DIDO1 (death inducer-obliterator 1)

Gene

• Entrez ID: 11083
• Gene name: Death inducer-obliterator 1
• Gene symbol: DIDO1
• Synonyms (NCBI Gene): BYE1, C20orf158, DATF-1, DATF1, DIDO2, DIDO3, DIO-1, DIO1, dJ885L7.8
• Chromosome: 20
• Chromosome location: 20q13.33
• Summary: Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic sig

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027693	hsa-miR-98-5p	Microarray	19088304
MIRT049289	hsa-miR-92a-3p	CLASH	23622248
MIRT047282	hsa-miR-181b-5p	CLASH	23622248
MIRT039740	hsa-miR-615-3p	CLASH	23622248
MIRT038853	hsa-miR-93-3p	CLASH	23622248
MIRT037435	hsa-miR-744-5p	CLASH	23622248
MIRT052663	hsa-miR-3157-5p	CLASH	23622248
MIRT558369	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT558373	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT558372	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT558371	hsa-miR-4731-3p	PAR-CLIP	20371350
MIRT558370	hsa-miR-4801	PAR-CLIP	20371350
MIRT558369	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT558368	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT558367	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT558366	hsa-miR-198	PAR-CLIP	20371350
MIRT407064	hsa-miR-3941	PAR-CLIP	20371350
MIRT558365	hsa-miR-4672	PAR-CLIP	20371350
MIRT558364	hsa-miR-466	PAR-CLIP	20371350
MIRT558363	hsa-miR-582-5p	PAR-CLIP	20371350
MIRT558369	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT558373	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT558372	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT558371	hsa-miR-4731-3p	PAR-CLIP	20371350
MIRT558370	hsa-miR-4801	PAR-CLIP	20371350
MIRT558369	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT558368	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT558367	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT558366	hsa-miR-198	PAR-CLIP	20371350
MIRT407064	hsa-miR-3941	PAR-CLIP	20371350
MIRT558365	hsa-miR-4672	PAR-CLIP	20371350
MIRT558364	hsa-miR-466	PAR-CLIP	20371350
MIRT558363	hsa-miR-582-5p	PAR-CLIP	20371350
MIRT558369	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT558373	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT558372	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT558371	hsa-miR-4731-3p	PAR-CLIP	20371350
MIRT558370	hsa-miR-4801	PAR-CLIP	20371350
MIRT558369	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT558368	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT558367	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT558366	hsa-miR-198	PAR-CLIP	20371350
MIRT407064	hsa-miR-3941	PAR-CLIP	20371350
MIRT558365	hsa-miR-4672	PAR-CLIP	20371350
MIRT558364	hsa-miR-466	PAR-CLIP	20371350
MIRT558363	hsa-miR-582-5p	PAR-CLIP	20371350
MIRT558369	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT558373	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT558372	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT558371	hsa-miR-4731-3p	PAR-CLIP	20371350
MIRT558370	hsa-miR-4801	PAR-CLIP	20371350
MIRT558369	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT558368	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT558367	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT558366	hsa-miR-198	PAR-CLIP	20371350
