MMP24-AS1-EDEM2 (-)

Gene

• Entrez ID: 111089941
• Gene name: -
• Gene symbol: MMP24-AS1-EDEM2
• Synonyms (NCBI Gene): -
• Chromosome: 20
• Chromosome location: 20q11.22
• Summary: This record represents naturally-occurring readthrough transcription between upstream GeneID:101410538 (MMP24 antisense RNA 1) and the ER degradation enhancing alpha-mannosidase like protein 2 (EDEM2) gene. Readthrough transcripts may encode proteins simi

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004571	Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IDA	15537790
GO:0004571	Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IMP	25092655
GO:0004571	Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS
GO:0005509	Function	Calcium ion binding	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	15537790, 24200403
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	IEA
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006986	Process	Response to unfolded protein	IEA
GO:0009100	Process	Glycoprotein metabolic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0019082	Process	Viral protein processing	TAS
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	IBA
GO:0036503	Process	ERAD pathway	IMP	15537790, 25092655
GO:0044322	Component	Endoplasmic reticulum quality control compartment	TAS
GO:0097466	Process	Ubiquitin-dependent glycoprotein ERAD pathway	IBA
GO:1904154	Process	Positive regulation of retrograde protein transport, ER to cytosol	IEA
GO:1904154	Process	Positive regulation of retrograde protein transport, ER to cytosol	IGI	24200403
GO:1904154	Process	Positive regulation of retrograde protein transport, ER to cytosol	IMP	24200403
GO:1904380	Process	Endoplasmic reticulum mannose trimming	IEA
GO:1904380	Process	Endoplasmic reticulum mannose trimming	TAS

Other IDs

• MIM: N/A
• HGNC: N/A
• e!Ensembl: N/A

Interactions View interactions

Pathways

KEGG:

Protein processing in endoplasmic reticulum

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
MATURITY ONSET DIABETES MELLITUS IN YOUNG	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations