Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	11043
Gene name	Midline 2
Gene symbol	MID2
Synonyms (NCBI Gene)	FXY2MRX101RNF60TRIM1XLID101
Chromosome	X
Chromosome location	Xq22.3
Summary	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures i

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021934	hsa-miR-128-3p	Microarray	17612493
MIRT043130	hsa-miR-324-5p	CLASH	23622248
MIRT1148576	hsa-miR-147	CLIP-seq
MIRT1148577	hsa-miR-155	CLIP-seq
MIRT1148578	hsa-miR-300	CLIP-seq
MIRT1148579	hsa-miR-3153	CLIP-seq
MIRT1148580	hsa-miR-346	CLIP-seq
MIRT1148581	hsa-miR-3614-3p	CLIP-seq
MIRT1148582	hsa-miR-3667-3p	CLIP-seq
MIRT1148583	hsa-miR-3690	CLIP-seq
MIRT1148584	hsa-miR-381	CLIP-seq
MIRT1148585	hsa-miR-3978	CLIP-seq
MIRT1148586	hsa-miR-4254	CLIP-seq
MIRT1148587	hsa-miR-4288	CLIP-seq
MIRT1148588	hsa-miR-4297	CLIP-seq
MIRT1148589	hsa-miR-4711-3p	CLIP-seq
MIRT1148590	hsa-miR-502-5p	CLIP-seq
MIRT1148591	hsa-miR-581	CLIP-seq
MIRT1148592	hsa-miR-632	CLIP-seq
MIRT1148593	hsa-miR-875-3p	CLIP-seq
MIRT1148594	hsa-miR-1208	CLIP-seq
MIRT1148595	hsa-miR-1224-5p	CLIP-seq
MIRT1148596	hsa-miR-1252	CLIP-seq
MIRT1148597	hsa-miR-1304	CLIP-seq
MIRT1148598	hsa-miR-1321	CLIP-seq
MIRT1148576	hsa-miR-147	CLIP-seq
MIRT1148599	hsa-miR-154	CLIP-seq
MIRT1148600	hsa-miR-196a	CLIP-seq
MIRT1148601	hsa-miR-196b	CLIP-seq
MIRT1148602	hsa-miR-210	CLIP-seq
MIRT1148603	hsa-miR-2110	CLIP-seq
MIRT1148604	hsa-miR-2113	CLIP-seq
MIRT1148605	hsa-miR-218	CLIP-seq
MIRT1148606	hsa-miR-219-2-3p	CLIP-seq
MIRT1148607	hsa-miR-2276	CLIP-seq
MIRT1148608	hsa-miR-28-5p	CLIP-seq
MIRT1148609	hsa-miR-2909	CLIP-seq
MIRT1148610	hsa-miR-297	CLIP-seq
MIRT1148611	hsa-miR-3134	CLIP-seq
MIRT1148612	hsa-miR-3139	CLIP-seq
MIRT1148613	hsa-miR-3150a-3p	CLIP-seq
MIRT1148614	hsa-miR-3150b-3p	CLIP-seq
MIRT1148579	hsa-miR-3153	CLIP-seq
MIRT1148615	hsa-miR-3160-5p	CLIP-seq
MIRT1148616	hsa-miR-3175	CLIP-seq
MIRT1148617	hsa-miR-3192	CLIP-seq
MIRT1148580	hsa-miR-346	CLIP-seq
MIRT1148581	hsa-miR-3614-3p	CLIP-seq
MIRT1148618	hsa-miR-3646	CLIP-seq
MIRT1148582	hsa-miR-3667-3p	CLIP-seq
MIRT1148619	hsa-miR-3668	CLIP-seq
MIRT1148620	hsa-miR-3675-3p	CLIP-seq
MIRT1148583	hsa-miR-3690	CLIP-seq
MIRT1148621	hsa-miR-3692	CLIP-seq
MIRT1148622	hsa-miR-369-3p	CLIP-seq
MIRT1148623	hsa-miR-374a	CLIP-seq
MIRT1148624	hsa-miR-374b	CLIP-seq
MIRT1148625	hsa-miR-376c	CLIP-seq
MIRT1148626	hsa-miR-3915	CLIP-seq
MIRT1148627	hsa-miR-3924	CLIP-seq
MIRT1148628	hsa-miR-3928	CLIP-seq
MIRT1148585	hsa-miR-3978	CLIP-seq