MIRT407064	hsa-miR-3941	PAR-CLIP	20371350
MIRT558365	hsa-miR-4672	PAR-CLIP	20371350
MIRT558364	hsa-miR-466	PAR-CLIP	20371350
MIRT558363	hsa-miR-582-5p	PAR-CLIP	20371350
MIRT558369	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT558373	hsa-miR-409-3p	PAR-CLIP	21572407
MIRT558372	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT558371	hsa-miR-4731-3p	PAR-CLIP	21572407
MIRT558370	hsa-miR-4801	PAR-CLIP	21572407
MIRT558369	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT558368	hsa-miR-144-3p	PAR-CLIP	21572407
MIRT558367	hsa-miR-6504-3p	PAR-CLIP	21572407
MIRT558366	hsa-miR-198	PAR-CLIP	21572407
MIRT407064	hsa-miR-3941	PAR-CLIP	21572407
MIRT558365	hsa-miR-4672	PAR-CLIP	21572407
MIRT558364	hsa-miR-466	PAR-CLIP	21572407
MIRT558363	hsa-miR-582-5p	PAR-CLIP	21572407
MIRT558369	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT558373	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT558372	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT558371	hsa-miR-4731-3p	PAR-CLIP	20371350
MIRT558370	hsa-miR-4801	PAR-CLIP	20371350
MIRT558369	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT558368	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT558367	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT558366	hsa-miR-198	PAR-CLIP	20371350
MIRT407064	hsa-miR-3941	PAR-CLIP	20371350
MIRT558365	hsa-miR-4672	PAR-CLIP	20371350
MIRT558364	hsa-miR-466	PAR-CLIP	20371350
MIRT558363	hsa-miR-582-5p	PAR-CLIP	20371350
MIRT558369	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT558373	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT558372	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT558371	hsa-miR-4731-3p	PAR-CLIP	20371350
MIRT558370	hsa-miR-4801	PAR-CLIP	20371350
MIRT558369	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT558368	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT558367	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT558366	hsa-miR-198	PAR-CLIP	20371350
MIRT407064	hsa-miR-3941	PAR-CLIP	20371350
MIRT558365	hsa-miR-4672	PAR-CLIP	20371350
MIRT558364	hsa-miR-466	PAR-CLIP	20371350
MIRT558363	hsa-miR-582-5p	PAR-CLIP	20371350
MIRT558369	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT558373	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT558372	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT558371	hsa-miR-4731-3p	PAR-CLIP	20371350
MIRT558370	hsa-miR-4801	PAR-CLIP	20371350
MIRT558369	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT558368	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT558367	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT558366	hsa-miR-198	PAR-CLIP	20371350
MIRT407064	hsa-miR-3941	PAR-CLIP	20371350
MIRT558365	hsa-miR-4672	PAR-CLIP	20371350
MIRT558364	hsa-miR-466	PAR-CLIP	20371350
MIRT558363	hsa-miR-582-5p	PAR-CLIP	20371350
MIRT558369	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT558373	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT558372	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT558371	hsa-miR-4731-3p	PAR-CLIP	20371350
MIRT558370	hsa-miR-4801	PAR-CLIP	20371350
MIRT558369	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT558368	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT558367	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT558366	hsa-miR-198	PAR-CLIP	20371350
