STON1 (stonin 1)

Gene

• Entrez ID: 11037
• Gene name: Stonin 1
• Gene symbol: STON1
• Synonyms (NCBI Gene): SALF, SBLF, STN1, STNB1
• Chromosome: 2
• Chromosome location: 2p16.3
• Summary: Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner surface of the plasma membrane. This gene encodes one of two human homologs of the Drosophila melanogaster stoned B protein. This protein is rela

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1399042	hsa-miR-1260	CLIP-seq
MIRT1399043	hsa-miR-1260b	CLIP-seq
MIRT1399044	hsa-miR-1285	CLIP-seq
MIRT1399045	hsa-miR-1827	CLIP-seq
MIRT1399046	hsa-miR-188-3p	CLIP-seq
MIRT1399047	hsa-miR-188-5p	CLIP-seq
MIRT1399048	hsa-miR-3140-3p	CLIP-seq
MIRT1399049	hsa-miR-3156-3p	CLIP-seq
MIRT1399050	hsa-miR-3187-5p	CLIP-seq
MIRT1399051	hsa-miR-3929	CLIP-seq
MIRT1399052	hsa-miR-425	CLIP-seq
MIRT1399053	hsa-miR-4419b	CLIP-seq
MIRT1399054	hsa-miR-4459	CLIP-seq
MIRT1399055	hsa-miR-4478	CLIP-seq
MIRT1399056	hsa-miR-4505	CLIP-seq
MIRT1399057	hsa-miR-4645-5p	CLIP-seq
MIRT1399058	hsa-miR-4649-3p	CLIP-seq
MIRT1399059	hsa-miR-4673	CLIP-seq
MIRT1399060	hsa-miR-4695-5p	CLIP-seq
MIRT1399061	hsa-miR-4722-5p	CLIP-seq
MIRT1399062	hsa-miR-4768-3p	CLIP-seq
MIRT1399063	hsa-miR-4780	CLIP-seq
MIRT1399064	hsa-miR-4793-3p	CLIP-seq
MIRT1399065	hsa-miR-508-5p	CLIP-seq
MIRT1399066	hsa-miR-603	CLIP-seq
MIRT1399067	hsa-miR-612	CLIP-seq
MIRT1399068	hsa-miR-623	CLIP-seq
MIRT1399069	hsa-miR-642b	CLIP-seq
MIRT1399070	hsa-miR-658	CLIP-seq
MIRT1399071	hsa-miR-665	CLIP-seq
MIRT1399072	hsa-miR-940	CLIP-seq
MIRT1399073	hsa-miR-103a	CLIP-seq
MIRT1399074	hsa-miR-105	CLIP-seq
MIRT1399075	hsa-miR-107	CLIP-seq
MIRT1399076	hsa-miR-1276	CLIP-seq
MIRT1399077	hsa-miR-15a	CLIP-seq
MIRT1399078	hsa-miR-15b	CLIP-seq
MIRT1399079	hsa-miR-16	CLIP-seq
MIRT1399045	hsa-miR-1827	CLIP-seq
MIRT1399047	hsa-miR-188-5p	CLIP-seq
MIRT1399080	hsa-miR-195	CLIP-seq
MIRT1399081	hsa-miR-2053	CLIP-seq
MIRT1399082	hsa-miR-2054	CLIP-seq
MIRT1399083	hsa-miR-3117-5p	CLIP-seq
MIRT1399084	hsa-miR-3143	CLIP-seq
MIRT1399085	hsa-miR-3189-3p	CLIP-seq
MIRT1399086	hsa-miR-3199	CLIP-seq
MIRT1399087	hsa-miR-3646	CLIP-seq
MIRT1399088	hsa-miR-369-3p	CLIP-seq
MIRT1399089	hsa-miR-374a	CLIP-seq
MIRT1399090	hsa-miR-374b	CLIP-seq
MIRT1399091	hsa-miR-375	CLIP-seq
MIRT1399092	hsa-miR-380	CLIP-seq
MIRT1399093	hsa-miR-3942-5p	CLIP-seq
MIRT1399094	hsa-miR-424	CLIP-seq
MIRT1399095	hsa-miR-4265	CLIP-seq
MIRT1399096	hsa-miR-4296	CLIP-seq
MIRT1399097	hsa-miR-4318	CLIP-seq
MIRT1399098	hsa-miR-4322	CLIP-seq
MIRT1399099	hsa-miR-4328	CLIP-seq
MIRT1399100	hsa-miR-4417	CLIP-seq
MIRT1399054	hsa-miR-4459	CLIP-seq
MIRT1399101	hsa-miR-451b	CLIP-seq
MIRT1399102	hsa-miR-4670-3p	CLIP-seq
MIRT1399060	hsa-miR-4695-5p	CLIP-seq
MIRT1399103	hsa-miR-4703-5p	CLIP-seq
MIRT1399104	hsa-miR-4711-5p	CLIP-seq
MIRT1399061	hsa-miR-4722-5p	CLIP-seq
MIRT1399062	hsa-miR-4768-3p	CLIP-seq
MIRT1399105	hsa-miR-4775	CLIP-seq
MIRT1399063	hsa-miR-4780	CLIP-seq
MIRT1399106	hsa-miR-497	CLIP-seq
MIRT1399107	hsa-miR-543	CLIP-seq
MIRT1399108	hsa-miR-569	CLIP-seq
MIRT1399109	hsa-miR-582-3p	CLIP-seq
MIRT1399068	hsa-miR-623	CLIP-seq
MIRT1399070	hsa-miR-658	CLIP-seq
MIRT1399071	hsa-miR-665	CLIP-seq
MIRT1399072	hsa-miR-940	CLIP-seq
