PRDM4 (PR/SET domain 4)

Gene

• Entrez ID: 11108
• Gene name: PR/SET domain 4
• Gene symbol: PRDM4
• Synonyms (NCBI Gene): PFM1
• Chromosome: 12
• Chromosome location: 12q23.3
• Summary: The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorig

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024430	hsa-miR-215-5p	Microarray	19074876
MIRT026161	hsa-miR-192-5p	Microarray	19074876
MIRT027024	hsa-miR-103a-3p	Sequencing	20371350
MIRT027471	hsa-miR-98-5p	Microarray	19088304
MIRT031524	hsa-miR-16-5p	Sequencing	20371350
MIRT052284	hsa-let-7b-5p	CLASH	23622248
MIRT031524	hsa-miR-16-5p	Luciferase reporter assay, Western blot, Microarray, qRT-PCR	23941513
MIRT031524	hsa-miR-16-5p	Luciferase reporter assay, Western blot, Microarray, qRT-PCR	23941513
MIRT031524	hsa-miR-16-5p	Luciferase reporter assay, Western blot, Microarray, qRT-PCR	23941513
MIRT031524	hsa-miR-16-5p	Luciferase reporter assay, Western blot, Microarray, qRT-PCR	23941513
MIRT555278	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT555277	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT555276	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT555275	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT031524	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT555274	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT555272	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT555273	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT555271	hsa-miR-323a-3p	PAR-CLIP	21572407
MIRT555270	hsa-miR-548p	PAR-CLIP	21572407
MIRT555269	hsa-miR-646	PAR-CLIP	21572407
MIRT555268	hsa-miR-545-3p	PAR-CLIP	21572407
MIRT555267	hsa-miR-1224-3p	PAR-CLIP	21572407
MIRT555266	hsa-miR-3909	PAR-CLIP	21572407
MIRT555265	hsa-miR-6852-3p	PAR-CLIP	21572407
MIRT555264	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT555263	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT555262	hsa-miR-188-3p	PAR-CLIP	21572407
MIRT555261	hsa-miR-1260a	PAR-CLIP	21572407
MIRT555260	hsa-miR-1260b	PAR-CLIP	21572407
MIRT555259	hsa-miR-3156-3p	PAR-CLIP	21572407
MIRT555258	hsa-miR-374b-3p	PAR-CLIP	21572407
MIRT555278	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT555277	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT555276	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT555275	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT031524	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT555274	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT555272	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT555273	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT555271	hsa-miR-323a-3p	PAR-CLIP	21572407
