Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID	11075
Gene name	Stathmin 2
Gene symbol	STMN2
Synonyms (NCBI Gene)	SCG10SCGN10
Chromosome	8
Chromosome location	8q21.13
Summary	This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogen

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Show/Hide all (186)

miRTarBase ID	miRNA	Experiments
MIRT1398827	hsa-miR-2681	CLIP-seq
MIRT1398828	hsa-miR-3674	CLIP-seq
MIRT1398829	hsa-miR-4642	CLIP-seq
MIRT1398830	hsa-miR-4705	CLIP-seq
MIRT1398831	hsa-miR-665	CLIP-seq
MIRT1554252	hsa-miR-122	CLIP-seq
MIRT1554253	hsa-miR-2052	CLIP-seq
MIRT1554254	hsa-miR-27a	CLIP-seq
MIRT1554255	hsa-miR-27b	CLIP-seq
MIRT1554256	hsa-miR-3659	CLIP-seq
MIRT1554257	hsa-miR-4534	CLIP-seq
MIRT1554258	hsa-miR-513a-5p	CLIP-seq
MIRT2119510	hsa-miR-4658	CLIP-seq
MIRT2119511	hsa-miR-4758-5p	CLIP-seq
MIRT1554252	hsa-miR-122	CLIP-seq
MIRT2341725	hsa-miR-2682	CLIP-seq
MIRT1554254	hsa-miR-27a	CLIP-seq
MIRT1554255	hsa-miR-27b	CLIP-seq
MIRT1554256	hsa-miR-3659	CLIP-seq
MIRT2341726	hsa-miR-3978	CLIP-seq
MIRT2341727	hsa-miR-4423-3p	CLIP-seq
MIRT2341728	hsa-miR-4481	CLIP-seq
MIRT2341729	hsa-miR-449c	CLIP-seq
MIRT1554257	hsa-miR-4534	CLIP-seq
MIRT2119510	hsa-miR-4658	CLIP-seq
MIRT2341730	hsa-miR-4703-3p	CLIP-seq
MIRT2341731	hsa-miR-4745-5p	CLIP-seq
MIRT2119511	hsa-miR-4758-5p	CLIP-seq
MIRT1554258	hsa-miR-513a-5p	CLIP-seq
MIRT2341732	hsa-miR-940	CLIP-seq
MIRT2395356	hsa-miR-1207-5p	CLIP-seq
MIRT2395357	hsa-miR-1909	CLIP-seq
MIRT2395358	hsa-miR-4450	CLIP-seq
MIRT2395359	hsa-miR-4525	CLIP-seq
MIRT2395360	hsa-miR-4699-3p	CLIP-seq
MIRT2395361	hsa-miR-4716-3p	CLIP-seq
MIRT2395362	hsa-miR-4763-3p	CLIP-seq
MIRT2341732	hsa-miR-940	CLIP-seq
MIRT2635513	hsa-miR-105	CLIP-seq
MIRT2635514	hsa-miR-1266	CLIP-seq
MIRT2635515	hsa-miR-1273e	CLIP-seq
MIRT2635516	hsa-miR-128	CLIP-seq
MIRT2635517	hsa-miR-1290	CLIP-seq
MIRT2635518	hsa-miR-129-5p	CLIP-seq
MIRT2635519	hsa-miR-1298	CLIP-seq
MIRT2635520	hsa-miR-1323	CLIP-seq
MIRT2635521	hsa-miR-146b-3p	CLIP-seq
MIRT2635522	hsa-miR-155	CLIP-seq
MIRT2635523	hsa-miR-199a-3p	CLIP-seq
MIRT2635524	hsa-miR-199b-3p	CLIP-seq
MIRT2635525	hsa-miR-2110	CLIP-seq
MIRT1554254	hsa-miR-27a	CLIP-seq
MIRT1554255	hsa-miR-27b	CLIP-seq
MIRT2635526	hsa-miR-297	CLIP-seq
MIRT2635527	hsa-miR-3065-3p	CLIP-seq
