Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	11096
Gene name	ADAM metallopeptidase with thrombospondin type 1 motif 5
Gene symbol	ADAMTS5
Synonyms (NCBI Gene)	ADAM-TS 11ADAM-TS 5ADAM-TS5ADAMTS-11ADAMTS-5ADAMTS11ADMP-2
Chromosome	21
Chromosome location	21q21.3
Summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegri

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miRTarBase ID	miRNA	Experiments	Reference
MIRT027846	hsa-miR-98-5p	Microarray	19088304
MIRT613357	hsa-miR-1283	HITS-CLIP	19536157
MIRT613356	hsa-miR-155-3p	HITS-CLIP	19536157
MIRT613355	hsa-miR-3685	HITS-CLIP	19536157
MIRT613354	hsa-miR-384	HITS-CLIP	19536157
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	19536157
MIRT613357	hsa-miR-1283	HITS-CLIP	19536157
MIRT613356	hsa-miR-155-3p	HITS-CLIP	19536157
MIRT613355	hsa-miR-3685	HITS-CLIP	19536157
MIRT613354	hsa-miR-384	HITS-CLIP	19536157
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	19536157
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT660911	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT660910	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT660909	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT660908	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT660907	hsa-miR-27b-3p	HITS-CLIP	23824327
MIRT660906	hsa-miR-27a-3p	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT660905	hsa-miR-4328	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT660904	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT449049	hsa-miR-548ac	PAR-CLIP	22100165
MIRT449048	hsa-miR-548bb-3p	PAR-CLIP	22100165
MIRT449047	hsa-miR-548d-3p	PAR-CLIP	22100165
MIRT449046	hsa-miR-548h-3p	PAR-CLIP	22100165
MIRT449045	hsa-miR-548z	PAR-CLIP	22100165
MIRT449044	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT449043	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT449042	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT449041	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT449040	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT449039	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT449038	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT449036	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT449037	hsa-miR-4490	PAR-CLIP	22100165
MIRT449035	hsa-miR-4774-5p	PAR-CLIP	22100165
MIRT449034	hsa-miR-4635	PAR-CLIP	22100165
MIRT449033	hsa-miR-7843-3p	PAR-CLIP	22100165
MIRT449032	hsa-miR-127-5p	PAR-CLIP	22100165
MIRT450371	hsa-miR-875-3p	PAR-CLIP	22100165
MIRT450370	hsa-miR-6128	PAR-CLIP	22100165
MIRT450369	hsa-miR-3148	PAR-CLIP	22100165
MIRT450368	hsa-miR-6124	PAR-CLIP	22100165
MIRT450367	hsa-miR-1299	PAR-CLIP	22100165
MIRT450366	hsa-miR-516b-5p	PAR-CLIP	22100165
MIRT450365	hsa-miR-4782-5p	PAR-CLIP	22100165
MIRT450364	hsa-miR-5706	PAR-CLIP	22100165
MIRT449049	hsa-miR-548ac	PAR-CLIP	22100165
MIRT449048	hsa-miR-548bb-3p	PAR-CLIP	22100165
MIRT449047	hsa-miR-548d-3p	PAR-CLIP	22100165
MIRT449046	hsa-miR-548h-3p	PAR-CLIP	22100165
MIRT449045	hsa-miR-548z	PAR-CLIP	22100165
MIRT449044	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT449043	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT449042	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT449041	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT449040	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT449039	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT449038	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT449036	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT449037	hsa-miR-4490	PAR-CLIP	22100165
