IRAK3 (interleukin 1 receptor associated kinase 3)

Gene

• Entrez ID: 11213
• Gene name: Interleukin 1 receptor associated kinase 3
• Gene symbol: IRAK3
• Synonyms (NCBI Gene): ASRT5, IRAKM
• Chromosome: 12
• Chromosome location: 12q14.3
• Summary: This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophag

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs121912630	G>A	Risk-factor	Coding sequence variant, intron variant, stop gained
rs150116809	G>A,T	Risk-factor	Splice donor variant
rs367600113	C>T	Likely-pathogenic	Stop gained, coding sequence variant
rs764674154	->TGA	Likely-pathogenic	Coding sequence variant, stop gained

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005808	hsa-miR-155-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	20852130
MIRT023129	hsa-miR-124-3p	Microarray	18668037
MIRT051159	hsa-miR-16-5p	CLASH	23622248
MIRT664811	hsa-miR-4486	HITS-CLIP	23824327
MIRT670949	hsa-miR-605-3p	HITS-CLIP	23824327
MIRT664810	hsa-miR-4493	HITS-CLIP	23824327
MIRT649846	hsa-miR-4284	HITS-CLIP	23824327
MIRT649845	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT664809	hsa-miR-4505	HITS-CLIP	23824327
MIRT664808	hsa-miR-5787	HITS-CLIP	23824327
MIRT664807	hsa-miR-3178	HITS-CLIP	23824327
MIRT649844	hsa-miR-7977	HITS-CLIP	23824327
MIRT664806	hsa-miR-6126	HITS-CLIP	23824327
MIRT664805	hsa-miR-4508	HITS-CLIP	23824327
MIRT519130	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT664811	hsa-miR-4486	HITS-CLIP	23824327
MIRT670949	hsa-miR-605-3p	HITS-CLIP	23824327
MIRT664810	hsa-miR-4493	HITS-CLIP	23824327
MIRT649846	hsa-miR-4284	HITS-CLIP	23824327
MIRT649845	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT664809	hsa-miR-4505	HITS-CLIP	23824327
MIRT664808	hsa-miR-5787	HITS-CLIP	23824327
MIRT664807	hsa-miR-3178	HITS-CLIP	23824327
MIRT649844	hsa-miR-7977	HITS-CLIP	23824327
MIRT664806	hsa-miR-6126	HITS-CLIP	23824327
MIRT664805	hsa-miR-4508	HITS-CLIP	23824327
MIRT510122	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT510121	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT510120	hsa-miR-940	HITS-CLIP	23824327
MIRT519130	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT510119	hsa-miR-4514	HITS-CLIP	23824327
MIRT510118	hsa-miR-4692	HITS-CLIP	23824327
MIRT510116	hsa-miR-3937	HITS-CLIP	23824327
MIRT510117	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT510115	hsa-miR-4673	HITS-CLIP	23824327
MIRT664811	hsa-miR-4486	HITS-CLIP	23824327
MIRT664810	hsa-miR-4493	HITS-CLIP	23824327
MIRT649846	hsa-miR-4284	HITS-CLIP	23824327
MIRT649845	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT664809	hsa-miR-4505	HITS-CLIP	23824327
MIRT664808	hsa-miR-5787	HITS-CLIP	23824327
MIRT510113	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT510112	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT510111	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT510110	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT510108	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT510109	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT664807	hsa-miR-3178	HITS-CLIP	23824327
MIRT649844	hsa-miR-7977	HITS-CLIP	23824327
MIRT664806	hsa-miR-6126	HITS-CLIP	23824327
MIRT510107	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT510106	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT510105	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT510104	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT510103	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT510102	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT510101	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT510100	hsa-miR-3689c	HITS-CLIP	23824327
MIRT510099	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT510098	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT510097	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT510096	hsa-miR-3122	HITS-CLIP	23824327
MIRT510095	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT510094	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT510093	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT510092	hsa-miR-1233-5p	HITS-CLIP	23824327
MIRT664805	hsa-miR-4508	HITS-CLIP	23824327
MIRT510122	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT510121	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT510120	hsa-miR-940	HITS-CLIP	23824327
MIRT519130	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT510119	hsa-miR-4514	HITS-CLIP	23824327
MIRT510118	hsa-miR-4692	HITS-CLIP	23824327
MIRT510117	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT510115	hsa-miR-4673	HITS-CLIP	23824327
MIRT510114	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT649846	hsa-miR-4284	HITS-CLIP	23824327