MIRT2119630	hsa-miR-1207-5p	CLIP-seq
MIRT1399044	hsa-miR-1285	CLIP-seq
MIRT2119631	hsa-miR-1321	CLIP-seq
MIRT2119632	hsa-miR-204	CLIP-seq
MIRT1399081	hsa-miR-2053	CLIP-seq
MIRT2119633	hsa-miR-211	CLIP-seq
MIRT2119634	hsa-miR-3121-5p	CLIP-seq
MIRT1399050	hsa-miR-3187-5p	CLIP-seq
MIRT1399085	hsa-miR-3189-3p	CLIP-seq
MIRT2119635	hsa-miR-3938	CLIP-seq
MIRT2119636	hsa-miR-3940-3p	CLIP-seq
MIRT2119637	hsa-miR-4270	CLIP-seq
MIRT2119638	hsa-miR-4441	CLIP-seq
MIRT2119639	hsa-miR-4494	CLIP-seq
MIRT2119640	hsa-miR-4739	CLIP-seq
MIRT2119641	hsa-miR-4755-5p	CLIP-seq
MIRT2119642	hsa-miR-4756-5p	CLIP-seq
MIRT2119643	hsa-miR-4763-3p	CLIP-seq
MIRT2119644	hsa-miR-490-3p	CLIP-seq
MIRT1399109	hsa-miR-582-3p	CLIP-seq
MIRT1399067	hsa-miR-612	CLIP-seq
MIRT1399068	hsa-miR-623	CLIP-seq
MIRT2119645	hsa-miR-649	CLIP-seq
MIRT2119630	hsa-miR-1207-5p	CLIP-seq
MIRT1399044	hsa-miR-1285	CLIP-seq
MIRT2341779	hsa-miR-132	CLIP-seq
MIRT2119631	hsa-miR-1321	CLIP-seq
MIRT2341780	hsa-miR-212	CLIP-seq
MIRT1399050	hsa-miR-3187-5p	CLIP-seq
MIRT1399085	hsa-miR-3189-3p	CLIP-seq
MIRT2341781	hsa-miR-329	CLIP-seq
MIRT2341782	hsa-miR-362-3p	CLIP-seq
MIRT2119636	hsa-miR-3940-3p	CLIP-seq
MIRT2341783	hsa-miR-3941	CLIP-seq
MIRT2119637	hsa-miR-4270	CLIP-seq
MIRT2119638	hsa-miR-4441	CLIP-seq
MIRT1399054	hsa-miR-4459	CLIP-seq
MIRT1399058	hsa-miR-4649-3p	CLIP-seq
MIRT2119640	hsa-miR-4739	CLIP-seq
MIRT2119642	hsa-miR-4756-5p	CLIP-seq
MIRT2119643	hsa-miR-4763-3p	CLIP-seq
MIRT1399062	hsa-miR-4768-3p	CLIP-seq
MIRT2341784	hsa-miR-4797-3p	CLIP-seq
MIRT2119644	hsa-miR-490-3p	CLIP-seq
MIRT2341785	hsa-miR-548p	CLIP-seq
MIRT1399109	hsa-miR-582-3p	CLIP-seq
MIRT1399066	hsa-miR-603	CLIP-seq
MIRT1399067	hsa-miR-612	CLIP-seq
MIRT2119645	hsa-miR-649	CLIP-seq
MIRT2119630	hsa-miR-1207-5p	CLIP-seq
MIRT1399044	hsa-miR-1285	CLIP-seq
MIRT2119631	hsa-miR-1321	CLIP-seq
MIRT1399050	hsa-miR-3187-5p	CLIP-seq
MIRT1399085	hsa-miR-3189-3p	CLIP-seq
MIRT2119637	hsa-miR-4270	CLIP-seq
MIRT2119638	hsa-miR-4441	CLIP-seq
MIRT2119640	hsa-miR-4739	CLIP-seq
MIRT2119642	hsa-miR-4756-5p	CLIP-seq
MIRT2119643	hsa-miR-4763-3p	CLIP-seq
MIRT2119644	hsa-miR-490-3p	CLIP-seq
MIRT1399109	hsa-miR-582-3p	CLIP-seq
MIRT1399067	hsa-miR-612	CLIP-seq
MIRT2119645	hsa-miR-649	CLIP-seq
MIRT2460704	hsa-miR-3120-5p	CLIP-seq
MIRT2460705	hsa-miR-3613-3p	CLIP-seq
MIRT2460706	hsa-miR-3664-5p	CLIP-seq
MIRT2460707	hsa-miR-3672	CLIP-seq
MIRT2460708	hsa-miR-371-5p	CLIP-seq
MIRT2460709	hsa-miR-371b-5p	CLIP-seq
MIRT2460710	hsa-miR-4522	CLIP-seq
MIRT2460711	hsa-miR-548a-5p	CLIP-seq
MIRT2460712	hsa-miR-548ab	CLIP-seq
MIRT2460713	hsa-miR-548ak	CLIP-seq
MIRT2460714	hsa-miR-548b-5p	CLIP-seq
MIRT2460715	hsa-miR-548c-5p	CLIP-seq
MIRT2460716	hsa-miR-548d-5p	CLIP-seq
MIRT2460717	hsa-miR-548h	CLIP-seq
MIRT2460718	hsa-miR-548i	CLIP-seq
MIRT2460719	hsa-miR-548j	CLIP-seq
MIRT2460720	hsa-miR-548n	CLIP-seq
MIRT2460721	hsa-miR-548w	CLIP-seq
MIRT2460722	hsa-miR-548y	CLIP-seq
MIRT2460723	hsa-miR-559	CLIP-seq
MIRT2635693	hsa-miR-1273f	CLIP-seq
MIRT1399044	hsa-miR-1285	CLIP-seq
MIRT1399077	hsa-miR-15a	CLIP-seq
MIRT1399078	hsa-miR-15b	CLIP-seq
MIRT1399079	hsa-miR-16	CLIP-seq
MIRT1399080	hsa-miR-195	CLIP-seq
MIRT1399083	hsa-miR-3117-5p	CLIP-seq