MIRT449035	hsa-miR-4774-5p	PAR-CLIP	22100165
MIRT449034	hsa-miR-4635	PAR-CLIP	22100165
MIRT449033	hsa-miR-7843-3p	PAR-CLIP	22100165
MIRT449032	hsa-miR-127-5p	PAR-CLIP	22100165
MIRT734499	hsa-miR-103b	Luciferase reporter assayWestern blottingqRT-PCR	32700984
MIRT734500	hsa-miR-144-3p	Luciferase reporter assayWestern blottingqRT-PCR	32700984
MIRT734501	hsa-miR-105-5p	Luciferase reporter assayWestern blottingqRT-PCR	32700984
MIRT613357	hsa-miR-1283	HITS-CLIP	19536157
MIRT613356	hsa-miR-155-3p	HITS-CLIP	19536157
MIRT613355	hsa-miR-3685	HITS-CLIP	19536157
MIRT613354	hsa-miR-384	HITS-CLIP	19536157
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	19536157
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT660911	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT660910	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT660909	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT660908	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT660907	hsa-miR-27b-3p	HITS-CLIP	23824327
MIRT660906	hsa-miR-27a-3p	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT660905	hsa-miR-4328	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT660904	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT613357	hsa-miR-1283	HITS-CLIP	23824327
MIRT613356	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT613355	hsa-miR-3685	HITS-CLIP	23824327
MIRT613354	hsa-miR-384	HITS-CLIP	23824327
MIRT613353	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT449049	hsa-miR-548ac	PAR-CLIP	22100165
MIRT449048	hsa-miR-548bb-3p	PAR-CLIP	22100165
MIRT449047	hsa-miR-548d-3p	PAR-CLIP	22100165
MIRT449046	hsa-miR-548h-3p	PAR-CLIP	22100165
MIRT449045	hsa-miR-548z	PAR-CLIP	22100165
MIRT449044	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT449043	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT449042	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT449041	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT449040	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT449039	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT449038	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT449036	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT449037	hsa-miR-4490	PAR-CLIP	22100165
MIRT449035	hsa-miR-4774-5p	PAR-CLIP	22100165
MIRT449034	hsa-miR-4635	PAR-CLIP	22100165
MIRT449033	hsa-miR-7843-3p	PAR-CLIP	22100165
MIRT449032	hsa-miR-127-5p	PAR-CLIP	22100165
MIRT450371	hsa-miR-875-3p	PAR-CLIP	22100165
MIRT450370	hsa-miR-6128	PAR-CLIP	22100165
MIRT450369	hsa-miR-3148	PAR-CLIP	22100165
MIRT450368	hsa-miR-6124	PAR-CLIP	22100165
MIRT450367	hsa-miR-1299	PAR-CLIP	22100165
MIRT450366	hsa-miR-516b-5p	PAR-CLIP	22100165
MIRT450365	hsa-miR-4782-5p	PAR-CLIP	22100165
MIRT450364	hsa-miR-5706	PAR-CLIP	22100165
MIRT449049	hsa-miR-548ac	PAR-CLIP	22100165
MIRT449048	hsa-miR-548bb-3p	PAR-CLIP	22100165
MIRT449047	hsa-miR-548d-3p	PAR-CLIP	22100165
MIRT449046	hsa-miR-548h-3p	PAR-CLIP	22100165
MIRT449045	hsa-miR-548z	PAR-CLIP	22100165
MIRT449044	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT449043	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT449042	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT449041	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT449040	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT449039	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT449038	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT449036	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT449037	hsa-miR-4490	PAR-CLIP	22100165
