Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	11179
Gene name	Zinc finger protein 277
Gene symbol	ZNF277
Synonyms (NCBI Gene)	NRIF4ZNF277P
Chromosome	7
Chromosome location	7q31.1

196

Show/Hide all (196)

miRTarBase ID	miRNA	Experiments	Reference
MIRT663217	hsa-miR-1197	HITS-CLIP	23824327
MIRT646293	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT663216	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT663215	hsa-miR-4751	HITS-CLIP	23824327
MIRT663214	hsa-miR-4316	HITS-CLIP	23824327
MIRT663213	hsa-miR-1294	HITS-CLIP	23824327
MIRT663212	hsa-miR-1224-5p	HITS-CLIP	23824327
MIRT646292	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT646291	hsa-miR-4646-3p	HITS-CLIP	23824327
MIRT646290	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT646293	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT646292	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT646291	hsa-miR-4646-3p	HITS-CLIP	23824327
MIRT646290	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT572787	hsa-miR-548u	PAR-CLIP	20371350
MIRT572786	hsa-miR-7161-5p	PAR-CLIP	20371350
MIRT572785	hsa-miR-8087	PAR-CLIP	20371350
MIRT572784	hsa-miR-143-3p	PAR-CLIP	20371350
MIRT572783	hsa-miR-4770	PAR-CLIP	20371350
MIRT572782	hsa-miR-6088	PAR-CLIP	20371350
MIRT572781	hsa-miR-4708-5p	PAR-CLIP	20371350
MIRT572780	hsa-miR-1273f	PAR-CLIP	20371350
MIRT572779	hsa-miR-8055	PAR-CLIP	20371350
MIRT572778	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT563628	hsa-miR-508-5p	PAR-CLIP	20371350
MIRT563627	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT563626	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT563625	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT563624	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT563623	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT563622	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT563621	hsa-miR-6849-3p	PAR-CLIP	20371350
MIRT563620	hsa-miR-766-3p	PAR-CLIP	20371350
MIRT563619	hsa-miR-3192-5p	PAR-CLIP	20371350
MIRT563618	hsa-miR-4524a-3p	PAR-CLIP	20371350
MIRT563617	hsa-miR-767-5p	PAR-CLIP	20371350
MIRT516632	hsa-miR-661	PAR-CLIP	20371350
MIRT563616	hsa-miR-6878-5p	PAR-CLIP	20371350
MIRT563615	hsa-miR-6731-5p	PAR-CLIP	20371350
MIRT563614	hsa-miR-8085	PAR-CLIP	20371350
MIRT563613	hsa-miR-6512-3p	PAR-CLIP	20371350
MIRT563612	hsa-miR-6720-5p	PAR-CLIP	20371350
MIRT516627	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT563611	hsa-miR-500a-3p	PAR-CLIP	20371350
MIRT563610	hsa-miR-7703	PAR-CLIP	20371350
MIRT563608	hsa-miR-4325	PAR-CLIP	20371350
MIRT563609	hsa-miR-30c-1-3p	PAR-CLIP	20371350
MIRT563607	hsa-miR-30c-2-3p	PAR-CLIP	20371350
MIRT563605	hsa-miR-6788-5p	PAR-CLIP	20371350
MIRT563606	hsa-miR-7113-5p	PAR-CLIP	20371350
MIRT516637	hsa-miR-4438	PAR-CLIP	23446348
MIRT516636	hsa-miR-3064-5p	PAR-CLIP	23446348
MIRT516635	hsa-miR-6504-5p	PAR-CLIP	23446348
MIRT516634	hsa-miR-1254	PAR-CLIP	23446348
MIRT516633	hsa-miR-3116	PAR-CLIP	23446348
MIRT516632	hsa-miR-661	PAR-CLIP	23446348
MIRT516631	hsa-miR-1271-3p	PAR-CLIP	23446348
MIRT516630	hsa-miR-550a-3-5p	PAR-CLIP	23446348
MIRT516629	hsa-miR-550a-5p	PAR-CLIP	23446348
MIRT516628	hsa-miR-5095	PAR-CLIP	23446348
MIRT516626	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT516627	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT663217	hsa-miR-1197	HITS-CLIP	23824327
MIRT646293	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT663216	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT663215	hsa-miR-4751	HITS-CLIP	23824327
MIRT663214	hsa-miR-4316	HITS-CLIP	23824327
MIRT663213	hsa-miR-1294	HITS-CLIP	23824327
MIRT663212	hsa-miR-1224-5p	HITS-CLIP	23824327
MIRT646292	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT646291	hsa-miR-4646-3p	HITS-CLIP	23824327
MIRT646290	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT646293	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT646292	hsa-miR-676-3p	HITS-CLIP	23824327
MIRT646291	hsa-miR-4646-3p	HITS-CLIP	23824327
MIRT646290	hsa-miR-2355-3p	HITS-CLIP	23824327
MIRT572787	hsa-miR-548u	PAR-CLIP	20371350
MIRT572786	hsa-miR-7161-5p	PAR-CLIP	20371350
MIRT572785	hsa-miR-8087	PAR-CLIP	20371350
MIRT572784	hsa-miR-143-3p	PAR-CLIP	20371350
MIRT572783	hsa-miR-4770	PAR-CLIP	20371350
MIRT572782	hsa-miR-6088	PAR-CLIP	20371350
MIRT572781	hsa-miR-4708-5p	PAR-CLIP	20371350
MIRT572780	hsa-miR-1273f	PAR-CLIP	20371350
MIRT572779	hsa-miR-8055	PAR-CLIP	20371350
