SNRNP35 (small nuclear ribonucleoprotein U11/U12 subunit 35)

Gene

• Entrez ID: 11066
• Gene name: Small nuclear ribonucleoprotein U11/U12 subunit 35
• Gene symbol: SNRNP35
• Synonyms (NCBI Gene): HM-1, HM1, U1SNRNPBP
• Chromosome: 12
• Chromosome location: 12q24.31
• Summary: The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is a characteristic of a variety of splicing facto

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023770	hsa-miR-1-3p	Microarray	18668037
MIRT045159	hsa-miR-186-5p	CLASH	23622248
MIRT1375971	hsa-miR-151-3p	CLIP-seq
MIRT1375972	hsa-miR-4272	CLIP-seq
MIRT1375973	hsa-miR-4798-3p	CLIP-seq
MIRT1375974	hsa-miR-488	CLIP-seq
MIRT2629107	hsa-miR-3170	CLIP-seq
MIRT2629108	hsa-miR-3692	CLIP-seq
MIRT2629109	hsa-miR-4260	CLIP-seq
MIRT2629110	hsa-miR-4436b-5p	CLIP-seq
MIRT1375974	hsa-miR-488	CLIP-seq
MIRT2629108	hsa-miR-3692	CLIP-seq
MIRT2629110	hsa-miR-4436b-5p	CLIP-seq
MIRT1375974	hsa-miR-488	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IBA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005634	Component	Nucleus	IDA	18559850
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005689	Component	U12-type spliceosomal complex	IBA
GO:0005689	Component	U12-type spliceosomal complex	IDA	15146077
GO:0005730	Component	Nucleolus	IDA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IC	15146077
GO:0008380	Process	RNA splicing	IEA
GO:0017069	Function	SnRNA binding	IBA
GO:1990904	Component	Ribonucleoprotein complex	IEA

Other IDs

• MIM: 619631
• HGNC: 30852
• e!Ensembl: ENSG00000184209

Protein

• UniProt ID: Q16560
• Protein name: U11/U12 small nuclear ribonucleoprotein 35 kDa protein (U11/U12 snRNP 35 kDa protein) (U11/U12-35K) (Protein HM-1) (U1 snRNP-binding protein homolog)
• PDB: 8R7N, 8Y6O, 9GBW, 9GBZ, 9GCM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	53 → 122	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in heart, liver, skeletal muscle and pancreas. {ECO:0000269|PubMed:10520751}.
• Sequence:

  MNDWMPIAKEYDPLKAGSIDGTDEDPHDRAVWRAMLARYVPNKGVIGDPLLTLFVARLNL
  QTKEDKLKEVFSRYGDIRRLRLVRDLVTGFSKGYAFIEYKEERAVIKAYRDADGLVIDQH
  EIFVDYELERTLKGWIPRRLGGGLGGKKESGQLRFGGRDRPFRKPINLPVVKNDLYREGK
  RERRERSRSRERHWDSRTRDRDHDRGREKRWQEREPTRVWPDNDWERERDFRDDRIKGRE
  KKERGK

• Sequence length: 246

Pathways

Reactome:

mRNA Splicing - Minor Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
OSTEOARTHRITIS, KNEE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations