Gene Gene information from NCBI Gene database.
Entrez ID 11165
Gene name Nudix hydrolase 3
Gene symbol NUDT3
Synonyms (NCBI Gene)
DIPPDIPP-1DIPP1
Chromosome 6
Chromosome location 6p21.31
Summary NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, wh
miRNA miRNA information provided by mirtarbase database.
676
miRTarBase ID miRNA Experiments Reference
MIRT051285 hsa-miR-16-5p CLASH 23622248
MIRT039048 hsa-miR-766-3p CLASH 23622248
MIRT720377 hsa-miR-548e-5p HITS-CLIP 19536157
MIRT720376 hsa-miR-6835-3p HITS-CLIP 19536157
MIRT720375 hsa-miR-1179 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
47
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IDA 19585659, 34788624
GO:0000298 Function Endopolyphosphatase activity IBA
GO:0000298 Function Endopolyphosphatase activity IDA 34788624
GO:0000298 Function Endopolyphosphatase activity IEA
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609228 8050 ENSG00000272325
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95989
Protein name Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine hexaphosphate hydrolase) (Ap6A hydrolase) (EC 3.6.1.61) (Endopolyphosphatase) (EC 3.6.1.10) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3) (m7GpppN-mR
Protein function Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:10585413, PubMed:1
PDB 2FVV , 2Q9P , 6PCK , 6PCL , 6WO7 , 6WO8 , 6WO9 , 6WOA , 6WOB , 6WOC , 6WOD , 6WOE , 6WOF , 6WOG , 6WOH , 6WOI , 7TN4 , 8G9C , 8G9D , 8T98 , 8T99 , 8TF9 , 8TFA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00293 NUDIX 16 143 NUDIX domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney. {ECO:0000269|PubMed:9822604}.
Sequence
Sequence length 172
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Synthesis of pyrophosphates in the cytosol
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Attention deficit hyperactivity disorder Attention Deficit Hyperactivity Disorder BEFREE 23533005
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 26932476 Associate
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus BEFREE 19473815
★☆☆☆☆
Found in Text Mining only
Endometrial Neoplasms Endometrial neoplasm Pubtator 36335189 Associate
★☆☆☆☆
Found in Text Mining only
Epilepsy Epilepsy Pubtator 40658715 Associate
★☆☆☆☆
Found in Text Mining only
Obesity Obesity BEFREE 22041983, 26168034
★☆☆☆☆
Found in Text Mining only
Obesity Obesity Pubtator 23539184, 23708086, 24885863, 26449484, 33198820 Associate
★☆☆☆☆
Found in Text Mining only
Sarcopenia Sarcopenia Pubtator 32093658, 35241739 Associate
★☆☆☆☆
Found in Text Mining only