MIRT2460704	hsa-miR-3120-5p	CLIP-seq
MIRT1399050	hsa-miR-3187-5p	CLIP-seq
MIRT2460705	hsa-miR-3613-3p	CLIP-seq
MIRT1399087	hsa-miR-3646	CLIP-seq
MIRT2460706	hsa-miR-3664-5p	CLIP-seq
MIRT2460707	hsa-miR-3672	CLIP-seq
MIRT2460708	hsa-miR-371-5p	CLIP-seq
MIRT2460709	hsa-miR-371b-5p	CLIP-seq
MIRT1399094	hsa-miR-424	CLIP-seq
MIRT1399056	hsa-miR-4505	CLIP-seq
MIRT1399101	hsa-miR-451b	CLIP-seq
MIRT2460710	hsa-miR-4522	CLIP-seq
MIRT1399057	hsa-miR-4645-5p	CLIP-seq
MIRT1399059	hsa-miR-4673	CLIP-seq
MIRT2635694	hsa-miR-4747-5p	CLIP-seq
MIRT2635695	hsa-miR-4765	CLIP-seq
MIRT1399064	hsa-miR-4793-3p	CLIP-seq
MIRT2341784	hsa-miR-4797-3p	CLIP-seq
MIRT2635696	hsa-miR-4797-5p	CLIP-seq
MIRT1399106	hsa-miR-497	CLIP-seq
MIRT1399065	hsa-miR-508-5p	CLIP-seq
MIRT2635697	hsa-miR-520a-5p	CLIP-seq
MIRT2635698	hsa-miR-525-5p	CLIP-seq
MIRT2460711	hsa-miR-548a-5p	CLIP-seq
MIRT2460712	hsa-miR-548ab	CLIP-seq
MIRT2460713	hsa-miR-548ak	CLIP-seq
MIRT2460714	hsa-miR-548b-5p	CLIP-seq
MIRT2460715	hsa-miR-548c-5p	CLIP-seq
MIRT2460716	hsa-miR-548d-5p	CLIP-seq
MIRT2460717	hsa-miR-548h	CLIP-seq
MIRT2460718	hsa-miR-548i	CLIP-seq
MIRT2460719	hsa-miR-548j	CLIP-seq
MIRT2460720	hsa-miR-548n	CLIP-seq
MIRT2341785	hsa-miR-548p	CLIP-seq
MIRT2460721	hsa-miR-548w	CLIP-seq
MIRT2460722	hsa-miR-548y	CLIP-seq
MIRT2460723	hsa-miR-559	CLIP-seq
MIRT1399066	hsa-miR-603	CLIP-seq
MIRT1399067	hsa-miR-612	CLIP-seq
MIRT1399069	hsa-miR-642b	CLIP-seq
MIRT2635699	hsa-miR-759	CLIP-seq
MIRT1399044	hsa-miR-1285	CLIP-seq
MIRT2692306	hsa-miR-1304	CLIP-seq
MIRT2119634	hsa-miR-3121-5p	CLIP-seq
MIRT2692307	hsa-miR-3184	CLIP-seq
MIRT1399050	hsa-miR-3187-5p	CLIP-seq
MIRT2692308	hsa-miR-3611	CLIP-seq
MIRT2692309	hsa-miR-3923	CLIP-seq
MIRT2692310	hsa-miR-423-5p	CLIP-seq
MIRT2692311	hsa-miR-4427	CLIP-seq
MIRT1399056	hsa-miR-4505	CLIP-seq
MIRT1399057	hsa-miR-4645-5p	CLIP-seq
MIRT1399059	hsa-miR-4673	CLIP-seq
MIRT2692312	hsa-miR-4688	CLIP-seq
MIRT2692313	hsa-miR-4714-3p	CLIP-seq
MIRT1399064	hsa-miR-4793-3p	CLIP-seq
MIRT2635696	hsa-miR-4797-5p	CLIP-seq
MIRT1399065	hsa-miR-508-5p	CLIP-seq
MIRT1399066	hsa-miR-603	CLIP-seq
MIRT1399067	hsa-miR-612	CLIP-seq
MIRT2692314	hsa-miR-628-5p	CLIP-seq
MIRT2119645	hsa-miR-649	CLIP-seq
MIRT2635699	hsa-miR-759	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0005905	Component	Clathrin-coated pit	IEA
GO:0006897	Process	Endocytosis	IEA
GO:0006897	Process	Endocytosis	IEA
GO:0006929	Process	Substrate-dependent cell migration	IEA
GO:0008021	Component	Synaptic vesicle	IBA
GO:0016020	Component	Membrane	IEA
GO:0030100	Process	Regulation of endocytosis	IBA
GO:0030100	Process	Regulation of endocytosis	IDA	11454741
GO:0030100	Process	Regulation of endocytosis	IEA
GO:0030122	Component	AP-2 adaptor complex	IBA
GO:0031252	Component	Cell leading edge	IEA
GO:0035615	Function	Clathrin adaptor activity	IBA
GO:0042995	Component	Cell projection	IEA
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	IEA
GO:0048041	Process	Focal adhesion assembly	IEA
GO:0048488	Process	Synaptic vesicle endocytosis	IBA
GO:0072583	Process	Clathrin-dependent endocytosis	IBA
GO:0097178	Process	Ruffle assembly	IEA
GO:0120181	Process	Focal adhesion disassembly	IEA
GO:0140312	Function	Cargo adaptor activity	IEA