MIRT1148629	hsa-miR-4251	CLIP-seq
MIRT1148586	hsa-miR-4254	CLIP-seq
MIRT1148630	hsa-miR-4261	CLIP-seq
MIRT1148631	hsa-miR-4263	CLIP-seq
MIRT1148632	hsa-miR-4271	CLIP-seq
MIRT1148633	hsa-miR-4278	CLIP-seq
MIRT1148587	hsa-miR-4288	CLIP-seq
MIRT1148588	hsa-miR-4297	CLIP-seq
MIRT1148634	hsa-miR-431	CLIP-seq
MIRT1148635	hsa-miR-4311	CLIP-seq
MIRT1148636	hsa-miR-4419a	CLIP-seq
MIRT1148637	hsa-miR-4420	CLIP-seq
MIRT1148638	hsa-miR-4422	CLIP-seq
MIRT1148639	hsa-miR-4428	CLIP-seq
MIRT1148640	hsa-miR-4438	CLIP-seq
MIRT1148641	hsa-miR-4459	CLIP-seq
MIRT1148642	hsa-miR-4476	CLIP-seq
MIRT1148643	hsa-miR-4487	CLIP-seq
MIRT1148644	hsa-miR-4496	CLIP-seq
MIRT1148645	hsa-miR-4510	CLIP-seq
MIRT1148646	hsa-miR-452	CLIP-seq
MIRT1148647	hsa-miR-4534	CLIP-seq
MIRT1148648	hsa-miR-4633-3p	CLIP-seq
MIRT1148649	hsa-miR-4643	CLIP-seq
MIRT1148650	hsa-miR-4659a-3p	CLIP-seq
MIRT1148651	hsa-miR-4659b-3p	CLIP-seq
MIRT1148652	hsa-miR-466	CLIP-seq
MIRT1148653	hsa-miR-4661-3p	CLIP-seq
MIRT1148654	hsa-miR-4676-3p	CLIP-seq
MIRT1148655	hsa-miR-4689	CLIP-seq
MIRT1148656	hsa-miR-4694-3p	CLIP-seq
MIRT1148657	hsa-miR-4710	CLIP-seq
MIRT1148589	hsa-miR-4711-3p	CLIP-seq
MIRT1148658	hsa-miR-4711-5p	CLIP-seq
MIRT1148659	hsa-miR-4725-3p	CLIP-seq
MIRT1148660	hsa-miR-4729	CLIP-seq
MIRT1148661	hsa-miR-4739	CLIP-seq
MIRT1148662	hsa-miR-4742-3p	CLIP-seq
MIRT1148663	hsa-miR-4756-5p	CLIP-seq
MIRT1148664	hsa-miR-4772-3p	CLIP-seq
MIRT1148665	hsa-miR-4779	CLIP-seq
MIRT1148666	hsa-miR-4784	CLIP-seq
MIRT1148667	hsa-miR-4789-3p	CLIP-seq
MIRT1148668	hsa-miR-4795-3p	CLIP-seq
MIRT1148669	hsa-miR-4797-5p	CLIP-seq
MIRT1148670	hsa-miR-4799-5p	CLIP-seq
MIRT1148671	hsa-miR-491-5p	CLIP-seq
MIRT1148672	hsa-miR-495	CLIP-seq
MIRT1148590	hsa-miR-502-5p	CLIP-seq
MIRT1148673	hsa-miR-5096	CLIP-seq
MIRT1148674	hsa-miR-513a-3p	CLIP-seq
MIRT1148675	hsa-miR-515-5p	CLIP-seq
MIRT1148676	hsa-miR-539	CLIP-seq
MIRT1148677	hsa-miR-542-3p	CLIP-seq
MIRT1148678	hsa-miR-548ac	CLIP-seq
MIRT1148679	hsa-miR-548ae	CLIP-seq
MIRT1148680	hsa-miR-548aj	CLIP-seq
MIRT1148681	hsa-miR-548am	CLIP-seq
MIRT1148682	hsa-miR-548d-3p	CLIP-seq
MIRT1148683	hsa-miR-548m	CLIP-seq
MIRT1148684	hsa-miR-548n	CLIP-seq
MIRT1148685	hsa-miR-548x	CLIP-seq
MIRT1148686	hsa-miR-548z	CLIP-seq
MIRT1148687	hsa-miR-567	CLIP-seq
MIRT1148688	hsa-miR-568	CLIP-seq
MIRT1148689	hsa-miR-570	CLIP-seq
MIRT1148690	hsa-miR-576-5p	CLIP-seq
MIRT1148691	hsa-miR-579	CLIP-seq
MIRT1148591	hsa-miR-581	CLIP-seq
MIRT1148692	hsa-miR-622	CLIP-seq