MIRT449035	hsa-miR-4774-5p	PAR-CLIP	22100165
MIRT449034	hsa-miR-4635	PAR-CLIP	22100165
MIRT449033	hsa-miR-7843-3p	PAR-CLIP	22100165
MIRT449032	hsa-miR-127-5p	PAR-CLIP	22100165
MIRT766700	hsa-miR-1197	CLIP-seq
MIRT766701	hsa-miR-1207-5p	CLIP-seq
MIRT766702	hsa-miR-1256	CLIP-seq
MIRT766703	hsa-miR-1271	CLIP-seq
MIRT766704	hsa-miR-1272	CLIP-seq
MIRT766705	hsa-miR-134	CLIP-seq
MIRT766706	hsa-miR-1343	CLIP-seq
MIRT766707	hsa-miR-138	CLIP-seq
MIRT766708	hsa-miR-148a	CLIP-seq
MIRT766709	hsa-miR-148b	CLIP-seq
MIRT766710	hsa-miR-151-3p	CLIP-seq
MIRT766711	hsa-miR-152	CLIP-seq
MIRT766712	hsa-miR-15a	CLIP-seq
MIRT766713	hsa-miR-15b	CLIP-seq
MIRT766714	hsa-miR-16	CLIP-seq
MIRT766715	hsa-miR-182	CLIP-seq
MIRT766716	hsa-miR-195	CLIP-seq
MIRT766717	hsa-miR-202	CLIP-seq
MIRT766718	hsa-miR-203	CLIP-seq
MIRT766719	hsa-miR-2053	CLIP-seq
MIRT766720	hsa-miR-2116	CLIP-seq
MIRT766721	hsa-miR-3074-5p	CLIP-seq
MIRT766722	hsa-miR-3118	CLIP-seq
MIRT766723	hsa-miR-3120-3p	CLIP-seq
MIRT766724	hsa-miR-3136-3p	CLIP-seq
MIRT766725	hsa-miR-3152-3p	CLIP-seq
MIRT766726	hsa-miR-3159	CLIP-seq
MIRT766727	hsa-miR-3164	CLIP-seq
MIRT766728	hsa-miR-3171	CLIP-seq
MIRT766729	hsa-miR-3682-3p	CLIP-seq
MIRT766730	hsa-miR-380	CLIP-seq
MIRT766731	hsa-miR-424	CLIP-seq
MIRT766732	hsa-miR-4266	CLIP-seq
MIRT766733	hsa-miR-4302	CLIP-seq
MIRT766734	hsa-miR-433	CLIP-seq
MIRT766735	hsa-miR-4477a	CLIP-seq
MIRT766736	hsa-miR-4502	CLIP-seq
MIRT766737	hsa-miR-4519	CLIP-seq
MIRT766738	hsa-miR-4639-3p	CLIP-seq
MIRT766739	hsa-miR-4642	CLIP-seq
MIRT766740	hsa-miR-4645-3p	CLIP-seq
MIRT766741	hsa-miR-4680-5p	CLIP-seq
MIRT766742	hsa-miR-4695-5p	CLIP-seq
MIRT766743	hsa-miR-4711-5p	CLIP-seq
MIRT766744	hsa-miR-4714-5p	CLIP-seq
MIRT766745	hsa-miR-4736	CLIP-seq
MIRT766746	hsa-miR-4763-3p	CLIP-seq
MIRT766747	hsa-miR-4779	CLIP-seq
MIRT766748	hsa-miR-497	CLIP-seq
MIRT766749	hsa-miR-514	CLIP-seq
MIRT766750	hsa-miR-514b-3p	CLIP-seq
MIRT766751	hsa-miR-518a-5p	CLIP-seq
MIRT766752	hsa-miR-527	CLIP-seq
MIRT766753	hsa-miR-545	CLIP-seq
MIRT766754	hsa-miR-548g	CLIP-seq
MIRT766755	hsa-miR-548n	CLIP-seq
MIRT766756	hsa-miR-548p	CLIP-seq
MIRT766757	hsa-miR-578	CLIP-seq
MIRT766758	hsa-miR-586	CLIP-seq
MIRT766759	hsa-miR-595	CLIP-seq
MIRT766760	hsa-miR-618	CLIP-seq
MIRT766761	hsa-miR-668	CLIP-seq
MIRT766762	hsa-miR-758	CLIP-seq
MIRT766763	hsa-miR-877	CLIP-seq
MIRT766764	hsa-miR-890	CLIP-seq
MIRT766765	hsa-miR-96	CLIP-seq
MIRT1545121	hsa-miR-101	CLIP-seq
MIRT1545122	hsa-miR-128	CLIP-seq
MIRT1545123	hsa-miR-144	CLIP-seq
MIRT1545124	hsa-miR-145	CLIP-seq
MIRT1545125	hsa-miR-196a	CLIP-seq
MIRT1545126	hsa-miR-196b	CLIP-seq
MIRT1545127	hsa-miR-197	CLIP-seq
MIRT1545128	hsa-miR-210	CLIP-seq
MIRT1545129	hsa-miR-331-5p	CLIP-seq
MIRT1545130	hsa-miR-3529	CLIP-seq
MIRT1545131	hsa-miR-3684	CLIP-seq
MIRT1545132	hsa-miR-377	CLIP-seq
MIRT1545133	hsa-miR-379	CLIP-seq
MIRT1545134	hsa-miR-3927	CLIP-seq
MIRT1545135	hsa-miR-455-3p	CLIP-seq
MIRT1545136	hsa-miR-4652-3p	CLIP-seq
MIRT1545137	hsa-miR-4717-3p	CLIP-seq
MIRT1545138	hsa-miR-503	CLIP-seq
MIRT1545139	hsa-miR-520d-5p	CLIP-seq
MIRT1545140	hsa-miR-524-5p	CLIP-seq
MIRT1545141	hsa-miR-582-5p	CLIP-seq
MIRT1545124	hsa-miR-145	CLIP-seq
MIRT1545135	hsa-miR-455-3p	CLIP-seq
MIRT1545137	hsa-miR-4717-3p	CLIP-seq
MIRT1545141	hsa-miR-582-5p	CLIP-seq
MIRT1925850	hsa-miR-1252	CLIP-seq
MIRT1925851	hsa-miR-136	CLIP-seq
MIRT1925852	hsa-miR-181a	CLIP-seq
