIRT775224	hsa-miR-4420	CLIP-seq
MIRT775225	hsa-miR-4424	CLIP-seq
MIRT775226	hsa-miR-4465	CLIP-seq
MIRT775227	hsa-miR-4473	CLIP-seq
MIRT775228	hsa-miR-4495	CLIP-seq
MIRT775229	hsa-miR-4533	CLIP-seq
MIRT775230	hsa-miR-4633-5p	CLIP-seq
MIRT775231	hsa-miR-4659a-5p	CLIP-seq
MIRT775232	hsa-miR-4659b-5p	CLIP-seq
MIRT775233	hsa-miR-4711-5p	CLIP-seq
MIRT775234	hsa-miR-4728-3p	CLIP-seq
MIRT775235	hsa-miR-4738-3p	CLIP-seq
MIRT775236	hsa-miR-4775	CLIP-seq
MIRT775237	hsa-miR-4776-3p	CLIP-seq
MIRT775238	hsa-miR-512-3p	CLIP-seq
MIRT775239	hsa-miR-520f	CLIP-seq
MIRT775240	hsa-miR-532-5p	CLIP-seq
MIRT775241	hsa-miR-542-3p	CLIP-seq
MIRT775242	hsa-miR-552	CLIP-seq
MIRT775243	hsa-miR-574-5p	CLIP-seq
MIRT775244	hsa-miR-590-3p	CLIP-seq
MIRT775245	hsa-miR-628-3p	CLIP-seq
MIRT775246	hsa-miR-648	CLIP-seq
MIRT775247	hsa-miR-892a	CLIP-seq
MIRT775203	hsa-miR-224	CLIP-seq
MIRT775216	hsa-miR-3173-3p	CLIP-seq
MIRT775224	hsa-miR-4420	CLIP-seq
MIRT775235	hsa-miR-4738-3p	CLIP-seq
MIRT775203	hsa-miR-224	CLIP-seq
MIRT775216	hsa-miR-3173-3p	CLIP-seq
MIRT775224	hsa-miR-4420	CLIP-seq
MIRT775235	hsa-miR-4738-3p	CLIP-seq
MIRT775199	hsa-miR-1255a	CLIP-seq
MIRT775200	hsa-miR-1255b	CLIP-seq
MIRT775201	hsa-miR-1297	CLIP-seq
MIRT1928742	hsa-miR-217	CLIP-seq
MIRT775203	hsa-miR-224	CLIP-seq
MIRT775204	hsa-miR-26a	CLIP-seq
MIRT775205	hsa-miR-26b	CLIP-seq
MIRT1928743	hsa-miR-3159	CLIP-seq
MIRT775214	hsa-miR-3162-5p	CLIP-seq
MIRT1928744	hsa-miR-3165	CLIP-seq
MIRT775215	hsa-miR-3168	CLIP-seq
MIRT775216	hsa-miR-3173-3p	CLIP-seq
MIRT1928745	hsa-miR-3190	CLIP-seq
MIRT775220	hsa-miR-3920	CLIP-seq
MIRT775223	hsa-miR-4277	CLIP-seq
MIRT775224	hsa-miR-4420	CLIP-seq
MIRT775225	hsa-miR-4424	CLIP-seq
MIRT775226	hsa-miR-4465	CLIP-seq
MIRT1928746	hsa-miR-4686	CLIP-seq
MIRT775233	hsa-miR-4711-5p	CLIP-seq
MIRT775235	hsa-miR-4738-3p	CLIP-seq
MIRT775243	hsa-miR-574-5p	CLIP-seq
MIRT1928747	hsa-miR-584	CLIP-seq
MIRT775246	hsa-miR-648	CLIP-seq
MIRT775198	hsa-miR-1208	CLIP-seq
MIRT775199	hsa-miR-1255a	CLIP-seq
MIRT775200	hsa-miR-1255b	CLIP-seq
MIRT775202	hsa-miR-137	CLIP-seq
MIRT2169539	hsa-miR-208a	CLIP-seq
MIRT2169540	hsa-miR-208b	CLIP-seq
MIRT2169541	hsa-miR-2115	CLIP-seq
MIRT775203	hsa-miR-224	CLIP-seq
MIRT775214	hsa-miR-3162-5p	CLIP-seq
