RER1 (retention in endoplasmic reticulum sorting receptor 1)

Gene

• Entrez ID: 11079
• Gene name: Retention in endoplasmic reticulum sorting receptor 1
• Gene symbol: RER1
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1p36.32
• Summary: The protein encoded by this gene is a multi-pass membrane protein that is localized to the golgi apparatus. It is involved in the retention of endoplasmic reticulum (ER) membrane proteins in the ER and retrieval of ER membrane proteins from the early Golg

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016241	hsa-miR-548b-3p	Sequencing	20371350
MIRT043203	hsa-miR-324-5p	CLASH	23622248
MIRT041841	hsa-miR-484	CLASH	23622248
MIRT469389	hsa-miR-143-3p	PAR-CLIP	23592263
MIRT469386	hsa-miR-6088	PAR-CLIP	23592263
MIRT469387	hsa-miR-4770	PAR-CLIP	23592263
MIRT337076	hsa-miR-4496	PAR-CLIP	23592263
MIRT469385	hsa-miR-1825	PAR-CLIP	23592263
MIRT469384	hsa-miR-199a-5p	PAR-CLIP	23592263
MIRT469383	hsa-miR-199b-5p	PAR-CLIP	23592263
MIRT469382	hsa-miR-766-3p	PAR-CLIP	23592263
MIRT469381	hsa-miR-3925-3p	PAR-CLIP	23592263
MIRT337078	hsa-miR-4720-5p	PAR-CLIP	23592263
MIRT337080	hsa-miR-4799-3p	PAR-CLIP	23592263
MIRT337082	hsa-miR-5588-5p	PAR-CLIP	23592263
MIRT337079	hsa-miR-4738-3p	PAR-CLIP	23592263
MIRT469380	hsa-miR-4708-5p	PAR-CLIP	23592263
MIRT337081	hsa-miR-1273f	PAR-CLIP	23592263
MIRT337067	hsa-miR-1256	PAR-CLIP	23592263
MIRT469379	hsa-miR-5687	PAR-CLIP	23592263
MIRT469389	hsa-miR-143-3p	PAR-CLIP	23592263
MIRT469386	hsa-miR-6088	PAR-CLIP	23592263
MIRT469387	hsa-miR-4770	PAR-CLIP	23592263
MIRT337076	hsa-miR-4496	PAR-CLIP	23592263
MIRT469385	hsa-miR-1825	PAR-CLIP	23592263
MIRT469384	hsa-miR-199a-5p	PAR-CLIP	23592263
MIRT469383	hsa-miR-199b-5p	PAR-CLIP	23592263
MIRT469382	hsa-miR-766-3p	PAR-CLIP	23592263
MIRT469381	hsa-miR-3925-3p	PAR-CLIP	23592263
MIRT337078	hsa-miR-4720-5p	PAR-CLIP	23592263
MIRT337080	hsa-miR-4799-3p	PAR-CLIP	23592263
MIRT337082	hsa-miR-5588-5p	PAR-CLIP	23592263
MIRT337079	hsa-miR-4738-3p	PAR-CLIP	23592263
MIRT469380	hsa-miR-4708-5p	PAR-CLIP	23592263
MIRT337081	hsa-miR-1273f	PAR-CLIP	23592263
MIRT337067	hsa-miR-1256	PAR-CLIP	23592263
MIRT469379	hsa-miR-5687	PAR-CLIP	23592263
MIRT1300536	hsa-miR-1184	CLIP-seq
MIRT1300537	hsa-miR-1233	CLIP-seq
MIRT1300538	hsa-miR-1301	CLIP-seq
MIRT1300539	hsa-miR-1343	CLIP-seq
MIRT1300540	hsa-miR-1976	CLIP-seq
MIRT1300541	hsa-miR-2861	CLIP-seq
MIRT1300542	hsa-miR-3157-5p	CLIP-seq
MIRT1300543	hsa-miR-3185	CLIP-seq
MIRT1300544	hsa-miR-331-5p	CLIP-seq
MIRT1300545	hsa-miR-3611	CLIP-seq
MIRT1300546	hsa-miR-370	CLIP-seq
MIRT1300547	hsa-miR-3910	CLIP-seq
MIRT1300548	hsa-miR-4307	CLIP-seq
MIRT1300549	hsa-miR-4488	CLIP-seq
MIRT1300550	hsa-miR-4501	CLIP-seq
MIRT1300551	hsa-miR-4659a-5p	CLIP-seq
MIRT1300552	hsa-miR-4659b-5p	CLIP-seq
MIRT1300553	hsa-miR-4660	CLIP-seq
MIRT1300554	hsa-miR-4687-5p	CLIP-seq