MIRT649845	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT510113	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT510112	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT510111	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT510110	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT510108	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT510109	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT649844	hsa-miR-7977	HITS-CLIP	23824327
MIRT510107	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT510106	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT510105	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT510104	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT510103	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT510102	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT510101	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT510100	hsa-miR-3689c	HITS-CLIP	23824327
MIRT510099	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT510098	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT510097	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT510096	hsa-miR-3122	HITS-CLIP	23824327
MIRT510095	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT510094	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT510093	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT510092	hsa-miR-1233-5p	HITS-CLIP	23824327
MIRT510122	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT510121	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT510120	hsa-miR-940	PAR-CLIP	20371350
MIRT510119	hsa-miR-4514	PAR-CLIP	20371350
MIRT510118	hsa-miR-4692	PAR-CLIP	20371350
MIRT510116	hsa-miR-3937	PAR-CLIP	20371350
MIRT510117	hsa-miR-4645-5p	PAR-CLIP	20371350
MIRT510115	hsa-miR-4673	PAR-CLIP	20371350
MIRT510114	hsa-miR-4755-3p	PAR-CLIP	20371350
MIRT510113	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT510112	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT510111	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT510110	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT510108	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT510109	hsa-miR-6799-5p	PAR-CLIP	20371350
MIRT510107	hsa-miR-30c-1-3p	PAR-CLIP	20371350
MIRT510106	hsa-miR-30c-2-3p	PAR-CLIP	20371350
MIRT510105	hsa-miR-6788-5p	PAR-CLIP	20371350
MIRT510104	hsa-miR-1273h-5p	PAR-CLIP	20371350
MIRT510103	hsa-miR-30b-3p	PAR-CLIP	20371350
MIRT510102	hsa-miR-3689a-3p	PAR-CLIP	20371350
MIRT510101	hsa-miR-3689b-3p	PAR-CLIP	20371350
MIRT510100	hsa-miR-3689c	PAR-CLIP	20371350
MIRT510099	hsa-miR-6779-5p	PAR-CLIP	20371350
MIRT510098	hsa-miR-6780a-5p	PAR-CLIP	20371350
MIRT510097	hsa-miR-450a-1-3p	PAR-CLIP	20371350
MIRT510096	hsa-miR-3122	PAR-CLIP	20371350
MIRT510095	hsa-miR-3913-5p	PAR-CLIP	20371350
MIRT510094	hsa-miR-887-5p	PAR-CLIP	20371350
MIRT510093	hsa-miR-6513-5p	PAR-CLIP	20371350
MIRT510092	hsa-miR-1233-5p	PAR-CLIP	20371350
MIRT510122	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT510121	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT510120	hsa-miR-940	PAR-CLIP	21572407
MIRT510119	hsa-miR-4514	PAR-CLIP	21572407
MIRT510118	hsa-miR-4692	PAR-CLIP	21572407
MIRT510116	hsa-miR-3937	PAR-CLIP	21572407
MIRT510117	hsa-miR-4645-5p	PAR-CLIP	21572407
MIRT510115	hsa-miR-4673	PAR-CLIP	21572407
MIRT510114	hsa-miR-4755-3p	PAR-CLIP	21572407
MIRT510113	hsa-miR-7106-5p	PAR-CLIP	21572407
MIRT510112	hsa-miR-149-3p	PAR-CLIP	21572407
MIRT510111	hsa-miR-4728-5p	PAR-CLIP	21572407
MIRT510110	hsa-miR-6785-5p	PAR-CLIP	21572407
MIRT510108	hsa-miR-6883-5p	PAR-CLIP	21572407
MIRT510109	hsa-miR-6799-5p	PAR-CLIP	21572407
MIRT510107	hsa-miR-30c-1-3p	PAR-CLIP	21572407
MIRT510106	hsa-miR-30c-2-3p	PAR-CLIP	21572407
MIRT510105	hsa-miR-6788-5p	PAR-CLIP	21572407
MIRT510104	hsa-miR-1273h-5p	PAR-CLIP	21572407
MIRT510103	hsa-miR-30b-3p	PAR-CLIP	21572407
MIRT510102	hsa-miR-3689a-3p	PAR-CLIP	21572407
MIRT510101	hsa-miR-3689b-3p	PAR-CLIP	21572407
MIRT510100	hsa-miR-3689c	PAR-CLIP	21572407
MIRT510099	hsa-miR-6779-5p	PAR-CLIP	21572407
MIRT510098	hsa-miR-6780a-5p	PAR-CLIP	21572407
MIRT510097	hsa-miR-450a-1-3p	PAR-CLIP	21572407
MIRT510096	hsa-miR-3122	PAR-CLIP	21572407
MIRT510095	hsa-miR-3913-5p	PAR-CLIP	21572407
MIRT510094	hsa-miR-887-5p	PAR-CLIP	21572407
MIRT510093	hsa-miR-6513-5p	PAR-CLIP	21572407
MIRT510092	hsa-miR-1233-5p	PAR-CLIP	21572407
MIRT510122	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT510121	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT510120	hsa-miR-940	PAR-CLIP	23446348
MIRT519130	hsa-miR-383-3p	PAR-CLIP	23446348
MIRT510119	hsa-miR-4514	PAR-CLIP	23446348
MIRT510118	hsa-miR-4692	PAR-CLIP	23446348
MIRT510116	hsa-miR-3937	PAR-CLIP	23446348
MIRT510117	hsa-miR-4645-5p	PAR-CLIP	23446348
MIRT510115	hsa-miR-4673	PAR-CLIP	23446348
MIRT510114	hsa-miR-4755-3p	PAR-CLIP	23446348
MIRT510113	hsa-miR-7106-5p	PAR-CLIP	23446348
MIRT510112	hsa-miR-149-3p	PAR-CLIP	23446348
MIRT510111	hsa-miR-4728-5p	PAR-CLIP	23446348
MIRT510110	hsa-miR-6785-5p	PAR-CLIP	23446348
MIRT510108	hsa-miR-6883-5p	PAR-CLIP	23446348
MIRT510109	hsa-miR-6799-5p	PAR-CLIP	23446348
