DDX52 (DExD-box helicase 52)

Gene

• Entrez ID: 11056
• Gene name: DExD-box helicase 52
• Gene symbol: DDX52
• Synonyms (NCBI Gene): HUSSY19, ROK1
• Chromosome: 17
• Chromosome location: 17q12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT031427	hsa-miR-16-5p	Proteomics	18668040
MIRT551090	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT551088	hsa-miR-8066	PAR-CLIP	21572407
MIRT551089	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT551087	hsa-miR-5692b	PAR-CLIP	21572407
MIRT551086	hsa-miR-5692c	PAR-CLIP	21572407
MIRT551085	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT551084	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT551083	hsa-miR-374c-5p	PAR-CLIP	21572407
MIRT551082	hsa-miR-655-3p	PAR-CLIP	21572407
MIRT551081	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT551080	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT551079	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT551078	hsa-miR-498	PAR-CLIP	21572407
MIRT551077	hsa-miR-1305	PAR-CLIP	21572407
MIRT551076	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT478222	hsa-miR-124-3p	PAR-CLIP	23592263
MIRT478234	hsa-miR-3714	PAR-CLIP	23592263
MIRT478233	hsa-miR-3910	PAR-CLIP	23592263
MIRT478232	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT478231	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT478230	hsa-miR-940	PAR-CLIP	23592263
MIRT478229	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT478227	hsa-miR-4459	PAR-CLIP	23592263
MIRT478228	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT478226	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT478225	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT478224	hsa-miR-4316	PAR-CLIP	23592263
MIRT478223	hsa-miR-1294	PAR-CLIP	23592263
MIRT478222	hsa-miR-124-3p	PAR-CLIP	23592263
MIRT478221	hsa-miR-506-3p	PAR-CLIP	23592263
MIRT478220	hsa-miR-6818-5p	PAR-CLIP	23592263
MIRT478219	hsa-miR-147a	PAR-CLIP	23592263
MIRT727892	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT727891	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT727890	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT727889	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT551090	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT551088	hsa-miR-8066	PAR-CLIP	21572407
MIRT551089	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT551087	hsa-miR-5692b	PAR-CLIP	21572407
MIRT551086	hsa-miR-5692c	PAR-CLIP	21572407
MIRT551085	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT551084	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT551083	hsa-miR-374c-5p	PAR-CLIP	21572407
MIRT551082	hsa-miR-655-3p	PAR-CLIP	21572407