MIRT572778	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT563628	hsa-miR-508-5p	PAR-CLIP	20371350
MIRT563627	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT563626	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT563625	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT563624	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT563623	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT563622	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT563621	hsa-miR-6849-3p	PAR-CLIP	20371350
MIRT563620	hsa-miR-766-3p	PAR-CLIP	20371350
MIRT563619	hsa-miR-3192-5p	PAR-CLIP	20371350
MIRT563618	hsa-miR-4524a-3p	PAR-CLIP	20371350
MIRT563617	hsa-miR-767-5p	PAR-CLIP	20371350
MIRT516632	hsa-miR-661	PAR-CLIP	20371350
MIRT563616	hsa-miR-6878-5p	PAR-CLIP	20371350
MIRT563615	hsa-miR-6731-5p	PAR-CLIP	20371350
MIRT563614	hsa-miR-8085	PAR-CLIP	20371350
MIRT563613	hsa-miR-6512-3p	PAR-CLIP	20371350
MIRT563612	hsa-miR-6720-5p	PAR-CLIP	20371350
MIRT516627	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT563611	hsa-miR-500a-3p	PAR-CLIP	20371350
MIRT563610	hsa-miR-7703	PAR-CLIP	20371350
MIRT563608	hsa-miR-4325	PAR-CLIP	20371350
MIRT563609	hsa-miR-30c-1-3p	PAR-CLIP	20371350
MIRT563607	hsa-miR-30c-2-3p	PAR-CLIP	20371350
MIRT563605	hsa-miR-6788-5p	PAR-CLIP	20371350
MIRT563606	hsa-miR-7113-5p	PAR-CLIP	20371350
MIRT516637	hsa-miR-4438	PAR-CLIP	23446348
MIRT516636	hsa-miR-3064-5p	PAR-CLIP	23446348
MIRT516635	hsa-miR-6504-5p	PAR-CLIP	23446348
MIRT516634	hsa-miR-1254	PAR-CLIP	23446348
MIRT516633	hsa-miR-3116	PAR-CLIP	23446348
MIRT516632	hsa-miR-661	PAR-CLIP	23446348
MIRT516631	hsa-miR-1271-3p	PAR-CLIP	23446348
MIRT516630	hsa-miR-550a-3-5p	PAR-CLIP	23446348
MIRT516629	hsa-miR-550a-5p	PAR-CLIP	23446348
MIRT516628	hsa-miR-5095	PAR-CLIP	23446348
MIRT516626	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT516627	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT1520627	hsa-miR-150	CLIP-seq
MIRT1520628	hsa-miR-1909	CLIP-seq
MIRT1520629	hsa-miR-2110	CLIP-seq
MIRT1520630	hsa-miR-218	CLIP-seq
MIRT1520631	hsa-miR-3150a-3p	CLIP-seq
MIRT1520632	hsa-miR-3150b-3p	CLIP-seq
MIRT1520633	hsa-miR-3157-5p	CLIP-seq
MIRT1520634	hsa-miR-3175	CLIP-seq
MIRT1520635	hsa-miR-3189-3p	CLIP-seq
MIRT1520636	hsa-miR-3606	CLIP-seq
MIRT1520637	hsa-miR-3671	CLIP-seq
MIRT1520638	hsa-miR-369-3p	CLIP-seq
MIRT1520639	hsa-miR-374a	CLIP-seq
MIRT1520640	hsa-miR-374b	CLIP-seq
MIRT1520641	hsa-miR-3977	CLIP-seq
MIRT1520642	hsa-miR-4272	CLIP-seq
MIRT1520643	hsa-miR-4499	CLIP-seq
MIRT1520644	hsa-miR-450b-5p	CLIP-seq
MIRT1520645	hsa-miR-4668-5p	CLIP-seq
MIRT1520646	hsa-miR-4738-3p	CLIP-seq
MIRT1520647	hsa-miR-4784	CLIP-seq
MIRT1520648	hsa-miR-507	CLIP-seq
MIRT1520649	hsa-miR-557	CLIP-seq
MIRT1520650	hsa-miR-578	CLIP-seq
MIRT1520651	hsa-miR-581	CLIP-seq
MIRT1520652	hsa-miR-606	CLIP-seq
MIRT1520653	hsa-miR-607	CLIP-seq
MIRT1520654	hsa-miR-636	CLIP-seq
MIRT1520655	hsa-miR-653	CLIP-seq
MIRT1520656	hsa-miR-664	CLIP-seq
MIRT1520657	hsa-miR-765	CLIP-seq
MIRT1520658	hsa-miR-891b	CLIP-seq
MIRT1520659	hsa-miR-921	CLIP-seq
MIRT1520660	hsa-miR-939	CLIP-seq
MIRT2157165	hsa-miR-1297	CLIP-seq
MIRT2157166	hsa-miR-1305	CLIP-seq
MIRT2157167	hsa-miR-26a	CLIP-seq
MIRT2157168	hsa-miR-26b	CLIP-seq
MIRT2157169	hsa-miR-4307	CLIP-seq
MIRT2157170	hsa-miR-4464	CLIP-seq
MIRT2157171	hsa-miR-4465	CLIP-seq
MIRT2157172	hsa-miR-4659a-3p	CLIP-seq
MIRT2157173	hsa-miR-4659b-3p	CLIP-seq
MIRT2157174	hsa-miR-4748	CLIP-seq
MIRT2157175	hsa-miR-498	CLIP-seq
MIRT1520658	hsa-miR-891b	CLIP-seq
MIRT2376832	hsa-miR-3152-5p	CLIP-seq
MIRT2376833	hsa-miR-3690	CLIP-seq
MIRT2376834	hsa-miR-4254	CLIP-seq
MIRT2376835	hsa-miR-4320	CLIP-seq
MIRT2376836	hsa-miR-4528	CLIP-seq
MIRT2376837	hsa-miR-4774-3p	CLIP-seq
MIRT2157175	hsa-miR-498	CLIP-seq
MIRT1520658	hsa-miR-891b	CLIP-seq
MIRT1520628	hsa-miR-1909	CLIP-seq
MIRT2668929	hsa-miR-340	CLIP-seq
MIRT2668930	hsa-miR-3609	CLIP-seq
MIRT1520645	hsa-miR-4668-5p	CLIP-seq
MIRT2668931	hsa-miR-4670-3p	CLIP-seq
MIRT2668932	hsa-miR-548ah	CLIP-seq
MIRT2668933	hsa-miR-548c-3p	CLIP-seq
MIRT2668934	hsa-miR-548t	CLIP-seq
MIRT1520628	hsa-miR-1909	CLIP-seq
MIRT2695887	hsa-miR-2964a-5p	CLIP-seq
MIRT2668930	hsa-miR-3609	CLIP-seq
MIRT1520645	hsa-miR-4668-5p	CLIP-seq
MIRT2668931	hsa-miR-4670-3p	CLIP-seq
MIRT2695888	hsa-miR-4796-5p	CLIP-seq
MIRT2668932	hsa-miR-548ah	CLIP-seq
MIRT2668934	hsa-miR-548t	CLIP-seq
MIRT2695889	hsa-miR-582-3p	CLIP-seq
MIRT2695890	hsa-miR-892b	CLIP-seq