MIRT510107	hsa-miR-30c-1-3p	PAR-CLIP	23446348
MIRT510106	hsa-miR-30c-2-3p	PAR-CLIP	23446348
MIRT510105	hsa-miR-6788-5p	PAR-CLIP	23446348
MIRT510104	hsa-miR-1273h-5p	PAR-CLIP	23446348
MIRT510103	hsa-miR-30b-3p	PAR-CLIP	23446348
MIRT510102	hsa-miR-3689a-3p	PAR-CLIP	23446348
MIRT510101	hsa-miR-3689b-3p	PAR-CLIP	23446348
MIRT510100	hsa-miR-3689c	PAR-CLIP	23446348
MIRT510099	hsa-miR-6779-5p	PAR-CLIP	23446348
MIRT510098	hsa-miR-6780a-5p	PAR-CLIP	23446348
MIRT510097	hsa-miR-450a-1-3p	PAR-CLIP	23446348
MIRT510096	hsa-miR-3122	PAR-CLIP	23446348
MIRT510095	hsa-miR-3913-5p	PAR-CLIP	23446348
MIRT510094	hsa-miR-887-5p	PAR-CLIP	23446348
MIRT510093	hsa-miR-6513-5p	PAR-CLIP	23446348
MIRT510092	hsa-miR-1233-5p	PAR-CLIP	23446348
MIRT510122	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT510121	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT510120	hsa-miR-940	PAR-CLIP	23446348
MIRT510119	hsa-miR-4514	PAR-CLIP	23446348
MIRT510118	hsa-miR-4692	PAR-CLIP	23446348
MIRT510116	hsa-miR-3937	PAR-CLIP	23446348
MIRT510117	hsa-miR-4645-5p	PAR-CLIP	23446348
MIRT510115	hsa-miR-4673	PAR-CLIP	23446348
MIRT510114	hsa-miR-4755-3p	PAR-CLIP	23446348
MIRT510113	hsa-miR-7106-5p	PAR-CLIP	23446348
MIRT510112	hsa-miR-149-3p	PAR-CLIP	23446348
MIRT510111	hsa-miR-4728-5p	PAR-CLIP	23446348
MIRT510110	hsa-miR-6785-5p	PAR-CLIP	23446348
MIRT510108	hsa-miR-6883-5p	PAR-CLIP	23446348
MIRT510109	hsa-miR-6799-5p	PAR-CLIP	23446348
MIRT510107	hsa-miR-30c-1-3p	PAR-CLIP	23446348
MIRT510106	hsa-miR-30c-2-3p	PAR-CLIP	23446348
MIRT510105	hsa-miR-6788-5p	PAR-CLIP	23446348
MIRT510104	hsa-miR-1273h-5p	PAR-CLIP	23446348
MIRT510103	hsa-miR-30b-3p	PAR-CLIP	23446348
MIRT510102	hsa-miR-3689a-3p	PAR-CLIP	23446348
MIRT510101	hsa-miR-3689b-3p	PAR-CLIP	23446348
MIRT510100	hsa-miR-3689c	PAR-CLIP	23446348
MIRT510099	hsa-miR-6779-5p	PAR-CLIP	23446348
MIRT510098	hsa-miR-6780a-5p	PAR-CLIP	23446348
MIRT510097	hsa-miR-450a-1-3p	PAR-CLIP	23446348
MIRT510096	hsa-miR-3122	PAR-CLIP	23446348
MIRT510095	hsa-miR-3913-5p	PAR-CLIP	23446348
MIRT510094	hsa-miR-887-5p	PAR-CLIP	23446348
MIRT510093	hsa-miR-6513-5p	PAR-CLIP	23446348
MIRT510092	hsa-miR-1233-5p	PAR-CLIP	23446348
MIRT664811	hsa-miR-4486	HITS-CLIP	23824327
MIRT670949	hsa-miR-605-3p	HITS-CLIP	23824327
MIRT664810	hsa-miR-4493	HITS-CLIP	23824327
MIRT649846	hsa-miR-4284	HITS-CLIP	23824327
MIRT649845	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT664809	hsa-miR-4505	HITS-CLIP	23824327
MIRT664808	hsa-miR-5787	HITS-CLIP	23824327
MIRT664807	hsa-miR-3178	HITS-CLIP	23824327
MIRT649844	hsa-miR-7977	HITS-CLIP	23824327
MIRT664806	hsa-miR-6126	HITS-CLIP	23824327
MIRT664805	hsa-miR-4508	HITS-CLIP	23824327
MIRT519130	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT664811	hsa-miR-4486	HITS-CLIP	23824327
MIRT670949	hsa-miR-605-3p	HITS-CLIP	23824327
MIRT664810	hsa-miR-4493	HITS-CLIP	23824327
MIRT649846	hsa-miR-4284	HITS-CLIP	23824327
MIRT649845	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT664809	hsa-miR-4505	HITS-CLIP	23824327
MIRT664808	hsa-miR-5787	HITS-CLIP	23824327
MIRT664807	hsa-miR-3178	HITS-CLIP	23824327
MIRT649844	hsa-miR-7977	HITS-CLIP	23824327
MIRT664806	hsa-miR-6126	HITS-CLIP	23824327
MIRT664805	hsa-miR-4508	HITS-CLIP	23824327
MIRT510122	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT510121	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT510120	hsa-miR-940	HITS-CLIP	23824327
MIRT519130	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT510119	hsa-miR-4514	HITS-CLIP	23824327
MIRT510118	hsa-miR-4692	HITS-CLIP	23824327
MIRT510116	hsa-miR-3937	HITS-CLIP	23824327
MIRT510117	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT510115	hsa-miR-4673	HITS-CLIP	23824327
MIRT664811	hsa-miR-4486	HITS-CLIP	23824327
MIRT664810	hsa-miR-4493	HITS-CLIP	23824327
MIRT649846	hsa-miR-4284	HITS-CLIP	23824327
MIRT649845	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT664809	hsa-miR-4505	HITS-CLIP	23824327
MIRT664808	hsa-miR-5787	HITS-CLIP	23824327
MIRT510113	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT510112	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT510111	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT510110	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT510108	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT510109	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT664807	hsa-miR-3178	HITS-CLIP	23824327
MIRT649844	hsa-miR-7977	HITS-CLIP	23824327
MIRT664806	hsa-miR-6126	HITS-CLIP	23824327
MIRT510107	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT510106	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT510105	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT510104	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT510103	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT510102	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT510101	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT510100	hsa-miR-3689c	HITS-CLIP	23824327