MIRT2635528	hsa-miR-3120-5p	CLIP-seq
MIRT2635529	hsa-miR-3123	CLIP-seq
MIRT2635530	hsa-miR-3129-5p	CLIP-seq
MIRT2635531	hsa-miR-3133	CLIP-seq
MIRT2635532	hsa-miR-3135	CLIP-seq
MIRT2635533	hsa-miR-3148	CLIP-seq
MIRT2635534	hsa-miR-3149	CLIP-seq
MIRT2635535	hsa-miR-3150a-3p	CLIP-seq
MIRT2635536	hsa-miR-3167	CLIP-seq
MIRT2635537	hsa-miR-3173-5p	CLIP-seq
MIRT2635538	hsa-miR-3175	CLIP-seq
MIRT2635539	hsa-miR-365	CLIP-seq
MIRT2635540	hsa-miR-3664-3p	CLIP-seq
MIRT2635541	hsa-miR-3689a-3p	CLIP-seq
MIRT2635542	hsa-miR-3689c	CLIP-seq
MIRT2635543	hsa-miR-3691-3p	CLIP-seq
MIRT2635544	hsa-miR-3925-5p	CLIP-seq
MIRT2635545	hsa-miR-3943	CLIP-seq
MIRT2635546	hsa-miR-3977	CLIP-seq
MIRT2635547	hsa-miR-4259	CLIP-seq
MIRT2635548	hsa-miR-4267	CLIP-seq
MIRT2635549	hsa-miR-4271	CLIP-seq
MIRT2635550	hsa-miR-4291	CLIP-seq
MIRT2635551	hsa-miR-4313	CLIP-seq
MIRT2635552	hsa-miR-4323	CLIP-seq
MIRT2635553	hsa-miR-4425	CLIP-seq
MIRT2635554	hsa-miR-4433	CLIP-seq
MIRT2635555	hsa-miR-4459	CLIP-seq
MIRT2635556	hsa-miR-4511	CLIP-seq
MIRT2635557	hsa-miR-4514	CLIP-seq
MIRT2635558	hsa-miR-4518	CLIP-seq
MIRT2119510	hsa-miR-4658	CLIP-seq
MIRT2635559	hsa-miR-4667-5p	CLIP-seq
MIRT2635560	hsa-miR-4692	CLIP-seq
MIRT2635561	hsa-miR-4700-3p	CLIP-seq
MIRT2635562	hsa-miR-4700-5p	CLIP-seq
MIRT2635563	hsa-miR-4709-3p	CLIP-seq
MIRT2635564	hsa-miR-4719	CLIP-seq
MIRT2635565	hsa-miR-4725-3p	CLIP-seq
MIRT2119511	hsa-miR-4758-5p	CLIP-seq
MIRT2635566	hsa-miR-4760-3p	CLIP-seq
MIRT2635567	hsa-miR-4765	CLIP-seq
MIRT2635568	hsa-miR-4768-3p	CLIP-seq
MIRT2635569	hsa-miR-509-3p	CLIP-seq
MIRT1554258	hsa-miR-513a-5p	CLIP-seq
MIRT2635570	hsa-miR-541	CLIP-seq
MIRT2635571	hsa-miR-548a-3p	CLIP-seq
MIRT2635572	hsa-miR-548e	CLIP-seq
MIRT2635573	hsa-miR-548f	CLIP-seq
MIRT2635574	hsa-miR-548o	CLIP-seq
MIRT2635575	hsa-miR-567	CLIP-seq
MIRT2635576	hsa-miR-571	CLIP-seq
MIRT2635577	hsa-miR-584	CLIP-seq
MIRT2635578	hsa-miR-599	CLIP-seq
MIRT2635579	hsa-miR-642b	CLIP-seq
MIRT2635580	hsa-miR-654-5p	CLIP-seq
MIRT2635581	hsa-miR-664	CLIP-seq
MIRT2635582	hsa-miR-874	CLIP-seq
MIRT2635583	hsa-miR-876-5p	CLIP-seq
MIRT2635584	hsa-miR-936	CLIP-seq
MIRT2635585	hsa-miR-939	CLIP-seq
MIRT2635586	hsa-miR-942	CLIP-seq
MIRT2635513	hsa-miR-105	CLIP-seq
MIRT2635515	hsa-miR-1273e	CLIP-seq
MIRT2635516	hsa-miR-128	CLIP-seq
MIRT2635517	hsa-miR-1290	CLIP-seq
