Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	11070
Gene name	Transmembrane protein 115
Gene symbol	TMEM115
Synonyms (NCBI Gene)	PL6
Chromosome	3
Chromosome location	3p21.31

118

Show/Hide all (118)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051990	hsa-let-7b-5p	CLASH	23622248
MIRT040622	hsa-miR-92b-3p	CLASH	23622248
MIRT040155	hsa-miR-615-3p	CLASH	23622248
MIRT037809	hsa-miR-455-3p	CLASH	23622248
MIRT1430009	hsa-miR-1207-5p	CLIP-seq
MIRT1430010	hsa-miR-1227	CLIP-seq
MIRT1430011	hsa-miR-132	CLIP-seq
MIRT1430012	hsa-miR-212	CLIP-seq
MIRT1430013	hsa-miR-3064-3p	CLIP-seq
MIRT1430014	hsa-miR-3192	CLIP-seq
MIRT1430015	hsa-miR-3545-5p	CLIP-seq
MIRT1430016	hsa-miR-3660	CLIP-seq
MIRT1430017	hsa-miR-3689a-3p	CLIP-seq
MIRT1430018	hsa-miR-3689c	CLIP-seq
MIRT1430019	hsa-miR-3689d	CLIP-seq
MIRT1430020	hsa-miR-378g	CLIP-seq
MIRT1430021	hsa-miR-4261	CLIP-seq
MIRT1430022	hsa-miR-4314	CLIP-seq
MIRT1430023	hsa-miR-4450	CLIP-seq
MIRT1430024	hsa-miR-4526	CLIP-seq
MIRT1430025	hsa-miR-4667-5p	CLIP-seq
MIRT1430026	hsa-miR-4700-5p	CLIP-seq
MIRT1430027	hsa-miR-4728-5p	CLIP-seq
MIRT1430028	hsa-miR-4763-3p	CLIP-seq
MIRT1430029	hsa-miR-486-5p	CLIP-seq
MIRT1430030	hsa-miR-604	CLIP-seq
MIRT1430031	hsa-miR-619	CLIP-seq
MIRT1430032	hsa-miR-637	CLIP-seq
MIRT1430033	hsa-miR-647	CLIP-seq
MIRT1430034	hsa-miR-661	CLIP-seq
MIRT1430035	hsa-miR-873	CLIP-seq
MIRT1430020	hsa-miR-378g	CLIP-seq
MIRT1430030	hsa-miR-604	CLIP-seq
MIRT1430033	hsa-miR-647	CLIP-seq
MIRT1430034	hsa-miR-661	CLIP-seq
MIRT2350449	hsa-miR-362-5p	CLIP-seq
MIRT2350450	hsa-miR-500a	CLIP-seq
MIRT2350451	hsa-miR-500b	CLIP-seq
MIRT2350452	hsa-miR-502-5p	CLIP-seq
MIRT1430009	hsa-miR-1207-5p	CLIP-seq
MIRT2643969	hsa-miR-1266	CLIP-seq
MIRT2643970	hsa-miR-1271	CLIP-seq
MIRT1430011	hsa-miR-132	CLIP-seq
MIRT2643971	hsa-miR-182	CLIP-seq
MIRT2643972	hsa-miR-1976	CLIP-seq
MIRT1430012	hsa-miR-212	CLIP-seq
MIRT2643973	hsa-miR-24	CLIP-seq
MIRT2643974	hsa-miR-2467-3p	CLIP-seq
MIRT2643975	hsa-miR-296-5p	CLIP-seq
MIRT2643976	hsa-miR-3127-5p	CLIP-seq
MIRT2643977	hsa-miR-361-3p	CLIP-seq
MIRT2350449	hsa-miR-362-5p	CLIP-seq
MIRT1430016	hsa-miR-3660	CLIP-seq
MIRT2643978	hsa-miR-3918	CLIP-seq
MIRT2643979	hsa-miR-3944-5p	CLIP-seq
MIRT1430021	hsa-miR-4261	CLIP-seq
MIRT2643980	hsa-miR-4284	CLIP-seq
MIRT2643981	hsa-miR-4312	CLIP-seq
MIRT1430022	hsa-miR-4314	CLIP-seq
MIRT2643982	hsa-miR-4323	CLIP-seq
MIRT1430023	hsa-miR-4450	CLIP-seq
MIRT2643983	hsa-miR-4470	CLIP-seq
MIRT2643984	hsa-miR-4518	CLIP-seq
MIRT1430024	hsa-miR-4526	CLIP-seq
MIRT1430025	hsa-miR-4667-5p	CLIP-seq
MIRT1430026	hsa-miR-4700-5p	CLIP-seq
MIRT2643985	hsa-miR-4726-3p	CLIP-seq
MIRT2643986	hsa-miR-4731-5p	CLIP-seq
MIRT1430028	hsa-miR-4763-3p	CLIP-seq
MIRT2643987	hsa-miR-4764-5p	CLIP-seq
MIRT2350450	hsa-miR-500a	CLIP-seq
MIRT2350451	hsa-miR-500b	CLIP-seq
MIRT2350452	hsa-miR-502-5p	CLIP-seq
MIRT1430032	hsa-miR-637	CLIP-seq
MIRT1430035	hsa-miR-873	CLIP-seq
MIRT2643988	hsa-miR-922	CLIP-seq
MIRT2643989	hsa-miR-96	CLIP-seq
MIRT1430009	hsa-miR-1207-5p	CLIP-seq
MIRT2643969	hsa-miR-1266	CLIP-seq
MIRT2643970	hsa-miR-1271	CLIP-seq
MIRT2693349	hsa-miR-1307	CLIP-seq
MIRT1430011	hsa-miR-132	CLIP-seq
MIRT2643971	hsa-miR-182	CLIP-seq
MIRT2643972	hsa-miR-1976	CLIP-seq
MIRT1430012	hsa-miR-212	CLIP-seq
MIRT2643973	hsa-miR-24	CLIP-seq
MIRT2643974	hsa-miR-2467-3p	CLIP-seq
MIRT2643975	hsa-miR-296-5p	CLIP-seq
MIRT2643976	hsa-miR-3127-5p	CLIP-seq
MIRT2643977	hsa-miR-361-3p	CLIP-seq
MIRT2693350	hsa-miR-3615	CLIP-seq
MIRT2350449	hsa-miR-362-5p	CLIP-seq
MIRT1430016	hsa-miR-3660	CLIP-seq
MIRT2643978	hsa-miR-3918	CLIP-seq
MIRT2643979	hsa-miR-3944-5p	CLIP-seq
MIRT1430021	hsa-miR-4261	CLIP-seq
MIRT2643980	hsa-miR-4284	CLIP-seq
MIRT2643981	hsa-miR-4312	CLIP-seq
MIRT1430022	hsa-miR-4314	CLIP-seq
MIRT2643982	hsa-miR-4323	CLIP-seq
MIRT1430023	hsa-miR-4450	CLIP-seq
MIRT2643983	hsa-miR-4470	CLIP-seq
MIRT2643984	hsa-miR-4518	CLIP-seq
MIRT1430024	hsa-miR-4526	CLIP-seq
MIRT2693351	hsa-miR-4638-5p	CLIP-seq
MIRT1430025	hsa-miR-4667-5p	CLIP-seq
MIRT1430026	hsa-miR-4700-5p	CLIP-seq
MIRT2643985	hsa-miR-4726-3p	CLIP-seq
MIRT2643986	hsa-miR-4731-5p	CLIP-seq
MIRT1430028	hsa-miR-4763-3p	CLIP-seq
MIRT2643987	hsa-miR-4764-5p	CLIP-seq
MIRT2350450	hsa-miR-500a	CLIP-seq
MIRT2350451	hsa-miR-500b	CLIP-seq
MIRT2350452	hsa-miR-502-5p	CLIP-seq
MIRT1430032	hsa-miR-637	CLIP-seq
MIRT1430035	hsa-miR-873	CLIP-seq
MIRT2643988	hsa-miR-922	CLIP-seq
MIRT2643989	hsa-miR-96	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0005515	Function	Protein binding	IPI	24806965, 25416956, 32296183, 32814053
GO:0005634	Component	Nucleus	IDA	17973242
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA	17973242
GO:0005794	Component	Golgi apparatus	IEA
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IEA
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP	24806965
GO:0008285	Process	Negative regulation of cell population proliferation	NAS	17973242
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0017119	Component	Golgi transport complex	IDA	24806965
GO:0032580	Component	Golgi cisterna membrane	IDA	24806965
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0042802	Function	Identical protein binding	IDA	24806965