MIRT1925853	hsa-miR-181b	CLIP-seq
MIRT1925854	hsa-miR-181c	CLIP-seq
MIRT1925855	hsa-miR-181d	CLIP-seq
MIRT1925856	hsa-miR-1913	CLIP-seq
MIRT1925857	hsa-miR-224	CLIP-seq
MIRT1925858	hsa-miR-3160-5p	CLIP-seq
MIRT1925859	hsa-miR-324-3p	CLIP-seq
MIRT1925860	hsa-miR-3646	CLIP-seq
MIRT1925861	hsa-miR-3671	CLIP-seq
MIRT1925862	hsa-miR-3924	CLIP-seq
MIRT1925863	hsa-miR-4262	CLIP-seq
MIRT1925864	hsa-miR-4263	CLIP-seq
MIRT1925865	hsa-miR-4427	CLIP-seq
MIRT1925866	hsa-miR-4464	CLIP-seq
MIRT1925867	hsa-miR-4476	CLIP-seq
MIRT1925868	hsa-miR-4533	CLIP-seq
MIRT1925869	hsa-miR-4699-3p	CLIP-seq
MIRT1925870	hsa-miR-4708-3p	CLIP-seq
MIRT1925871	hsa-miR-4727-5p	CLIP-seq
MIRT1925872	hsa-miR-4748	CLIP-seq
MIRT1925873	hsa-miR-4768-5p	CLIP-seq
MIRT1925874	hsa-miR-4775	CLIP-seq
MIRT1925875	hsa-miR-4795-3p	CLIP-seq
MIRT1925876	hsa-miR-4799-5p	CLIP-seq
MIRT766751	hsa-miR-518a-5p	CLIP-seq
MIRT766752	hsa-miR-527	CLIP-seq
MIRT1925877	hsa-miR-544	CLIP-seq
MIRT766754	hsa-miR-548g	CLIP-seq
MIRT1925878	hsa-miR-576-5p	CLIP-seq
MIRT1925879	hsa-miR-590-3p	CLIP-seq
MIRT1925880	hsa-miR-607	CLIP-seq
MIRT1925881	hsa-miR-938	CLIP-seq
MIRT2167236	hsa-miR-1245b-3p	CLIP-seq
MIRT766710	hsa-miR-151-3p	CLIP-seq
MIRT2167237	hsa-miR-186	CLIP-seq
MIRT766719	hsa-miR-2053	CLIP-seq
MIRT2167238	hsa-miR-30a	CLIP-seq
MIRT2167239	hsa-miR-30b	CLIP-seq
MIRT2167240	hsa-miR-30c	CLIP-seq
MIRT2167241	hsa-miR-30d	CLIP-seq
MIRT2167242	hsa-miR-30e	CLIP-seq
MIRT2167243	hsa-miR-3133	CLIP-seq
MIRT2167244	hsa-miR-3647-3p	CLIP-seq
MIRT2167245	hsa-miR-3692	CLIP-seq
MIRT766730	hsa-miR-380	CLIP-seq
MIRT2167246	hsa-miR-3909	CLIP-seq
MIRT1925864	hsa-miR-4263	CLIP-seq
MIRT766732	hsa-miR-4266	CLIP-seq
MIRT2167247	hsa-miR-4330	CLIP-seq
MIRT1925867	hsa-miR-4476	CLIP-seq
MIRT2167248	hsa-miR-4495	CLIP-seq
MIRT2167249	hsa-miR-452	CLIP-seq
MIRT2167250	hsa-miR-4676-3p	CLIP-seq
MIRT766741	hsa-miR-4680-5p	CLIP-seq
MIRT766742	hsa-miR-4695-5p	CLIP-seq
MIRT2167251	hsa-miR-4719	CLIP-seq
MIRT766747	hsa-miR-4779	CLIP-seq
MIRT2167252	hsa-miR-4786-3p	CLIP-seq
MIRT2167253	hsa-miR-496	CLIP-seq
MIRT1545139	hsa-miR-520d-5p	CLIP-seq
MIRT1545140	hsa-miR-524-5p	CLIP-seq
MIRT2167254	hsa-miR-526b	CLIP-seq
MIRT2167255	hsa-miR-548u	CLIP-seq
MIRT1925878	hsa-miR-576-5p	CLIP-seq
MIRT766760	hsa-miR-618	CLIP-seq
MIRT2167256	hsa-miR-888	CLIP-seq
MIRT2383906	hsa-miR-421	CLIP-seq
MIRT2383907	hsa-miR-4272	CLIP-seq
MIRT2383908	hsa-miR-4709-5p	CLIP-seq
MIRT2383909	hsa-miR-556-5p	CLIP-seq
MIRT2426001	hsa-miR-1	CLIP-seq
MIRT2426002	hsa-miR-155	CLIP-seq
MIRT2426003	hsa-miR-1976	CLIP-seq
MIRT2426004	hsa-miR-206	CLIP-seq
MIRT1925857	hsa-miR-224	CLIP-seq
MIRT2167238	hsa-miR-30a	CLIP-seq
MIRT2167239	hsa-miR-30b	CLIP-seq
MIRT2167240	hsa-miR-30c	CLIP-seq
MIRT2167241	hsa-miR-30d	CLIP-seq
MIRT2167242	hsa-miR-30e	CLIP-seq
MIRT2426005	hsa-miR-3175	CLIP-seq
MIRT2426006	hsa-miR-3190	CLIP-seq
MIRT2426007	hsa-miR-3673	CLIP-seq
MIRT1545132	hsa-miR-377	CLIP-seq
MIRT2426008	hsa-miR-3934	CLIP-seq
MIRT2426009	hsa-miR-4277	CLIP-seq
MIRT2426010	hsa-miR-4445	CLIP-seq
MIRT766735	hsa-miR-4477a	CLIP-seq
MIRT766737	hsa-miR-4519	CLIP-seq
MIRT2426011	hsa-miR-4716-3p	CLIP-seq
MIRT2426012	hsa-miR-4723-5p	CLIP-seq
MIRT1925871	hsa-miR-4727-5p	CLIP-seq
MIRT2426013	hsa-miR-4752	CLIP-seq
MIRT2426014	hsa-miR-4769-3p	CLIP-seq
MIRT1925874	hsa-miR-4775	CLIP-seq
MIRT2426015	hsa-miR-4789-3p	CLIP-seq
MIRT2426016	hsa-miR-486-5p	CLIP-seq
MIRT1545139	hsa-miR-520d-5p	CLIP-seq
MIRT1545140	hsa-miR-524-5p	CLIP-seq
MIRT2426017	hsa-miR-552	CLIP-seq
MIRT1545141	hsa-miR-582-5p	CLIP-seq