MIRT2635518	hsa-miR-129-5p	CLIP-seq
MIRT2635519	hsa-miR-1298	CLIP-seq
MIRT2635520	hsa-miR-1323	CLIP-seq
MIRT2635521	hsa-miR-146b-3p	CLIP-seq
MIRT2635522	hsa-miR-155	CLIP-seq
MIRT2635523	hsa-miR-199a-3p	CLIP-seq
MIRT2635524	hsa-miR-199b-3p	CLIP-seq
MIRT2635525	hsa-miR-2110	CLIP-seq
MIRT1554254	hsa-miR-27a	CLIP-seq
MIRT1554255	hsa-miR-27b	CLIP-seq
MIRT2635526	hsa-miR-297	CLIP-seq
MIRT2635527	hsa-miR-3065-3p	CLIP-seq
MIRT2635529	hsa-miR-3123	CLIP-seq
MIRT2635530	hsa-miR-3129-5p	CLIP-seq
MIRT2635531	hsa-miR-3133	CLIP-seq
MIRT2635532	hsa-miR-3135	CLIP-seq
MIRT2635533	hsa-miR-3148	CLIP-seq
MIRT2635534	hsa-miR-3149	CLIP-seq
MIRT2635535	hsa-miR-3150a-3p	CLIP-seq
MIRT2635536	hsa-miR-3167	CLIP-seq
MIRT2635537	hsa-miR-3173-5p	CLIP-seq
MIRT2635538	hsa-miR-3175	CLIP-seq
MIRT2635539	hsa-miR-365	CLIP-seq
MIRT2635541	hsa-miR-3689a-3p	CLIP-seq
MIRT2635542	hsa-miR-3689c	CLIP-seq
MIRT2635543	hsa-miR-3691-3p	CLIP-seq
MIRT2635544	hsa-miR-3925-5p	CLIP-seq
MIRT2635545	hsa-miR-3943	CLIP-seq
MIRT2635546	hsa-miR-3977	CLIP-seq
MIRT2635547	hsa-miR-4259	CLIP-seq
MIRT2635548	hsa-miR-4267	CLIP-seq
MIRT2635549	hsa-miR-4271	CLIP-seq
MIRT2635550	hsa-miR-4291	CLIP-seq
MIRT2635551	hsa-miR-4313	CLIP-seq
MIRT2635552	hsa-miR-4323	CLIP-seq
MIRT2635553	hsa-miR-4425	CLIP-seq
MIRT2635554	hsa-miR-4433	CLIP-seq
MIRT2635555	hsa-miR-4459	CLIP-seq
MIRT2635556	hsa-miR-4511	CLIP-seq
MIRT2635557	hsa-miR-4514	CLIP-seq
MIRT2119510	hsa-miR-4658	CLIP-seq
MIRT2635559	hsa-miR-4667-5p	CLIP-seq
MIRT2635560	hsa-miR-4692	CLIP-seq
MIRT2635561	hsa-miR-4700-3p	CLIP-seq
MIRT2635562	hsa-miR-4700-5p	CLIP-seq
MIRT2635563	hsa-miR-4709-3p	CLIP-seq
MIRT2635564	hsa-miR-4719	CLIP-seq
MIRT2635565	hsa-miR-4725-3p	CLIP-seq
MIRT2119511	hsa-miR-4758-5p	CLIP-seq
MIRT2635566	hsa-miR-4760-3p	CLIP-seq
MIRT2635567	hsa-miR-4765	CLIP-seq
MIRT2635568	hsa-miR-4768-3p	CLIP-seq
MIRT2635571	hsa-miR-548a-3p	CLIP-seq
MIRT2635572	hsa-miR-548e	CLIP-seq
MIRT2635573	hsa-miR-548f	CLIP-seq
MIRT2635574	hsa-miR-548o	CLIP-seq
MIRT2635575	hsa-miR-567	CLIP-seq
MIRT2635576	hsa-miR-571	CLIP-seq
MIRT2635578	hsa-miR-599	CLIP-seq
MIRT2635579	hsa-miR-642b	CLIP-seq
MIRT2635581	hsa-miR-664	CLIP-seq
MIRT2635582	hsa-miR-874	CLIP-seq
MIRT2635583	hsa-miR-876-5p	CLIP-seq
MIRT2635584	hsa-miR-936	CLIP-seq
MIRT2635585	hsa-miR-939	CLIP-seq