MIRT551081	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT551080	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT551079	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT551078	hsa-miR-498	PAR-CLIP	21572407
MIRT551077	hsa-miR-1305	PAR-CLIP	21572407
MIRT551076	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT478222	hsa-miR-124-3p	PAR-CLIP	23592263
MIRT478234	hsa-miR-3714	PAR-CLIP	23592263
MIRT478233	hsa-miR-3910	PAR-CLIP	23592263
MIRT478232	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT478231	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT478230	hsa-miR-940	PAR-CLIP	23592263
MIRT478229	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT478227	hsa-miR-4459	PAR-CLIP	23592263
MIRT478228	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT478226	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT478225	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT478224	hsa-miR-4316	PAR-CLIP	23592263
MIRT478223	hsa-miR-1294	PAR-CLIP	23592263
MIRT478222	hsa-miR-124-3p	PAR-CLIP	23592263
MIRT478221	hsa-miR-506-3p	PAR-CLIP	23592263
MIRT478220	hsa-miR-6818-5p	PAR-CLIP	23592263
MIRT478219	hsa-miR-147a	PAR-CLIP	23592263
MIRT930992	hsa-miR-124	CLIP-seq
MIRT930993	hsa-miR-1254	CLIP-seq
MIRT930994	hsa-miR-1273g	CLIP-seq
MIRT930995	hsa-miR-1297	CLIP-seq
MIRT930996	hsa-miR-147	CLIP-seq
MIRT930997	hsa-miR-181a	CLIP-seq
MIRT930998	hsa-miR-181b	CLIP-seq
MIRT930999	hsa-miR-181c	CLIP-seq
MIRT931000	hsa-miR-181d	CLIP-seq
MIRT931001	hsa-miR-202	CLIP-seq
MIRT931002	hsa-miR-216a	CLIP-seq
MIRT931003	hsa-miR-216b	CLIP-seq
MIRT931004	hsa-miR-26a	CLIP-seq
MIRT931005	hsa-miR-26b	CLIP-seq
MIRT931006	hsa-miR-3074-3p	CLIP-seq
MIRT931007	hsa-miR-30a	CLIP-seq
MIRT931008	hsa-miR-30b	CLIP-seq
MIRT931009	hsa-miR-30c	CLIP-seq
MIRT931010	hsa-miR-30d	CLIP-seq
MIRT931011	hsa-miR-30e	CLIP-seq
MIRT931012	hsa-miR-3116	CLIP-seq
MIRT931013	hsa-miR-3143	CLIP-seq
MIRT931014	hsa-miR-3180-5p	CLIP-seq
MIRT931015	hsa-miR-3190	CLIP-seq
MIRT931016	hsa-miR-3622a-5p	CLIP-seq
MIRT931017	hsa-miR-3647-3p	CLIP-seq
MIRT931018	hsa-miR-3664-3p	CLIP-seq
MIRT931019	hsa-miR-3690	CLIP-seq
MIRT931020	hsa-miR-3924	CLIP-seq
MIRT931021	hsa-miR-3975	CLIP-seq
MIRT931022	hsa-miR-4257	CLIP-seq
MIRT931023	hsa-miR-4262	CLIP-seq
MIRT931024	hsa-miR-4264	CLIP-seq
MIRT931025	hsa-miR-4423-3p	CLIP-seq
MIRT931026	hsa-miR-4433	CLIP-seq
MIRT931027	hsa-miR-4452	CLIP-seq
MIRT931028	hsa-miR-4464	CLIP-seq
MIRT931029	hsa-miR-4465	CLIP-seq
MIRT931030	hsa-miR-4529-5p	CLIP-seq
MIRT931031	hsa-miR-4638-3p	CLIP-seq
MIRT931032	hsa-miR-4652-3p	CLIP-seq
MIRT931033	hsa-miR-4695-5p	CLIP-seq
MIRT931034	hsa-miR-4748	CLIP-seq
MIRT931035	hsa-miR-4752	CLIP-seq
MIRT931036	hsa-miR-4753-5p	CLIP-seq
MIRT931037	hsa-miR-4797-3p	CLIP-seq
MIRT931038	hsa-miR-499-5p	CLIP-seq