MIRT1148592	hsa-miR-632	CLIP-seq
MIRT1148693	hsa-miR-636	CLIP-seq
MIRT1148694	hsa-miR-665	CLIP-seq
MIRT1148695	hsa-miR-708	CLIP-seq
MIRT1148593	hsa-miR-875-3p	CLIP-seq
MIRT1148696	hsa-miR-889	CLIP-seq
MIRT1148697	hsa-miR-939	CLIP-seq
MIRT1148594	hsa-miR-1208	CLIP-seq
MIRT2042252	hsa-miR-1324	CLIP-seq
MIRT2042253	hsa-miR-136	CLIP-seq
MIRT2042254	hsa-miR-149	CLIP-seq
MIRT1148599	hsa-miR-154	CLIP-seq
MIRT2042255	hsa-miR-183	CLIP-seq
MIRT2042256	hsa-miR-185	CLIP-seq
MIRT2042257	hsa-miR-193a-3p	CLIP-seq
MIRT2042258	hsa-miR-193b	CLIP-seq
MIRT1148600	hsa-miR-196a	CLIP-seq
MIRT1148601	hsa-miR-196b	CLIP-seq
MIRT1148604	hsa-miR-2113	CLIP-seq
MIRT2042259	hsa-miR-28-3p	CLIP-seq
MIRT2042260	hsa-miR-3064-5p	CLIP-seq
MIRT2042261	hsa-miR-3074-5p	CLIP-seq
MIRT2042262	hsa-miR-3117-5p	CLIP-seq
MIRT2042263	hsa-miR-3125	CLIP-seq
MIRT1148615	hsa-miR-3160-5p	CLIP-seq
MIRT2042264	hsa-miR-3163	CLIP-seq
MIRT2042265	hsa-miR-3183	CLIP-seq
MIRT2042266	hsa-miR-3189-3p	CLIP-seq
MIRT2042267	hsa-miR-325	CLIP-seq
MIRT2042268	hsa-miR-338-5p	CLIP-seq
MIRT2042269	hsa-miR-3611	CLIP-seq
MIRT2042270	hsa-miR-3613-3p	CLIP-seq
MIRT2042271	hsa-miR-3617	CLIP-seq
MIRT1148618	hsa-miR-3646	CLIP-seq
MIRT2042272	hsa-miR-3663-3p	CLIP-seq
MIRT2042273	hsa-miR-3671	CLIP-seq
MIRT1148621	hsa-miR-3692	CLIP-seq
MIRT2042274	hsa-miR-3916	CLIP-seq
MIRT2042275	hsa-miR-3926	CLIP-seq
MIRT2042276	hsa-miR-3929	CLIP-seq
MIRT2042277	hsa-miR-3942-3p	CLIP-seq
MIRT2042278	hsa-miR-410	CLIP-seq
MIRT2042279	hsa-miR-411	CLIP-seq
MIRT2042280	hsa-miR-4272	CLIP-seq
MIRT2042281	hsa-miR-4273	CLIP-seq
MIRT1148588	hsa-miR-4297	CLIP-seq
MIRT2042282	hsa-miR-4306	CLIP-seq
MIRT1148634	hsa-miR-431	CLIP-seq
MIRT2042283	hsa-miR-4312	CLIP-seq
MIRT2042284	hsa-miR-432	CLIP-seq
MIRT2042285	hsa-miR-4419b	CLIP-seq
MIRT2042286	hsa-miR-4435	CLIP-seq
MIRT2042287	hsa-miR-4443	CLIP-seq
MIRT2042288	hsa-miR-4448	CLIP-seq
MIRT2042289	hsa-miR-4478	CLIP-seq
MIRT1148644	hsa-miR-4496	CLIP-seq
MIRT1148646	hsa-miR-452	CLIP-seq
MIRT2042290	hsa-miR-4639-3p	CLIP-seq
MIRT2042291	hsa-miR-4644	CLIP-seq
MIRT2042292	hsa-miR-4652-3p	CLIP-seq
MIRT1148650	hsa-miR-4659a-3p	CLIP-seq
MIRT1148651	hsa-miR-4659b-3p	CLIP-seq
MIRT2042293	hsa-miR-4663	CLIP-seq
MIRT1148654	hsa-miR-4676-3p	CLIP-seq
MIRT2042294	hsa-miR-4693-3p	CLIP-seq
MIRT2042295	hsa-miR-4698	CLIP-seq
MIRT2042296	hsa-miR-4699-3p	CLIP-seq
MIRT1148658	hsa-miR-4711-5p	CLIP-seq
MIRT2042297	hsa-miR-4712-3p	CLIP-seq
MIRT2042298	hsa-miR-4712-5p	CLIP-seq
MIRT2042299	hsa-miR-4723-3p	CLIP-seq