MIRT555270	hsa-miR-548p	PAR-CLIP	21572407
MIRT555269	hsa-miR-646	PAR-CLIP	21572407
MIRT555268	hsa-miR-545-3p	PAR-CLIP	21572407
MIRT555267	hsa-miR-1224-3p	PAR-CLIP	21572407
MIRT555266	hsa-miR-3909	PAR-CLIP	21572407
MIRT555265	hsa-miR-6852-3p	PAR-CLIP	21572407
MIRT555264	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT555263	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT555262	hsa-miR-188-3p	PAR-CLIP	21572407
MIRT555261	hsa-miR-1260a	PAR-CLIP	21572407
MIRT555260	hsa-miR-1260b	PAR-CLIP	21572407
MIRT555259	hsa-miR-3156-3p	PAR-CLIP	21572407
MIRT555258	hsa-miR-374b-3p	PAR-CLIP	21572407
MIRT1260246	hsa-miR-1287	CLIP-seq
MIRT1260247	hsa-miR-1298	CLIP-seq
MIRT1260248	hsa-miR-150	CLIP-seq
MIRT1260249	hsa-miR-15a	CLIP-seq
MIRT1260250	hsa-miR-15b	CLIP-seq
MIRT1260251	hsa-miR-16	CLIP-seq
MIRT1260252	hsa-miR-181a	CLIP-seq
MIRT1260253	hsa-miR-181b	CLIP-seq
MIRT1260254	hsa-miR-181c	CLIP-seq
MIRT1260255	hsa-miR-181d	CLIP-seq
MIRT1260256	hsa-miR-195	CLIP-seq
MIRT1260257	hsa-miR-214	CLIP-seq
MIRT1260258	hsa-miR-22	CLIP-seq
MIRT1260259	hsa-miR-224	CLIP-seq
MIRT1260260	hsa-miR-2681	CLIP-seq
MIRT1260261	hsa-miR-302a	CLIP-seq
MIRT1260262	hsa-miR-302b	CLIP-seq
MIRT1260263	hsa-miR-302c	CLIP-seq
MIRT1260264	hsa-miR-302d	CLIP-seq
MIRT1260265	hsa-miR-302e	CLIP-seq
MIRT1260266	hsa-miR-3125	CLIP-seq
MIRT1260267	hsa-miR-3136-5p	CLIP-seq
MIRT1260268	hsa-miR-3182	CLIP-seq
MIRT1260269	hsa-miR-323-3p	CLIP-seq
MIRT1260270	hsa-miR-3607-3p	CLIP-seq
MIRT1260271	hsa-miR-3619-5p	CLIP-seq
MIRT1260272	hsa-miR-3657	CLIP-seq
MIRT1260273	hsa-miR-3667-3p	CLIP-seq
MIRT1260274	hsa-miR-3686	CLIP-seq
MIRT1260275	hsa-miR-372	CLIP-seq
MIRT1260276	hsa-miR-373	CLIP-seq
MIRT1260277	hsa-miR-384	CLIP-seq
MIRT1260278	hsa-miR-3916	CLIP-seq
MIRT1260279	hsa-miR-424	CLIP-seq
MIRT1260280	hsa-miR-4262	CLIP-seq
MIRT1260281	hsa-miR-4439	CLIP-seq
MIRT1260282	hsa-miR-4480	CLIP-seq
MIRT1260283	hsa-miR-4495	CLIP-seq
MIRT1260284	hsa-miR-4513	CLIP-seq
MIRT1260285	hsa-miR-4524	CLIP-seq
MIRT1260286	hsa-miR-4530	CLIP-seq
MIRT1260287	hsa-miR-4646-5p	CLIP-seq
MIRT1260288	hsa-miR-4669	CLIP-seq
MIRT1260289	hsa-miR-4694-3p	CLIP-seq
MIRT1260290	hsa-miR-4700-3p	CLIP-seq
MIRT1260291	hsa-miR-4713-5p	CLIP-seq
MIRT1260292	hsa-miR-4728-3p	CLIP-seq
MIRT1260293	hsa-miR-4747-5p	CLIP-seq
MIRT1260294	hsa-miR-4764-5p	CLIP-seq
MIRT1260295	hsa-miR-4778-5p	CLIP-seq
MIRT1260296	hsa-miR-497	CLIP-seq
MIRT1260297	hsa-miR-503	CLIP-seq
MIRT1260298	hsa-miR-507	CLIP-seq
MIRT1260299	hsa-miR-513a-5p	CLIP-seq
MIRT1260300	hsa-miR-519a	CLIP-seq
MIRT1260301	hsa-miR-519b-3p	CLIP-seq
MIRT1260302	hsa-miR-519c-3p	CLIP-seq
MIRT1260303	hsa-miR-520a-3p	CLIP-seq
MIRT1260304	hsa-miR-520b	CLIP-seq