MIRT407064	hsa-miR-3941	PAR-CLIP	20371350
MIRT558365	hsa-miR-4672	PAR-CLIP	20371350
MIRT558364	hsa-miR-466	PAR-CLIP	20371350
MIRT558363	hsa-miR-582-5p	PAR-CLIP	20371350
MIRT558369	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT558373	hsa-miR-409-3p	PAR-CLIP	21572407
MIRT558372	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT558371	hsa-miR-4731-3p	PAR-CLIP	21572407
MIRT558370	hsa-miR-4801	PAR-CLIP	21572407
MIRT558369	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT558368	hsa-miR-144-3p	PAR-CLIP	21572407
MIRT558367	hsa-miR-6504-3p	PAR-CLIP	21572407
MIRT558366	hsa-miR-198	PAR-CLIP	21572407
MIRT407064	hsa-miR-3941	PAR-CLIP	21572407
MIRT558365	hsa-miR-4672	PAR-CLIP	21572407
MIRT558364	hsa-miR-466	PAR-CLIP	21572407
MIRT558363	hsa-miR-582-5p	PAR-CLIP	21572407
MIRT936329	hsa-miR-1204	CLIP-seq
MIRT936330	hsa-miR-216b	CLIP-seq
MIRT936331	hsa-miR-3156-5p	CLIP-seq
MIRT936332	hsa-miR-3607-3p	CLIP-seq
MIRT936333	hsa-miR-3647-3p	CLIP-seq
MIRT936334	hsa-miR-3675-3p	CLIP-seq
MIRT936335	hsa-miR-3686	CLIP-seq
MIRT936336	hsa-miR-375	CLIP-seq
MIRT936337	hsa-miR-3912	CLIP-seq
MIRT936338	hsa-miR-4652-3p	CLIP-seq
MIRT936339	hsa-miR-4666-3p	CLIP-seq
MIRT936340	hsa-miR-4700-3p	CLIP-seq
MIRT936341	hsa-miR-548n	CLIP-seq
MIRT936342	hsa-miR-548t	CLIP-seq
MIRT936343	hsa-miR-561	CLIP-seq
MIRT936344	hsa-miR-607	CLIP-seq
MIRT936345	hsa-miR-95	CLIP-seq
MIRT936346	hsa-miR-1206	CLIP-seq
MIRT936347	hsa-miR-122	CLIP-seq
MIRT936348	hsa-miR-1226	CLIP-seq
MIRT936349	hsa-miR-1294	CLIP-seq
MIRT936350	hsa-miR-147	CLIP-seq
MIRT936351	hsa-miR-186	CLIP-seq
MIRT936352	hsa-miR-18a	CLIP-seq
MIRT936353	hsa-miR-18b	CLIP-seq
MIRT936354	hsa-miR-197	CLIP-seq
MIRT936355	hsa-miR-2115	CLIP-seq
MIRT936356	hsa-miR-214	CLIP-seq
MIRT936357	hsa-miR-219-2-3p	CLIP-seq
MIRT936358	hsa-miR-2964a-3p	CLIP-seq
MIRT936359	hsa-miR-299-3p	CLIP-seq
MIRT936360	hsa-miR-299-5p	CLIP-seq
MIRT936361	hsa-miR-3133	CLIP-seq
MIRT936362	hsa-miR-3148	CLIP-seq
MIRT936363	hsa-miR-3151	CLIP-seq
MIRT936364	hsa-miR-3194-3p	CLIP-seq
MIRT936365	hsa-miR-3607-5p	CLIP-seq
MIRT936366	hsa-miR-3612	CLIP-seq
MIRT936367	hsa-miR-3619-5p	CLIP-seq
MIRT936333	hsa-miR-3647-3p	CLIP-seq
MIRT936368	hsa-miR-3660	CLIP-seq
MIRT936369	hsa-miR-3690	CLIP-seq
MIRT936370	hsa-miR-3911	CLIP-seq
MIRT936371	hsa-miR-3978	CLIP-seq
MIRT936372	hsa-miR-4251	CLIP-seq
MIRT936373	hsa-miR-4254	CLIP-seq
MIRT936374	hsa-miR-4293	CLIP-seq
MIRT936375	hsa-miR-4324	CLIP-seq
MIRT936376	hsa-miR-4433	CLIP-seq
MIRT936377	hsa-miR-4436b-3p	CLIP-seq
MIRT936378	hsa-miR-4437	CLIP-seq
MIRT936379	hsa-miR-4459	CLIP-seq
MIRT936380	hsa-miR-4526	CLIP-seq
MIRT936381	hsa-miR-4638-3p	CLIP-seq
MIRT936382	hsa-miR-4674	CLIP-seq
MIRT936383	hsa-miR-4693-3p	CLIP-seq
MIRT936384	hsa-miR-4695-5p	CLIP-seq
MIRT936385	hsa-miR-4705	CLIP-seq
MIRT936386	hsa-miR-4722-5p	CLIP-seq
MIRT936387	hsa-miR-4733-3p	CLIP-seq
MIRT936388	hsa-miR-4735-3p	CLIP-seq
MIRT936389	hsa-miR-4756-3p	CLIP-seq
MIRT936390	hsa-miR-4793-5p	CLIP-seq
MIRT936391	hsa-miR-516a-3p	CLIP-seq
MIRT936392	hsa-miR-539	CLIP-seq
MIRT936393	hsa-miR-542-3p	CLIP-seq
MIRT936394	hsa-miR-548a-3p	CLIP-seq
MIRT936395	hsa-miR-548e	CLIP-seq