MIRT2426018	hsa-miR-587	CLIP-seq
MIRT1925879	hsa-miR-590-3p	CLIP-seq
MIRT2426019	hsa-miR-613	CLIP-seq
MIRT2435205	hsa-miR-2052	CLIP-seq
MIRT2435206	hsa-miR-4307	CLIP-seq
MIRT2435207	hsa-miR-4539	CLIP-seq
MIRT2435208	hsa-miR-628-5p	CLIP-seq
MIRT2469849	hsa-miR-133a	CLIP-seq
MIRT2469850	hsa-miR-133b	CLIP-seq
MIRT1925851	hsa-miR-136	CLIP-seq
MIRT766708	hsa-miR-148a	CLIP-seq
MIRT766709	hsa-miR-148b	CLIP-seq
MIRT766711	hsa-miR-152	CLIP-seq
MIRT1925856	hsa-miR-1913	CLIP-seq
MIRT2469851	hsa-miR-219-1-3p	CLIP-seq
MIRT2469852	hsa-miR-2278	CLIP-seq
MIRT2167238	hsa-miR-30a	CLIP-seq
MIRT2167239	hsa-miR-30b	CLIP-seq
MIRT2167240	hsa-miR-30c	CLIP-seq
MIRT2167241	hsa-miR-30d	CLIP-seq
MIRT2167242	hsa-miR-30e	CLIP-seq
MIRT1925858	hsa-miR-3160-5p	CLIP-seq
MIRT1925859	hsa-miR-324-3p	CLIP-seq
MIRT2469853	hsa-miR-3607-3p	CLIP-seq
MIRT2469854	hsa-miR-3613-3p	CLIP-seq
MIRT2469855	hsa-miR-3668	CLIP-seq
MIRT2469856	hsa-miR-371b-5p	CLIP-seq
MIRT2469857	hsa-miR-3921	CLIP-seq
MIRT2426008	hsa-miR-3934	CLIP-seq
MIRT1925865	hsa-miR-4427	CLIP-seq
MIRT2426010	hsa-miR-4445	CLIP-seq
MIRT2469858	hsa-miR-4446-5p	CLIP-seq
MIRT1925866	hsa-miR-4464	CLIP-seq
MIRT2469859	hsa-miR-4468	CLIP-seq
MIRT766737	hsa-miR-4519	CLIP-seq
MIRT2469860	hsa-miR-4641	CLIP-seq
MIRT766740	hsa-miR-4645-3p	CLIP-seq
MIRT2469861	hsa-miR-4653-5p	CLIP-seq
MIRT2469862	hsa-miR-4668-3p	CLIP-seq
MIRT2469863	hsa-miR-4680-3p	CLIP-seq
MIRT1925871	hsa-miR-4727-5p	CLIP-seq
MIRT1925872	hsa-miR-4748	CLIP-seq
MIRT2469864	hsa-miR-4760-5p	CLIP-seq
MIRT1925873	hsa-miR-4768-5p	CLIP-seq
MIRT766751	hsa-miR-518a-5p	CLIP-seq
MIRT766752	hsa-miR-527	CLIP-seq
MIRT1925877	hsa-miR-544	CLIP-seq
MIRT766754	hsa-miR-548g	CLIP-seq
MIRT2426017	hsa-miR-552	CLIP-seq
MIRT2469865	hsa-miR-568	CLIP-seq
MIRT2469866	hsa-miR-571	CLIP-seq
MIRT766757	hsa-miR-578	CLIP-seq
MIRT2426018	hsa-miR-587	CLIP-seq
MIRT2469867	hsa-miR-642b	CLIP-seq
MIRT2469868	hsa-miR-802	CLIP-seq
MIRT766763	hsa-miR-877	CLIP-seq
MIRT2167256	hsa-miR-888	CLIP-seq
MIRT2674439	hsa-miR-105	CLIP-seq
MIRT2674440	hsa-miR-1267	CLIP-seq
MIRT2674441	hsa-miR-1269	CLIP-seq
MIRT2674442	hsa-miR-1269b	CLIP-seq
MIRT2674443	hsa-miR-1282	CLIP-seq
MIRT2674444	hsa-miR-1323	CLIP-seq
MIRT2469849	hsa-miR-133a	CLIP-seq
MIRT2469850	hsa-miR-133b	CLIP-seq
MIRT1925851	hsa-miR-136	CLIP-seq
MIRT2674445	hsa-miR-140-3p	CLIP-seq
MIRT766708	hsa-miR-148a	CLIP-seq
MIRT766709	hsa-miR-148b	CLIP-seq
MIRT2674446	hsa-miR-149	CLIP-seq
MIRT766711	hsa-miR-152	CLIP-seq
MIRT1925852	hsa-miR-181a	CLIP-seq
MIRT1925853	hsa-miR-181b	CLIP-seq
MIRT1925854	hsa-miR-181c	CLIP-seq
MIRT1925855	hsa-miR-181d	CLIP-seq
MIRT2674447	hsa-miR-188-5p	CLIP-seq
MIRT1925856	hsa-miR-1913	CLIP-seq
MIRT2674448	hsa-miR-1915	CLIP-seq
MIRT2674449	hsa-miR-194	CLIP-seq
MIRT2674450	hsa-miR-204	CLIP-seq
MIRT2674451	hsa-miR-211	CLIP-seq
MIRT2674452	hsa-miR-218	CLIP-seq
MIRT2469851	hsa-miR-219-1-3p	CLIP-seq
MIRT2469852	hsa-miR-2278	CLIP-seq
MIRT2674453	hsa-miR-3064-5p	CLIP-seq
MIRT2167238	hsa-miR-30a	CLIP-seq
MIRT2167239	hsa-miR-30b	CLIP-seq
MIRT2167240	hsa-miR-30c	CLIP-seq
MIRT2167241	hsa-miR-30d	CLIP-seq
MIRT2167242	hsa-miR-30e	CLIP-seq
MIRT2674454	hsa-miR-3117-5p	CLIP-seq
MIRT2674455	hsa-miR-3126-3p	CLIP-seq
MIRT2674456	hsa-miR-3145-3p	CLIP-seq
MIRT2674457	hsa-miR-3149	CLIP-seq
MIRT2426005	hsa-miR-3175	CLIP-seq
MIRT1925859	hsa-miR-324-3p	CLIP-seq
MIRT2674458	hsa-miR-331-3p	CLIP-seq
MIRT2469853	hsa-miR-3607-3p	CLIP-seq
MIRT2469854	hsa-miR-3613-3p	CLIP-seq
MIRT2674459	hsa-miR-3622a-3p	CLIP-seq