MIRT1260305	hsa-miR-520c-3p	CLIP-seq
MIRT1260306	hsa-miR-520d-3p	CLIP-seq
MIRT1260307	hsa-miR-520e	CLIP-seq
MIRT1260308	hsa-miR-520f	CLIP-seq
MIRT1260309	hsa-miR-532-3p	CLIP-seq
MIRT1260310	hsa-miR-545	CLIP-seq
MIRT1260311	hsa-miR-549	CLIP-seq
MIRT1260312	hsa-miR-557	CLIP-seq
MIRT1260313	hsa-miR-562	CLIP-seq
MIRT1260314	hsa-miR-587	CLIP-seq
MIRT1260315	hsa-miR-634	CLIP-seq
MIRT1260316	hsa-miR-664	CLIP-seq
MIRT1260317	hsa-miR-7	CLIP-seq
MIRT1260318	hsa-miR-761	CLIP-seq
MIRT1260319	hsa-miR-877	CLIP-seq
MIRT2076627	hsa-miR-125a-3p	CLIP-seq
MIRT2076628	hsa-miR-1260	CLIP-seq
MIRT2076629	hsa-miR-1280	CLIP-seq
MIRT1260247	hsa-miR-1298	CLIP-seq
MIRT2076630	hsa-miR-141	CLIP-seq
MIRT1260249	hsa-miR-15a	CLIP-seq
MIRT1260250	hsa-miR-15b	CLIP-seq
MIRT1260251	hsa-miR-16	CLIP-seq
MIRT1260256	hsa-miR-195	CLIP-seq
MIRT2076631	hsa-miR-200a	CLIP-seq
MIRT1260259	hsa-miR-224	CLIP-seq
MIRT2076632	hsa-miR-3145-5p	CLIP-seq
MIRT2076633	hsa-miR-3157-3p	CLIP-seq
MIRT2076634	hsa-miR-3646	CLIP-seq
MIRT1260273	hsa-miR-3667-3p	CLIP-seq
MIRT2076635	hsa-miR-3934	CLIP-seq
MIRT1260279	hsa-miR-424	CLIP-seq
MIRT2076636	hsa-miR-4257	CLIP-seq
MIRT2076637	hsa-miR-4269	CLIP-seq
MIRT2076638	hsa-miR-4290	CLIP-seq
MIRT2076639	hsa-miR-4312	CLIP-seq
MIRT2076640	hsa-miR-4468	CLIP-seq
MIRT1260285	hsa-miR-4524	CLIP-seq
MIRT2076641	hsa-miR-4645-5p	CLIP-seq
MIRT2076642	hsa-miR-4673	CLIP-seq
MIRT2076643	hsa-miR-4690-3p	CLIP-seq
MIRT2076644	hsa-miR-4768-3p	CLIP-seq
MIRT2076645	hsa-miR-4803	CLIP-seq
MIRT2076646	hsa-miR-494	CLIP-seq
MIRT1260296	hsa-miR-497	CLIP-seq
MIRT1260297	hsa-miR-503	CLIP-seq
MIRT2076647	hsa-miR-508-5p	CLIP-seq
MIRT1260310	hsa-miR-545	CLIP-seq
MIRT2076648	hsa-miR-548ag	CLIP-seq
MIRT2076649	hsa-miR-548ai	CLIP-seq
MIRT2076650	hsa-miR-550a	CLIP-seq
MIRT1260314	hsa-miR-587	CLIP-seq
MIRT1260316	hsa-miR-664	CLIP-seq
MIRT2076651	hsa-miR-764	CLIP-seq
MIRT2076652	hsa-miR-766	CLIP-seq
MIRT2076653	hsa-miR-874	CLIP-seq
MIRT2303354	hsa-miR-124	CLIP-seq
MIRT2303355	hsa-miR-1243	CLIP-seq
MIRT2076628	hsa-miR-1260	CLIP-seq
MIRT2076629	hsa-miR-1280	CLIP-seq
MIRT1260246	hsa-miR-1287	CLIP-seq
MIRT1260247	hsa-miR-1298	CLIP-seq
MIRT1260249	hsa-miR-15a	CLIP-seq
MIRT1260250	hsa-miR-15b	CLIP-seq
MIRT1260251	hsa-miR-16	CLIP-seq
MIRT1260252	hsa-miR-181a	CLIP-seq
MIRT1260253	hsa-miR-181b	CLIP-seq
MIRT1260254	hsa-miR-181c	CLIP-seq
MIRT1260255	hsa-miR-181d	CLIP-seq
MIRT1260256	hsa-miR-195	CLIP-seq
MIRT1260261	hsa-miR-302a	CLIP-seq
MIRT1260262	hsa-miR-302b	CLIP-seq
MIRT1260263	hsa-miR-302c	CLIP-seq
MIRT1260264	hsa-miR-302d	CLIP-seq
MIRT1260265	hsa-miR-302e	CLIP-seq
MIRT1260266	hsa-miR-3125	CLIP-seq
MIRT2303356	hsa-miR-3129-3p	CLIP-seq
MIRT2076632	hsa-miR-3145-5p	CLIP-seq