MIRT510099	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT510098	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT510097	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT510096	hsa-miR-3122	HITS-CLIP	23824327
MIRT510095	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT510094	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT510093	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT510092	hsa-miR-1233-5p	HITS-CLIP	23824327
MIRT664805	hsa-miR-4508	HITS-CLIP	23824327
MIRT510122	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT510121	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT510120	hsa-miR-940	HITS-CLIP	23824327
MIRT519130	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT510119	hsa-miR-4514	HITS-CLIP	23824327
MIRT510118	hsa-miR-4692	HITS-CLIP	23824327
MIRT510117	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT510115	hsa-miR-4673	HITS-CLIP	23824327
MIRT510114	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT649846	hsa-miR-4284	HITS-CLIP	23824327
MIRT649845	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT510113	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT510112	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT510111	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT510110	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT510108	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT510109	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT649844	hsa-miR-7977	HITS-CLIP	23824327
MIRT510107	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT510106	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT510105	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT510104	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT510103	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT510102	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT510101	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT510100	hsa-miR-3689c	HITS-CLIP	23824327
MIRT510099	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT510098	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT510097	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT510096	hsa-miR-3122	HITS-CLIP	23824327
MIRT510095	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT510094	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT510093	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT510092	hsa-miR-1233-5p	HITS-CLIP	23824327
MIRT510122	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT510121	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT510120	hsa-miR-940	PAR-CLIP	20371350
MIRT510119	hsa-miR-4514	PAR-CLIP	20371350
MIRT510118	hsa-miR-4692	PAR-CLIP	20371350
MIRT510116	hsa-miR-3937	PAR-CLIP	20371350
MIRT510117	hsa-miR-4645-5p	PAR-CLIP	20371350
MIRT510115	hsa-miR-4673	PAR-CLIP	20371350
MIRT510114	hsa-miR-4755-3p	PAR-CLIP	20371350
MIRT510113	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT510112	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT510111	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT510110	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT510108	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT510109	hsa-miR-6799-5p	PAR-CLIP	20371350
MIRT510107	hsa-miR-30c-1-3p	PAR-CLIP	20371350
MIRT510106	hsa-miR-30c-2-3p	PAR-CLIP	20371350
MIRT510105	hsa-miR-6788-5p	PAR-CLIP	20371350
MIRT510104	hsa-miR-1273h-5p	PAR-CLIP	20371350
MIRT510103	hsa-miR-30b-3p	PAR-CLIP	20371350
MIRT510102	hsa-miR-3689a-3p	PAR-CLIP	20371350
MIRT510101	hsa-miR-3689b-3p	PAR-CLIP	20371350
MIRT510100	hsa-miR-3689c	PAR-CLIP	20371350
MIRT510099	hsa-miR-6779-5p	PAR-CLIP	20371350
MIRT510098	hsa-miR-6780a-5p	PAR-CLIP	20371350
MIRT510097	hsa-miR-450a-1-3p	PAR-CLIP	20371350
MIRT510096	hsa-miR-3122	PAR-CLIP	20371350
MIRT510095	hsa-miR-3913-5p	PAR-CLIP	20371350
MIRT510094	hsa-miR-887-5p	PAR-CLIP	20371350
MIRT510093	hsa-miR-6513-5p	PAR-CLIP	20371350
MIRT510092	hsa-miR-1233-5p	PAR-CLIP	20371350
MIRT510122	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT510121	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT510120	hsa-miR-940	PAR-CLIP	21572407
MIRT510119	hsa-miR-4514	PAR-CLIP	21572407
MIRT510118	hsa-miR-4692	PAR-CLIP	21572407
MIRT510116	hsa-miR-3937	PAR-CLIP	21572407
MIRT510117	hsa-miR-4645-5p	PAR-CLIP	21572407
MIRT510115	hsa-miR-4673	PAR-CLIP	21572407
MIRT510114	hsa-miR-4755-3p	PAR-CLIP	21572407
MIRT510113	hsa-miR-7106-5p	PAR-CLIP	21572407
MIRT510112	hsa-miR-149-3p	PAR-CLIP	21572407
MIRT510111	hsa-miR-4728-5p	PAR-CLIP	21572407
MIRT510110	hsa-miR-6785-5p	PAR-CLIP	21572407
MIRT510108	hsa-miR-6883-5p	PAR-CLIP	21572407
MIRT510109	hsa-miR-6799-5p	PAR-CLIP	21572407
MIRT510107	hsa-miR-30c-1-3p	PAR-CLIP	21572407
MIRT510106	hsa-miR-30c-2-3p	PAR-CLIP	21572407
MIRT510105	hsa-miR-6788-5p	PAR-CLIP	21572407
MIRT510104	hsa-miR-1273h-5p	PAR-CLIP	21572407