MIRT2674460	hsa-miR-3622b-3p	CLIP-seq
MIRT1925860	hsa-miR-3646	CLIP-seq
MIRT2469855	hsa-miR-3668	CLIP-seq
MIRT1925861	hsa-miR-3671	CLIP-seq
MIRT2674461	hsa-miR-3672	CLIP-seq
MIRT2674462	hsa-miR-3677-3p	CLIP-seq
MIRT2674463	hsa-miR-3689d	CLIP-seq
MIRT2674464	hsa-miR-3713	CLIP-seq
MIRT2469856	hsa-miR-371b-5p	CLIP-seq
MIRT2674465	hsa-miR-375	CLIP-seq
MIRT2674466	hsa-miR-378	CLIP-seq
MIRT2674467	hsa-miR-378b	CLIP-seq
MIRT2674468	hsa-miR-378c	CLIP-seq
MIRT2674469	hsa-miR-378d	CLIP-seq
MIRT2674470	hsa-miR-378e	CLIP-seq
MIRT2674471	hsa-miR-378f	CLIP-seq
MIRT2674472	hsa-miR-378h	CLIP-seq
MIRT2674473	hsa-miR-378i	CLIP-seq
MIRT766730	hsa-miR-380	CLIP-seq
MIRT2167246	hsa-miR-3909	CLIP-seq
MIRT2469857	hsa-miR-3921	CLIP-seq
MIRT2674474	hsa-miR-3925-3p	CLIP-seq
MIRT2426008	hsa-miR-3934	CLIP-seq
MIRT2674475	hsa-miR-422a	CLIP-seq
MIRT1925863	hsa-miR-4262	CLIP-seq
MIRT1925864	hsa-miR-4263	CLIP-seq
MIRT766732	hsa-miR-4266	CLIP-seq
MIRT2426009	hsa-miR-4277	CLIP-seq
MIRT766733	hsa-miR-4302	CLIP-seq
MIRT1925865	hsa-miR-4427	CLIP-seq
MIRT2674476	hsa-miR-4428	CLIP-seq
MIRT2674477	hsa-miR-4434	CLIP-seq
MIRT2426010	hsa-miR-4445	CLIP-seq
MIRT2469858	hsa-miR-4446-5p	CLIP-seq
MIRT2469859	hsa-miR-4468	CLIP-seq
MIRT2167248	hsa-miR-4495	CLIP-seq
MIRT2674478	hsa-miR-4509	CLIP-seq
MIRT2674479	hsa-miR-4516	CLIP-seq
MIRT766737	hsa-miR-4519	CLIP-seq
MIRT2674480	hsa-miR-4529-3p	CLIP-seq
MIRT2674481	hsa-miR-4531	CLIP-seq
MIRT2674482	hsa-miR-4638-3p	CLIP-seq
MIRT2469860	hsa-miR-4641	CLIP-seq
MIRT766740	hsa-miR-4645-3p	CLIP-seq
MIRT2469861	hsa-miR-4653-5p	CLIP-seq
MIRT2469862	hsa-miR-4668-3p	CLIP-seq
MIRT2469863	hsa-miR-4680-3p	CLIP-seq
MIRT766741	hsa-miR-4680-5p	CLIP-seq
MIRT766742	hsa-miR-4695-5p	CLIP-seq
MIRT2674483	hsa-miR-4704-5p	CLIP-seq
MIRT2426011	hsa-miR-4716-3p	CLIP-seq
MIRT2167251	hsa-miR-4719	CLIP-seq
MIRT2426012	hsa-miR-4723-5p	CLIP-seq
MIRT1925871	hsa-miR-4727-5p	CLIP-seq
MIRT2674484	hsa-miR-4744	CLIP-seq
MIRT2674485	hsa-miR-4755-5p	CLIP-seq
MIRT2469864	hsa-miR-4760-5p	CLIP-seq
MIRT2674486	hsa-miR-4764-5p	CLIP-seq
MIRT1925873	hsa-miR-4768-5p	CLIP-seq
MIRT2426014	hsa-miR-4769-3p	CLIP-seq
MIRT1925874	hsa-miR-4775	CLIP-seq
MIRT766747	hsa-miR-4779	CLIP-seq
MIRT2674487	hsa-miR-4794	CLIP-seq
MIRT1925875	hsa-miR-4795-3p	CLIP-seq
MIRT1925876	hsa-miR-4799-5p	CLIP-seq
MIRT2674488	hsa-miR-513b	CLIP-seq
MIRT2674489	hsa-miR-515-5p	CLIP-seq
MIRT2674490	hsa-miR-516b	CLIP-seq
MIRT766751	hsa-miR-518a-5p	CLIP-seq
MIRT766752	hsa-miR-527	CLIP-seq
MIRT766754	hsa-miR-548g	CLIP-seq
MIRT2674491	hsa-miR-548o	CLIP-seq
MIRT2426017	hsa-miR-552	CLIP-seq
MIRT2469865	hsa-miR-568	CLIP-seq
MIRT2469866	hsa-miR-571	CLIP-seq
MIRT1925878	hsa-miR-576-5p	CLIP-seq
MIRT766757	hsa-miR-578	CLIP-seq
MIRT2426018	hsa-miR-587	CLIP-seq
MIRT1925879	hsa-miR-590-3p	CLIP-seq
MIRT2674492	hsa-miR-604	CLIP-seq
MIRT2674493	hsa-miR-606	CLIP-seq
MIRT1925880	hsa-miR-607	CLIP-seq
MIRT766760	hsa-miR-618	CLIP-seq
MIRT2674494	hsa-miR-623	CLIP-seq
MIRT2674495	hsa-miR-626	CLIP-seq
MIRT2674496	hsa-miR-636	CLIP-seq
MIRT2469867	hsa-miR-642b	CLIP-seq
MIRT2674497	hsa-miR-643	CLIP-seq
MIRT2674498	hsa-miR-647	CLIP-seq
MIRT2674499	hsa-miR-651	CLIP-seq
MIRT2674500	hsa-miR-659	CLIP-seq
MIRT2674501	hsa-miR-665	CLIP-seq
MIRT766761	hsa-miR-668	CLIP-seq
MIRT2674502	hsa-miR-766	CLIP-seq
MIRT2469868	hsa-miR-802	CLIP-seq
MIRT766763	hsa-miR-877	CLIP-seq
MIRT2167256	hsa-miR-888	CLIP-seq
MIRT2674503	hsa-miR-942	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
SIRT1	Repression	21337390