MIRT2042300	hsa-miR-4761-5p	CLIP-seq
MIRT2042301	hsa-miR-4778-5p	CLIP-seq
MIRT2042302	hsa-miR-4794	CLIP-seq
MIRT1148669	hsa-miR-4797-5p	CLIP-seq
MIRT2042303	hsa-miR-4802-3p	CLIP-seq
MIRT2042304	hsa-miR-485-3p	CLIP-seq
MIRT2042305	hsa-miR-494	CLIP-seq
MIRT1148672	hsa-miR-495	CLIP-seq
MIRT1148590	hsa-miR-502-5p	CLIP-seq
MIRT2042306	hsa-miR-513c	CLIP-seq
MIRT2042307	hsa-miR-514	CLIP-seq
MIRT2042308	hsa-miR-514b-3p	CLIP-seq
MIRT2042309	hsa-miR-514b-5p	CLIP-seq
MIRT1148675	hsa-miR-515-5p	CLIP-seq
MIRT2042310	hsa-miR-518e	CLIP-seq
MIRT2042311	hsa-miR-526b	CLIP-seq
MIRT2042312	hsa-miR-548g	CLIP-seq
MIRT2042313	hsa-miR-548s	CLIP-seq
MIRT2042314	hsa-miR-556-5p	CLIP-seq
MIRT1148689	hsa-miR-570	CLIP-seq
MIRT1148691	hsa-miR-579	CLIP-seq
MIRT2042315	hsa-miR-610	CLIP-seq
MIRT2042316	hsa-miR-621	CLIP-seq
MIRT1148692	hsa-miR-622	CLIP-seq
MIRT2042317	hsa-miR-628-3p	CLIP-seq
MIRT2042318	hsa-miR-641	CLIP-seq
MIRT2042319	hsa-miR-668	CLIP-seq
MIRT2042320	hsa-miR-765	CLIP-seq
MIRT2042321	hsa-miR-770-5p	CLIP-seq
MIRT2271945	hsa-miR-1276	CLIP-seq
MIRT2042253	hsa-miR-136	CLIP-seq
MIRT2042262	hsa-miR-3117-5p	CLIP-seq
MIRT2042266	hsa-miR-3189-3p	CLIP-seq
MIRT1148635	hsa-miR-4311	CLIP-seq
MIRT2042284	hsa-miR-432	CLIP-seq
MIRT2042287	hsa-miR-4443	CLIP-seq
MIRT2042290	hsa-miR-4639-3p	CLIP-seq
MIRT2271946	hsa-miR-4744	CLIP-seq
MIRT1148590	hsa-miR-502-5p	CLIP-seq
MIRT2271947	hsa-miR-583	CLIP-seq
MIRT1148692	hsa-miR-622	CLIP-seq
MIRT2042320	hsa-miR-765	CLIP-seq
MIRT1148604	hsa-miR-2113	CLIP-seq
MIRT1148605	hsa-miR-218	CLIP-seq
MIRT1148615	hsa-miR-3160-5p	CLIP-seq
MIRT2042273	hsa-miR-3671	CLIP-seq
MIRT2042280	hsa-miR-4272	CLIP-seq
MIRT2570918	hsa-miR-4658	CLIP-seq
MIRT1148650	hsa-miR-4659a-3p	CLIP-seq
MIRT1148651	hsa-miR-4659b-3p	CLIP-seq
MIRT2570919	hsa-miR-4758-5p	CLIP-seq
MIRT2570920	hsa-miR-4765	CLIP-seq
MIRT2570921	hsa-miR-562	CLIP-seq
MIRT1148693	hsa-miR-636	CLIP-seq
MIRT2685018	hsa-miR-1231	CLIP-seq
MIRT1148604	hsa-miR-2113	CLIP-seq
MIRT2685019	hsa-miR-216b	CLIP-seq
MIRT1148605	hsa-miR-218	CLIP-seq
MIRT1148615	hsa-miR-3160-5p	CLIP-seq
MIRT2685020	hsa-miR-3607-3p	CLIP-seq
MIRT2685021	hsa-miR-3655	CLIP-seq
MIRT2685022	hsa-miR-3686	CLIP-seq
MIRT1148587	hsa-miR-4288	CLIP-seq
MIRT2570918	hsa-miR-4658	CLIP-seq
MIRT1148650	hsa-miR-4659a-3p	CLIP-seq
MIRT1148651	hsa-miR-4659b-3p	CLIP-seq
MIRT2570919	hsa-miR-4758-5p	CLIP-seq
MIRT2570920	hsa-miR-4765	CLIP-seq
MIRT2570921	hsa-miR-562	CLIP-seq
MIRT1148592	hsa-miR-632	CLIP-seq
MIRT1148693	hsa-miR-636	CLIP-seq