MIRT775216	hsa-miR-3173-3p	CLIP-seq
MIRT2169542	hsa-miR-3658	CLIP-seq
MIRT775220	hsa-miR-3920	CLIP-seq
MIRT775222	hsa-miR-4275	CLIP-seq
MIRT775224	hsa-miR-4420	CLIP-seq
MIRT775225	hsa-miR-4424	CLIP-seq
MIRT2169543	hsa-miR-4432	CLIP-seq
MIRT1928746	hsa-miR-4686	CLIP-seq
MIRT775233	hsa-miR-4711-5p	CLIP-seq
MIRT775234	hsa-miR-4728-3p	CLIP-seq
MIRT775235	hsa-miR-4738-3p	CLIP-seq
MIRT2169544	hsa-miR-499-5p	CLIP-seq
MIRT2169545	hsa-miR-516a-3p	CLIP-seq
MIRT775247	hsa-miR-892a	CLIP-seq
MIRT775203	hsa-miR-224	CLIP-seq
MIRT775216	hsa-miR-3173-3p	CLIP-seq
MIRT775220	hsa-miR-3920	CLIP-seq
MIRT775224	hsa-miR-4420	CLIP-seq
MIRT775234	hsa-miR-4728-3p	CLIP-seq
MIRT775235	hsa-miR-4738-3p	CLIP-seq
MIRT2472108	hsa-miR-10a	CLIP-seq
MIRT2472109	hsa-miR-10b	CLIP-seq
MIRT775198	hsa-miR-1208	CLIP-seq
MIRT2472110	hsa-miR-1228	CLIP-seq
MIRT2472111	hsa-miR-1229	CLIP-seq
MIRT2472112	hsa-miR-1237	CLIP-seq
MIRT2472113	hsa-miR-1254	CLIP-seq
MIRT775199	hsa-miR-1255a	CLIP-seq
MIRT775200	hsa-miR-1255b	CLIP-seq
MIRT2472114	hsa-miR-1266	CLIP-seq
MIRT2472115	hsa-miR-127-5p	CLIP-seq
MIRT2472116	hsa-miR-130a	CLIP-seq
MIRT2472117	hsa-miR-130b	CLIP-seq
MIRT2472118	hsa-miR-149	CLIP-seq
MIRT2472119	hsa-miR-155	CLIP-seq
MIRT2472120	hsa-miR-185	CLIP-seq
MIRT2472121	hsa-miR-1909	CLIP-seq
MIRT1928742	hsa-miR-217	CLIP-seq
MIRT2472122	hsa-miR-22	CLIP-seq
MIRT2472123	hsa-miR-223	CLIP-seq
MIRT2472124	hsa-miR-29a	CLIP-seq
MIRT2472125	hsa-miR-29b	CLIP-seq
MIRT2472126	hsa-miR-29c	CLIP-seq
MIRT2472127	hsa-miR-301a	CLIP-seq
MIRT2472128	hsa-miR-301b	CLIP-seq
MIRT2472129	hsa-miR-3116	CLIP-seq
MIRT2472130	hsa-miR-3123	CLIP-seq
MIRT2472131	hsa-miR-3151	CLIP-seq
MIRT775214	hsa-miR-3162-5p	CLIP-seq
MIRT2472132	hsa-miR-3175	CLIP-seq
MIRT2472133	hsa-miR-3182	CLIP-seq
MIRT2472134	hsa-miR-3202	CLIP-seq
MIRT2472135	hsa-miR-320a	CLIP-seq
MIRT2472136	hsa-miR-320b	CLIP-seq
MIRT2472137	hsa-miR-320c	CLIP-seq
MIRT2472138	hsa-miR-320d	CLIP-seq
MIRT2472139	hsa-miR-330-3p	CLIP-seq
MIRT775218	hsa-miR-3607-5p	CLIP-seq
MIRT2472140	hsa-miR-3615	CLIP-seq
MIRT2472141	hsa-miR-3620	CLIP-seq
MIRT2472142	hsa-miR-3622a-3p	CLIP-seq
MIRT2472143	hsa-miR-3622b-3p	CLIP-seq
MIRT2472144	hsa-miR-365	CLIP-seq
MIRT2472145	hsa-miR-3662	CLIP-seq