MIRT2303357	hsa-miR-320e	CLIP-seq
MIRT1260269	hsa-miR-323-3p	CLIP-seq
MIRT2303358	hsa-miR-3654	CLIP-seq
MIRT1260273	hsa-miR-3667-3p	CLIP-seq
MIRT2303359	hsa-miR-370	CLIP-seq
MIRT2303360	hsa-miR-3714	CLIP-seq
MIRT1260275	hsa-miR-372	CLIP-seq
MIRT1260276	hsa-miR-373	CLIP-seq
MIRT1260277	hsa-miR-384	CLIP-seq
MIRT2303361	hsa-miR-3910	CLIP-seq
MIRT1260278	hsa-miR-3916	CLIP-seq
MIRT1260279	hsa-miR-424	CLIP-seq
MIRT1260280	hsa-miR-4262	CLIP-seq
MIRT2303362	hsa-miR-4270	CLIP-seq
MIRT2303363	hsa-miR-4441	CLIP-seq
MIRT1260285	hsa-miR-4524	CLIP-seq
MIRT2076643	hsa-miR-4690-3p	CLIP-seq
MIRT2303364	hsa-miR-4736	CLIP-seq
MIRT1260294	hsa-miR-4764-5p	CLIP-seq
MIRT1260296	hsa-miR-497	CLIP-seq
MIRT2303365	hsa-miR-500a	CLIP-seq
MIRT1260297	hsa-miR-503	CLIP-seq
MIRT2303366	hsa-miR-506	CLIP-seq
MIRT2076647	hsa-miR-508-5p	CLIP-seq
MIRT1260300	hsa-miR-519a	CLIP-seq
MIRT1260301	hsa-miR-519b-3p	CLIP-seq
MIRT1260302	hsa-miR-519c-3p	CLIP-seq
MIRT1260303	hsa-miR-520a-3p	CLIP-seq
MIRT1260304	hsa-miR-520b	CLIP-seq
MIRT1260305	hsa-miR-520c-3p	CLIP-seq
MIRT1260306	hsa-miR-520d-3p	CLIP-seq
MIRT1260307	hsa-miR-520e	CLIP-seq
MIRT1260308	hsa-miR-520f	CLIP-seq
MIRT1260310	hsa-miR-545	CLIP-seq
MIRT1260314	hsa-miR-587	CLIP-seq
MIRT1260316	hsa-miR-664	CLIP-seq
MIRT2076652	hsa-miR-766	CLIP-seq
MIRT1260319	hsa-miR-877	CLIP-seq
MIRT2303367	hsa-miR-940	CLIP-seq
MIRT1260310	hsa-miR-545	CLIP-seq
MIRT2076651	hsa-miR-764	CLIP-seq
MIRT2599948	hsa-miR-1197	CLIP-seq
MIRT2303354	hsa-miR-124	CLIP-seq
MIRT2076630	hsa-miR-141	CLIP-seq
MIRT2599949	hsa-miR-1470	CLIP-seq
MIRT2599950	hsa-miR-182	CLIP-seq
MIRT2076631	hsa-miR-200a	CLIP-seq
MIRT2599951	hsa-miR-204	CLIP-seq
MIRT2599952	hsa-miR-211	CLIP-seq
MIRT2599953	hsa-miR-219-1-3p	CLIP-seq
MIRT2599954	hsa-miR-3117-5p	CLIP-seq
MIRT2599955	hsa-miR-3140-3p	CLIP-seq
MIRT2599956	hsa-miR-3148	CLIP-seq
MIRT2599957	hsa-miR-3156-5p	CLIP-seq
MIRT2076633	hsa-miR-3157-3p	CLIP-seq
MIRT2076634	hsa-miR-3646	CLIP-seq
MIRT2599958	hsa-miR-3677-5p	CLIP-seq
MIRT2599959	hsa-miR-3691-3p	CLIP-seq
MIRT2303359	hsa-miR-370	CLIP-seq
MIRT2303360	hsa-miR-3714	CLIP-seq
MIRT2303361	hsa-miR-3910	CLIP-seq
MIRT2599960	hsa-miR-3938	CLIP-seq
MIRT2599961	hsa-miR-3978	CLIP-seq
MIRT2599962	hsa-miR-409-3p	CLIP-seq
MIRT2076637	hsa-miR-4269	CLIP-seq
MIRT2076638	hsa-miR-4290	CLIP-seq
MIRT2599963	hsa-miR-4307	CLIP-seq
MIRT2599964	hsa-miR-4328	CLIP-seq
MIRT2599965	hsa-miR-4435	CLIP-seq
MIRT2599966	hsa-miR-4436a	CLIP-seq
MIRT2599967	hsa-miR-4446-5p	CLIP-seq
MIRT2599968	hsa-miR-455-3p	CLIP-seq
MIRT2599969	hsa-miR-4643	CLIP-seq
MIRT2076641	hsa-miR-4645-5p	CLIP-seq
MIRT1260287	hsa-miR-4646-5p	CLIP-seq
MIRT2599970	hsa-miR-4667-3p	CLIP-seq