Show/Hide all (35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IDA	23077300
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 26871637, 28514442, 30886144, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IBA
GO:0005874	Component	Microtubule	IDA	10400986
GO:0005874	Component	Microtubule	IDA	11806752
GO:0005874	Component	Microtubule	IEA
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IEA
GO:0008017	Function	Microtubule binding	IMP	11806752
GO:0008270	Function	Zinc ion binding	IEA
GO:0010508	Process	Positive regulation of autophagy	IMP	26347139
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019899	Function	Enzyme binding	IEA
GO:0019899	Function	Enzyme binding	IPI	11806752
GO:0032897	Process	Negative regulation of viral transcription	IDA	18248090
GO:0035372	Process	Protein localization to microtubule	IBA
GO:0035372	Process	Protein localization to microtubule	IEA
GO:0035372	Process	Protein localization to microtubule	IMP	11806752
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0042803	Function	Protein homodimerization activity	IDA	11806752
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IDA	23077300
GO:0044790	Process	Suppression of viral release by host	IDA	18248090
GO:0045087	Process	Innate immune response	IDA	18248090
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046597	Process	Host-mediated suppression of symbiont invasion	IDA	18248090
GO:0046872	Function	Metal ion binding	IEA
GO:0051219	Function	Phosphoprotein binding	IEA
GO:0051219	Function	Phosphoprotein binding	IPI	11806752
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:1902533	Process	Positive regulation of intracellular signal transduction	IEA