MIRT931039	hsa-miR-506	CLIP-seq
MIRT931040	hsa-miR-510	CLIP-seq
MIRT931041	hsa-miR-512-5p	CLIP-seq
MIRT931042	hsa-miR-513b	CLIP-seq
MIRT931043	hsa-miR-520a-5p	CLIP-seq
MIRT931044	hsa-miR-525-5p	CLIP-seq
MIRT931045	hsa-miR-543	CLIP-seq
MIRT931046	hsa-miR-550a	CLIP-seq
MIRT931047	hsa-miR-802	CLIP-seq
MIRT931048	hsa-miR-935	CLIP-seq
MIRT1975516	hsa-miR-103a	CLIP-seq
MIRT1975517	hsa-miR-105	CLIP-seq
MIRT1975518	hsa-miR-107	CLIP-seq
MIRT1975519	hsa-miR-1179	CLIP-seq
MIRT1975520	hsa-miR-1228	CLIP-seq
MIRT930995	hsa-miR-1297	CLIP-seq
MIRT1975521	hsa-miR-205	CLIP-seq
MIRT931002	hsa-miR-216a	CLIP-seq
MIRT931003	hsa-miR-216b	CLIP-seq
MIRT1975522	hsa-miR-224	CLIP-seq
MIRT931004	hsa-miR-26a	CLIP-seq
MIRT931005	hsa-miR-26b	CLIP-seq
MIRT1975523	hsa-miR-300	CLIP-seq
MIRT931007	hsa-miR-30a	CLIP-seq
MIRT931008	hsa-miR-30b	CLIP-seq
MIRT931009	hsa-miR-30c	CLIP-seq
MIRT931010	hsa-miR-30d	CLIP-seq
MIRT931011	hsa-miR-30e	CLIP-seq
MIRT1975524	hsa-miR-3179	CLIP-seq
MIRT931014	hsa-miR-3180-5p	CLIP-seq
MIRT931015	hsa-miR-3190	CLIP-seq
MIRT1975525	hsa-miR-361-5p	CLIP-seq
MIRT931016	hsa-miR-3622a-5p	CLIP-seq
MIRT1975526	hsa-miR-3667-3p	CLIP-seq
MIRT1975527	hsa-miR-3671	CLIP-seq
MIRT1975528	hsa-miR-3675-3p	CLIP-seq
MIRT1975529	hsa-miR-377	CLIP-seq
MIRT1975530	hsa-miR-381	CLIP-seq
MIRT1975531	hsa-miR-3944-5p	CLIP-seq
MIRT1975532	hsa-miR-4251	CLIP-seq
MIRT931024	hsa-miR-4264	CLIP-seq
MIRT1975533	hsa-miR-4310	CLIP-seq
MIRT1975534	hsa-miR-4330	CLIP-seq
MIRT931025	hsa-miR-4423-3p	CLIP-seq
MIRT931026	hsa-miR-4433	CLIP-seq
MIRT931028	hsa-miR-4464	CLIP-seq
MIRT931029	hsa-miR-4465	CLIP-seq
MIRT1975535	hsa-miR-4487	CLIP-seq
MIRT1975536	hsa-miR-4635	CLIP-seq
MIRT1975537	hsa-miR-4663	CLIP-seq
MIRT1975538	hsa-miR-4668-5p	CLIP-seq
MIRT1975539	hsa-miR-4678	CLIP-seq
MIRT931034	hsa-miR-4748	CLIP-seq
MIRT931035	hsa-miR-4752	CLIP-seq
MIRT931037	hsa-miR-4797-3p	CLIP-seq
MIRT1975540	hsa-miR-4797-5p	CLIP-seq
MIRT931040	hsa-miR-510	CLIP-seq
MIRT931041	hsa-miR-512-5p	CLIP-seq
MIRT931043	hsa-miR-520a-5p	CLIP-seq
MIRT931044	hsa-miR-525-5p	CLIP-seq
MIRT1975541	hsa-miR-539	CLIP-seq
MIRT931045	hsa-miR-543	CLIP-seq
MIRT1975542	hsa-miR-548ag	CLIP-seq
MIRT1975543	hsa-miR-548ai	CLIP-seq
MIRT1975544	hsa-miR-548an	CLIP-seq
MIRT931046	hsa-miR-550a	CLIP-seq
MIRT1975545	hsa-miR-586	CLIP-seq
MIRT1975546	hsa-miR-607	CLIP-seq
MIRT1975547	hsa-miR-646	CLIP-seq
MIRT931048	hsa-miR-935	CLIP-seq
MIRT1975516	hsa-miR-103a	CLIP-seq
MIRT1975517	hsa-miR-105	CLIP-seq
MIRT1975518	hsa-miR-107	CLIP-seq
MIRT1975519	hsa-miR-1179	CLIP-seq
MIRT2210977	hsa-miR-1207-3p	CLIP-seq
MIRT1975520	hsa-miR-1228	CLIP-seq
MIRT930992	hsa-miR-124	CLIP-seq
MIRT930993	hsa-miR-1254	CLIP-seq
MIRT2210978	hsa-miR-125a-3p	CLIP-seq