MIRT1300555	hsa-miR-4690-3p	CLIP-seq
MIRT1300556	hsa-miR-4697-5p	CLIP-seq
MIRT1300557	hsa-miR-4716-5p	CLIP-seq
MIRT1300558	hsa-miR-4731-5p	CLIP-seq
MIRT1300559	hsa-miR-4733-3p	CLIP-seq
MIRT1300560	hsa-miR-4768-3p	CLIP-seq
MIRT1300561	hsa-miR-4769-3p	CLIP-seq
MIRT1300562	hsa-miR-5047	CLIP-seq
MIRT1300563	hsa-miR-541	CLIP-seq
MIRT1300564	hsa-miR-548an	CLIP-seq
MIRT1300565	hsa-miR-548u	CLIP-seq
MIRT1300566	hsa-miR-604	CLIP-seq
MIRT1300567	hsa-miR-637	CLIP-seq
MIRT1300568	hsa-miR-654-5p	CLIP-seq
MIRT1300569	hsa-miR-665	CLIP-seq
MIRT1300540	hsa-miR-1976	CLIP-seq
MIRT2089372	hsa-miR-2052	CLIP-seq
MIRT2089373	hsa-miR-3647-3p	CLIP-seq
MIRT2089374	hsa-miR-4251	CLIP-seq
MIRT2089375	hsa-miR-4261	CLIP-seq
MIRT2089376	hsa-miR-4282	CLIP-seq
MIRT2089377	hsa-miR-4303	CLIP-seq
MIRT2089378	hsa-miR-4329	CLIP-seq
MIRT2089379	hsa-miR-4448	CLIP-seq
MIRT2089380	hsa-miR-4722-3p	CLIP-seq
MIRT1300558	hsa-miR-4731-5p	CLIP-seq
MIRT2089381	hsa-miR-520d-5p	CLIP-seq
MIRT2089382	hsa-miR-524-5p	CLIP-seq
MIRT2089383	hsa-miR-627	CLIP-seq
MIRT2089384	hsa-miR-651	CLIP-seq
MIRT2089385	hsa-miR-935	CLIP-seq
MIRT2314130	hsa-miR-1179	CLIP-seq
MIRT2314131	hsa-miR-124	CLIP-seq
MIRT2314132	hsa-miR-1245b-5p	CLIP-seq
MIRT2314133	hsa-miR-1269	CLIP-seq
MIRT2314134	hsa-miR-1269b	CLIP-seq
MIRT2314135	hsa-miR-1288	CLIP-seq
MIRT2314136	hsa-miR-299-5p	CLIP-seq
MIRT2314137	hsa-miR-3117-5p	CLIP-seq
MIRT2314138	hsa-miR-3142	CLIP-seq
MIRT2314139	hsa-miR-3152-3p	CLIP-seq
MIRT2314140	hsa-miR-3714	CLIP-seq
MIRT1300547	hsa-miR-3910	CLIP-seq
MIRT2314141	hsa-miR-4326	CLIP-seq
MIRT2314142	hsa-miR-4420	CLIP-seq
MIRT2314143	hsa-miR-4421	CLIP-seq
MIRT2314144	hsa-miR-4469	CLIP-seq
MIRT2314145	hsa-miR-4503	CLIP-seq
MIRT2314146	hsa-miR-4515	CLIP-seq
MIRT2314147	hsa-miR-4650-5p	CLIP-seq
MIRT2314148	hsa-miR-4655-3p	CLIP-seq
MIRT2314149	hsa-miR-4668-3p	CLIP-seq
MIRT2314150	hsa-miR-4691-5p	CLIP-seq
MIRT2314151	hsa-miR-4740-5p	CLIP-seq
MIRT2314152	hsa-miR-4761-5p	CLIP-seq
MIRT2314153	hsa-miR-486-3p	CLIP-seq
MIRT2314154	hsa-miR-506	CLIP-seq
MIRT2314155	hsa-miR-518e	CLIP-seq
MIRT2314156	hsa-miR-622	CLIP-seq
MIRT2314157	hsa-miR-659	CLIP-seq
MIRT2393619	hsa-miR-2110	CLIP-seq
MIRT2393620	hsa-miR-4271	CLIP-seq
MIRT1300549	hsa-miR-4488	CLIP-seq
MIRT2393621	hsa-miR-4667-5p	CLIP-seq
MIRT1300556	hsa-miR-4697-5p	CLIP-seq
MIRT2393622	hsa-miR-4700-5p	CLIP-seq
MIRT2393623	hsa-miR-4725-3p	CLIP-seq
MIRT1300558	hsa-miR-4731-5p	CLIP-seq
MIRT2393624	hsa-miR-4747-5p	CLIP-seq
MIRT1300567	hsa-miR-637	CLIP-seq
MIRT2314130	hsa-miR-1179	CLIP-seq
MIRT2458032	hsa-miR-1200	CLIP-seq
MIRT2458033	hsa-miR-1281	CLIP-seq
MIRT1300539	hsa-miR-1343	CLIP-seq
MIRT2458034	hsa-miR-136	CLIP-seq
MIRT2458035	hsa-miR-1539	CLIP-seq
MIRT2458036	hsa-miR-1912	CLIP-seq
MIRT2458037	hsa-miR-3074-5p	CLIP-seq
MIRT2314137	hsa-miR-3117-5p	CLIP-seq
MIRT2458038	hsa-miR-3140-5p	CLIP-seq