MIRT2472146	hsa-miR-3664-3p	CLIP-seq
MIRT2472147	hsa-miR-3666	CLIP-seq
MIRT2472148	hsa-miR-3667-3p	CLIP-seq
MIRT775220	hsa-miR-3920	CLIP-seq
MIRT2472149	hsa-miR-4252	CLIP-seq
MIRT775222	hsa-miR-4275	CLIP-seq
MIRT2472150	hsa-miR-4283	CLIP-seq
MIRT2472151	hsa-miR-4295	CLIP-seq
MIRT2472152	hsa-miR-4306	CLIP-seq
MIRT2472153	hsa-miR-4328	CLIP-seq
MIRT775225	hsa-miR-4424	CLIP-seq
MIRT2472154	hsa-miR-4429	CLIP-seq
MIRT2472155	hsa-miR-4433	CLIP-seq
MIRT2472156	hsa-miR-4459	CLIP-seq
MIRT2472157	hsa-miR-4489	CLIP-seq
MIRT2472158	hsa-miR-4518	CLIP-seq
MIRT2472159	hsa-miR-4524	CLIP-seq
MIRT775229	hsa-miR-4533	CLIP-seq
MIRT2472160	hsa-miR-454	CLIP-seq
MIRT775230	hsa-miR-4633-5p	CLIP-seq
MIRT2472161	hsa-miR-4644	CLIP-seq
MIRT2472162	hsa-miR-4652-3p	CLIP-seq
MIRT2472163	hsa-miR-4671-3p	CLIP-seq
MIRT2472164	hsa-miR-4690-5p	CLIP-seq
MIRT2472165	hsa-miR-4697-3p	CLIP-seq
MIRT775233	hsa-miR-4711-5p	CLIP-seq
MIRT775234	hsa-miR-4728-3p	CLIP-seq
MIRT775235	hsa-miR-4738-3p	CLIP-seq
MIRT2472166	hsa-miR-4764-3p	CLIP-seq
MIRT2472167	hsa-miR-4768-3p	CLIP-seq
MIRT2472168	hsa-miR-4790-3p	CLIP-seq
MIRT775240	hsa-miR-532-5p	CLIP-seq
MIRT775242	hsa-miR-552	CLIP-seq
MIRT2472169	hsa-miR-570	CLIP-seq
MIRT2472170	hsa-miR-572	CLIP-seq
MIRT775243	hsa-miR-574-5p	CLIP-seq
MIRT2472171	hsa-miR-618	CLIP-seq
MIRT2472172	hsa-miR-621	CLIP-seq
MIRT775246	hsa-miR-648	CLIP-seq
MIRT2472173	hsa-miR-661	CLIP-seq
MIRT2472174	hsa-miR-760	CLIP-seq
MIRT2472175	hsa-miR-765	CLIP-seq
MIRT2472176	hsa-miR-888	CLIP-seq
MIRT775247	hsa-miR-892a	CLIP-seq
MIRT2472108	hsa-miR-10a	CLIP-seq
MIRT2472109	hsa-miR-10b	CLIP-seq
MIRT775198	hsa-miR-1208	CLIP-seq
MIRT2472110	hsa-miR-1228	CLIP-seq
MIRT2472111	hsa-miR-1229	CLIP-seq
MIRT2472112	hsa-miR-1237	CLIP-seq
MIRT2472113	hsa-miR-1254	CLIP-seq
MIRT775199	hsa-miR-1255a	CLIP-seq
MIRT775200	hsa-miR-1255b	CLIP-seq
MIRT2472114	hsa-miR-1266	CLIP-seq
MIRT2472115	hsa-miR-127-5p	CLIP-seq
MIRT775201	hsa-miR-1297	CLIP-seq
MIRT2472116	hsa-miR-130a	CLIP-seq
MIRT2472117	hsa-miR-130b	CLIP-seq
MIRT2472118	hsa-miR-149	CLIP-seq
MIRT2472119	hsa-miR-155	CLIP-seq
MIRT2472120	hsa-miR-185	CLIP-seq
MIRT2472121	hsa-miR-1909	CLIP-seq
MIRT1928742	hsa-miR-217	CLIP-seq
MIRT2472122	hsa-miR-22	CLIP-seq