MIRT510103	hsa-miR-30b-3p	PAR-CLIP	21572407
MIRT510102	hsa-miR-3689a-3p	PAR-CLIP	21572407
MIRT510101	hsa-miR-3689b-3p	PAR-CLIP	21572407
MIRT510100	hsa-miR-3689c	PAR-CLIP	21572407
MIRT510099	hsa-miR-6779-5p	PAR-CLIP	21572407
MIRT510098	hsa-miR-6780a-5p	PAR-CLIP	21572407
MIRT510097	hsa-miR-450a-1-3p	PAR-CLIP	21572407
MIRT510096	hsa-miR-3122	PAR-CLIP	21572407
MIRT510095	hsa-miR-3913-5p	PAR-CLIP	21572407
MIRT510094	hsa-miR-887-5p	PAR-CLIP	21572407
MIRT510093	hsa-miR-6513-5p	PAR-CLIP	21572407
MIRT510092	hsa-miR-1233-5p	PAR-CLIP	21572407
MIRT510122	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT510121	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT510120	hsa-miR-940	PAR-CLIP	23446348
MIRT519130	hsa-miR-383-3p	PAR-CLIP	23446348
MIRT510119	hsa-miR-4514	PAR-CLIP	23446348
MIRT510118	hsa-miR-4692	PAR-CLIP	23446348
MIRT510116	hsa-miR-3937	PAR-CLIP	23446348
MIRT510117	hsa-miR-4645-5p	PAR-CLIP	23446348
MIRT510115	hsa-miR-4673	PAR-CLIP	23446348
MIRT510114	hsa-miR-4755-3p	PAR-CLIP	23446348
MIRT510113	hsa-miR-7106-5p	PAR-CLIP	23446348
MIRT510112	hsa-miR-149-3p	PAR-CLIP	23446348
MIRT510111	hsa-miR-4728-5p	PAR-CLIP	23446348
MIRT510110	hsa-miR-6785-5p	PAR-CLIP	23446348
MIRT510108	hsa-miR-6883-5p	PAR-CLIP	23446348
MIRT510109	hsa-miR-6799-5p	PAR-CLIP	23446348
MIRT510107	hsa-miR-30c-1-3p	PAR-CLIP	23446348
MIRT510106	hsa-miR-30c-2-3p	PAR-CLIP	23446348
MIRT510105	hsa-miR-6788-5p	PAR-CLIP	23446348
MIRT510104	hsa-miR-1273h-5p	PAR-CLIP	23446348
MIRT510103	hsa-miR-30b-3p	PAR-CLIP	23446348
MIRT510102	hsa-miR-3689a-3p	PAR-CLIP	23446348
MIRT510101	hsa-miR-3689b-3p	PAR-CLIP	23446348
MIRT510100	hsa-miR-3689c	PAR-CLIP	23446348
MIRT510099	hsa-miR-6779-5p	PAR-CLIP	23446348
MIRT510098	hsa-miR-6780a-5p	PAR-CLIP	23446348
MIRT510097	hsa-miR-450a-1-3p	PAR-CLIP	23446348
MIRT510096	hsa-miR-3122	PAR-CLIP	23446348
MIRT510095	hsa-miR-3913-5p	PAR-CLIP	23446348
MIRT510094	hsa-miR-887-5p	PAR-CLIP	23446348
MIRT510093	hsa-miR-6513-5p	PAR-CLIP	23446348
MIRT510092	hsa-miR-1233-5p	PAR-CLIP	23446348
MIRT510122	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT510121	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT510120	hsa-miR-940	PAR-CLIP	23446348
MIRT510119	hsa-miR-4514	PAR-CLIP	23446348
MIRT510118	hsa-miR-4692	PAR-CLIP	23446348
MIRT510116	hsa-miR-3937	PAR-CLIP	23446348
MIRT510117	hsa-miR-4645-5p	PAR-CLIP	23446348
MIRT510115	hsa-miR-4673	PAR-CLIP	23446348
MIRT510114	hsa-miR-4755-3p	PAR-CLIP	23446348
MIRT510113	hsa-miR-7106-5p	PAR-CLIP	23446348
MIRT510112	hsa-miR-149-3p	PAR-CLIP	23446348
MIRT510111	hsa-miR-4728-5p	PAR-CLIP	23446348
MIRT510110	hsa-miR-6785-5p	PAR-CLIP	23446348
MIRT510108	hsa-miR-6883-5p	PAR-CLIP	23446348
MIRT510109	hsa-miR-6799-5p	PAR-CLIP	23446348
MIRT510107	hsa-miR-30c-1-3p	PAR-CLIP	23446348
MIRT510106	hsa-miR-30c-2-3p	PAR-CLIP	23446348
MIRT510105	hsa-miR-6788-5p	PAR-CLIP	23446348
MIRT510104	hsa-miR-1273h-5p	PAR-CLIP	23446348
MIRT510103	hsa-miR-30b-3p	PAR-CLIP	23446348
MIRT510102	hsa-miR-3689a-3p	PAR-CLIP	23446348
MIRT510101	hsa-miR-3689b-3p	PAR-CLIP	23446348
MIRT510100	hsa-miR-3689c	PAR-CLIP	23446348
MIRT510099	hsa-miR-6779-5p	PAR-CLIP	23446348
MIRT510098	hsa-miR-6780a-5p	PAR-CLIP	23446348
MIRT510097	hsa-miR-450a-1-3p	PAR-CLIP	23446348
MIRT510096	hsa-miR-3122	PAR-CLIP	23446348
MIRT510095	hsa-miR-3913-5p	PAR-CLIP	23446348
MIRT510094	hsa-miR-887-5p	PAR-CLIP	23446348
MIRT510093	hsa-miR-6513-5p	PAR-CLIP	23446348
MIRT510092	hsa-miR-1233-5p	PAR-CLIP	23446348
MIRT1070479	hsa-miR-1183	CLIP-seq
MIRT1070480	hsa-miR-1200	CLIP-seq
MIRT1070481	hsa-miR-1254	CLIP-seq
MIRT1070482	hsa-miR-1255a	CLIP-seq
MIRT1070483	hsa-miR-1255b	CLIP-seq
MIRT1070484	hsa-miR-1286	CLIP-seq
MIRT1070485	hsa-miR-1324	CLIP-seq
MIRT1070486	hsa-miR-143	CLIP-seq
MIRT1070487	hsa-miR-1827	CLIP-seq
MIRT1070488	hsa-miR-24	CLIP-seq
MIRT1070489	hsa-miR-3116	CLIP-seq
MIRT1070490	hsa-miR-3130-3p	CLIP-seq
MIRT1070491	hsa-miR-3137	CLIP-seq
MIRT1070492	hsa-miR-3200-3p	CLIP-seq
MIRT1070493	hsa-miR-3612	CLIP-seq
MIRT1070494	hsa-miR-3662	CLIP-seq
MIRT1070495	hsa-miR-3684	CLIP-seq
MIRT1070496	hsa-miR-376c	CLIP-seq
MIRT1070497	hsa-miR-3943	CLIP-seq
MIRT1070498	hsa-miR-4267	CLIP-seq
MIRT1070499	hsa-miR-4297	CLIP-seq
MIRT1070500	hsa-miR-4307	CLIP-seq
MIRT1070501	hsa-miR-4323	CLIP-seq
MIRT1070502	hsa-miR-4324	CLIP-seq
MIRT1070503	hsa-miR-4423-5p	CLIP-seq
MIRT1070504	hsa-miR-4436a	CLIP-seq
MIRT1070505	hsa-miR-4468	CLIP-seq
MIRT1070506	hsa-miR-4537	CLIP-seq
MIRT1070507	hsa-miR-4666-5p	CLIP-seq
MIRT1070508	hsa-miR-4683	CLIP-seq
MIRT1070509	hsa-miR-4722-3p	CLIP-seq
MIRT1070510	hsa-miR-4722-5p	CLIP-seq
MIRT1070511	hsa-miR-4746-3p	CLIP-seq
MIRT1070512	hsa-miR-4768-3p	CLIP-seq
MIRT1070513	hsa-miR-4770	CLIP-seq
MIRT1070514	hsa-miR-4777-5p	CLIP-seq
MIRT1070515	hsa-miR-4786-5p	CLIP-seq
MIRT1070516	hsa-miR-4792	CLIP-seq
MIRT1070517	hsa-miR-4793-3p	CLIP-seq
MIRT1070518	hsa-miR-4793-5p	CLIP-seq
MIRT1070519	hsa-miR-487a	CLIP-seq