MIRT2458039	hsa-miR-3150b-3p	CLIP-seq
MIRT1300542	hsa-miR-3157-5p	CLIP-seq
MIRT2458040	hsa-miR-3180-5p	CLIP-seq
MIRT1300544	hsa-miR-331-5p	CLIP-seq
MIRT2458041	hsa-miR-3689d	CLIP-seq
MIRT2458042	hsa-miR-3940-3p	CLIP-seq
MIRT2089374	hsa-miR-4251	CLIP-seq
MIRT2458043	hsa-miR-4258	CLIP-seq
MIRT2089375	hsa-miR-4261	CLIP-seq
MIRT2089377	hsa-miR-4303	CLIP-seq
MIRT1300548	hsa-miR-4307	CLIP-seq
MIRT2089378	hsa-miR-4329	CLIP-seq
MIRT2458044	hsa-miR-4426	CLIP-seq
MIRT2458045	hsa-miR-4532	CLIP-seq
MIRT2458046	hsa-miR-4647	CLIP-seq
MIRT1300551	hsa-miR-4659a-5p	CLIP-seq
MIRT1300552	hsa-miR-4659b-5p	CLIP-seq
MIRT2458047	hsa-miR-4662b	CLIP-seq
MIRT2314149	hsa-miR-4668-3p	CLIP-seq
MIRT2458048	hsa-miR-4689	CLIP-seq
MIRT1300555	hsa-miR-4690-3p	CLIP-seq
MIRT1300557	hsa-miR-4716-5p	CLIP-seq
MIRT2458049	hsa-miR-4731-3p	CLIP-seq
MIRT2458050	hsa-miR-4749-3p	CLIP-seq
MIRT2458051	hsa-miR-4784	CLIP-seq
MIRT2458052	hsa-miR-4798-3p	CLIP-seq
MIRT2458053	hsa-miR-4801	CLIP-seq
MIRT2458054	hsa-miR-521	CLIP-seq
MIRT2458055	hsa-miR-548m	CLIP-seq
MIRT1300565	hsa-miR-548u	CLIP-seq
MIRT2458056	hsa-miR-596	CLIP-seq
MIRT2458057	hsa-miR-759	CLIP-seq
MIRT2458033	hsa-miR-1281	CLIP-seq
MIRT2458034	hsa-miR-136	CLIP-seq
MIRT2458036	hsa-miR-1912	CLIP-seq
MIRT1300542	hsa-miR-3157-5p	CLIP-seq
MIRT2458040	hsa-miR-3180-5p	CLIP-seq
MIRT1300544	hsa-miR-331-5p	CLIP-seq
MIRT2458041	hsa-miR-3689d	CLIP-seq
MIRT2458043	hsa-miR-4258	CLIP-seq
MIRT1300548	hsa-miR-4307	CLIP-seq
MIRT1300551	hsa-miR-4659a-5p	CLIP-seq
MIRT1300552	hsa-miR-4659b-5p	CLIP-seq
MIRT1300555	hsa-miR-4690-3p	CLIP-seq
MIRT1300557	hsa-miR-4716-5p	CLIP-seq
MIRT2458050	hsa-miR-4749-3p	CLIP-seq
MIRT2458052	hsa-miR-4798-3p	CLIP-seq
MIRT2458054	hsa-miR-521	CLIP-seq
MIRT2458055	hsa-miR-548m	CLIP-seq
MIRT1300565	hsa-miR-548u	CLIP-seq
MIRT1300536	hsa-miR-1184	CLIP-seq
MIRT2610672	hsa-miR-1202	CLIP-seq
MIRT2610673	hsa-miR-1224-3p	CLIP-seq
MIRT2314132	hsa-miR-1245b-5p	CLIP-seq
MIRT2610674	hsa-miR-1249	CLIP-seq
MIRT2458033	hsa-miR-1281	CLIP-seq
MIRT1300538	hsa-miR-1301	CLIP-seq
MIRT2458034	hsa-miR-136	CLIP-seq
MIRT2610675	hsa-miR-1908	CLIP-seq
MIRT1300540	hsa-miR-1976	CLIP-seq
MIRT2393619	hsa-miR-2110	CLIP-seq
MIRT2314138	hsa-miR-3142	CLIP-seq
MIRT2610676	hsa-miR-3144-5p	CLIP-seq
MIRT1300542	hsa-miR-3157-5p	CLIP-seq
MIRT2458040	hsa-miR-3180-5p	CLIP-seq
MIRT2610677	hsa-miR-3194-5p	CLIP-seq
MIRT2610678	hsa-miR-3613-3p	CLIP-seq
MIRT2610679	hsa-miR-3972	CLIP-seq
MIRT2458043	hsa-miR-4258	CLIP-seq
MIRT2610680	hsa-miR-4268	CLIP-seq
MIRT2393620	hsa-miR-4271	CLIP-seq
MIRT2314141	hsa-miR-4326	CLIP-seq
MIRT2610681	hsa-miR-4437	CLIP-seq
MIRT2089379	hsa-miR-4448	CLIP-seq
MIRT2314144	hsa-miR-4469	CLIP-seq
MIRT2314147	hsa-miR-4650-5p	CLIP-seq
MIRT2314148	hsa-miR-4655-3p	CLIP-seq
MIRT1300553	hsa-miR-4660	CLIP-seq
MIRT2393621	hsa-miR-4667-5p	CLIP-seq
MIRT2610682	hsa-miR-4674	CLIP-seq
MIRT1300555	hsa-miR-4690-3p	CLIP-seq