MIRT2472123	hsa-miR-223	CLIP-seq
MIRT775204	hsa-miR-26a	CLIP-seq
MIRT775205	hsa-miR-26b	CLIP-seq
MIRT2472124	hsa-miR-29a	CLIP-seq
MIRT2472125	hsa-miR-29b	CLIP-seq
MIRT2472126	hsa-miR-29c	CLIP-seq
MIRT2472127	hsa-miR-301a	CLIP-seq
MIRT2472128	hsa-miR-301b	CLIP-seq
MIRT2472129	hsa-miR-3116	CLIP-seq
MIRT2472130	hsa-miR-3123	CLIP-seq
MIRT775214	hsa-miR-3162-5p	CLIP-seq
MIRT2472132	hsa-miR-3175	CLIP-seq
MIRT2472133	hsa-miR-3182	CLIP-seq
MIRT2472135	hsa-miR-320a	CLIP-seq
MIRT2472136	hsa-miR-320b	CLIP-seq
MIRT2472137	hsa-miR-320c	CLIP-seq
MIRT2472138	hsa-miR-320d	CLIP-seq
MIRT2472139	hsa-miR-330-3p	CLIP-seq
MIRT775218	hsa-miR-3607-5p	CLIP-seq
MIRT2472140	hsa-miR-3615	CLIP-seq
MIRT2472141	hsa-miR-3620	CLIP-seq
MIRT2472144	hsa-miR-365	CLIP-seq
MIRT2472145	hsa-miR-3662	CLIP-seq
MIRT2472146	hsa-miR-3664-3p	CLIP-seq
MIRT2472147	hsa-miR-3666	CLIP-seq
MIRT2472148	hsa-miR-3667-3p	CLIP-seq
MIRT775220	hsa-miR-3920	CLIP-seq
MIRT2472149	hsa-miR-4252	CLIP-seq
MIRT775222	hsa-miR-4275	CLIP-seq
MIRT2472151	hsa-miR-4295	CLIP-seq
MIRT2472152	hsa-miR-4306	CLIP-seq
MIRT2472153	hsa-miR-4328	CLIP-seq
MIRT775225	hsa-miR-4424	CLIP-seq
MIRT2472154	hsa-miR-4429	CLIP-seq
MIRT2472155	hsa-miR-4433	CLIP-seq
MIRT2472156	hsa-miR-4459	CLIP-seq
MIRT775226	hsa-miR-4465	CLIP-seq
MIRT2472158	hsa-miR-4518	CLIP-seq
MIRT2472159	hsa-miR-4524	CLIP-seq
MIRT2472160	hsa-miR-454	CLIP-seq
MIRT775230	hsa-miR-4633-5p	CLIP-seq
MIRT2472161	hsa-miR-4644	CLIP-seq
MIRT2472162	hsa-miR-4652-3p	CLIP-seq
MIRT2472163	hsa-miR-4671-3p	CLIP-seq
MIRT2472164	hsa-miR-4690-5p	CLIP-seq
MIRT2472165	hsa-miR-4697-3p	CLIP-seq
MIRT775233	hsa-miR-4711-5p	CLIP-seq
MIRT775234	hsa-miR-4728-3p	CLIP-seq
MIRT775235	hsa-miR-4738-3p	CLIP-seq
MIRT2472166	hsa-miR-4764-3p	CLIP-seq
MIRT2472167	hsa-miR-4768-3p	CLIP-seq
MIRT2472168	hsa-miR-4790-3p	CLIP-seq
MIRT775240	hsa-miR-532-5p	CLIP-seq
MIRT775242	hsa-miR-552	CLIP-seq
MIRT2472170	hsa-miR-572	CLIP-seq
MIRT775243	hsa-miR-574-5p	CLIP-seq
MIRT2472171	hsa-miR-618	CLIP-seq
MIRT2472172	hsa-miR-621	CLIP-seq
MIRT775246	hsa-miR-648	CLIP-seq
MIRT2472173	hsa-miR-661	CLIP-seq
MIRT2472174	hsa-miR-760	CLIP-seq
MIRT2472175	hsa-miR-765	CLIP-seq
MIRT2472176	hsa-miR-888	CLIP-seq
MIRT775247	hsa-miR-892a	CLIP-seq