MIRT2210979	hsa-miR-1263	CLIP-seq
MIRT2210980	hsa-miR-1278	CLIP-seq
MIRT2210981	hsa-miR-1279	CLIP-seq
MIRT2210982	hsa-miR-1283	CLIP-seq
MIRT2210983	hsa-miR-1286	CLIP-seq
MIRT930995	hsa-miR-1297	CLIP-seq
MIRT2210984	hsa-miR-1298	CLIP-seq
MIRT2210985	hsa-miR-1323	CLIP-seq
MIRT2210986	hsa-miR-134	CLIP-seq
MIRT930996	hsa-miR-147	CLIP-seq
MIRT930997	hsa-miR-181a	CLIP-seq
MIRT930998	hsa-miR-181b	CLIP-seq
MIRT930999	hsa-miR-181c	CLIP-seq
MIRT931000	hsa-miR-181d	CLIP-seq
MIRT931001	hsa-miR-202	CLIP-seq
MIRT1975521	hsa-miR-205	CLIP-seq
MIRT931002	hsa-miR-216a	CLIP-seq
MIRT931003	hsa-miR-216b	CLIP-seq
MIRT1975522	hsa-miR-224	CLIP-seq
MIRT2210987	hsa-miR-2277-3p	CLIP-seq
MIRT931004	hsa-miR-26a	CLIP-seq
MIRT931005	hsa-miR-26b	CLIP-seq
MIRT2210988	hsa-miR-28-5p	CLIP-seq
MIRT1975523	hsa-miR-300	CLIP-seq
MIRT931006	hsa-miR-3074-3p	CLIP-seq
MIRT931012	hsa-miR-3116	CLIP-seq
MIRT2210989	hsa-miR-3118	CLIP-seq
MIRT2210990	hsa-miR-3123	CLIP-seq
MIRT2210991	hsa-miR-3128	CLIP-seq
MIRT2210992	hsa-miR-3135	CLIP-seq
MIRT2210993	hsa-miR-3139	CLIP-seq
MIRT931013	hsa-miR-3143	CLIP-seq
MIRT2210994	hsa-miR-3144-3p	CLIP-seq
MIRT2210995	hsa-miR-3168	CLIP-seq
MIRT1975524	hsa-miR-3179	CLIP-seq
MIRT931014	hsa-miR-3180-5p	CLIP-seq
MIRT2210996	hsa-miR-320e	CLIP-seq
MIRT2210997	hsa-miR-338-5p	CLIP-seq
MIRT1975525	hsa-miR-361-5p	CLIP-seq
MIRT2210998	hsa-miR-3618	CLIP-seq
MIRT931016	hsa-miR-3622a-5p	CLIP-seq
MIRT2210999	hsa-miR-3646	CLIP-seq
MIRT2211000	hsa-miR-3653	CLIP-seq
MIRT2211001	hsa-miR-3662	CLIP-seq
MIRT931018	hsa-miR-3664-3p	CLIP-seq
MIRT1975526	hsa-miR-3667-3p	CLIP-seq
MIRT1975527	hsa-miR-3671	CLIP-seq
MIRT2211002	hsa-miR-3674	CLIP-seq
MIRT1975528	hsa-miR-3675-3p	CLIP-seq
MIRT931019	hsa-miR-3690	CLIP-seq
MIRT1975529	hsa-miR-377	CLIP-seq
MIRT1975530	hsa-miR-381	CLIP-seq
MIRT2211003	hsa-miR-3940-5p	CLIP-seq
MIRT1975531	hsa-miR-3944-5p	CLIP-seq
MIRT2211004	hsa-miR-3973	CLIP-seq
MIRT2211005	hsa-miR-425	CLIP-seq
MIRT1975532	hsa-miR-4251	CLIP-seq
MIRT931022	hsa-miR-4257	CLIP-seq
MIRT931023	hsa-miR-4262	CLIP-seq
MIRT931024	hsa-miR-4264	CLIP-seq
MIRT2211006	hsa-miR-4272	CLIP-seq
MIRT1975533	hsa-miR-4310	CLIP-seq
MIRT1975534	hsa-miR-4330	CLIP-seq
MIRT931025	hsa-miR-4423-3p	CLIP-seq
MIRT931026	hsa-miR-4433	CLIP-seq
MIRT2211007	hsa-miR-4436a	CLIP-seq
MIRT931027	hsa-miR-4452	CLIP-seq
MIRT931029	hsa-miR-4465	CLIP-seq
MIRT2211008	hsa-miR-4470	CLIP-seq
MIRT2211009	hsa-miR-4474-5p	CLIP-seq
MIRT1975535	hsa-miR-4487	CLIP-seq
MIRT2211010	hsa-miR-4506	CLIP-seq
MIRT2211011	hsa-miR-4507	CLIP-seq
MIRT2211012	hsa-miR-4511	CLIP-seq
MIRT2211013	hsa-miR-4536	CLIP-seq
MIRT931031	hsa-miR-4638-3p	CLIP-seq
MIRT2211014	hsa-miR-4645-3p	CLIP-seq
MIRT931032	hsa-miR-4652-3p	CLIP-seq