MIRT2314150	hsa-miR-4691-5p	CLIP-seq
MIRT2393622	hsa-miR-4700-5p	CLIP-seq
MIRT2610683	hsa-miR-4706	CLIP-seq
MIRT2089380	hsa-miR-4722-3p	CLIP-seq
MIRT2393623	hsa-miR-4725-3p	CLIP-seq
MIRT1300558	hsa-miR-4731-5p	CLIP-seq
MIRT2393624	hsa-miR-4747-5p	CLIP-seq
MIRT2458050	hsa-miR-4749-3p	CLIP-seq
MIRT2610684	hsa-miR-4749-5p	CLIP-seq
MIRT2610685	hsa-miR-4763-5p	CLIP-seq
MIRT2610686	hsa-miR-4781-5p	CLIP-seq
MIRT1300562	hsa-miR-5047	CLIP-seq
MIRT2610687	hsa-miR-539	CLIP-seq
MIRT2314156	hsa-miR-622	CLIP-seq
MIRT2610688	hsa-miR-639	CLIP-seq
MIRT2610689	hsa-miR-663	CLIP-seq
MIRT2610690	hsa-miR-767-3p	CLIP-seq
MIRT2610691	hsa-miR-939	CLIP-seq
MIRT1300536	hsa-miR-1184	CLIP-seq
MIRT2610672	hsa-miR-1202	CLIP-seq
MIRT2610673	hsa-miR-1224-3p	CLIP-seq
MIRT2314132	hsa-miR-1245b-5p	CLIP-seq
MIRT2610674	hsa-miR-1249	CLIP-seq
MIRT2458033	hsa-miR-1281	CLIP-seq
MIRT1300538	hsa-miR-1301	CLIP-seq
MIRT2610675	hsa-miR-1908	CLIP-seq
MIRT1300540	hsa-miR-1976	CLIP-seq
MIRT2393619	hsa-miR-2110	CLIP-seq
MIRT2314138	hsa-miR-3142	CLIP-seq
MIRT2610676	hsa-miR-3144-5p	CLIP-seq
MIRT1300542	hsa-miR-3157-5p	CLIP-seq
MIRT2610677	hsa-miR-3194-5p	CLIP-seq
MIRT2610679	hsa-miR-3972	CLIP-seq
MIRT2458043	hsa-miR-4258	CLIP-seq
MIRT2610680	hsa-miR-4268	CLIP-seq
MIRT2393620	hsa-miR-4271	CLIP-seq
MIRT2314141	hsa-miR-4326	CLIP-seq
MIRT2610681	hsa-miR-4437	CLIP-seq
MIRT2089379	hsa-miR-4448	CLIP-seq
MIRT2314144	hsa-miR-4469	CLIP-seq
MIRT2314147	hsa-miR-4650-5p	CLIP-seq
MIRT2314148	hsa-miR-4655-3p	CLIP-seq
MIRT1300553	hsa-miR-4660	CLIP-seq
MIRT2393621	hsa-miR-4667-5p	CLIP-seq
MIRT2610682	hsa-miR-4674	CLIP-seq
MIRT1300555	hsa-miR-4690-3p	CLIP-seq
MIRT2314150	hsa-miR-4691-5p	CLIP-seq
MIRT2393622	hsa-miR-4700-5p	CLIP-seq
MIRT2610683	hsa-miR-4706	CLIP-seq
MIRT2089380	hsa-miR-4722-3p	CLIP-seq
MIRT2393623	hsa-miR-4725-3p	CLIP-seq
MIRT1300558	hsa-miR-4731-5p	CLIP-seq
MIRT2393624	hsa-miR-4747-5p	CLIP-seq
MIRT2458050	hsa-miR-4749-3p	CLIP-seq
MIRT2610684	hsa-miR-4749-5p	CLIP-seq
MIRT2610685	hsa-miR-4763-5p	CLIP-seq
MIRT2610686	hsa-miR-4781-5p	CLIP-seq
MIRT1300562	hsa-miR-5047	CLIP-seq
MIRT2314156	hsa-miR-622	CLIP-seq
MIRT2610688	hsa-miR-639	CLIP-seq
MIRT2610689	hsa-miR-663	CLIP-seq
MIRT2610690	hsa-miR-767-3p	CLIP-seq
MIRT2610691	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0000139	Component	Golgi membrane	IDA	9309388
GO:0000139	Component	Golgi membrane	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006621	Process	Protein retention in ER lumen	IBA
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IDA	9309388
GO:0007528	Process	Neuromuscular junction development	IEA
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0033130	Function	Acetylcholine receptor binding	IEA
GO:0071340	Process	Skeletal muscle acetylcholine-gated channel clustering	IEA
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IEA