MIRT1070520	hsa-miR-502-5p	CLIP-seq
MIRT1070521	hsa-miR-508-5p	CLIP-seq
MIRT1070522	hsa-miR-518d-5p	CLIP-seq
MIRT1070523	hsa-miR-519b-5p	CLIP-seq
MIRT1070524	hsa-miR-519c-5p	CLIP-seq
MIRT1070525	hsa-miR-520c-5p	CLIP-seq
MIRT1070526	hsa-miR-520f	CLIP-seq
MIRT1070527	hsa-miR-526a	CLIP-seq
MIRT1070528	hsa-miR-539	CLIP-seq
MIRT1070529	hsa-miR-544b	CLIP-seq
MIRT1070530	hsa-miR-580	CLIP-seq
MIRT1070531	hsa-miR-650	CLIP-seq
MIRT1070532	hsa-miR-766	CLIP-seq
MIRT1070533	hsa-miR-889	CLIP-seq
MIRT1070534	hsa-miR-1224-3p	CLIP-seq
MIRT1070535	hsa-miR-1260	CLIP-seq
MIRT1070536	hsa-miR-1260b	CLIP-seq
MIRT1070537	hsa-miR-1280	CLIP-seq
MIRT1070485	hsa-miR-1324	CLIP-seq
MIRT1070538	hsa-miR-139-5p	CLIP-seq
MIRT1070539	hsa-miR-1908	CLIP-seq
MIRT1070540	hsa-miR-2114	CLIP-seq
MIRT1070541	hsa-miR-3174	CLIP-seq
MIRT1070542	hsa-miR-3613-3p	CLIP-seq
MIRT1070543	hsa-miR-3677-5p	CLIP-seq
MIRT1070544	hsa-miR-425	CLIP-seq
MIRT1070545	hsa-miR-4272	CLIP-seq
MIRT1070546	hsa-miR-4502	CLIP-seq
MIRT1070547	hsa-miR-4684-5p	CLIP-seq
MIRT1070548	hsa-miR-4700-3p	CLIP-seq
MIRT1070549	hsa-miR-4762-3p	CLIP-seq
MIRT1070550	hsa-miR-4767	CLIP-seq
MIRT1070551	hsa-miR-4790-3p	CLIP-seq
MIRT1070552	hsa-miR-4797-5p	CLIP-seq
MIRT1070553	hsa-miR-548c-3p	CLIP-seq
MIRT1070554	hsa-miR-566	CLIP-seq
MIRT1070555	hsa-miR-582-5p	CLIP-seq
MIRT1070556	hsa-miR-585	CLIP-seq
MIRT1070557	hsa-miR-633	CLIP-seq
MIRT1070558	hsa-miR-663	CLIP-seq
MIRT2017328	hsa-miR-1270	CLIP-seq
MIRT2017329	hsa-miR-185	CLIP-seq
MIRT2017330	hsa-miR-3125	CLIP-seq
MIRT2017331	hsa-miR-3189-3p	CLIP-seq
MIRT1070542	hsa-miR-3613-3p	CLIP-seq
MIRT2017332	hsa-miR-3647-3p	CLIP-seq
MIRT2017333	hsa-miR-3714	CLIP-seq
MIRT2017334	hsa-miR-3916	CLIP-seq
MIRT2017335	hsa-miR-4306	CLIP-seq
MIRT2017336	hsa-miR-432	CLIP-seq
MIRT2017337	hsa-miR-4448	CLIP-seq
MIRT2017338	hsa-miR-4531	CLIP-seq
MIRT2017339	hsa-miR-4644	CLIP-seq
MIRT1070553	hsa-miR-548c-3p	CLIP-seq
MIRT2017340	hsa-miR-620	CLIP-seq
MIRT2249220	hsa-miR-1227	CLIP-seq
MIRT2249221	hsa-miR-1245	CLIP-seq
MIRT1070481	hsa-miR-1254	CLIP-seq
MIRT1070482	hsa-miR-1255a	CLIP-seq
MIRT1070483	hsa-miR-1255b	CLIP-seq
MIRT2249222	hsa-miR-1266	CLIP-seq
MIRT2249223	hsa-miR-1267	CLIP-seq
MIRT2249224	hsa-miR-1305	CLIP-seq
MIRT1070485	hsa-miR-1324	CLIP-seq
MIRT1070489	hsa-miR-3116	CLIP-seq
MIRT2249225	hsa-miR-3127-3p	CLIP-seq
MIRT2249226	hsa-miR-3148	CLIP-seq
MIRT2249227	hsa-miR-3545-3p	CLIP-seq
MIRT2249228	hsa-miR-3616-5p	CLIP-seq
MIRT2017332	hsa-miR-3647-3p	CLIP-seq
MIRT2249229	hsa-miR-3647-5p	CLIP-seq
MIRT2249230	hsa-miR-3664-3p	CLIP-seq
MIRT2249231	hsa-miR-4252	CLIP-seq
MIRT2249232	hsa-miR-4282	CLIP-seq
MIRT2249233	hsa-miR-4420	CLIP-seq
MIRT2249234	hsa-miR-4484	CLIP-seq
MIRT2249235	hsa-miR-4518	CLIP-seq
MIRT2249236	hsa-miR-4539	CLIP-seq
MIRT2249237	hsa-miR-4724-5p	CLIP-seq
MIRT2249238	hsa-miR-4747-5p	CLIP-seq
MIRT1070512	hsa-miR-4768-3p	CLIP-seq
MIRT2249239	hsa-miR-4789-3p	CLIP-seq
MIRT1070517	hsa-miR-4793-3p	CLIP-seq
MIRT1070521	hsa-miR-508-5p	CLIP-seq
MIRT2249240	hsa-miR-548an	CLIP-seq
MIRT2249241	hsa-miR-573	CLIP-seq
MIRT2249242	hsa-miR-605	CLIP-seq
MIRT2249243	hsa-miR-635	CLIP-seq
MIRT2249244	hsa-miR-653	CLIP-seq
MIRT2249245	hsa-miR-660	CLIP-seq
MIRT2249246	hsa-miR-668	CLIP-seq
MIRT1070532	hsa-miR-766	CLIP-seq
MIRT2249247	hsa-miR-873	CLIP-seq
MIRT2249248	hsa-miR-875-3p	CLIP-seq
MIRT1070481	hsa-miR-1254	CLIP-seq
MIRT1070489	hsa-miR-3116	CLIP-seq
MIRT1070539	hsa-miR-1908	CLIP-seq
MIRT1070542	hsa-miR-3613-3p	CLIP-seq
MIRT1070543	hsa-miR-3677-5p	CLIP-seq
MIRT1070547	hsa-miR-4684-5p	CLIP-seq
MIRT1070550	hsa-miR-4767	CLIP-seq
MIRT1070553	hsa-miR-548c-3p	CLIP-seq
MIRT1070554	hsa-miR-566	CLIP-seq
MIRT1070556	hsa-miR-585	CLIP-seq
MIRT1070558	hsa-miR-663	CLIP-seq
MIRT2552769	hsa-miR-1185	CLIP-seq
MIRT1070481	hsa-miR-1254	CLIP-seq
MIRT1070482	hsa-miR-1255a	CLIP-seq
MIRT1070483	hsa-miR-1255b	CLIP-seq
MIRT2017329	hsa-miR-185	CLIP-seq
MIRT1070539	hsa-miR-1908	CLIP-seq
MIRT2552770	hsa-miR-204	CLIP-seq
MIRT2552771	hsa-miR-2052	CLIP-seq
MIRT2552772	hsa-miR-211	CLIP-seq
MIRT1070540	hsa-miR-2114	CLIP-seq
MIRT2552773	hsa-miR-219-5p	CLIP-seq
MIRT1070489	hsa-miR-3116	CLIP-seq
MIRT2552774	hsa-miR-3134	CLIP-seq
MIRT2552775	hsa-miR-323-3p	CLIP-seq
MIRT2552776	hsa-miR-3605-5p	CLIP-seq
MIRT1070542	hsa-miR-3613-3p	CLIP-seq
MIRT1070543	hsa-miR-3677-5p	CLIP-seq
MIRT2552777	hsa-miR-3679-5p	CLIP-seq
MIRT2552778	hsa-miR-371-5p	CLIP-seq
MIRT2552779	hsa-miR-371b-5p	CLIP-seq
MIRT2249231	hsa-miR-4252	CLIP-seq
MIRT2017335	hsa-miR-4306	CLIP-seq
MIRT2552780	hsa-miR-4445	CLIP-seq
MIRT2552781	hsa-miR-4464	CLIP-seq
MIRT2552782	hsa-miR-4477b	CLIP-seq
MIRT2552783	hsa-miR-4534	CLIP-seq
MIRT2017339	hsa-miR-4644	CLIP-seq
MIRT1070547	hsa-miR-4684-5p	CLIP-seq
MIRT2552784	hsa-miR-4748	CLIP-seq
MIRT1070550	hsa-miR-4767	CLIP-seq
MIRT2552785	hsa-miR-4782-3p	CLIP-seq
MIRT1070517	hsa-miR-4793-3p	CLIP-seq
MIRT2552786	hsa-miR-508-3p	CLIP-seq
MIRT1070521	hsa-miR-508-5p	CLIP-seq