MIRT2211015	hsa-miR-4661-3p	CLIP-seq
MIRT1975537	hsa-miR-4663	CLIP-seq
MIRT2211016	hsa-miR-4666-3p	CLIP-seq
MIRT2211017	hsa-miR-4666-5p	CLIP-seq
MIRT2211018	hsa-miR-4691-3p	CLIP-seq
MIRT2211019	hsa-miR-4703-3p	CLIP-seq
MIRT2211020	hsa-miR-4729	CLIP-seq
MIRT2211021	hsa-miR-4738-3p	CLIP-seq
MIRT2211022	hsa-miR-4789-5p	CLIP-seq
MIRT931037	hsa-miR-4797-3p	CLIP-seq
MIRT1975540	hsa-miR-4797-5p	CLIP-seq
MIRT931038	hsa-miR-499-5p	CLIP-seq
MIRT931039	hsa-miR-506	CLIP-seq
MIRT931040	hsa-miR-510	CLIP-seq
MIRT931041	hsa-miR-512-5p	CLIP-seq
MIRT2211023	hsa-miR-515-5p	CLIP-seq
MIRT931043	hsa-miR-520a-5p	CLIP-seq
MIRT2211024	hsa-miR-520g	CLIP-seq
MIRT2211025	hsa-miR-520h	CLIP-seq
MIRT931044	hsa-miR-525-5p	CLIP-seq
MIRT1975541	hsa-miR-539	CLIP-seq
MIRT931045	hsa-miR-543	CLIP-seq
MIRT2211026	hsa-miR-548b-3p	CLIP-seq
MIRT2211027	hsa-miR-548c-3p	CLIP-seq
MIRT2211028	hsa-miR-548n	CLIP-seq
MIRT2211029	hsa-miR-548o	CLIP-seq
MIRT2211030	hsa-miR-548t	CLIP-seq
MIRT931046	hsa-miR-550a	CLIP-seq
MIRT2211031	hsa-miR-550b	CLIP-seq
MIRT2211032	hsa-miR-552	CLIP-seq
MIRT1975545	hsa-miR-586	CLIP-seq
MIRT1975546	hsa-miR-607	CLIP-seq
MIRT2211033	hsa-miR-616	CLIP-seq
MIRT2211034	hsa-miR-633	CLIP-seq
MIRT1975547	hsa-miR-646	CLIP-seq
MIRT2211035	hsa-miR-651	CLIP-seq
MIRT2211036	hsa-miR-708	CLIP-seq
MIRT2211037	hsa-miR-767-5p	CLIP-seq
MIRT931047	hsa-miR-802	CLIP-seq
MIRT2211038	hsa-miR-875-5p	CLIP-seq
MIRT2211039	hsa-miR-888	CLIP-seq
MIRT931048	hsa-miR-935	CLIP-seq
MIRT2211040	hsa-miR-943	CLIP-seq
MIRT2210978	hsa-miR-125a-3p	CLIP-seq
MIRT2210979	hsa-miR-1263	CLIP-seq
MIRT2210986	hsa-miR-134	CLIP-seq
MIRT931002	hsa-miR-216a	CLIP-seq
MIRT931003	hsa-miR-216b	CLIP-seq
MIRT2210989	hsa-miR-3118	CLIP-seq
MIRT2386821	hsa-miR-3163	CLIP-seq
MIRT2386822	hsa-miR-3591-3p	CLIP-seq
MIRT1975525	hsa-miR-361-5p	CLIP-seq
MIRT931024	hsa-miR-4264	CLIP-seq
MIRT2211009	hsa-miR-4474-5p	CLIP-seq
MIRT931037	hsa-miR-4797-3p	CLIP-seq
MIRT2211023	hsa-miR-515-5p	CLIP-seq
MIRT931045	hsa-miR-543	CLIP-seq
MIRT931046	hsa-miR-550a	CLIP-seq
MIRT2211032	hsa-miR-552	CLIP-seq
MIRT2211034	hsa-miR-633	CLIP-seq
MIRT931048	hsa-miR-935	CLIP-seq
MIRT2211040	hsa-miR-943	CLIP-seq
MIRT2210987	hsa-miR-2277-3p	CLIP-seq
MIRT1975523	hsa-miR-300	CLIP-seq
MIRT2679153	hsa-miR-323b-3p	CLIP-seq
MIRT1975530	hsa-miR-381	CLIP-seq
MIRT1975539	hsa-miR-4678	CLIP-seq
MIRT1975542	hsa-miR-548ag	CLIP-seq
MIRT1975543	hsa-miR-548ai	CLIP-seq
MIRT2679154	hsa-miR-624	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003724	Function	RNA helicase activity	IEA
GO:0004386	Function	Helicase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0030490	Process	Maturation of SSU-rRNA	IBA
GO:0030490	Process	Maturation of SSU-rRNA	IEA