Show/Hide all (7)

GO ID	Ontology	Definition	Evidence
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070301	Process	Cellular response to hydrogen peroxide	IEA
GO:2000772	Process	Regulation of cellular senescence	IEA

MIM	HGNC	e!Ensembl
605465	13070	ENSG00000198839

Q9NRM2

Protein name

Zinc finger protein 277 (Nuclear receptor-interacting factor 4)

Protein function

Probable transcription factor. Involved in modulation of cellular senescence; represses transcription of the tumor suppressor gene INK4A/ARF, perhaps acting via the Polycomb group (PcG) complex PRC1.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12756	zf-C2H2_2	58 → 128	C2H2 type zinc-finger (2 copies)	Family
PF12756	zf-C2H2_2	172 → 269	C2H2 type zinc-finger (2 copies)	Family
PF12756	zf-C2H2_2	301 → 406	C2H2 type zinc-finger (2 copies)	Family

Sequence

MAASKTQGAVARMQEDRDGSCSTVGGVGYGDSKDCILEPLSLPESPGGTTTLEGSPSVPC
IFCEEHFPVAEQDKLLKHMIIEHKIVIADVKLVADFQRYILYWRKRFTEQPITDFCSVIR
INSTAPFEEQENYFLLCDVLPEDRILREELQKQRLREILEQQQQERNDTNFHGVCMFCNE
EFLGNRSVILNHMAREHAFNIGLPDNIVNCNEFLCTLQKKLDNLQCLYCEKTFRDKNTLK
DHMRKKQHRKINPKNREYDRFYVINYLELGKSWEEVQLEDDRELLDHQEDDWSDWEEHPA
SAVCLFCEKQAETIEKLYVHMEDAHEFDLLKIKSELGLNFYQQVKLVNFIRRQVHQCRCY
GCHVKFKSKADLRTHMEETKHTSLLPDRKTWDQLEYYFPTYENDTLLCTLSDSESDLTAQ
EQNENVPIISEDTSKLYALKQSSILNQLLL

Sequence length

450

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Colon adenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DENTAL CARIES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (13)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autism Spectrum Disorder	Autism	Pubtator	24518835	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	BEFREE	24518835		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	24518835	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	31114246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	24694019		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	BEFREE	24694019		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	31114246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	24694019		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	24694019		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	31114246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Specific Language Disorder	Specific language disorder	Pubtator	24518835	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Specific language impairment	Specific Language Impairment	BEFREE	24518835		★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNF277 (zinc finger protein 277)