MIRT936396	hsa-miR-548f	CLIP-seq
MIRT936397	hsa-miR-570	CLIP-seq
MIRT936398	hsa-miR-574-5p	CLIP-seq
MIRT936399	hsa-miR-644	CLIP-seq
MIRT936400	hsa-miR-650	CLIP-seq
MIRT936401	hsa-miR-663b	CLIP-seq
MIRT936402	hsa-miR-760	CLIP-seq
MIRT936403	hsa-miR-761	CLIP-seq
MIRT1977072	hsa-miR-3614-5p	CLIP-seq
MIRT1977073	hsa-miR-380	CLIP-seq
MIRT1977074	hsa-miR-3942-5p	CLIP-seq
MIRT1977075	hsa-miR-4703-5p	CLIP-seq
MIRT1977076	hsa-miR-4766-5p	CLIP-seq
MIRT2212472	hsa-miR-101	CLIP-seq
MIRT2212473	hsa-miR-1245	CLIP-seq
MIRT2212474	hsa-miR-1264	CLIP-seq
MIRT2212475	hsa-miR-128	CLIP-seq
MIRT2212476	hsa-miR-1297	CLIP-seq
MIRT2212477	hsa-miR-135a	CLIP-seq
MIRT2212478	hsa-miR-135b	CLIP-seq
MIRT2212479	hsa-miR-144	CLIP-seq
MIRT936330	hsa-miR-216b	CLIP-seq
MIRT2212480	hsa-miR-26a	CLIP-seq
MIRT2212481	hsa-miR-26b	CLIP-seq
MIRT2212482	hsa-miR-27a	CLIP-seq
MIRT2212483	hsa-miR-27b	CLIP-seq
MIRT2212484	hsa-miR-34c-3p	CLIP-seq
MIRT936334	hsa-miR-3675-3p	CLIP-seq
MIRT1977074	hsa-miR-3942-5p	CLIP-seq
MIRT2212485	hsa-miR-4260	CLIP-seq
MIRT2212486	hsa-miR-4276	CLIP-seq
MIRT2212487	hsa-miR-4277	CLIP-seq
MIRT2212488	hsa-miR-4421	CLIP-seq
MIRT2212489	hsa-miR-4432	CLIP-seq
MIRT2212490	hsa-miR-4446-5p	CLIP-seq
MIRT2212491	hsa-miR-4465	CLIP-seq
MIRT2212492	hsa-miR-4532	CLIP-seq
MIRT2212493	hsa-miR-4697-3p	CLIP-seq
MIRT936340	hsa-miR-4700-3p	CLIP-seq
MIRT1977075	hsa-miR-4703-5p	CLIP-seq
MIRT2212494	hsa-miR-4713-5p	CLIP-seq
MIRT2212495	hsa-miR-4716-5p	CLIP-seq
MIRT2212496	hsa-miR-4744	CLIP-seq
MIRT1977076	hsa-miR-4766-5p	CLIP-seq
MIRT2212497	hsa-miR-493	CLIP-seq
MIRT2212498	hsa-miR-499-5p	CLIP-seq
MIRT936391	hsa-miR-516a-3p	CLIP-seq
MIRT2212499	hsa-miR-526b	CLIP-seq
MIRT2212500	hsa-miR-579	CLIP-seq
MIRT2212501	hsa-miR-610	CLIP-seq
MIRT2448236	hsa-miR-1207-3p	CLIP-seq
MIRT2448237	hsa-miR-125a-5p	CLIP-seq
MIRT2448238	hsa-miR-125b	CLIP-seq
MIRT2448239	hsa-miR-1270	CLIP-seq
MIRT2448240	hsa-miR-1285	CLIP-seq
MIRT2448241	hsa-miR-143	CLIP-seq
MIRT2448242	hsa-miR-2277-3p	CLIP-seq
MIRT2448243	hsa-miR-3187-5p	CLIP-seq
MIRT2448244	hsa-miR-331-3p	CLIP-seq
MIRT2448245	hsa-miR-3616-3p	CLIP-seq
MIRT936368	hsa-miR-3660	CLIP-seq
MIRT2448246	hsa-miR-3691-3p	CLIP-seq
MIRT2448247	hsa-miR-4319	CLIP-seq
MIRT936380	hsa-miR-4526	CLIP-seq
MIRT2448248	hsa-miR-4531	CLIP-seq
MIRT2448249	hsa-miR-4683	CLIP-seq
MIRT2448250	hsa-miR-4721	CLIP-seq
MIRT2448251	hsa-miR-4770	CLIP-seq
MIRT2448252	hsa-miR-544b	CLIP-seq
MIRT2448253	hsa-miR-612	CLIP-seq
MIRT2448254	hsa-miR-620	CLIP-seq
MIRT936356	hsa-miR-214	CLIP-seq
MIRT936364	hsa-miR-3194-3p	CLIP-seq
MIRT936366	hsa-miR-3612	CLIP-seq
MIRT936367	hsa-miR-3619-5p	CLIP-seq
MIRT936369	hsa-miR-3690	CLIP-seq
MIRT936373	hsa-miR-4254	CLIP-seq
MIRT936377	hsa-miR-4436b-3p	CLIP-seq
MIRT936378	hsa-miR-4437	CLIP-seq
MIRT936379	hsa-miR-4459	CLIP-seq
MIRT936381	hsa-miR-4638-3p	CLIP-seq
MIRT936382	hsa-miR-4674	CLIP-seq
MIRT936384	hsa-miR-4695-5p	CLIP-seq
MIRT936386	hsa-miR-4722-5p	CLIP-seq
MIRT936390	hsa-miR-4793-5p	CLIP-seq
MIRT936400	hsa-miR-650	CLIP-seq
MIRT936402	hsa-miR-760	CLIP-seq
MIRT936403	hsa-miR-761	CLIP-seq
MIRT2448239	hsa-miR-1270	CLIP-seq
MIRT2448241	hsa-miR-143	CLIP-seq
MIRT2448242	hsa-miR-2277-3p	CLIP-seq
MIRT936368	hsa-miR-3660	CLIP-seq