MIM	HGNC	e!Ensembl
300204	7096	ENSG00000080561

Q9UJV3

Protein name

Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1)

Protein function

E3 ubiquitin ligase that plays a role in microtubule stabilization. Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2

PDB

2DJA , 2DMK , 7QRZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13445	zf-RING_UBOX	30 → 77	RING-type zinc-finger	Domain
PF00643	zf-B_box	191 → 232	B-box zinc finger	Domain
PF18568	COS	343 → 394	TRIM C-terminal subgroup One Signature domain	Domain
PF00622	SPRY	590 → 705	SPRY domain	Family

Tissue specificity

TISSUE SPECIFICITY: Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine.

Sequence

MGESPASVVLNASGGLFSLKMETLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILVS
SCSSGESIEPITAFQCPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSES
RRERTYRPTTAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPFTSHR
LVEPVPDTHLRGITCLDHENEKVNMYCVSDDQLICALCKLVGRHRDHQVASLNDRFEKLK
QTLEMNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLMEECDELVEIIQQRKQMI
AVKIKETKVMKLRKLAQQVANCRQCLERSTVLINQAEHILKENDQARFLQSAKNIAERVA
MATASSQVLIPDINFNDAFENFALDFSREKKLLEGLDYLTAPNPPSIREELCTASHDTIT
VHWISDDEFSISSYELQYTIFTGQANFISKSWCSWGLWPEIRKCKEAVSCSRLAGAPRGL
YNSVDSWMIVPNIKQNHYTVHGLQSGTRYIFIVKAINQAGSRNSEPTRLKTNSQPFKLDP
KMTHKKLKISNDGLQMEKDESSLKKSHTPERFSGTGCYGAAGNIFIDSGCHYWEVVMGSS
TWYAIGIAYKSAPKNEWIGKNASSWVFSRCNSNFVVRHNNKEMLVDVPPHLKRLGVLLDY
DNNMLSFYDPANSLHLHTFDVTFILPVCPTFTIWNKSLMILSGLPAPDFIDYPERQECNC
RPQESPYVSGMKTCH

Sequence length

735

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Intellectual disability, X-linked 101	Likely pathogenic; Pathogenic	rs1933190705, rs200917006, rs587777605	RCV001352687 RCV001843845 RCV000133396	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Esophageal atresia	Uncertain significance	ClinVar Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED 101	—	CTD, Disgenet, HPO CTD, Disgenet, HPO CTD, Disgenet, HPO	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL RETARDATION, X-LINKED NONSYNDROMIC	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MID2-related disorder	Likely benign; Uncertain significance; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SYNDROMIC X-LINKED INTELLECTUAL DISABILITY	—	Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pyloric stenosis	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
X-LINKED NON-SYNDROMIC INTELLECTUAL DISABILITY	—	Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (31)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
2-3 toe syndactyly	Syndactyly Of The Toes	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	29794786	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Attention deficit hyperactivity disorder	Attention Deficit Hyperactivity Disorder	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic behavior	Autism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	39245738	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	11806752	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Facial paralysis	Facial paralysis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
FG syndrome	FG Syndrome	BEFREE	16283679		★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	24115387		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Intellectual developmental disorder	Pubtator	26748699	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Macrocephaly	Macrocephaly	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Meckel Diverticulum	Meckel Diverticulum	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Retardation, X-Linked	Mental retardation	BEFREE	24115387		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Retardation, X-Linked 1	Mental Retardation, X-Linked	ORPHANET_DG	24115387		★★★★★ ★☆☆☆☆ Found in Text Mining only
MENTAL RETARDATION, X-LINKED 101	Mental Retardation, X-Linked	UNIPROT_DG	24115387		★★★★★ ★☆☆☆☆ Found in Text Mining only
MENTAL RETARDATION, X-LINKED 101	Mental Retardation, X-Linked	CTD_human_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
MENTAL RETARDATION, X-LINKED 101	Mental Retardation, X-Linked	CLINVAR_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Mild neurosensory hearing impairment	Neurosensory Hearing impairment	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Moderate intellectual disability	Mental retardation	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Mouth neoplasm	Pubtator	39245738	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Opitz GBBB Syndrome, X-Linked	Opitz GBBB Syndrome, X-Linked	BEFREE	10400986, 10644436, 11806752		★★★★★ ★☆☆☆☆ Found in Text Mining only
Opitz-G syndrome, type 2	Opitz GBBB syndrome	BEFREE	11806752, 16283679, 20534674		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	23791107	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	35266954	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Severe intellectual disability	Mental retardation	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Strabismus	Strabismus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Tonic - clonic seizures	Seizure	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
X-linked non-syndromic intellectual disability	Non-Syndromic Intellectual Disability, X-Linked	Orphanet			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

MID2 (midline 2)