MIRT1070553	hsa-miR-548c-3p	CLIP-seq
MIRT1070554	hsa-miR-566	CLIP-seq
MIRT1070556	hsa-miR-585	CLIP-seq
MIRT2552787	hsa-miR-647	CLIP-seq
MIRT1070558	hsa-miR-663	CLIP-seq
MIRT1070532	hsa-miR-766	CLIP-seq
MIRT1070539	hsa-miR-1908	CLIP-seq
MIRT1070540	hsa-miR-2114	CLIP-seq
MIRT1070542	hsa-miR-3613-3p	CLIP-seq
MIRT1070543	hsa-miR-3677-5p	CLIP-seq
MIRT1070547	hsa-miR-4684-5p	CLIP-seq
MIRT1070550	hsa-miR-4767	CLIP-seq
MIRT1070553	hsa-miR-548c-3p	CLIP-seq
MIRT1070554	hsa-miR-566	CLIP-seq
MIRT1070556	hsa-miR-585	CLIP-seq
MIRT1070558	hsa-miR-663	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IDA	10383454
GO:0000287	Function	Magnesium ion binding	IEA
GO:0001819	Process	Positive regulation of cytokine production	IEA
GO:0001960	Process	Negative regulation of cytokine-mediated signaling pathway	IC	12150927
GO:0001960	Process	Negative regulation of cytokine-mediated signaling pathway	IEA
GO:0002684	Process	Positive regulation of immune system process	IEA
GO:0002755	Process	MyD88-dependent toll-like receptor signaling pathway	TAS	10383454
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	10383454
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	29686383, 32296183
GO:0005524	Function	ATP binding	IDA	10383454
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	17379480
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	17379480
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0006468	Process	Protein phosphorylation	IDA	10383454
GO:0007165	Process	Signal transduction	IEA
GO:0008063	Process	Toll signaling pathway	IBA
GO:0009615	Process	Response to virus	IC	12150927
GO:0009615	Process	Response to virus	IEA
GO:0010933	Process	Positive regulation of macrophage tolerance induction	IEA
GO:0010933	Process	Positive regulation of macrophage tolerance induction	ISS	12150927
GO:0010936	Process	Negative regulation of macrophage cytokine production	IEA
GO:0010936	Process	Negative regulation of macrophage cytokine production	ISS	12150927
GO:0019221	Process	Cytokine-mediated signaling pathway	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	ISS
GO:0019901	Function	Protein kinase binding	IPI	33238146
GO:0031663	Process	Lipopolysaccharide-mediated signaling pathway	IBA
GO:0031663	Process	Lipopolysaccharide-mediated signaling pathway	IMP	18156187
GO:0032494	Process	Response to peptidoglycan	IEA
GO:0032494	Process	Response to peptidoglycan	ISS	12150927
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0032496	Process	Response to lipopolysaccharide	ISS	12150927
GO:0032695	Process	Negative regulation of interleukin-12 production	IEA
GO:0032695	Process	Negative regulation of interleukin-12 production	IMP	18156187
GO:0032695	Process	Negative regulation of interleukin-12 production	ISS	12150927
GO:0032715	Process	Negative regulation of interleukin-6 production	IEA
GO:0032715	Process	Negative regulation of interleukin-6 production	IMP	18156187
GO:0032715	Process	Negative regulation of interleukin-6 production	ISS	12150927
GO:0032720	Process	Negative regulation of tumor necrosis factor production	IEA
GO:0032720	Process	Negative regulation of tumor necrosis factor production	IMP	15728517
GO:0034122	Process	Negative regulation of toll-like receptor signaling pathway	IEA
GO:0034122	Process	Negative regulation of toll-like receptor signaling pathway	ISS	12150927
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0042177	Process	Negative regulation of protein catabolic process	IEA
GO:0042177	Process	Negative regulation of protein catabolic process	IMP	17379480
GO:0042803	Function	Protein homodimerization activity	IDA	33238146
GO:0042803	Function	Protein homodimerization activity	IPI	10383454
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IBA
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IMP	10383454
GO:0043242	Process	Negative regulation of protein-containing complex disassembly	IMP	12150927
GO:0043244	Process	Regulation of protein-containing complex disassembly	IEA
GO:0043244	Process	Regulation of protein-containing complex disassembly	ISS
GO:0043330	Process	Response to exogenous dsRNA	IEA
GO:0043330	Process	Response to exogenous dsRNA	ISS	12150927
GO:0043409	Process	Negative regulation of MAPK cascade	IEA
GO:0043409	Process	Negative regulation of MAPK cascade	IMP	17379480
GO:0045088	Process	Regulation of innate immune response	IEA
GO:0045824	Process	Negative regulation of innate immune response	IEA
GO:0045824	Process	Negative regulation of innate immune response	ISS	12150927
GO:0046982	Function	Protein heterodimerization activity	IPI	10383454
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IBA
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IEA
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IEA
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IMP	10383454
GO:0070555	Process	Response to interleukin-1	IMP	10383454