Show/Hide all (44)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003180	Process	Aortic valve morphogenesis	IEA
GO:0003180	Process	Aortic valve morphogenesis	ISS
GO:0003184	Process	Pulmonary valve morphogenesis	IEA
GO:0003184	Process	Pulmonary valve morphogenesis	ISS
GO:0003203	Process	Endocardial cushion morphogenesis	IEA
GO:0003203	Process	Endocardial cushion morphogenesis	ISS
GO:0004175	Function	Endopeptidase activity	IEA
GO:0004175	Function	Endopeptidase activity	ISS
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IDA	25122765, 26668318
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	TAS
GO:0005178	Function	Integrin binding	TAS	10438522
GO:0005515	Function	Protein binding	IPI	22406378, 25122765, 29720262
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	TAS	10438522
GO:0007520	Process	Myoblast fusion	IEA
GO:0007520	Process	Myoblast fusion	ISS
GO:0008201	Function	Heparin binding	IEA
GO:0008233	Function	Peptidase activity	IDA	23845380
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IDA	21370305, 33719441
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	TAS	10438522
GO:0008270	Function	Zinc ion binding	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0022617	Process	Extracellular matrix disassembly	IEA
GO:0022617	Process	Extracellular matrix disassembly	ISS
GO:0022617	Process	Extracellular matrix disassembly	TAS
GO:0030198	Process	Extracellular matrix organization	IBA
GO:0030198	Process	Extracellular matrix organization	IEA
GO:0031012	Component	Extracellular matrix	IBA
GO:0031012	Component	Extracellular matrix	TAS	10438522
GO:0042742	Process	Defense response to bacterium	IEA
GO:0042802	Function	Identical protein binding	IPI	26668318
GO:0046872	Function	Metal ion binding	IEA
GO:0050840	Function	Extracellular matrix binding	IEA
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	IEA
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	ISS	28702327