Other IDs

• MIM: 605357
• HGNC: 17003
• e!Ensembl: ENSG00000243244

Interactions View interactions

Pathways

Reactome:

Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Myoepithelial tumor	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POST-OPERATIVE ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPORADIC AMYOTROPHIC LATERAL SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute leukemia	Leukemia	BEFREE	17135274		★☆☆☆☆ Found in Text Mining only
Adrenoleukodystrophy	Adrenoleukodystrophy	BEFREE	28274107		★☆☆☆☆ Found in Text Mining only
Blood Coagulation Disorders	Blood Coagulation Disorders	BEFREE	29194678		★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	36759775	Inhibit	★☆☆☆☆ Found in Text Mining only
Encephalopathies	Epileptic encephalopathy	BEFREE	30368998		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	29685768		★☆☆☆☆ Found in Text Mining only
Esophageal Varices	Esophageal varix	BEFREE	30368998		★☆☆☆☆ Found in Text Mining only
FRAXE Syndrome	Fragile X syndrome	BEFREE	17135274		★☆☆☆☆ Found in Text Mining only
Fulminant hepatitis	Fulminant Hepatitis	BEFREE	28736976		★☆☆☆☆ Found in Text Mining only
Hepatolenticular Degeneration	Hepatolenticular Degeneration	BEFREE	30359967, 30368998		★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney Disease	BEFREE	28259424		★☆☆☆☆ Found in Text Mining only
Liver Failure, Acute	Liver failure	BEFREE	21143345, 29946176, 30359967		★☆☆☆☆ Found in Text Mining only
Macular Degeneration	Macular degeneration	Pubtator	28775256	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29777796		★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic ovary syndrome	Pubtator	26305227	Stimulate	★☆☆☆☆ Found in Text Mining only