Other IDs

• MIM: 620048
• HGNC: 30309
• e!Ensembl: ENSG00000157916

Protein

• UniProt ID: O15258
• Protein name: Protein RER1
• Protein function: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03248	Rer1	20 → 185	Rer1 family	Family

• Sequence:

  MSEGDSVGESVHGKPSVVYRFFTRLGQIYQSWLDKSTPYTAVRWVVTLGLSFVYMIRVYL
  LQGWYIVTYALGIYHLNLFIAFLSPKVDPSLMEDSDDGPSLPTKQNEEFRPFIRRLPEFK
  FWHAATKGILVAMVCTFFDAFNVPVFWPILVMYFIMLFCITMKRQIKHMIKYRYIPFTHG
  KRRYRGKEDAGKAFAS

• Sequence length: 196

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
PEROXISOME BIOGENESIS DISORDER 1A	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PEROXISOME BIOGENESIS DISORDER 6A	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	28877262	Associate	★☆☆☆☆ Found in Text Mining only
Charcot-Marie-Tooth Disease	Charcot-Marie-Tooth Disease	BEFREE	25385046		★☆☆☆☆ Found in Text Mining only
Charcot-Marie-Tooth Disease, Type Ia (disorder)	Charcot-Marie-Tooth disease	BEFREE	25385046		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	37934565	Associate	★☆☆☆☆ Found in Text Mining only
Lewy Body Disease	Lewy body disease	Pubtator	28877262	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	30630537		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31138119		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30630537		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	30630537		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	28877262		★☆☆☆☆ Found in Text Mining only