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Transcription factor	Regulation	Reference
CTNNBIP1	Unknown	16712787

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 18452648, 21215777, 25416956, 31515488, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	21215777
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007019	Process	Microtubule depolymerization	IBA
GO:0007026	Process	Negative regulation of microtubule depolymerization	IDA	18452648
GO:0010976	Process	Positive regulation of neuron projection development	IDA	18452648, 21215777
GO:0010977	Process	Negative regulation of neuron projection development	IDA	18452648
GO:0015631	Function	Tubulin binding	IBA
GO:0016020	Component	Membrane	IEA
GO:0030027	Component	Lamellipodium	IDA	21215777
GO:0030027	Component	Lamellipodium	IEA
GO:0030424	Component	Axon	IEA
GO:0030426	Component	Growth cone	IBA
GO:0030426	Component	Growth cone	IDA	21215777
GO:0030426	Component	Growth cone	IEA
GO:0031110	Process	Regulation of microtubule polymerization or depolymerization	IBA
GO:0031110	Process	Regulation of microtubule polymerization or depolymerization	IEA
GO:0031115	Process	Negative regulation of microtubule polymerization	IDA	18452648, 21215777
GO:0031117	Process	Positive regulation of microtubule depolymerization	IDA	18452648
GO:0031175	Process	Neuron projection development	IBA
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IBA
GO:0043005	Component	Neuron projection	IDA	21215777
GO:0043025	Component	Neuronal cell body	IDA	21215777
GO:0048306	Function	Calcium-dependent protein binding	IPI	21215777
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	18452648
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:1990090	Process	Cellular response to nerve growth factor stimulus	IDA	21215777

MIM	HGNC	e!Ensembl
600621	10577	ENSG00000104435

Q93045

Protein name

Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10)

Protein function

Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and reta

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00836	Stathmin	39 → 174	Stathmin family	Family

Tissue specificity

TISSUE SPECIFICITY: Neuron specific.

Sequence

MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKP
PSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKA
LEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG

Sequence length

179

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUDITORY SYSTEM DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METASTATIC COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (32)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	38175301	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	30643292, 30643298		★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	30643292, 34496257, 35034660, 38175301, 39486415	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	30643298	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia Telangiectasia	BEFREE	25032865		★★★★★ ★☆☆☆☆ Found in Text Mining only
Budd-Chiari Syndrome	Budd-Chiari syndrome	BEFREE	16162682		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cone-Rod Dystrophy 2	Cone-rod dystrophy	BEFREE	29393906		★★★★★ ★☆☆☆☆ Found in Text Mining only
Creutzfeldt-Jakob Disease, Sporadic	Creutzfeldt-Jakob disease	BEFREE	24414001		★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	GWASDB_DG	22763110		★★★★★ ★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down Syndrome	BEFREE	11830198		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dysautonomia, Familial	Dysautonomia	BEFREE	21273291		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibrosis, Liver	Liver Fibrosis	BEFREE	15661146, 20802173		★★★★★ ★☆☆☆☆ Found in Text Mining only
Frontotemporal dementia	Frontotemporal dementia	BEFREE	30643298		★★★★★ ★☆☆☆☆ Found in Text Mining only
Frontotemporal Dementia	Frontotemporal dementia	Pubtator	32790644, 38175301	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Frontotemporal Dementia	Frontotemporal dementia	Pubtator	37466726	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatic Vein Thrombosis	Hepatic Vein Thrombosis	BEFREE	16162682		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hirschsprung Disease	Hirschsprung Disease	BEFREE	21187955		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lesion of Sciatic Nerve	Lesion Of Sciatic Nerve	BEFREE	30927067		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver cirrhosis	Pubtator	15661146	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Failure	Liver failure	Pubtator	16162682	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	25897834		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	21273291		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	30643298, 38175301	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
New Variant Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Disease	BEFREE	19081515		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	35720295	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Diseases	Ovarian diseases	Pubtator	31646556	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	32510146	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	31748532		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	22675524		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	22675524	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Scleroderma Systemic	Systemic sclerosis	Pubtator	33253093	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Torsades de Pointes	Torsades de pointes	Pubtator	40478310	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

STMN2 (stathmin 2)