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	20159461
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0007165	Process	Signal transduction	TAS	9326583
GO:0008104	Process	Intracellular protein localization	IBA
GO:0008104	Process	Intracellular protein localization	IEA
GO:0008104	Process	Intracellular protein localization	TAS	9326583
GO:0016020	Component	Membrane	IEA
GO:0032991	Component	Protein-containing complex	IDA	25097019
GO:0051018	Function	Protein kinase A binding	IEA
GO:0051018	Function	Protein kinase A binding	IPI	25097019

MIM	HGNC	e!Ensembl
604694	368	ENSG00000108599

O43572

Protein name

A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10)

Protein function

Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not

PDB

3IM4 , 3TMH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00615	RGS	261 → 368	Regulator of G protein signaling domain	Domain
PF00615	RGS	379 → 504	Regulator of G protein signaling domain	Domain

Sequence

MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKNH
ALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQETKS
SLSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQS
SLAEPVSPSKKHETTASFLTDSLDKRLEDSGSAQLFMTHSEGIDLNNRTNSTQNHLLLSQ
ECDSAHSLRLEMARAGTHQVSMETQESSSTLTVASRNSPASPLKELSGKLMKSIEQDAVN
TFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFL
RSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLA
AKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPL
RQAWTTMEKVFLPGFLSSNLYYKYLNDLIHSVRGDEFLGGNVSLTAPGSVGPPDESHPGS
SDSSASQSSVKKASIKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRE
SEPEPDVRKSKGSMFSQAMKKWVQGNTDEAQEELAWKIAKMIVSDIMQQAQYDQPLEKST
KL

Sequence length

662

Interactions

View interactions

	Reactome
			Factors involved in megakaryocyte development and platelet production

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AKAP10-related disorder	Conflicting classifications of pathogenicity; Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Conduction disorder of the heart	Uncertain significance	ClinVar Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Reclassified - variant of unknown significance	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUDDEN INFANT DEATH SYNDROME	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (21)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenoma	Adenoma	BEFREE	23468363		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	BEFREE	21382426		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	PSYGENET_DG	21382426		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Cancer, Familial	Breast Cancer	BEFREE	16956908		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	16956908		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	23468363	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	25213315		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	19209010, 23468363, 25213315		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	LHGDN	19209010		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	23468363	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Conduction disorder of the heart	Conduction Disorder Of The Heart	CTD_human_DG			★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Conduction disorder of the heart	Conduction Disorder Of The Heart	GENOMICS_ENGLAND_DG			★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Hypercholesterolemia	Hypercholesterolemia	BEFREE	17143557		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	22817328	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	22817328, 23095189		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intracranial Aneurysm	Intracranial Aneurysm	BEFREE	16618819		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	23468363	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	16956908		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	25213315		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	17786291		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23468363		★★★★★ ★☆☆☆☆ Found in Text Mining only

AKAP10 (A-kinase anchoring protein 10)