MIM	HGNC	e!Ensembl
605007	221	ENSG00000154736

Q9UNA0

Protein name

A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 11) (ADAM-TS 11) (ADAMTS-11) (ADMP-2) (Aggrecanase-2)

Protein function

Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin

PDB

2RJQ , 3B8Z , 3HY7 , 3HY9 , 3HYG , 3LJT , 6YJM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01562	Pep_M12B_propep	38 → 182	Reprolysin family propeptide	Family
PF01421	Reprolysin	267 → 476	Reprolysin (M12B) family zinc metalloprotease	Domain
PF17771	ADAM_CR_2	487 → 554	ADAM cysteine-rich domain	Domain
PF00090	TSP_1	571 → 621	Thrombospondin type 1 domain	Domain
PF05986	ADAM_spacer1	732 → 852	ADAM-TS Spacer 1	Family
PF19030	TSP1_ADAMTS	879 → 930		Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient.

Sequence

MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGH
PHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGT
SAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGR
VYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLD
QSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANR
LYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD
AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH
DDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
LGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGT
PCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPR
NNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVL
PADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDK
CGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKK
NGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPT
KPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTV
QCQDGNRKLAKGCPLSQRPSAFKQCLLKKC

Sequence length

930

Interactions

View interactions

	Reactome
			Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEPATOMEGALY	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN FAILURE, PREMATURE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Premature ovarian failure	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (90)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Aortic Aneurysm	Aortic Aneurysm	BEFREE	29622560		★★★★★ ★☆☆☆☆ Found in Text Mining only
Aortic Aneurysm Abdominal	Aortic aneurysm	Pubtator	31473210	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Aortic Aneurysm, Abdominal	Aortic Aneurysm	BEFREE	31473210		★★★★★ ★☆☆☆☆ Found in Text Mining only
Aortic Diseases	Aortic disease	Pubtator	28546218	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Aortic valve disorder	Aortic Valve Disease	BEFREE	28546218		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	22493487		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	BEFREE	29720262, 31484722		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	Pubtator	31484722	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Psoriatic	Psoriatic arthritis	Pubtator	27706574, 31484722	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	35955467	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthropathy	Arthropathy	BEFREE	31734379		★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthenozoospermia	Asthenozoospermia	Pubtator	30544396	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	22493487		★★★★★ ★☆☆☆☆ Found in Text Mining only
Azoospermia	Azoospermia	BEFREE	29737873		★★★★★ ★☆☆☆☆ Found in Text Mining only
Azoospermia, Nonobstructive	Azoospermia	BEFREE	29737873		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bicuspid aortic valve	Bicuspid aortic valve	BEFREE	29162281		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	28099917		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28099917, 31292488	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	40472834	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33522433	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of larynx	Laryngeal carcinoma	BEFREE	23131589		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	26738863		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	30958594		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carpal Tunnel Syndrome	Carpal Tunnel Syndrome	BEFREE	28666239		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cartilage Diseases	Cartilage disease	Pubtator	18240210, 18671975, 30652828, 34116684, 39293776	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	30958594		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	37798683	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	25786261, 27906093, 29143120		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	21298349, 25786261, 27906093, 35317099	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	29638194		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	31929842	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Stenosis	Coronary stenosis	Pubtator	31929842	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic fibrosis	Pubtator	39260370	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	11801682, 16806998, 18195133, 18240210, 18328163, 18541144, 18941754, 19684582, 21566131, 22890185, 22961118, 23064555, 23491141, 23926636, 23963448 View all (36 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	LHGDN	11801682, 17265492, 18240210, 18830934		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	23369495, 25299465, 28570296, 31497227		★★★★★ ★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down syndrome	Pubtator	38095646	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	29951943, 31782329	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gestational Trophoblastic Disease	Gestational trophoblastic disease	Pubtator	24786121	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	Pubtator	36982708	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	16003758, 16133547		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	LHGDN	16133547		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	16003758, 16133547		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioma	Glioma	BEFREE	16133547		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioma	Glioma	LHGDN	16133547		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glomerulonephritis IGA	Iga nephropathy	Pubtator	32917786	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemophilia A	Hemophilia	BEFREE	28439941, 31796337		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemophilia, NOS	Hemophilia	BEFREE	28439941, 31796337		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypercholesterolemia	Hypercholesterolemia	Pubtator	35168639	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	23965235	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	30468453	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intervertebral Disc Degeneration	Intervertebral disc disease	Pubtator	19180493, 21809381, 24415654, 25299465, 30468453, 37329158, 37354087	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intervertebral Disc Degeneration	Intervertebral Disc Degeneration	BEFREE	28341660, 28570296, 30439528, 30468453		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intervertebral Disc Degeneration	Intervertebral disc disease	Pubtator	39287911	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intervertebral disc disease	Intervertebral disc disease	Pubtator	24415654, 28081267, 28583914	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intervertebral disc disorder	Intervertebral Disc Disorder	BEFREE	23369495, 25299465, 28570296, 31497227		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kashin-Beck Disease	Kashin-Beck Disease	BEFREE	31734379		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney disease	Pubtator	32917786	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Laryngeal Squamous Cell Carcinoma	Laryngeal Carcinoma	BEFREE	23131589		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lhermitte-Duclos disease	Lhermitte-Duclos disease	BEFREE	28081267		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	26677209, 30439528		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lumbar disc disease	Lumbar Disc Disease	BEFREE	28081267		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	26738863	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	28099917		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	26738863		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	30105548		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	17355265, 25151965, 29143120		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	28099917		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic Diseases	BEFREE	28702327		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	33097606	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy, Duchenne	Duchenne Muscular Dystrophy	BEFREE	26594036		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30105548		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	26738863		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nonalcoholic Steatohepatitis	Non-alcoholic Fatty Liver Disease	BEFREE	29293679		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	28702327		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obstructive azoospermia	Obstructive azoospermia	BEFREE	29737873		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	14730609, 30655094	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	20109188, 21337390, 23143889, 25430712, 25501175, 29241192, 30466988, 30572032, 30652828, 31637891, 32380078, 33441904, 34140036, 35225755, 35352613 View all (6 more)	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	34502489, 35955467	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis Knee	Osteoarthritis	Pubtator	18240210, 30652828, 34889297, 39192347	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis, Knee	Knee osteoarthritis	BEFREE	25501175, 27706574		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteopenia	Osteopenia	BEFREE	28570296		★★★★★ ★☆☆☆☆ Found in Text Mining only
Peripheral Arterial Diseases	Vascular Diseases	BEFREE	29638194		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic ovary syndrome	Pubtator	33444494	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	LHGDN	15599946		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	11801682, 18541144, 22324945		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	LHGDN	11801682		★★★★★ ★☆☆☆☆ Found in Text Mining only
Scoliosis	Scoliosis	Pubtator	28583914	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Status Epilepticus	Status Epilepticus	BEFREE	28292736		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	30105548		★★★★★ ★☆☆☆☆ Found in Text Mining only

ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif 5)