Other IDs

• MIM: 612500
• HGNC: 20038
• e!Ensembl: ENSG00000278053

Protein

• UniProt ID: Q9Y2R4
• Protein name: Probable ATP-dependent RNA helicase DDX52 (EC 3.6.4.13) (ATP-dependent RNA helicase ROK1-like) (DEAD box protein 52)
• Protein function: Required for efficient ribosome biogenesis (By similarity). May control cell cycle progression by regulating translation of mRNAs that contain a terminal oligo pyrimidine (TOP) motif in their 5' UTRs, such as GTPBP4 (By similarity). {ECO:0000250
• PDB: 3DKP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00270	DEAD	189 → 363	DEAD/DEAH box helicase	Domain
  PF00271	Helicase_C	398 → 507	Helicase conserved C-terminal domain	Family

• Sequence:

  MDVHDLFRRLGAGAKFDTRRFSADAARFQIGKRKYDFDSSEVLQGLDFFGNKKSVPGVCG
  ASQTHQKPQNGEKKEESLTERKREQSKKKRKTMTSEIASQEEGATIQWMSSVEAKIEDKK
  VQRESKLTSGKLENLRKEKINFLRNKHKIHVQGTDLPDPIATFQQLDQEYKINSRLLQNI
  LDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPANKGFRALII
  SPTRELASQIHRELIKISEGTGFRIHMIHKAAVAAKKFGPKSSKKFDILVTTPNRLIYLL
  KQDPPGIDLASVEWLVVDESDKLFEDGKTGFRDQLASIFLACTSHKVRRAMFSATFAYDV
  EQWCKLNLDNVISVSIGARNSAVETVEQELLFVGSETGKLLAMRELVKKGFNPPVLVFVQ
  SIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKG
  VNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFTEDDKPLLRSVANVIQQAGCPVPE
  YIKGFQKLLSKQKKKMIKKPLERESISTTPKCFLEKAKDKQKKVTGQNSKKKVALEDKS

• Sequence length: 599

Pathways

Reactome:

Major pathway of rRNA processing in the nucleolus and cytosol

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Malignant neoplasm of prostate	Prostate cancer	BEFREE	16864594		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	16864594		★☆☆☆☆ Found in Text Mining only
Thrombocytopenia	Thrombocytopenia	Pubtator	31692082	Associate	★☆☆☆☆ Found in Text Mining only