MIRT2448246	hsa-miR-3691-3p	CLIP-seq
MIRT936380	hsa-miR-4526	CLIP-seq
MIRT2448248	hsa-miR-4531	CLIP-seq
MIRT2448249	hsa-miR-4683	CLIP-seq
MIRT2448251	hsa-miR-4770	CLIP-seq
MIRT2448254	hsa-miR-620	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	24981860, 27705803, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0006351	Process	DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006915	Process	Apoptotic process	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0097190	Process	Apoptotic signaling pathway	IEA
GO:0097190	Process	Apoptotic signaling pathway	IEA

Other IDs

• MIM: 604140
• HGNC: 2680
• e!Ensembl: ENSG00000101191

Protein

• UniProt ID: Q9BTC0
• Protein name: Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1)
• Protein function: Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. ; [Isoform 2]: Displaces isoform 4
• PDB: 2M3H, 4L7X
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00628	PHD	270 → 322	PHD-finger	Domain
  PF07500	TFIIS_M	668 → 781	Transcription factor S-II (TFIIS), central domain	Domain
  PF07744	SPOC	1047 → 1197	SPOC domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous.
• Sequence:

  MDDKGDPSNEEAPKAIKPTSKEFRKTWGFRRTTIAKREGAGDAEADPLEPPPPQQQLGLS
  LRRSGRQPKRTERVEQFLTIARRRGRRSMPVSLEDSGEPTSCPATDAETASEGSVESASE
  TRSGPQSASTAVKERPASSEKVKGGDDHDDTSDSDSDGLTLKELQNRLRRKREQEPTERP
  LKGIQSRLRKKRREEGPAETVGSEASDTVEGVLPSKQEPENDQGVVSQAGKDDRESKLEG
  KAAQDIKDEEPGDLGRPKPECEGYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGIS
  EARGRLLERNGEDYICPNCTILQVQDETHSETADQQEAKWRPGDADGTDCTSIGTIEQKS
  SEDQGIKGRIEKAANPSGKKKLKIFQPVIEAPGASKCIGPGCCHVAQPDSVYCSNDCILK
  HAAATMKFLSSGKEQKPKPKEKMKMKPEKPSLPKCGAQAGIKISSVHKRPAPEKKETTVK
  KAVVVPARSEALGKEAACESSTPSWASDHNYNAVKPEKTAAPSPSLLYKSTKEDRRSEEK
  AAAMAASKKTAPPGSAVGKQPAPRNLVPKKSSFANVAAATPAIKKPPSGFKGTIPKRPWL
  SATPSSGASAARQAGPAPAAATAASKKFPGSAALVGAVRKPVVPSVPMASPAPGRLGAMS
  AAPSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTENEVGKIALHIEKEMFNLFQVTDNR
  YKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRLKPEELVSKELSTWKERPARSVME
  SRTKLHNESKKTAPRQEAIPDLEDSPPVSDSEEQQESARAVPEKSTAPLLDVFSSMLKDT
  TSQHRAHLFDLNCKICTGQVPSAEDEPAPKKQKLSASVKKEDLKSKHDSSAPDPAPDSAD
  EVMPEAVPEVASEPGLESASHPNVDRTYFPGPPGDGHPEPSPLEDLSPCPASCGSGVVTT
  VTVSGRDPRTAPSSSCTAVASAASRPDSTHMVEARQDVPKPVLTSVMVPKSILAKPSSSP
  DPRYLSVPPSPNISTSESRSPPEGDTTLFLSRLSTIWKGFINMQSVAKFVTKAYPVSGCF
  DYLSEDLPDTIHIGGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEEVAYISLYSYF
  SSRGRFGVVANNNRHVKDLYLIPLSAQDPVPSKLLPFEGPGLESPRPNIILGLVICQKIK
  RPANSGELDKMDEKRTRLQPEEADVPAYPKVATVPQSEKKPSKYPLCSADAAVSTTPPGS
  PPPPPPLPEPPVLKVLSSLKPAAPSPATAATTAAAASTAASSTASSASKTASPLEHILQT
  LFGKKKSFDPSAREPPGSTAGLPQEPKTTAEDGVPAPPLLDPIVQQFGQFSKDKALEEEE
  DDRPYDPEEEYDPERAFDTQLVERGRRHEVERAPEAAAAEREEVAYDPEDETILEEAKVT
  VDDLPNRMCADVRRNSVERPAEPVAGAATPSLVEQQKMLEELNKQIEEQKRQLEEQEEAL
  RQQRAAVGVSMAHFSVSDALMSPPPKSSLPKAELFQQEQQSADKPASLPPASQASNHRDP
  RQARRLATETGEGEGEPLSRLSARGAQGALPERDASRGGLVGQAPMPVPEEKEPASSPWA
  SGEKPPAGSEQDGWKAEPGEGTRPATVGDSSARPARRVLLPTPPCGALQPGFPLQHDGER
  DPFTCPGFASQDKALGSAQYEDPRNLHSAGRSSSPAGETEGDREPQARPGEGTAPLPPPG
  QKVGGSQPPFQGQREPGPHALGMSGLHGPNFPGPRGPAPPFPEENIASNDGPRGPPPARF
  GAQKGPIPSLFSGQHGPPPYGDSRGPSPSYLGGPRGVAPSQFEERKDPHGEKREFQDAPY
