Gene Gene information from NCBI Gene database.
Entrez ID 11163
Gene name Nudix hydrolase 4
Gene symbol NUDT4
Synonyms (NCBI Gene)
DIPP-2BDIPP2DIPP2alphaDIPP2betaHDCMB47PNUDT4B
Chromosome 12
Chromosome location 12q22
Summary The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular swi
miRNA miRNA information provided by mirtarbase database.
1157
miRTarBase ID miRNA Experiments Reference
MIRT052476 hsa-let-7a-5p CLASH 23622248
MIRT051407 hsa-let-7f-5p CLASH 23622248
MIRT275277 hsa-miR-548c-3p HITS-CLIP 21572407
MIRT708007 hsa-miR-6732-3p HITS-CLIP 21572407
MIRT708006 hsa-miR-10a-5p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28
GO ID Ontology Definition Evidence Reference
GO:0000298 Function Endopolyphosphatase activity IBA
GO:0003723 Function RNA binding IEA
GO:0005515 Function Protein binding IPI 25416956, 32814053
GO:0005634 Component Nucleus IBA
GO:0005737 Component Cytoplasm IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609229 8051 ENSG00000173598
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NZJ9
Protein name Diphosphoinositol polyphosphate phosphohydrolase 2 (DIPP-2) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2) (EC 3.6.1.61) (Nucleoside diphosphate-linked moiety X motif 4) (Nudix motif 4)
Protein function Cleaves the beta-phosphate from diphosphoinositol polyphosphates such as PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 (diphosphoinositol tetrakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it
PDB 5LTU , 7NNJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00293 NUDIX 17 143 NUDIX domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in heart and, at lower level in skeletal muscle, pancreas and kidney. {ECO:0000269|PubMed:10777568}.
Sequence
Sequence length 180
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Synthesis of pyrophosphates in the cytosol
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COLORECTAL CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SPORADIC AMYOTROPHIC LATERAL SCLEROSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Heart Failure Heart failure Pubtator 36782329 Associate
★☆☆☆☆
Found in Text Mining only
Pancreatic Neoplasms Pancreatic neoplasm Pubtator 38297362 Associate
★☆☆☆☆
Found in Text Mining only