MIRT2076642	hsa-miR-4673	CLIP-seq
MIRT1260290	hsa-miR-4700-3p	CLIP-seq
MIRT2599971	hsa-miR-4715-5p	CLIP-seq
MIRT2303364	hsa-miR-4736	CLIP-seq
MIRT1260293	hsa-miR-4747-5p	CLIP-seq
MIRT2599972	hsa-miR-4755-5p	CLIP-seq
MIRT2076645	hsa-miR-4803	CLIP-seq
MIRT2076646	hsa-miR-494	CLIP-seq
MIRT2303366	hsa-miR-506	CLIP-seq
MIRT1260298	hsa-miR-507	CLIP-seq
MIRT2076648	hsa-miR-548ag	CLIP-seq
MIRT2076649	hsa-miR-548ai	CLIP-seq
MIRT1260311	hsa-miR-549	CLIP-seq
MIRT1260312	hsa-miR-557	CLIP-seq
MIRT2599973	hsa-miR-570	CLIP-seq
MIRT2599974	hsa-miR-571	CLIP-seq
MIRT2599975	hsa-miR-586	CLIP-seq
MIRT2599976	hsa-miR-623	CLIP-seq
MIRT2599977	hsa-miR-642a	CLIP-seq
MIRT2599978	hsa-miR-642b	CLIP-seq
MIRT2599979	hsa-miR-665	CLIP-seq
MIRT1260317	hsa-miR-7	CLIP-seq
MIRT2076653	hsa-miR-874	CLIP-seq
MIRT2303367	hsa-miR-940	CLIP-seq
MIRT2599948	hsa-miR-1197	CLIP-seq
MIRT2303354	hsa-miR-124	CLIP-seq
MIRT2076630	hsa-miR-141	CLIP-seq
MIRT2599949	hsa-miR-1470	CLIP-seq
MIRT2599950	hsa-miR-182	CLIP-seq
MIRT2076631	hsa-miR-200a	CLIP-seq
MIRT2599953	hsa-miR-219-1-3p	CLIP-seq
MIRT2599954	hsa-miR-3117-5p	CLIP-seq
MIRT2599955	hsa-miR-3140-3p	CLIP-seq
MIRT2599956	hsa-miR-3148	CLIP-seq
MIRT2599957	hsa-miR-3156-5p	CLIP-seq
MIRT2076633	hsa-miR-3157-3p	CLIP-seq
MIRT2076634	hsa-miR-3646	CLIP-seq
MIRT2599958	hsa-miR-3677-5p	CLIP-seq
MIRT2599959	hsa-miR-3691-3p	CLIP-seq
MIRT2303359	hsa-miR-370	CLIP-seq
MIRT2303360	hsa-miR-3714	CLIP-seq
MIRT2303361	hsa-miR-3910	CLIP-seq
MIRT2599961	hsa-miR-3978	CLIP-seq
MIRT2599962	hsa-miR-409-3p	CLIP-seq
MIRT2076637	hsa-miR-4269	CLIP-seq
MIRT2076638	hsa-miR-4290	CLIP-seq
MIRT2599963	hsa-miR-4307	CLIP-seq
MIRT2599964	hsa-miR-4328	CLIP-seq
MIRT2599965	hsa-miR-4435	CLIP-seq
MIRT2599966	hsa-miR-4436a	CLIP-seq
MIRT2599967	hsa-miR-4446-5p	CLIP-seq
MIRT2599968	hsa-miR-455-3p	CLIP-seq
MIRT2599969	hsa-miR-4643	CLIP-seq
MIRT2076641	hsa-miR-4645-5p	CLIP-seq
MIRT1260287	hsa-miR-4646-5p	CLIP-seq
MIRT2599970	hsa-miR-4667-3p	CLIP-seq
MIRT2076642	hsa-miR-4673	CLIP-seq
MIRT1260289	hsa-miR-4694-3p	CLIP-seq
MIRT1260290	hsa-miR-4700-3p	CLIP-seq
MIRT2599971	hsa-miR-4715-5p	CLIP-seq
MIRT2303364	hsa-miR-4736	CLIP-seq
MIRT1260293	hsa-miR-4747-5p	CLIP-seq
MIRT2076645	hsa-miR-4803	CLIP-seq
MIRT2076646	hsa-miR-494	CLIP-seq
MIRT2303366	hsa-miR-506	CLIP-seq
MIRT1260298	hsa-miR-507	CLIP-seq
MIRT2076648	hsa-miR-548ag	CLIP-seq
MIRT2076649	hsa-miR-548ai	CLIP-seq
MIRT1260311	hsa-miR-549	CLIP-seq
MIRT1260312	hsa-miR-557	CLIP-seq
MIRT2599973	hsa-miR-570	CLIP-seq
MIRT2599974	hsa-miR-571	CLIP-seq
MIRT2599975	hsa-miR-586	CLIP-seq
MIRT2599977	hsa-miR-642a	CLIP-seq
MIRT2599978	hsa-miR-642b	CLIP-seq
MIRT2599979	hsa-miR-665	CLIP-seq