  NEVTGAPAQFEGTEQAPFLGSRGGAPFQFGGQRRPLLSQLKGPRGGPPPSQFGGQRGPPP
  GHFVGPRGPHPSQFETARGPHPNQFEGPRGQAPNFMPGPRGIQPQQFEDQRVHSPPRFTN
  QRAPAPLQFGGLRGSAPFSEKNEQTPSRFHFQGQAPQVMKPGPRPLLELPSHPPQHRKDR
  WEEAGPPSALSSSAPGQGPEADGQWASADFREGKGHEYRNQTFEGRQRERFDVGPKEKPL
  EEPDAQGRASEDRRRERERGRNWSRERDWDRPREWDRHRDKDSSRDWDRNRERSANRDRE
  READRGKEWDRSRERSRNRERERDRRRDRDRSRSRERDRDKARDRERGRDRKDRSKSKES
  ARDPKPEASRASDAGTASQA

• Sequence length: 2240

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Clear cell carcinoma of kidney	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL SQUAMOUS CELL CARCINOMA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenoma of large intestine	Colorectal adenoma	BEFREE	22711543		★☆☆☆☆ Found in Text Mining only
Anaplasia	Anaplasia	BEFREE	15943828		★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	26199857	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	21912701	Inhibit	★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	31022560		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	22711543		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	22711543, 30809968, 37728516	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms Hereditary Nonpolyposis	Lynch syndrome	Pubtator	37728516	Associate	★☆☆☆☆ Found in Text Mining only
Congenital Hypothyroidism	Congenital hypothyroidism	Pubtator	34128397	Associate	★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	20691260, 21912701		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	29641285		★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	26866568, 27351946, 29182613		★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	34128397	Associate	★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	37728516	Associate	★☆☆☆☆ Found in Text Mining only
Endometrial Stromal Sarcoma	Endometrial Stromal Sarcoma	BEFREE	29894998, 30152254		★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty liver	Pubtator	39312733	Associate	★☆☆☆☆ Found in Text Mining only
Follicular adenoma	Adenoma	BEFREE	15943828		★☆☆☆☆ Found in Text Mining only
Follicular thyroid carcinoma	Follicular Thyroid Carcinoma	BEFREE	15943828		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	31452060		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	31452060		★☆☆☆☆ Found in Text Mining only
Graves Disease	Graves Disease	BEFREE	23109646		★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	28749946	Associate	★☆☆☆☆ Found in Text Mining only
Hemolytic Uremic Syndrome	Hemolytic uremic syndrome	Pubtator	25174507	Inhibit	★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	29641285		★☆☆☆☆ Found in Text Mining only
Hyperthyroidism	Hyperthyroidism	BEFREE	30610492, 31636683		★☆☆☆☆ Found in Text Mining only
Hyperthyroxinemia	Hyperthyroxinemia	CTD_human_DG	3346351		★☆☆☆☆ Found in Text Mining only
Hypothyroidism	Hypothyroidism	BEFREE	28466400		★☆☆☆☆ Found in Text Mining only
Hypothyroidism	Hypothyroidism	Pubtator	35813623, 37563580	Associate	★☆☆☆☆ Found in Text Mining only
Inborn Errors of Metabolism	Inborn Errors Of Metabolism	CTD_human_DG	17105838		★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	33980776	Associate	★☆☆☆☆ Found in Text Mining only