Other IDs

• MIM: 604459
• HGNC: 17020
• e!Ensembl: ENSG00000090376

Protein

• UniProt ID: Q9Y616
• Protein name: Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3)
• Protein function: Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling c
• PDB: 5UKE, 6RUU, 6ZIW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00531	Death	26 → 106	Death domain	Domain
  PF00069	Pkinase	165 → 443	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in eosinophils, dendritic cells and/or monocytes (at protein level) (PubMed:29686383). Expressed predominantly in peripheral blood lymphocytes (PubMed:10383454). {ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:29686383}.
• Sequence:

  MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEK
  YVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNYGAVLSPSEKSYQEGG
  FPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVY
  RVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLI
  YPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANIL
  LDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSF
  GIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFC
  LAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVE
  DDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCE
  ESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE

• Sequence length: 596

Pathways

KEGG:

Neurotrophin signaling pathway

Reactome:

MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Interleukin-1 signaling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Asthma-related traits, susceptibility to, 5	risk factor	ClinVar CTD, ClinVar, GenCC CTD, ClinVar, GenCC	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Familial cancer of breast	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hirschsprung disease, susceptibility to, 1	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IRAK3-related disorder	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Multisystem inflammatory syndrome in children	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	risk factor; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SMOOTH SURFACE DENTAL CARIES	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Susceptibility to severe COVID-19	Likely risk allele	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	32755048	Associate	★☆☆☆☆ Found in Text Mining only
Aortic Dissection	Aortic dissection	Pubtator	35178459	Associate	★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	LHGDN	17503328		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Asthma	Asthma	Pubtator	17503328, 33156843, 37029363	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Asthma	Asthma	BEFREE	19013233, 28665693, 30617222		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Asthma	Asthma	Pubtator	28223794	Stimulate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	25852282	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	21278795		★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Hypertrophic	Hypertrophic cardiomyopathy	Pubtator	38277535	Associate	★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Ischemic stroke	Pubtator	35432334	Associate	★☆☆☆☆ Found in Text Mining only
Chronic Kidney Diseases	Kidney Disease	BEFREE	28701510		★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	28713897		★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	25232259, 26462859	Stimulate	★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	36419192	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	27150039, 27939424		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	26462859		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	26462859	Associate	★☆☆☆☆ Found in Text Mining only
Dental caries of smooth surface	Dental caries	GWASCAT_DG	24556642		★☆☆☆☆ Found in Text Mining only
Dermatitis, Atopic	Dermatitis	BEFREE	19013233		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	28783585		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	28783585		★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	BEFREE	19013233		★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	Pubtator	40187212	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	26956052	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	19423540	Associate	★☆☆☆☆ Found in Text Mining only
Hemorrhage	Hemorrhage	Pubtator	23468366	Associate	★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	27939424		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	25852282		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	21278795		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	25481771	Associate	★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	29898456		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	21278795		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28713897		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	33373316	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Metabolic Syndrome	Metabolic syndrome	Pubtator	22272346, 37138862	Associate	★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	22272346		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	35432334	Associate	★☆☆☆☆ Found in Text Mining only
Necrotizing enterocolitis in fetus OR newborn	Necrotizing Enterocolitis	BEFREE	21445298		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	21278795, 25852282, 27150039		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	22272346		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	22272346	Inhibit	★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	31900140	Associate	★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	33658057, 37138862, 39849508	Associate	★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	BEFREE	17576820		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	31690262	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	28223794	Stimulate	★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	36655999	Associate	★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	27698401, 28607508		★☆☆☆☆ Found in Text Mining only
Sarcoidosis	Sarcoidosis	Pubtator	27402699	Stimulate	★☆☆☆☆ Found in Text Mining only
Sepsis	Sepsis	Pubtator	21297081	Associate	★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	21297081, 21811575, 23588345, 29257295, 29434744		★☆☆☆☆ Found in Text Mining only
ST segment elevation myocardial infarction	ST Segment Elevation Myocardial Infarction	BEFREE	26025919		★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	23468366	Associate	★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	LHGDN	17558906		★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	25232259, 26462859		★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	40755754	Associate	★☆☆☆☆ Found in Text Mining only