MIRT1260317	hsa-miR-7	CLIP-seq
MIRT2076653	hsa-miR-874	CLIP-seq
MIRT2303367	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	ISS
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006366	Process	Transcription by RNA polymerase II	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010468	Process	Regulation of gene expression	IBA
GO:0016740	Function	Transferase activity	IEA
GO:0032259	Process	Methylation	IEA
GO:0035097	Component	Histone methyltransferase complex	NAS	23048031
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:1990226	Function	Histone methyltransferase binding	IEA
GO:1990226	Function	Histone methyltransferase binding	NAS	23048031
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 605780
• HGNC: 9348
• e!Ensembl: ENSG00000110851

Protein

• UniProt ID: Q9UKN5
• Protein name: PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4)
• Protein function: May function as a transcription factor involved in cell differentiation.
• PDB: 2L9Z, 3DB5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF18445	zf_PR_Knuckle	365 → 402	PR zinc knuckle motif	Motif
  PF00096	zf-C2H2	618 → 640	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	646 → 668	Zinc finger, C2H2 type	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in many tissues. Highly expressed in ovary, testis, pancreas, brain, heart and prostate.
• Sequence:

  MHHRMNEMNLSPVGMEQLTSSSVSNALPVSGSHLGLAASPTHSAIPAPGLPVAIPNLGPS
  LSSLPSALSLMLPMGIGDRGVMCGLPERNYTLPPPPYPHLESSYFRTILPGILSYLADRP
  PPQYIHPNSINVDGNTALSITNNPSALDPYQSNGNVGLEPGIVSIDSRSVNTHGAQSLHP
  SDGHEVALDTAITMENVSRVTSPISTDGMAEELTMDGVAGEHSQIPNGSRSHEPLSVDSV
  SNNLAADAVGHGGVIPMHGNGLELPVVMETDHIASRVNGMSDSALSDSIHTVAMSTNSVS
  VALSTSHNLASLESVSLHEVGLSLEPVAVSSITQEVAMGTGHVDVSSDSLSFVSPSLQME
  DSNSNKENMATLFTIWCTLCDRAYPSDCPEHGPVTFVPDTPIESRARLSLPKQLVLRQSI
  VGAEVGVWTGETIPVRTCFGPLIGQQSHSMEVAEWTDKAVNHIWKIYHNGVLEFCIITTD
  ENECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQQIGVPE
  HPDVHLCNCGKECNSYTEFKAHLTSHIHNHLPTQGHSGSHGPSHSKERKWKCSMCPQAFI
  SPSKLHVHFMGHMGMKPHKCDFCSKAFSDPSNLRTHLKIHTGQKNYRCTLCDKSFTQKAH
  LESHMVIHTGEKNLKCDYCDKLFMRRQDLKQHVLIHTQERQIKCPKCDKLFLRTNHLKKH
  LNSHEGKRDYVCEKCTKAYLTKYHLTRHLKTCKGPTSSSSAPEEEEEDDSEEEDLADSVG
  TEDCRINSAVYSADESLSAHK

• Sequence length: 801

Pathways

KEGG:

Neurotrophin signaling pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIGESTIVE SYSTEM DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, KNEE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Metastatic Prostate Carcinoma	Metastatic Prostate Carcinoma	BEFREE	29669796		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	30158592		★☆☆☆☆ Found in Text Mining only