Ischemic Attack Transient	Transient ischemic attack	Pubtator	34103026	Associate	★☆☆☆☆ Found in Text Mining only
Ischemic Stroke	Ischemic stroke	Pubtator	34103026	Associate	★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney disease	Pubtator	21912701	Inhibit	★☆☆☆☆ Found in Text Mining only
Kidney Failure Chronic	Kidney failure	Pubtator	29894998	Associate	★☆☆☆☆ Found in Text Mining only
Kidney Failure, Chronic	Kidney Failure	BEFREE	29894998, 30152254		★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Kidney neoplasm	Pubtator	29272308	Associate	★☆☆☆☆ Found in Text Mining only
Laryngeal Squamous Cell Carcinoma	Laryngeal Carcinoma	BEFREE	31127661, 31367490		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	25944909		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of kidney	Kidney Cancer	BEFREE	19534619, 29272308		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	28120266		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	19534619, 29272308, 30809968		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	17274741		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	22469980		★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	26866568, 27351946, 29182613		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	GWASDB_DG	23502783		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	GWASCAT_DG	23502783		★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	LHGDN	16127461		★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	27282563		★☆☆☆☆ Found in Text Mining only
Myeloproliferative disease	Myeloproliferative disorder	BEFREE	27282563		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	GWASDB_DG	21211798		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	32514186	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	15943828, 19036015, 21415143, 21912701, 22711543		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	28576870		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	15785240, 15943828, 26690675		★☆☆☆☆ Found in Text Mining only
Pituitary Neoplasms	Pituitary Neoplasms	LHGDN	12153750		★☆☆☆☆ Found in Text Mining only
Polyostotic fibrous dysplasia	Polyostotic Fibrous Dysplasia	LHGDN	18349068		★☆☆☆☆ Found in Text Mining only
POPLITEAL PTERYGIUM SYNDROME, LETHAL TYPE	Bartsocas-Papas syndrome	BEFREE	28467477		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	28120266		★☆☆☆☆ Found in Text Mining only
Recurrent depressive disorder	Mental Depression	BEFREE	26866568, 27351946		★☆☆☆☆ Found in Text Mining only
Renal carcinoma	Renal Carcinoma	BEFREE	19534619, 29272308		★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	29118715		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	CTD_human_DG	30431698		★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	26690675, 36465624	Associate	★☆☆☆☆ Found in Text Mining only
THYROID CARCINOMA, SPORADIC MEDULLARY	Thyroid Carcinoma	BEFREE	26690675		★☆☆☆☆ Found in Text Mining only
Thyroid Diseases	Thyroid Diseases	CTD_human_DG	17105838		★☆☆☆☆ Found in Text Mining only
Thyroid Gland Follicular Adenoma	Thyroid Gland Follicular Adenoma	BEFREE	15943828		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	16675914	Associate	★☆☆☆☆ Found in Text Mining only