MIM	HGNC	e!Ensembl
607069	30055	ENSG00000126062

Q12893

Protein name

Transmembrane protein 115 (Placental protein 6) (Protein PL6)

Protein function

May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08551	DUF1751	49 → 151	Eukaryotic integral membrane protein (DUF1751)	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed strongly in kidney and skeletal muscle, followed by liver, placenta, pancreas, and lung, with low amounts in heart and only traces in brain (PubMed:11085536). Widely expressed with ubiquitous expression in epithelial tissues

Sequence

MQRALPGARQHLGAILASASVVVKALCAAVLFLYLLSFAVDTGCLAVTPGYLFPPNFWIW
TLATHGLMEQHVWDVAISLTTVVVAGRLLEPLWGALELLIFFSVVNVSVGLLGAFAYLLT
YMASFNLVYLFTVRIHGALGFLGGVLVALKQTMGDCVVLRVPQVRVSVMPMLLLALLLLL
RLATLLQSPALASYGFGLLSSWVYLRFYQRHSRGRGDMADHFAFATFFPEILQPVVGLLA
NLVHSLLVKVKICQKTVKRYDVGAPSSITISLPGTDPQDAERRRQLALKALNERLKRVED
QSIWPSMDDDEEESGAKVDSPLPSDKAPTPPGKGAAPESSLITFEAAPPTL

Sequence length

351

Interactions

View interactions

	Reactome
			COPI-mediated anterograde transport

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma	Carcinoma	BEFREE	17973242		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	40552281	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28551387		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mesothelioma Malignant	Mesothelioma	Pubtator	18973227	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pheochromocytoma	Pheochromocytoma	Pubtator	19110720	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

TMEM115 (transmembrane protein 115)