Gene Gene information from NCBI Gene database.
Entrez ID 11076
Gene name Tubulin polymerization promoting protein
Gene symbol TPPP
Synonyms (NCBI Gene)
TPPP/p25TPPP1p24p25p25alpha
Chromosome 5
Chromosome location 5p15.33
miRNA miRNA information provided by mirtarbase database.
488
miRTarBase ID miRNA Experiments Reference
MIRT025429 hsa-miR-34a-5p Sequencing 20371350
MIRT029260 hsa-miR-26b-5p Microarray 19088304
MIRT520548 hsa-miR-204-5p HITS-CLIP 21572407
MIRT520547 hsa-miR-211-5p HITS-CLIP 21572407
MIRT510608 hsa-miR-410-3p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
53
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IDA 21316364
GO:0001578 Process Microtubule bundle formation IBA
GO:0001578 Process Microtubule bundle formation IDA 17105200, 26289831
GO:0001578 Process Microtubule bundle formation ISS
GO:0003924 Function GTPase activity IDA 21316364
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608773 24164 ENSG00000171368
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O94811
Protein name Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha)
Protein function Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05517 p25-alpha 52 207 p25-alpha Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10083737}.
Sequence
Sequence length 219
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
10
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BARRETT'S ESOPHAGUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BRUGADA SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DEPRESSION IN CHILDREN Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 27527254
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Esophageal Cancer GWASCAT_DG 27527254
★☆☆☆☆
Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia T-Cell Lymphoma/Leukemia BEFREE 2895757, 6090008, 6331549
★☆☆☆☆
Found in Text Mining only
Amyloidosis Amyloidosis BEFREE 21832049
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 12657672, 22262900, 28444573, 29602913
★☆☆☆☆
Found in Text Mining only
Antiphospholipid Syndrome Antiphospholipid syndrome Pubtator 8706335 Associate
★☆☆☆☆
Found in Text Mining only
Barrett Esophagus Barrett esophagus GWASCAT_DG 27527254
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm BEFREE 18025801
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm LHGDN 18025801
★☆☆☆☆
Found in Text Mining only
Bone Marrow Diseases Bone Marrow Diseases BEFREE 1537894
★☆☆☆☆
Found in Text Mining only